NFL Week 2 Game Preview: Tennessee Titans at Buffalo Bills Odds

Written By Jeffrey Schreiber on September 18, 2022 - Last Updated on September 19, 2022
titans bills odds

The Tennessee Titans visit the Buffalo Bills at 7:15 p.m. ET on Monday, Sept. 19. The first of two Monday night primetime games to kick off NFL Week 2 odds shows the Bills as spread favorites and on the moneyline. The point total in Bills Titans odds is set at .

In this article, we break down everything you need to know before placing a bet on the game, including team matchups, key metrics, and the best available odds. Click on any Bills – Titans odds in this post to bet now.


When using the odds table above, click the dropdown menu and select the type of bet you wish to make. 

Wagering on the point spread is when you wager on how many points a team will win or lose by. A “plus” sign in front of the spread is the underdog, and a “minus” sign is the favorite. The Bills would need at least a ten-point win if you bet on Buffalo to cover the point spread (-9.5). A spread bet on the Titans would win if Tennessee wins the game or loses by nine points or fewer. When there is no flat number like this one (-9.5) no push comes into play.

Betting the moneyline is simply betting on which particular team will win a game.

The total is the number of combined points the two teams will score. Bettors can choose to bet the over or under on how many total points will be scored in the game.


In the props tool search bar, type in a team or player and hit enter. You’ll see the various proposition bets offered by leading online sportsbooks.  This is a valuable tool that allows bettors to compare odds and stats when considering a prop bet. 


As of Thursday, the spread for this game on Fanduel Sportsbook is Bills -9.5. Most Sportsbooks have this spread at Bills . Additional updates can be found below.


The weather isn’t expected to have much of an impact on this matchup, as the temperature is expected to settle in at 70 degrees by kickoff. There is a small chance for light rain, though models are showing it may be clear by kickoff on Monday Night. Even so, you should be wary of allowing the potential weather to impact your handicap — unless it’s like the 49ers at Bears torrential downpour that we witnessed in Week 1


PlayerPositionInjuryThuFriSatGame Status
Tommy DoyleOTFootFPFPFPUnspecified
Dane JacksonCBKneeDNPDNPFPQuestionable
Quintin MorrisTEHamstringFPFPFPUnspecified
Tim SettleDTCalfDNPDNPLPDoubtful
Gabe DavisWRAnkleLPQuestionable
Stefon DiggsWRVet restLPUnspecified
Kristian FultonCBHamstringDNPDNPDNPOut
Dontrell HilliardRBHamstringDNPDNPDNPOut
Kyle PhilipsWRShoulderDNPLPLPQuestionable
Ola AdeniyiOLBNeckLPLPLP(-)
Ben JonesCNot Injury RelatedLPFPFP(-)
Jamarco JonesOTElbowLPDNPDNPOut
Taylor LewanOTKneeLPFPFP(-)
Dillon RadunzOTNeckLPLPLP(-)
Lonnie JohnsonCBGroinFPFPFP(-)
Nate DavisGKnee(-)DNPFP(-)


Bills OStats (Rank)Titans D
31 (#4)Points/Gm21 (#16)
0.534 (#2)Points/Play0.362 (#19)
413 (#6)Yards/Gm394 (#24)
292 (#8)Pass Yards/Gm156 (#4)
121 (#13)Rush Yards/Gm238 (#32)
7.1 (#1)Yards/Play6.8 (#30)
9.6 (#1)Yards/Pass7.4 (#23)
4.8 (#13)Yards/Rush7.4 (#31)
90 (#1)3rd Down %20 (#2)
100 (#1)Red Zone TD %66.67 (#18)
4 (#31)Turnovers2 (#6)
2 (#15)Sacks5 (#1)


Titans OStats (Rank)Bills D
20 (#17)Points/Gm10 (#5)
0.333 (#20)Points/Play0.152 (#6)
359 (#16)Yards/Gm243 (#2)
266 (#10)Pass Yards/Gm191 (#7)
93 (#15)Rush Yards/Gm52 (#1)
6.0 (#9)Yards/Play3.7 (#2)
8.1 (#3)Yards/Pass4.7 (#4)
3.6 (#22)Yards/Rush2.9 (#6)
27.27 (#26)3rd Down %46.15 (#23)
66.67 (#11)Red Zone TD %50.00 (#12)
1 (#9)Turnovers3 (#3)
1 (#8)Sacks7 (#2)


Why Bills Can Cover The Spread

Last year’s Bills finished top five in pass attempts (655) and plays ran under OC Brian Daboll. Continuity with New OC Ken Dorsey did not prove to be an issue in Week 1, as Buffalo scored 31 points against the defending Super Bowl champs. Stefon Diggs looks positioned for extreme volume again in Week 2, after producing 8/122/1 receiving line in Week 1. Diggs role is so secure following Cole Beasley and Emmanuel Sanders’ offseason departures. Including playoffs, Diggs has averaged 9.8 targets per game since joining the Bills. Gabriel Davis checks in as the Bills every down number 2 receiver in a pass-first offense. Davis has played 65% or more of Buffalo’s offensive snaps in 14 career games including playoffs banking a combined 50/816/11 receiving line in them.

The Titans’ secondary is extremely exposable, coming off a 2021 season where they finished in the top 10 of most passing yards and receiving yards allowed. The Bills were the only team apart from the Chiefs to win their first game by more than three scores, and it appears Vegas expects them to win by multiple scores for the second week in a row.

Why Titans Can Cover The Spread

Buffalo is missing top CB Tre’Davious White (ACL, reserve/PUP) and may only get limited doses of SS Jordan Poyer (elbow). Regardless of personnel, Sean McDermott’s zone system tends to suffocate opponent passing production which shouldn’t affect the way Tennessee wants to play as a run first team.

While the Titans struggled to stop the run against the Giants last week, there should not be reason of concern as the Bills do not have any lethal running backs, and do not intend on getting too much rushing production. The way these 2 teams play set up the Titans to play into their strength of riding Derrick Henry. In last year’s meeting with the Bills, the Titans won outright 34-31. Henry ran all over Buffalo totaling 143 rushing yards.

Reasons To Bet The Over

In addition to ranking top 10 in yards per play, top five in total yards, and top three in scoring in 2021, the Bills averaged the third-most overtime-adjusted plays per game. Buffalo threw on first down at a league-leading 63% clip. The Bills were also at the top of the league in pace and pass rate in 2020, and there is little reason to expect they’ll change their approach now, even if they are forecast to control game script in almost every game they play as a big favorite. Buffalo deployed the eighth-fastest offense, with the seventh-highest pass rate, when leading by at least two touchdowns last year. The drafting of pass-catching specialist RB James Cook is more evidence that the Bills have no intention of allowing the game down. If the Titans fall behind in this game, they will be forced to abandon the run and throw more. Titans’ games as double-digit underdogs since 2010, have hit the over in five of eight games.

Reasons To Bet The Under

The clear plan for Titans HC Mike Vrabel heading into this game will be to control the clock and feed RB Derrick Henry. If the Titans see success on the ground, they will burn a lot of clock, limiting the Bills potential of running a lot of plays. Bills games as double digit favorites under coach Sean McDermott since 2017, have gone under the total in six of those nine contests.


Buffalo seems to be playing with a little chip on their shoulder, indicating that they won’t take their foot off the gas in any game they play in 2022. The Titans are at least two scores worse than Buffalo. It’s a big number to swallow but playing at home has me confident the Bills cover this 9.5.

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Written by
Jeffrey Schreiber

Jeffrey Schreiber is a sports betting writer with TheLines and Catena Media. Jeff is recent college graduate with a background in finance and analytics. His goal is to provide readers with data and information behind the "why" to make a bet. His most memorable betting moment came during the divisional round of the 2022 NFL playoffs when he turned $37 in same-game parlay bets into $25,000.

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