NCAA Basketball Tournament Odds: Second Round Spreads, Totals And Moneylines

Written By Matt Burke on March 19, 2021 - Last Updated on March 22, 2021
Second Round odds Round 2 Abilene Christian lines moneyline spread

The March Madness field is already starting to narrow as teams were bumped off every half hour or so Friday and Saturday. We are now into Round 2, with those games taking place on Sunday and Monday this year. We will update this article with new NCAA tournament second round odds as soon as they are made available by the top legal sportsbooks in the US.

The tourney started with a bang on Friday as 15-seed Oral Roberts upended 2-seed Ohio State, ruining plenty of brackets. More upsets followed on Saturday, with 14-seeded Abilene Christian stunning Texas and 13-seed Ohio taking down Virginia.

Here is also the schedule for second round games with start time and TV information, as well as National Title futures.

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Second round odds: NCAA Tournament

The best live lines for second round games in the 2021 NCAA Tournament. Here are the games for Monday, March 22. All times are Eastern Standard.

Oregon vs. Iowa (12:10 p.m. CBS)

Oklahoma vs. Gonzaga (2:40 p.m. CBS)

Abilene Christian vs. UCLA (5:15 p.m. TBS)

Ohio vs. Creighton (6:10 p.m. TNT)

LSU vs. Michigan (7:10 p.m. CBS)

Colorado vs. Florida State (7:45 p.m. TBS)

Maryland vs. Alabama (8:45 p.m. TNT)

USC vs. Kansas (9:40 p.m. CBS)


Betting previews

Click on the links below for full betting previews of each game.

Monday, March 22

What’s on tap?

The 2021 Big Dance has multiple Cinderellas – two of which are already headed to the Sweet 16. Oral Roberts, which upset 2-seeded Ohio State on Friday, won again on Sunday. Old friend Loyola Chicago also pulled off an upset Sunday, sending 1 seed Illinois packing.

Abilene Christian, a 14 seed, and Ohio, a 13 seed, will look to score upsets on Monday as well. AC will match up against No. 11 UCLA Monday afternoon while Ohio will play Big East power Creighton.

College basketball National Title futures

Here are live futures odds to win the National Championship.

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Written by
Matt Burke

Matt Burke is the Sports Editor and Head of Evergreen/SEO Content at He is the Founder and former Editor-in-Chief of MetroBet, a digital and print sports betting platform, and was the Executive Sports Editor at Metro US Newspapers (New York, Philadelphia, Boston) from 2014-2020. Matt has covered Super Bowls and Final Fours, and his work has appeared for Sports Illustrated, CBS Sports, the Eagle Tribune, Gloucester Daily Times and Newburyport Daily News. Matt is a graduate of the University of Connecticut.

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