MLS Best Bets and Picks for Sept. 19: Can St. Louis Win Again?

Written By Gareth Hinton | Published at September 19, 2026
Aug 15, 2026; Nashville, Tennessee, USA; Nashville SC starters pose for a team photo before their game against Inter Miami CF at Geodis Park. Mandatory Credit: Alan Poizner-Imagn Images

MLS is the gift that keeps on giving, as we have more exciting soccer action to look forward to today.

CF Montreal hosts struggling Columbus Crew, in-form Nashville SC entertains Chicago Fire FC, and high-flying St. Louis City SC takes on Toronto FC. Check out our MLS best bets and picks.

CF Montreal vs Columbus Crew MLS Best Bets: Canadians to Snap Winless MLS Streak

Montreal takes on Columbus at Saputo Stadium today. Impact has picked up just one win in 14 MLS games, while Crew has lost six of seven regular-season matches.

Montreal’s MLS form is poor, but the Canadians did secure their passage through to the Canadian Championship final in midweek, beating rival Vancouver Whitecaps FC.

It has been a miserable season for Columbus, who sits just two points above Montreal in the Eastern Conference table. The Ohio team heads to Quebec having lost six of seven MLS matches.

Montreal’s last league victory was against Columbus in August. Goals from Prince Owusu and Noah Streit gave Impact a 2-1 win at ScottsMiracle-Gro Field. The Canadians would love a repeat scoreline today.

This could be another tight tussle between two struggling sides, but we can see the host picking up a vital victory. We like the look of BetMGM’s +280 for Montreal to win and both teams to score.

Our Prediction: CF Montreal to Win & Both Teams to Score – +280, BetMGM

Nashville SC vs Chicago Fire FC MLS Predictions: Leader to Get Back to Winning Ways

Eastern Conference leader Nashville welcomes Chicago to Geodis Park later today. Despite looking nailed on to win the Supporters’ Shield, the Boys in Gold are winless in three MLS games.

B. J. Callaghan’s side picked up a 2-2 draw at Inter Miami CF last weekend, keeping the Herons nine points behind. Nashville is looking for its first league win in four after two draws and a loss in the last three.

Chicago heads to Tennessee without a win in five MLS games. After four consecutive draws with New York Red Bulls, Seattle Sounders, Toronto, and Inter Miami, Fire lost 2-1 at home to New England Revolution last time. That was Chicago’s first MLS reverse since July.

We are backing Nashville to get back to winning ways on home soil today. Check out BetMGM’s top MLS soccer odds of +190 for the home team to win -1.

Our Prediction: Nashville SC to Win -1 – +190, BetMGM

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St. Louis City SC vs Toronto FC MLS Picks: City to Extend Unbeaten Run to 16

St. Louis and Toronto meet at Energizer Park for the first time. The home team is looking to extend its unbeaten league run to 16 with another three points.

Yoann Damet’s troops are the form team in MLS, picking up ten wins and five ties from the last 15. The incredible run of results has lifted City up to fifth in the Western Conference, just five points behind leader Vancouver Whitecaps.

Toronto’s form has improved massively, as Robin Fraser’s men won three and drew four of seven. However, the Canadians were brought back down to earth with a bump last weekend, suffering a 3-0 defeat to Orlando City SC in Florida.

These two have only met once before, with St. Louis winning 1-0 in Ontario in 2023. We can see the Missouri team picking up another victory over the Reds this weekend.

City returned to winning ways with a thumping 4-2 home triumph over Minnesota United, and there is good value in +110 for the St. Louis win and over 2.5 combined goals scored.

Our Prediction: St. Louis City SC to Win & Over 2.5 Combined Goals Scored – +110, BetMGM

MLS Odds taken from BetMGM at 08:00 ET time, on September 19