Week 8 NFL Lines, Odds, and Best Bets for Every Game
Written By Blaise Bourgeois | Last Updated at October 25, 2025
Week 8 of the NFL season delivers some of the most intriguing matchups of the year, with a rematch of the New York Giants' upset over their NFC East rivals, the Philadelphia Eagles, dominating the early slate.
A real contender-or-pretender matchup between the Dallas Cowboys and Denver Broncos is the marquee game in the afternoon window, while Sunday Night Football sees Aaron Rodgers face his former team for the first and possibly the only time as the 4-2 Steelers host the 4-1-1 Packers.
Finally, Monday Night Football brings us a phenomenal clash between the Washington Commanders and the Kansas City Chiefs, though Marcus Mariota will start in place of Jayden Daniels.
The betting market will be awfully juicy this week, with large lines across the board allowing you to take advantage of massive value. Before you lock in your Week 8 NFL best bets, compare odds across the top sports betting apps. You can check out the latest odds below.
Many of our favorite sportsbooks are putting out new promos ahead of Sunday’s slate, so combining those with our value picks can maximize your edge. Without further ado, here's your guide to all the NFL Week 8 games, complete with odds, analysis, and the best value plays.
NFL Sunday Early Afternoon
Buffalo Bills @ Carolina Panthers
Odds: Bills -7.5 (ML: Bills -400, Panthers +315 | Over/Under: 46.5 (via FanDuel)
Best Bets:
- Panthers +7.5
- Rico Dowdle Anytime Touchdown (+150)
The Bills showed how vulnerable they are against elite rushing attacks, allowing Bijan Robinson to have the best game of his career. They now have to take on a dual threat in Chuba Hubbard and Rico Dowdle with the league's second-worst rush defense.
Dowdle got most of the touches last week in Hubbard's return to action, and will likely still do so, given his top performances in Hubbard's absence.
The Bills have not looked great this season, despite their 4-0 start. They've lost two straight against the Patriots and the Falcons, while their four wins have come against teams with a combined 3-24 record. They now take on an upstart Panthers side that is 3-0 at home this season and looking better every week.
As long as the Bills still have expectations of years past, you should continue to bet against them. I actually think the Panthers can pull the upset and are worth getting action at +315.
Chicago Bears @ Baltimore Ravens
Odds: Ravens -3.5 (ML: Bears +164, Ravens -198 | Over/Under: 48.5 (via DraftKings)
Best Bets:
- Bears ML
- Over 48.5
The Chicago Bears are on a four-game winning streak and have scored 25 points or more in each of those wins. They haven't accomplished such a feat since the 1990 season. On Sunday, they have a very winnable game in Baltimore.
As of early Saturday, Lamar Jackson is questionable to finally make his return, and is leaning towards not playing. If Jackson is unable to start, Tyler Huntley will get the nod ahead of Cooper Rush.
While the Ravens have been injury-plagued over the last couple of weeks, they will get LB Roquan Smith, OT Ronnie Stanley, and FB Patrick Ricard back to look more like their former selves.
The line has shifted dramatically over the last few hours after being at Ravens -7 since the beginning of the week. Expect the line to continue to shift in the Bears' favor and bet Chicago for plus-money while you still can.
Miami Dolphins @ Atlanta Falcons
Odds: Falcons -7.5 (ML: Falcons -425, Dolphins +325 | Over/Under: 44.5 (via BetMGM Sportsbook)
Best Bets:
- Falcons -7.5
- Bijan Robinson Over 137.5 Rushing and Receiving Yards
It's Bijan Robinson at home against the worst rushing defense in all of football. That's really all you need to know.
We think that the Dolphins will struggle to do anything on either side of the ball, and Robinson will have one of the best games of his career in a Falcons blowout win.
New York Jets @ Cincinnati Bengals
Odds: Bengals -6 (ML: Jets +240, Bengals -310 | Over/Under: 44.5 (via Caesars Sportsbook)
Best Bets:
- Bengals -6
- Samaje Perine 50+ Rushing Yards (+425)
Are we really going to bet against Joe Flacco with the Bengals offense at home against the winless Jets? Absolutely not. We're shocked that the Bengals are only six-point favorites and would take -14.5 at over +200 (+210 on Caesars Sportsbook) where you can find it.
The game could be out of reach early, which could give Samaje Perine a great chance to get a ton of carries. Perine has already started earning more touches since Flacco took over and had 31 yards on seven carries in a close game last week. If he gets the chance to touch the ball at least 12 times, this +425 could be an incredible shout.
San Francisco 49ers @ Houston Texans
Odds: Texans -2 (ML: 49ers +110, Texans -130 | Over/Under: 42 (via BetMGM Sportsbook)
Best Bets:
- Under 42
- Eddy Pineiro Over 1.5 Field Goals (-145)
In one of the stranger and more unpredictable matchups in the NFL this season, the 5-2 49ers take on the stingiest defense they've faced all season in the 2-4 Texans.
Despite the huge gap in the records and San Francisco beginning the week as -1.5 point betting favorites, the line has gradually shifted in Houston's favor.
The Texans have allowed a league-best 14.7 points per game this season, with opponents scoring on just 22.4% of all drives this season. Predictably, that number is the best in the NFL, and it's not even close, with the Vikings ranking second at 30.9%.
Whether Mac Jones and the 49ers will have enough to take down the Texans is anyone's guess. However, the Texans' defense should keep this game low-scoring, and 49ers kicker Eddy Pineiro should get plenty of action.
Cleveland Browns @ New England Patriots
Odds: Patriots -7 (ML: Browns +290, Patriots -360 | Over/Under: 40.5 (via FanDuel)
Best Bets:
- Under 40.5
- Quinshon Judkins Anytime Touchdown
If we think two things are true this year, it's this: The New England Patriots are the most underrated team in football, and Quinshon Judkins may be the best running back in all of football.
The Patriots could very easily be 6-0 this season, and Judkins would likely be one of the NFL's leading rushers if he had a full offseason camp and any semblance of an offensive line to run behind.
Although the Browns' defense is incredibly stout, we don't think the Patriots will have much trouble taking care of the Browns on their own turf. However, we don't see many points in this one and aren't confident that they'll blow them out, either.
New York Giants @ Philadelphia Eagles
Odds: Eagles -7.5 (ML: Giants +310, Eagles -395 | Over/Under: 43.5 (via DraftKings)
Best Bets:
- Eagles -7.5
- DeVonta Smith Anytime Touchdown (+145)
After the Giants stunned the Eagles on Thursday Night Football, the league recognized a couple of key aspects: The Giants aren't pushovers anymore, and Saquon Barkley is far from the player he was last season.
New Customers: Bet $5+ Get $300 in Bonus Bets If Your Bet Wins + 3 Months of League Pass On Us! With Barkley averaging just 3.3 yards per attempt this season, Jalen Hurts has still managed to lead the Eagles to a 5-2 record this season, putting far more emphasis on the passing game.
With A.J. Brown out, you can expect Dallas Goedert and DeVonta Smith to be the focal points of the Philly offense. After exploding for over 100 yards in two of Philly's last three games, including 183 yards and a touchdown in Minnesota last week, Smith should play a major role this weekend.
NFL Sunday Late Afternoon
Tampa Bay Buccaneers @ New Orleans Saints
Odds: Buccaneers -3.5 (ML: Buccaneers -218, Saints +175 | Over/Under: 46.5 (via Caesars Sportsbook)
Best Bets:
- Saints ML
- Under 46.5
- Chris Olave Anytime Touchdown (+175)
The line has dropped from Buccaneers -6 to just -3.5 against the lowly Saints, mostly due to Tampa Bay's lengthy injury report. Tampa Bay looked awful in their 24-9 loss to the Detroit Lions, and their situation will not be any better this Sunday.
The Buccaneers will be without WRs Chris Godwin and Mike Evans, while rookie star Emeka Egbuka will be less than 100% after dealing with a hamstring injury all week. Furthermore, Bucky Irving will also be out.
Though the Saints have only won once this season, Spencer Rattler has passed the ball very well and has only thrown four picks. New Orleans has only scored about 18 points a game, but that could be enough against this beleaguered offense.
Tennessee Titans @ Indianapolis Colts
Odds: Colts -14.5 (ML: Titans +850, Colts -1400 | Over/Under: 49 (via BetMGM Sportsbook)
Best Bets:
- Colts -14.5
- Jonathan Taylor 2+ Touchdowns (+125)
Prior to this season, only 13 out of 168 underdogs of at least 14 points have pulled off the upset since 2005. That's a lowly 7.7%. With the lowly Titans off to play red-hot Indy, we don't think this is the week that happens.
Jonathan Taylor should get the ball early and often against the NFL's 29th-ranked defense. The way we see this one going, Taylor could score a couple of touchdowns before being shelved in the third quarter.
Dallas Cowboys @ Denver Broncos
Odds: Broncos -3.5 (ML: Cowboys +154, Broncos -184 | Over/Under: 50.5 (via FanDuel)
Best Bets:
- Over 50.5
- Javonte Williams 90+ Rushing Yards (+265)
We think this will be the most exciting game of the weekend by some distance, which could be a back-and-forth offensive explosion that could be decided by the final possession.
We love Javonte Williams having an insane "revenge game" in his return to Denver, looking like a reborn star since his move to Dallas. While we're taking plus-money at 90+ rushing yards, he could legitimately have well over 100 yards and multiple touchdowns.
The Cowboys have the worst-ranked defense in the league and the best-ranked offense in football, which means practically every game could legitimately be a shootout, akin to the 2024 Bengals.
NFL Sunday Night Football
Green Bay Packers @ Pittsburgh Steelers
Odds: Packers -3 (ML: Packers -162, Steelers +136 | Over/Under: 45.5 (via DraftKings)
Best Bets
- DK Metcalf Anytime Touchdown (+150)
- Tucker Kraft Anytime Touchdown (+125)
As far as overall records and storylines go, this is the best game of the weekend as the 4-1-1 Packers travel to face the 4-2 Steelers in the much-anticipated Aaron Rodgers showdown against his former team. Should Rodgers win, he'll become the seventh quarterback to earn a victory against all 32 NFL teams.
We expect this game to be a very even game all around, with a lot of red zone possessions. Tucker Kraft has become one of Jordan Love's favorite goal-line targets, scoring in four of six games so far this season. Pittsburgh has been vulnerable against tight ends this season, so we expect Kraft to have a great game.
Since entering the NFL, DK Metcalf has more red zone targets than anyone in football. He has quickly emerged as Rodgers' favorite receiver in Pittsburgh and will certainly have a huge target share on Sunday night.
NFL Monday Night Football
Washington Commanders @ Kansas City Chiefs
Odds: Chiefs -12.5 (ML: Commanders +525, Chiefs -800 | Over/Under: 48 (via Caesars Sportsbook)
Best Bets:
- Rashee Rice Anytime Touchdown (-108)
- Travis Kelce Over 3.5 Receptions (-150)
With Rashee Rice back in the squad, the Chiefs looked like their old selves in their easy 31-0 slaughter of the Las Vegas Raiders, with Rice scoring two touchdowns on seven receptions.
Bet $1, Double your Winnings on your Next 20 Wagers. Up to $25 Max Bet Per Boost The Chiefs should have another easy test on Monday night, hosting a Commanders side that's missing quarterback Jayden Daniels and possibly their best defensive star in Daron Payne.
As for where the ball goes, that is very much in question. No matter what, we do expect the Chiefs to play mistake-free football and breeze to a win.
Mandatory Credit: Denny Medley-Imagn Images
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