Sweet 16 Schedule & NCAA Tournament Odds

Written By Bill Gelman | Published at March 25, 2025

March Madness continues this week with the NCAA Tournament Regional Semifinals. The Sweet 16 schedule is now set and odds for Thursday and Friday games are available at the Best March Madness betting sites. Regional semifinal games will be played in Newark, San Francisco, Atlanta and Indianapolis.

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Sweet 16 odds

Here are Sweet 16 odds. These March Madness odds are for games played on Thursday, March 27 and Friday, March 28.

BYU (+4.5) vs. Alabama (-4.5)

Alabama opened as a -4.5 favorite over BYU. The initial total was 175.5.

Maryland (+6.5) vs. Florida (-6.5)

Maryland opened as a +6.5 underdog to Florida. The initial total was 154.5.

Arizona (+8.5) vs. Duke (-8.5)

Duke opened as a -8.5 favorite over Arizona. The initial total was 153.5.

Arkansas (+5.5) vs. Texas Tech (-5.5)

Arkansas opened as a +5.5 Underdog against Texas Tech. The opening total was 146.5.

Ole Miss (+3.5) vs. Michigan State (-3.5)

Michigan State opened as a -3.5 favorite against Ole Miss. The initial total was 143.5.

Auburn (-7.5) vs. Michigan (+7.5)

Auburn opened as a -7.5 betting favorite over Michigan. The game over under was initially 150.5.

Kentucky (+4.5) vs. Tennessee (-4.5)

The Kentucky Wildcats opened as a +4.5 betting underdog to the Tennessee Volunteers. The opening total was 145.5.

Purdue (+7.5) vs. Houston (-7.5)

The Houston Cougars opened as a -7.5 favorite over the Purdue Boilermakers. The opening total was 132.5.

Sweet 16 schedule

Below is the updated Sweet 16 schedule. All of the listed times are Eastern Standard.

Thursday, March 27

Here are the Sweet 16 tip times and locations for each game. Also included is the TV channel for each game.

East Region: No. 6 BYU vs. No. 2 Alabama (7:09 p.m., CBS), Newark
West Region: No. 4 Maryland vs. No. 1 Florida (7:39 p.m., TBS\truTV), San Francisco
East Region: No. 4 Arizona vs. No. 1 Duke (9:39 p.m., CBS), Newark
West Region: No. 3 Texas Tech vs. No. 10 Arkansas (10:09 p.m., TBS/truTV), San Francisco

Friday, March 29

South Region: No. 6 Ole Miss vs. No. 2 Michigan State (7:09 p.m., CBS), Atlanta
Midwest Region: No. 3 Kentucky vs. No. 2 Tennessee (7:39 p.m., TBS/truTV), Indianapolis
South Region: No. 5 Michigan vs. No. 1 Auburn (9:39 p.m., CBS), Atlanta
Midwest Region: No. 4 Purdue vs. No. 1 Houston, (10:09 p.m., TBS/truTV), Indianpolis

Here are the TV announcers for the Sweet 16 schedule.