MLS Best Bets and Picks for Sept. 26: Will Nashville Win Again?

MLS continues this weekend with several mouth-watering matches, and we have the latest odds and MLS best bets in this in-depth betting preview.
The action is heating up as the playoffs approach. We are focusing on odds from the BetMGM sportsbook for the biggest MLS games taking place today.
MLS Best Bets, Odds & Picks
With just over a month of the regular season to play, the table is starting to take shape. Nashville SC is closing in on the Supporters’ Shield, and B. J. Callaghan’s Coyotes are looking for another three points when they face Toronto FC.
We are previewing that game at Geodis Park as well as more exciting soccer action from America’s top tier today. Read on for the MLS best bets and soccer picks from BetMGM.
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Atlanta United FC welcomes New York City FC to Mercedes-Benz Stadium tonight. It has been a tough season for the home team, though the Five Stripes picked up a rare victory last time out.
United recently went four games without a win, drawing two and losing two. However, Gerardo Martino’s men bounced back with a hard-fought 1-0 triumph at Portland Timbers last weekend.
New York is frantically chasing a playoff berth, currently tenth in the Eastern Conference, a point behind ninth-place FC Cincinnati. City is in poor form, though, with just one win in nine MLS matches.
New York desperately needs to put a winning run together to track down the teams above, and we fancy the away side to snatch a big three points in Georgia. Check out BetMGM’s MLS odds of +185 for the New York victory.
Best Bet: New York City FC to Win (+185, BetMGM)
Montreal to Snap MLS Losing Streak
CF Montreal and Cincinnati lock horns today at Saputo Stadium in Quebec. Impact has suffered five straight defeats and has won just one MLS game since May. Still, they can end the woeful run today.
Since winning 2-1 at Columbus Crew in late August, Montreal has taken just one point from a possible 18. Last weekend’s 2-0 loss to Crew was a low point in a forgettable season, leaving CFM at the bottom of the East.
Cincinnati is winless in five MLS games since beating New York 2-1 at home. Nevertheless, the Orange and Blue have drawn their last two with Charlotte FC and Houston Dynamo FC. The Ohio outfit is clinging on to the final playoff berth in the Eastern Conference table.
This one could go either way in Canada, but we are picking the home win and both teams to score (+270, BetMGM) in our MLS best bets for today.
Best Bet: CF Montreal to Win & Both Teams to Score (+270, BetMGM)
MLS Leader to Rack Up Another Routine Victory
Nashville has been the real deal in MLS this season, winning 17 of 26. The Tennessee team is closing in on the Supporters’ Shield, and Callaghan’s troops will be targeting another three points when Toronto visits Geodis Park tonight.
Nashville is having a sensational season, suffering just three league defeats. After going three matches without a win, the Boys in Gold responded with an excellent 3-0 home success over Chicago Fire last weekend.
Toronto’s form has been up and down of late. Robin Fraser’s side recently went seven MLS games unbeaten (three wins, four draws), but the Canadians have crashed to back-to-back defeats to Orlando City SC and St. Louis City SC.
We cannot see past another comfortable home victory for the Eastern Conference leader. Our money is going on Nashville to win -1 at +110.
Best Bet: Nashville SC to Win -1 (+110, BetMGM)
Dallas & LAFC to Play Out Texas Tie
FC Dallas takes on Los Angeles FC in MLS action at Toyota Stadium in Frisco. The odds market is tight, but the home team is the slight favorite at +125.
Dallas should make the playoffs and finish in the top seven of the West. The Texas team is currently fourth, three points above LAFC. Dallas has won three of its last four and has lost just one MLS game in nine.
Los Angeles has struggled for wins since MLS returned after the 2026 FIFA World Cup break. The Californians have won only one of their previous nine MLS fixtures, drawing at San Jose Earthquakes last time.
With both teams close in the table and pushing for the playoffs, this is tricky to call. Dallas has the momentum, though LAFC’s roster is glittering with talent. With that in mind, our money is going on the draw and both teams to score (+290).
Best Bet: Draw & Both Teams to Score (+290, BetMGM)
Rapids to Return to Colorado with Huge Three Points
LA Galaxy entertains Colorado Rapids at Dignity Health Sports Park. The pair are close in the Western table, making this fixture in California tough to call.
Galaxy got its playoff push back on track with a 3-2 victory at Minnesota United FC last Saturday. Colorado is unbeaten in three and has only lost two MLS games since July.
When the sides clashed in Denver in March, the Rapids picked up an impressive 4-1 victory. The game was tied at 1-1 with 15 minutes to play, but late goals from Rafael Navarro (2) and Alexis Manyoma gave Colorado a big margin of victory on home soil.
Today’s game is likely to be much closer on the scoreline, but we fancy Colorado to see off LAFC once again. BetMGM's +360 offers good value for the away team to win at half time and full time.
Best Bet: Colorado Rapids HT/FT (+360, BetMGM)
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