San Francisco 49ers vs. Philadelphia Eagles: Best Picks & Player Props

Written By Blaise Bourgeois | Published at January 11, 2026

Nov 23, 2025; Arlington, Texas, USA; Philadelphia Eagles quarterback Jalen Hurts (1) throws the ball in the fourth quarter against the Dallas Cowboys at AT&T Stadium. Mandatory Credit: Kevin Jairaj-Imagn Images

After Saturday's incredible, thrilling NFC Wild Card contests, we cannot wait for tonight's matchup between the 11-6 defending Super Bowl Champions Philadelphia Eagles, and the 12-5 San Francisco 49ers. As of the time of writing, the Eagles are massive six-point favorites (odds via Caesars Sportsbook) to advance and play the Chicago Bears. If the 49ers pull off the upset, they will advance and play their huge NFC rivals, the Seattle Seahawks.

Without further ado, here are our best bets for Sunday's fantastic contest. Make sure you browse all of our favorite sports betting apps and take advantage of all of the latest sportsbook promos.

Game Lines

San Francisco 49ers - Philadelphia Eagles Under 44.5 (-112)

🏈Odds via DraftKings📈

The Philadelphia Eagles have the best red-zone defense in all of football and will take on San Francisco's elite scoring offense.

The 49ers are incredibly banged up and are clearly not the same offense with Trent Williams, Ricky Pearsall, and George Kittle far below 100%.

The Eagles aren't that high-scoring a team to begin with, averaging just 22.3 points per game (19th in the NFL). They also have offensive line concerns that have caused their offensive efficiency to decline.

San Francisco 49ers +6 (-112)

🏈Odds via Caesars Sportsbook📈

This is one of those "if you had to put a gun to my head" kind of bets. I don't think the 49ers are going to win, but I do think they'll keep it close. I have the Eagles winning a 20-17 ugly grudge match.

Player Props

Christian McCaffrey Over 59.5 Rushing Yards (-112)

🏈Odds via FanDuel📈

When have you ever seen McCaffrey's rushing prop this low? Yes, he went under 60 rushing yards nine times this season, but he's only been under 49 rushing yards three times.

There's nothing special about Philly's run defense. They rank 22nd in all of football, having allowed 124.4 rushing yards per game and 20 rushing touchdowns in the regular season.

The only time he's been held under 49 yards rushing, he faced the Seahawks (#3 run defense), the Texans (#4), and the Rams (#12). McCaffrey also averaged fewer than 10 carries in each of those three games.

We're taking McCaffrey to hit 80+ rushing yards at +235 today. The 49ers must recognize this defensive mismatch.

Jalen Hurts Under 0.5 Interceptions (-190)

🏈Odds via DraftKings📈

Yes, it's not the greatest payout for a quarterback not to throw an interception, but the stats back this one up. San Francisco's defense has only generated six interceptions all season (T-2nd worst in the NFL), while Hurts has only thrown for six interceptions this season. We have extreme confidence in this bet; throw two units on this to get a little over one unit back.

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Saquon Barkley Anytime Touchdown Scorer (-125)

🏈Odds via FanDuel📈

Expect a heavy dose of Saquon Barkley today. Most of the top sportsbooks expect Barkley to have around 85 rushing yards, as well as three receptions. We think he's going to hit over both of those numbers, having saved his best for the playoffs. However, we're much more confident in him finding paydirt.

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