Italy Serie A Opening Odds for 2026/2027: Can Anyone Topple Inter Milan?

Written By James Chittick | Published at August 4, 2026

Serie A odds — Jun 30, 2025; Charlotte, North Carolina, USA; FC Inter Milan defender Stefan de Vrij (6) dribbles the ball during the first half during a round of 16 match of the 2025 FIFA Club World Cup at Bank of America Stadium. Mandatory Credit: Scott Kinser-Imagn Images

We're taking a closer look at the Serie A opening odds and early predictions ahead of the 2026/27 campaign, which begins in just a few weeks.

Inter Milan enter the new season as defending champions and the clear favourites to retain their crown, but several challengers will believe they can disrupt the Nerazzurri’s dominance.

Serie A Predictions 2026/27

Inter have been the benchmark in Italy for several seasons, combining consistency, depth and a strong tactical identity.

With most UK betting sites placing them at 1/1, Simone Inzaghi’s side remain the team everyone else must chase.

Napoli, priced at 9/2, look the most likely to apply pressure.

Their squad has evolved well over the past two years, and a strong summer window could push them closer to Inter’s level.

Juventus sit at 5/1, and while their rebuild has been slower than expected, they still possess the quality to mount a serious challenge if they find stability.

AC Milan, available at 11/2, continue to develop under new leadership and could be one of the season’s most intriguing teams.

Roma at 9/1 also have the potential to surprise, especially if their younger players take another step forward.

Further down the table, Atalanta and newly‑resurgent Como share 33/1 odds, suggesting outside chances of a top‑four push.

Lazio at 80/1 and Bologna at 100/1 will aim to stay competitive, while Fiorentina, Udinese and Torino face longer odds as they try to break into the top half.

The remaining clubs - Cagliari, Parma, Frosinone, Venezia, Monza and Lecce - will focus on survival, with odds ranging from 750/1 to 1000/1.

The upcoming season promises plenty of storylines, from Inter’s title defence to the resurgence of Italy’s historic clubs.

With new signings, tactical shifts and rising stars, Serie A looks set for another compelling campaign.