NCAA Tournament Prediction Markets: East Region Round of 64 Picks & Preview

The NCAA Tournament bracket is out, and March Madness is officially underway. The East Region is one of the NCAA Basketball Tournament's toughest regions. It is full of Blue Bloods, including the number one overall seed, Duke, and other heavyweights like UConn, Michigan State, Kansas, and St. John's. Sports Prediction Markets are going to be a fun way to get in on March Madness.

We are going to take you through the prices and probabilities for each of the NCAA Tournament East Region first-round games from the best Prediction Market apps. We will preview each game, share where to watch NCAA Tournament matchups, the NCAA Tournament locations for East Region games, and much more.

Prices for all games below via Kalshi, taken on March 15, at 8:47 AM ET

#1-#16 Duke vs. Sienna Prediction Markets

There have only been two 16-seed upsets over 1-seeds in NCAA Tournament history, and this won't be another one. Sienna has had a strong season, but just won't have the talent to keep up with Duke. Cameron Boozer (22.5 PPG & 10.2 RPG) will have a big first half, and the Blue Devils will win big, resting their stars in the second half.

Where/When to Watch Duke vs. Sienna: Thu. March 19, 2:50 p.m. CBS

Duke vs. Sienna Location: Bon Secours Wellness Arena, Greenville, SC

#8-#9 Ohio State vs. TCU Predictions Markets

One of the most exciting round of 64 matchups is Ohio State against TCU, as both teams are peaking at the right time. The Buckeyes have a strong star duo with Bruce Thornton (20.2 PPG & 5.1 RPG) and John Mobley (15.7 PPG) carrying a heavy load. While TCU has more depth, it lacks a set of elite go-to players like Ohio State. This one will be close, but we favor Thornton's elite-level scoring to help the Buckeyes find a way to win.

Where/When to Watch Ohio State vs. TCU: Thu. March 19, 12:15 p.m. CBS

Ohio State vs. TCU Location: Bon Secours Wellness Arena, Greenville, SC

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Brand

Bonus

Features

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1

$10 Bonus

• Allows users to buy and sell outcome-based event contracts
• Uses a real-time pricing model with flexible entry and exit
• Markets are based on trader sentiment around team performance, injuries, and schedules

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2

100% up to $250

• Place Bets on top sporting events using quick-resolution outcome contracts
• Trade with capped risk and fully transparent payout structures
• View live odds that shift dynamically with market sentiment

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#5-#12 St. Johns vs. Northern Iowa Predictions Markets

St. John's is coming off an electric Big East Conference Tournament championship run. While Northern Iowa has a strong history as an upset special. Ali Farokhmanesh is not walking through the door, though, for the Panthers. Legendary coach Rick Pitino will have the Red Storm ready, and there is no chance they get upset in the first round.

Where/When to Watch St. John's vs. Northern Iowa: Fri. March 20, 7:10 p.m. CBS

St. John's vs. Northern Iowa Location: Viejas Arena San Diego, CA

#4-#13 Kansas vs. CA Baptist Predictions Markets

Most fans would assume that potential lottery pick Darryn Peterson would be the highest level score in Kansas' first round matchup. That is not the case, though, as CA Baptist's Dominque Daniels (23.2 PPG) is a top-five leading scorer in all of college basketball. Daniels will likely have a big game, but that won't be enough for the Lancers to pull off the upset unless Peterson for Kansas isnt 100% healthy, as he struggled to stay on the floor all season.

Where/When to Watch Kansas vs. CA Baptist: Fri. March 20, 9:45 p.m. CBS

Kansas vs. CA Baptist Location: Viejas Arena San Diego, CA

$10 Bonus

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#6-#11 Louisville vs. South Florida Predictions Markets

If there is an upset brewing in the East Region of the NCAA Tournament, it could be this matchup between Louisville and South Florida. Louisville ends the season battling injuries, and if some of its guys aren't a full go, South Florida can take advantage. The Cardinals' front court has been a weakness all season, too, and South Florida's Izaiyah Nelson (15.7 PPG & 9.6 RPG) is a handful in the paint, which could spell trouble for Louisville.

Where/When to Watch Louisville vs. South Florida: Thu. March 19, 1:30 p.m. TNT

Louisville vs. South Florida Location: KeyBank Center, Buffalo, NY

#3-#14 Michigan State vs. North Dakota State Predictions Markets

January, February, IZZO, a long-accustomed term this time of year. Tom Izzo regularly does more with less, and this year, he has a pretty talented veteran-led team. The Spartans are poised for a deep run, and while NDSU is solid, it's doubtful they give Michigan State much trouble.

Where/When to Watch Michigan State vs. North Dakota State: Thu. March 19, 4:05 p.m. TNT

Michigan State vs. North Dakota State Location: KeyBank Center, Buffalo, NY

$10 Bonus

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#7-#10 UCLA vs. UCF Predictions Markets

This one is going to be a battle between the Bruins and the Knights. The key to watch in this matchup is UCLA's health. Their top two scorers, Tyler Bilodeau (17.6 PPG & 5.6 RPG) and Donovan Dent (13.5 PPG & 7.6 APG), both left the Big Ten Tournament injured. If either player is limited, UCF will likely win this one. Even if both players are a full go, this one will be a battle, and make sure to keep an eye on the probabilities at Kalshi as player availability becomes known.

Where/When to Watch UCLA vs. UCF: Fri. March 20, 7:25 p.m. TBS

UCLA vs. UCF Location: Xfinity Mobile Arena, Philadelphia, PA

#2-#15 UConn vs. Furman Predictions Markets

UConn had a disappointing result to finish the Big East Tournament, getting handled by St. John's. That spells bad news for Furman because a motivated UConn team is not to be trifled with. Consistency has been their problem, but they have handled business against lesser opponents this season and should again vs. Furman.

Where/When to Watch UConn vs. Furman: Fri. March 20, 10:00 p.m. TBS

UConn vs. Furman Location: Xfinity Mobile Arena, Philadelphia, PA