SEC College Football Week 2 Odds: Game Notes & Betting Guide

Written By Road to CFB | Last Updated at September 11, 2024

A 10-game slate is on tap for the Southeastern Conference this weekend. The top games on the schedule include Arkansas at No. 16 Oklahoma State, South Carolina at Kentucky, No. 14 Tennessee vs. No. 24 NC State, and the headliner: No. 3 Texas at No. 9 Michigan. Texas A&M, LSU, and Florida look to rebound after losses on opening weekend. Let's go over the entire slate, including betting notes, weather, injuries, and much more for this weekend's slate of SEC football odds.

SEC Football Odds: Week 2

Browse the best odds for SEC football in Week 2 below. Games without odds as of Wednesday (including FCS foes) were omitted. Games not shown below include McNeese at Texas A&M, Tennessee Tech at Georgia, Samford at Florida, Nicholls at LSU, and Alcorn State at Vanderbilt. Click inside the odds tables to bet now.

Arkansas at No. 16 Oklahoma State, Saturday (12:00 p.m., ABC)

Opening odds: ARK +8.5, O/U 59.5
This point total moved three points higher by Wednesday morning
First meeting since 1980 when the two teams played in the Southwest Conference (annual rivalry)
Since 2017, Oklahoma State is 4-0 straight up and against the spread (ATS) against non-conference Power opponents
First non-conference Power opponent for Arkansas since 2021 and first true road game against a non-conference Power opponent since 2016
Razorbacks are 1-6 straight up at 2-5 ATS in road openers since 2017
WR Andrew Armstrong missed Week 1 and is questionable for Week 2. Armstrong led Arkansas with 764 receiving yards last year

Notable injuries: LB Justin Wright (OKST), WR Andrew Armstrong (ARK)

No. 3 Texas at No. 10 Michigan, Saturday (12:00 p.m., FOX)

Opening odds: TEX -3.5, O/U 44.5
Despite combining for 1,953 wins, Texas and Michigan have only played once ever (2005 Rose Bowl)
Michigan holds the most all-time wins (1,005), while Texas ties for fourth (948)
Without Jim Harbaugh, Michigan is 0-4 ATS against non-conference opponents (last year and Week 1)
Texas snapped a five-game losing streak in true road games against Power Conference foes when it beat Alabama last year

Notable injuries: SAF Rod Moore (MICH), QB Jack Tuttle (MICH), RB C.J. Baxter (TEX)

Cal at Auburn, Saturday (3:30 p.m., ESPN2)

Opening odds: AUB -11.5, O/U 52.5
Auburn (-6) won this game 14-10 in Berkeley last year despite just 230 yards of total offense
Cal is 7-0 ATS in non-conference road games since 2016 (notables: Notre Dame, TCU, Ole Miss)
First home game against non-SEC Power Conference foe since 2016
RB Jadyn Ott left Week 1 with an injury and was listed as "probable" early in the week

Notable injuries: RB Jadyn Ott (CAL), WR Kyioin Grayes (CAL), K Alex McPherson (AUB)

South Carolina at Kentucky, Saturday (3:30 p.m., ABC)

Opening odds: UK -9.5, O/U 45.5
South Carolina has won in each of the last two seasons (-2 favorites in '23, +6 underdogs in '22)
Kentucky only played three quarters last week and led Southern Miss 31-0 before lightning ended the game (officially ruled a win for UK)
Game has gone under the total eight of the last nine times
RB Chip Traynum missed Week 1 and is doubtful for Week 2 after breaking his hand during fall camp

Notable injuries: RB Chip Traynum (UK), TE Josh Kattus (UK)

Middle Tennessee at No. 6 Ole Miss, Saturday (4:15 p.m., SEC Network)

Opening odds: MISS -40.5, O/U 62.5
Ole Miss won only prior meeting, 45-17, in 2001
Lane Kiffin is 12-0 straight up and 9-3 ATS against non-conference foes at Ole Miss (avg. +31 ppg difference, three Power Conference foes)
Derek Mason beat Ole Miss twice at Vanderbilt (2016, '19)

Notable injuries: OG Jeremy James (MISS), WR Jordan Watkins (MISS), RB Logan Diggs (MISS)

Buffalo at No. 9 Missouri, Saturday (7:00 p.m., ESPN+)

Opening odds: MIZ -34.5, O/U 52.5
Missouri is just 2-6-1 ATS against non-league Group of Five foes since 2021
Eliah Drinkwitz is just 4-10-1 ATS as a home favorite at Missouri
Buffalo is 3-0 ATS against ranked opponents since 2019 (Wisconsin 2023, Coastal Carolina '21, Penn State '19)

Notable injuries: DE Darris Smith (MIZ)

USF at No. 4 Alabama, Saturday (7:00 p.m., ESPN)

Opening odds: BAMA -30.5, O/U 63.5
Alabama (-34) won last year's meeting, 17-3, under QB Tyler Buchner
Crimson Tide have average point margin of +52.9 against last seven Group of Five foes at home
Alabama posted the second-best net success rate in its Week 1 win over Western Kentucky (63-0)
Kalen DeBoer has a 21-2 record at home as a coach in the FBS

Notable injuries: OG Kadyn Proctor (BAMA)

College Football National Title odds

No. 14 Tennessee vs. No. 24 NC State, Saturday (7:30 p.m., ABC)

Opening odds: TEN -5.5, O/U 58.5
Game is played in Charlotte, North Carolina
Vols lead the all-time series 2-1 (two matchups pre-World War II)
Tennessee is 5-2 ATS against its last seven ACC foes (only straight up loss 2022 vs. Pitt)
NC State trailed Western Carolina 21-17 heading into the fourth quarter before scoring three straight TDs

Notable injuries: SAF Devan Boykin (NCST), WR Braylon Staley (TEN), SAF Jourdan Thomas (TEN)

Houston at No. 15 Oklahoma, Saturday (7:45 p.m., SEC Network)

Opening odds: OU -27.5, O/U 52.5
Oklahoma leads the all-time series, 3-1
Houston (-3) lost to UNLV in Week 1, 27-7
Oklahoma has won their last 15 non-conference home games, including a 49-31 win over Houston in 2019
Oklahoma is dealing with cluster injuries to its receiving room, including Nic Anderson, Jalil Farooq (broken hand), and Jayden Gibson (season)
Sooners starting center Branson Hickman left Week 1 with an ankle injury

Notable injuries: RB Tony Mathis (HOU), C Branson Hickman (OU)

Mississippi State at Arizona State, Saturday (10:30 p.m., ESPN)

Opening odds: MSST +4.5, O/U 58.5
Watch for weather! Temperatures in this game are forecast to still be near 100º at kickoff. Phoenix recently crossed a 100-day streak of 100º+ temps
First ever meeting between these two programs
Mississippi State beat Arizona in Tucson in 2022, 39-17 (-10 favorites)
Arizona State has not hosted an SEC foe since Georgia in 2008
Starting RB Jeffrey Pittman is no longer with Mississippi State, a surprising development that unfolded just before Week 1
Top WR Kelly Akharaiyi and starting corner CB Corey Ellington both missed Week 1 and are questionable for Week 2

Notable injuries: WR Kelly Akharaiyi (MSST), CB Corey Ellington (MSST)