Champions League Predictions and Betting Tips: Roma to Heap More Misery on Man United

Written By Gareth Hinton | Published at November 3, 2026
Atletico Madrid Vs Man united prediction
Warrington cheshire UK - april 11 2024: Manchester united logo on tshirt.

We have Champions League predictions and picks for the biggest midweek European matches. Premier League sides Aston Villa and Manchester United feature tonight.

Champions League Predictions Today

Unai Emery takes his Villa side to Barcelona for a tough game against the Spanish champions, while out-of-form Man United host Roma. In one of the standout games of the night, giants Atletico Madrid and Bayern Munich lock horns in the Spanish capital.

We scoured bet365’s sportsbook for the best odds so we can give you our Champions League predictions, picks, and tips for tonight’s action.

Barca to Ease Past Villans

On paper, Aston Villa have one of the toughest Champions League assignments of the week, as the English side travel to the Camp Nou to face Barcelona. Going by bet365’s latest Champions League odds, Villa are the big underdogs at 7/1.

Barcelona won their opening 11 matches before the 4-2 loss at Paris Saint-Germain in the UCL. They then lost the El Clasico to rivals Real Madrid, but Hansi Flick’s boys bounced back with a 6-1 home victory over Alaves in La Liga.

Aston Villa are winless in two, but their form has been superb of late. Emery’s men are joint top of the Champions League standings after three impressive wins.

The Villans have been excellent in Europe so far, but this will be their toughest challenge yet. Our money is going on the hosts, and you can get 3/2 for Blaugrana to win -2.

Best Bet: Barcelona to Win -2 (3/2, bet365)

Roma to Leave Old Trafford with All 3 Points

Man United and Roma lock horns in a huge Champions League fixture at Old Trafford tonight. Despite United’s woeful run of form, Michael Carrick remains in charge.

These are desperate times for the Red Devils. The Manchester club head into this one having lost three on the bounce and six of their last nine league and cup games. They have not won since beating Sabah in mid-September. Last weekend, Carrick’s side lost 2-0 at Chelsea in the EPL.

Roma make the trip to England in high spirits, winning four and drawing one of five since losing 4-3 to Real Madrid in the Champions League. The club from Rome are third in Serie A after seven wins and three draws from ten.

Unfortunately for Carrick and his wounded Man United team, we can see the Italian side piling more misery on them tonight. There is good value in 2/1 for the Roma win.

Best Bet: Roma to Win (2/1, bet365)

Atleti & Bayern to Play Out Thrilling Score Draw

Atleti and Bayern go head-to-head in a mouth-watering tie at the Estadio Riyadh Air Metropolitano tonight. Both clubs are looking to go far in the competition this season, but who will come out on top in Madrid?

Los Colchoneros are in stunning form right now, winning eight and drawing one of nine since losing to Liverpool in their Champions League opener. They beat Man United on matchday two but drew with Stuttgart in their last UCL outing.

Bayern Munich dropped points in the Bundesliga at home to rivals Borussia Dortmund last weekend, and they have also drawn their last two in the Champions League. Sitting on five points from three UCL games, the Bavarians could do with a win.

This will be the first meeting between the pair since they clashed in the Champions League group stage in the 2020-21 season. Bayern hammered Atleti 4-0 in Germany, but the pair played out a 1-1 draw in the Spanish capital.

Both teams will be targeting all three points from this one, which should make for a thrilling contest. It could go either way, but our money is going on the stalemate. Check out bet365’s solid odds of 7/2 for the draw and both teams to score.

Best Bet: Draw & Both Teams to Score (7/2, bet365)