Saturday NFL Divisional Round: Best Picks and Player Props

Written By Blaise Bourgeois | Published at January 16, 2026

Dec 7, 2025; Atlanta, Georgia, USA; Seattle Seahawks wide receiver Jaxon Smith-Njigba (11) and quarterback Sam Darnold (14) celebrate after a touchdown against the Atlanta Falcons in the fourth quarter at Mercedes-Benz Stadium. Mandatory Credit: Brett Davis-Imagn Images

After a historic NFL Wild Card round, already with more comebacks in the final two minutes than any other postseason in NFL history, we're ready for the NFL Divisional Round. Saturday's highly-anticipated games start us off with both number one seeds in action, as the Buffalo Bills travel to take on the Denver Broncos, followed by NFC West rivals the San Francisco 49ers and the Seattle Seahawks battling in the nightcap.

The Buffalo Bills have struggled to find a footing all season, but pulled it off last weekend against the Jacksonville Jaguars, leading many to believe that Josh Allen and James Cook may be able to win it all virtually on their own. However, the Denver Broncos and their incredible defense stand in their way, though Bo Nix and their offense raise many question marks. Even though the Broncos won 14 games, only three of their wins were by multiple scores, giving the public plenty of doubt about whether they'll be able to sustain their winning form throughout the playoffs.

As for the NFC West clash in the evening, it's a rematch from just two weeks ago, where the Seahawks tamed the 49ers 13-3 in a winner-takes-all for the top seed in the conference. The 49ers did win the first contest, though that came all the way back in Week 1, and they have sustained plenty of injuries since then.

The Seahawks shocked many by winning 14 games with Sam Darnold at quarterback, having joined in free agency after a successful one-year stint in Minnesota. On Friday, many in the league raised their eyebrows as Darnold showed up on the Seattle injury report as questionable with an oblique injury. However, ESPN reporter Adam Schefter claims that Darnold expects to play, which should diminish any concerns.

Here are the best bets for Saturday. Make sure you browse all of our favorite sports betting sites and take advantage of all of the latest sportsbook promos.

Saturday's NFL Odds

🏈Odds via Caesars Sportsbook📈

Buffalo Bills @ Denver Broncos

Spread: Buffalo Bills +1.5 (-115); Denver Broncos -1.5 (-105)

Money Line: Buffalo Bills +100; Denver Broncos -118

Total: 46.5 (Over -102, Under -120)

San Francisco 49ers @ Seattle Seahawks

Spread: San Francisco 49ers +7 (-112); Seattle Seahawks -7 (-108)

Money Line: San Francisco 49ers +270; Seattle Seahawks -335

Total: 44.5 (Over -112, Under -108)

NFL Game Lines

Buffalo Bills ML (+100), Over 46.5 (-102)

🏈Odds via FanDuel📈

It seems like there's little reason that the Buffalo Bills should pull this off. Josh Allen is pushing through pain, and the Buffalo Bills currently only have three healthy wide receivers on their roster. The Broncos will be one of the best defenses that the Bills have faced all year.

But, as crazy as it sounds, these are the kind of games that Josh Allen has won historically, as long as their opponents haven't been the Kansas City Chiefs. Bo Nix certainly isn't Patrick Mahomes, and despite it being the worst Bills team since Josh Allen started taking them to the playoffs, this could end up being their year. We're not betting against Allen and company and we're smashing the over.

Seattle Seahawks -7 (-108), Under 44.5 (-108)

🏈Odds via FanDuel📈

The Seahawks, for lack of better words, absolutely dogged the 49ers with everything on the line two weeks ago. They're clearly on another level, and although the 49ers defeated the defending Super Bowl champs in the Wild Card, those Eagles won the Super Bowl with their defense. Their offense wasn't on the same level as it was last season, either.

While the 49ers have done a miraculous job to get into the Divisional, we're afraid the buck stops here. We have the Seahawks routing the 49ers in another terribly low-scoring game.

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NFL Player Props

Josh Allen Anytime Touchdown (-108), 50+ Rushing Yards (+160)

🏈Odds via Caesars Sportsbook📈

The deeper the Bills go into the playoffs, the more Josh Allen has historically depended on himself to get the job done. He averages nearly nine carries and 50 rushing yards per postseason game in his career, running for nine touchdowns in 14 career games. With limited options at wide receiver, these are slam-dunk props for us.

Khalil Shakir 80+ Receiving Yards (+283)

🏈Odds via DraftKings📈

With Allen having limited reliable options, Shakir arguably becomes Buffalo's number one target, an honor perhaps shared by Dalton Kincaid. In Allen's playoff career, he has only thrown for under 200 yards on two occasions and has topped 300 yards four times. We're predicting he goes for about 260 yards, even though his over/under is about 210.5 at the moment. Smash Shakir's over (52.5 yards) at the worst.

RJ Harvey 80+ Rushing Yards (+230)

🏈Odds via Caesars Sportsbook📈

Buffalo's run defense is awful. God awful. Harvey doesn't split carries either, so he could be the bulk of their offense and flirt with a career high in rushing yards today. Take his over at the least, and go as high as you want to for his rushing yards.

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