Our Guide to NFL Week 9: Schedule, Matchups, Predictions, Injury Report

Written By Nick Crain | Last Updated at October 30, 2025

With the midseason stretch of the NFL campaign officially here, the Week 9 slate features several high-stakes matchups that could shape division races and playoff positioning. Bettors scanning this week's schedule will find intriguing lines across the board, from heavy favorites like Green Bay and Los Angeles to tight, coin-flip contests between Denver and Houston.

Here’s your full NFL Week 9 betting guide, including a preview and predictions for every game, plus a quick look at where injuries could play the biggest role.

All odds via BetMGM.

Thursday Night Football

Baltimore Ravens @ Miami Dolphins (Ravens -7)

The Week 9 opener features two AFC playoff hopefuls who have struggled to this point. Expect the Ravens to control the pace and lean on their run game as clear favorites, especially with Lamar Jackson coming back into the fold.

📊 Prediction: Ravens 27, Dolphins 17 — Ravens cover

Sunday Slate

Chicago Bears @ Cincinnati Bengals (Bears -1.5)

This Sunday matchup is as close as it gets on the betting board. Cincinnati’s offensive line depth remains a concern per the latest injury report, and Chicago’s defense has quietly rounded into form. The Bears’ versatility should give them the slight edge in a low-scoring affair, hoping to slow down Joe Flacco.

📊 Prediction: Bears 24, Bengals 21 — Bears cover

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Minnesota Vikings @ Detroit Lions (Lions -8.5)

Detroit enters as one of the stronger favorites on the schedule, facing a Vikings defense riddled with injuries and an offense that lacks a consistent QB. The Lions’ front seven has been dominant at home, and Jared Goff continues to find success in the dome.

📊 Prediction: Lions 33, Vikings 13 — Lions cover

Carolina Panthers @ Green Bay Packers (Packers -12.5)

The Packers are the week’s biggest favorites and should validate that line. Carolina’s offense remains inconsistent and the defense has been known to give up chunk plays. Expect Green Bay to cruise.

📊 Prediction: Packers 35, Panthers 17 — Packers cover

Denver Broncos @ Houston Texans (Broncos -1.5)

Denver enters this preview as a slight road favorite, but this matchup projects to be tight. Both teams boast elite defenses, so it could come down to which offensive unit can find any sort of rhythm.

📊 Prediction: Broncos 27, Texans 23 — Broncos cover

Atlanta Falcons @ New England Patriots (Patriots -5.5)

New England’s defense has returned to form, while Atlanta continues to battle injuries on offense. The Patriots’ physicality should give them the upper hand at home, especially with how Drake Maye is playing.

📊 Prediction: Patriots 27, Falcons 21 — Patriots cover

San Francisco 49ers @ New York Giants (49ers -2.5)

The injury report for San Francisco’s quarterback situation looms large, but the 49ers’ defensive line remains their anchor. Expect a close contest that leans toward the visitors, assuming the Niners can keep Jaxson Dart in check.

📊 Prediction: 49ers 24, Giants 17 — 49ers cover

Indianapolis Colts @ Pittsburgh Steelers (Colts -3)

The Colts have emerged as steady road favorites, even though the Steelers are historically tough to beat at home. Expect Indianapolis to control time of possession and find enough explosive plays to pull away late, especially with the Colts' MVP-caliber RB, Jonathan Taylor.

📊 Prediction: Colts 31, Steelers 21 — Colts cover

Los Angeles Chargers @ Tennessee Titans (Chargers -10)

The Chargers enter as double-digit favorites against a Titans squad that has gaps in talent across the board. Against a motivated Los Angeles team that wants to maintain its positioning in the AFC, this one spells blowout.

📊 Prediction: Chargers 35, Titans 10 — Chargers cover

Jacksonville Jaguars @ Las Vegas Raiders (Jaguars -3)

The Raiders simply haven't been competitive this season, even at home. Trevor Lawrence should find his rhythm early and lead a controlled road win, especially if his offensive weapons are able to take advantage of this Las Vegas defense.

📊 Prediction: Jaguars 27, Raiders 14 — Jaguars cover

New Orleans Saints @ Los Angeles Rams (Rams -13.5)

The Rams are major favorites, facing a New Orleans team hit hard by injuries on offense and starting a new QB this week. Los Angeles should roll behind a balanced attack led by veteran QB Matthew Stafford.

📊 Prediction: Rams 35, Saints 10 — Rams cover

Kansas City Chiefs @ Buffalo Bills (Chiefs -1.5)

This marquee matchup between elite AFC contenders could swing postseason seeding. Buffalo’s defense remains talented, but it will have its hands full today against a Chiefs team that is starting to figure it out. Even then, expect the Bills to make one more big play than Kansas City at home.

📊 Prediction: Bills 35, Chiefs 28 — Bills cover

Seattle Seahawks @ Washington Commanders (Seahawks -3.5)

Seattle travels east as modest favorites. Washington’s defense is undermanned and might to play a backup quarterback. Meanwhile, the Seahawks’ balanced attack should prove too steady down the stretch, especially with their great defense.

📊 Prediction: Seahawks 23, Commanders 15 — Seahawks cover

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Monday Night Football

Arizona Cardinals @ Dallas Cowboys (Cowboys -3)

Week 9 wraps with a primetime matchup on Monday night in Dallas. The Cowboys’ defense continues to give up points in a hurry, but Arizona’s offensive struggles could make it difficult to sustain drives. Expect Dallas to handle business at home, but it won't be pretty.

📊 Prediction: Cowboys 30, Cardinals 23 — Cowboys cover

As the season nears its midpoint, betting lines continue to tighten across the league. Favorites have held strong through recent weeks, but with depth being tested and the injury report expanding, underdogs could start stealing covers down the stretch. With so many key matchups and opportunities on the board, bettors will find no shortage of value in this Week 9 slate.

All Odds as of 11:59 p.m. on Oct. 28