Our Guide to NFL Week 11: Schedule, Matchups, Predictions, and Injury Report
Written By Blaise Bourgeois | Published at November 12, 2025
After last week's wacky, wild NFL slate, we're off to Week 11, where the postseason picture will continue to become clearer. At the moment, the official NFL playoff picture probabilities have given 10 teams a 2% chance or lower to make the playoffs. An additional six teams have been given at least a 90% chance to make the playoffs.
Barring any miraculous turn of events, that leaves the remaining 16 teams fighting over the final eight playoff spots. According to the numbers, the Week 11 games that will have the most impact on the playoff standings are the Bears-Vikings and the Chargers-Jaguars.
While a bunch of stinkers flood the schedule this week, there are some elite matchups in the Buccaneers-Bills, the Seahawks-Rams, the Chiefs-Broncos, and the Lions-Eagles.
Here’s your full NFL Week 11 betting guide, including brief previews and predictions for each game. We'll also take a look at where injuries could make the biggest impacts.
NFL Thursday Night Football
New York Jets @ New England Patriots
Odds: Patriots -12.5 (ML: Jets +610, Patriots -900 | Over/Under: 43.5 (via FanDuel)
An old-school AFC East rivalry kicks off Week 11 on Thursday Night Football, as the struggling New York Jets travel to Foxboro to face the 8-2 New England Patriots. Drake Maye and the Patriots are on a league-high seven-game winning streak, while the Jets have won two straight after starting the season 0-7.
Garrett Wilson and Harrison Phillips are still out of practice, while Austin Hooper and Joshua Farmer have yet to participate this week for New England.
The Patriots have covered the spread in all five games so far against teams with a .400 record or worse. There's no reason why they won't destroy the hapless Jets.
📊 Prediction: Patriots 30 Jets 9
NFL Madrid Game
Washington Commanders @ Miami Dolphins
Odds: Dolphins -2.5 (ML: Commanders +120, Dolphins -145 | Over/Under: 47.5 (via BetMGM)
Billed as a phenomenal matchup in the preseason, the Commanders and the Dolphins have been incredibly disappointing, with both Jayden Daniels and Tyreek Hill suffering horrific season-ending injuries.
The Dolphins have been all over the map lately, though they pummeled the Bills and the Falcons in two of the last three weeks, while the Commanders are on a five-game skid, also going 0-5 against the spread during that stretch.
Without Daniels, the Commanders are very much the Commanders of old. The Dolphins look in prime position to comfortably win once again.
📊 Prediction: Dolphins 27 Commanders 13
NFL Sunday Early Afternoon
Green Bay Packers @ New York Giants
Odds: Packers -7 (ML: Packers -380, Jets +300 | Over/Under: 43.5 (via DraftKings)
The incredibly inconsistent Green Bay Packers head to MetLife Stadium to take on the New York Giants. The Giants have moved on from Brian Daboll, with offensive coordinator Mike Kafka taking over in the interim role.
With the Giants at 2-8 and Jaxson Dart still in concussion protocol, it's unclear who will be under center this week. It could even be Jameis Winston, as Kafka has yet to confirm anything.
We think the Giants will beat the spread if Dart starts. However, our prediction is based on either Wilson or Winston getting the nod.
📊 Prediction: Packers 24 Giants 12
New Customers: Bet $5+ and get $200 in Bonus Bets if it wins! Houston Texans @ Tennessee Titans
Odds: Texans -7 (ML: Texans -360, Titans +280 | Over/Under: 38.5 (via Caesars Sportsbook)
The Texans obliterated the Titans 26-0 in their first matchup, and nothing much has changed since then. While CJ Stroud has suffered from a concussion, Davis Mills came in and led the Texans to a remarkable comeback win over the Jags.
The Titans have been miserable, and whether or not Stroud suits up, the Texans should have no trouble getting the job done.
📊 Prediction: Texans 20 Titans 6
Carolina Panthers @ Atlanta Falcons
Odds: Falcons -3.5 (ML: Panthers +156, Falcons -186 | Over/Under: 42.5 (via FanDuel)
Earlier in the season, the Panthers pulled off one of the most surprising results of the season, stunning the Falcons 30-0. Carolina and Atlanta are two of the most inconsistent teams in all of football. We simply don't know how they're going to perform week-to-week.
Rico Dowdle ran all over the Falcons last time out, and Atlanta just gave up 323 rushing yards to the Colts last week. While we think that this game will be closer, we can't see the Falcons coming up with a complete bounce-back.
📊 Prediction: Panthers 27 Falcons 23
Chicago Bears @ Minnesota Vikings
Odds: Vikings -3 (ML: Bears +135, Vikings -160 | Over/Under: 48.5 (via BetMGM)
While the Bears are 6-3, the Vikings have clearly been a better team with J.J. McCarthy under center. However, the Bears have won six of their last seven, and this is a real chance for Caleb Williams to prove that he can take the Bears to new heights.
However, it just feels like the Bears are going to Bears this weekend. Vikings win this one in a close back-and-forth battle.
📊 Prediction: Vikings 27 Bears 24
Los Angeles Chargers @ Jacksonville Jaguars
Odds: Chargers -3 (ML: Chargers -152, Jaguars +127 | Over/Under: 43.5 (via Caesars Sportsbook)
After a terrible stretch following a string of injuries, the Chargers are fully back, having won four of their last five games. Their defense has been firing on all cylinders, allowing just 10 points in two of their last three games.
The Jaguars are coming off an absolute heartbreaker against the Texans, which may have killed off their playoff chances... unless they win this weekend.
With the Cardinals, Titans, and Jets making up three of their four upcoming games, Jacksonville can keep themselves in the wild-card race. However, we see them taking a massive slip, especially with Travis Hunter being ruled out for the rest of the season.
📊 Prediction: Chargers 27 Jaguars 16
Tampa Bay Buccaneers @ Buffalo Bills
Odds: Bills -5.5 (ML: Buccaneers +220, Bills -270 | Over/Under: 47.5 (via FanDuel)
This game pits two of the better sides in the NFL, who have both seen their fantastic seasons take a turn for the worse.
The old adage of warm-weather cities playing in the cold feels like it should ring true. After all, it did snow in Buffalo today, and it's looking like it will be a rainy day in the 40s.
The Buccaneers will likely still have Chris Godwin and Bucky Irving out, while LB Markees Watts, LB Haason Reddick, and OT Luke Haggard remain out.
The line feels much too low, and we expect the Bills to take full advantage of the climate difference and Tampa Bay's depleted roster.
📊 Prediction: Bills 38 Buccaneers 17
Bet $5 Get $150 in Bonus Bets If Your Bet Wins! Cincinnati Bengals @ Pittsburgh Steelers
Odds: Steelers -5.5 (ML: Bengals +195, Steelers -238 | Over/Under: 49.5 (via DraftKings)
While the Steelers have lost three of their last four, they'll be awfully determined to keep their lead in the AFC North, now that the Ravens are healthy and on a three-game winning streak of their own.
The Bengals are coming off a bye, and Ja'Marr Chase has been back to his old self with Joe Flacco under center. However, Cincy missed out on getting back into the playoff picture, blowing late leads against the Bears and the Jets to deny themselves a share of the lead in the AFC North. Their offense has been clicking though, scoring 113 points over their last three games.
We see the Bengals completing the season sweep, with Pittsburgh simply not being able to keep up offensively.
📊 Prediction: Bengals 34 Steelers 28
NFL Sunday Late Afternoon
San Francisco 49ers @ Arizona Cardinals
Odds: 49ers -2.5 (ML: 49ers -150, Cardinals +125 | Over/Under: 48.5 (via BetMGM)
Marvin Harrison Jr. has started to make himself the focal point of the Cardinals offense, having a breakout game against Dallas and scoring a touchdown in the blowout loss against the Seahawks.
The 49ers offense, most notably Brock Purdy, Brandon Aiyuk, and Rickey Pearsall, continues to be forever questionable. This continuous uncertainty has held San Francisco back from their potential.
Though they narrowly beat the Cardinals the first time around, we see a disappointing defeat in their future.
📊 Prediction: Cardinals 23 49ers 22
Seattle Seahawks @ Los Angeles Rams
Odds: Rams -3 (ML: Seahawks +138, Rams -164 | Over/Under: 48.5 (via FanDuel)
For what it's worth, this could be an NFC Championship preview and this matchup will be treated as such by both teams. Of course, this is also a fantastic NFC West rivalry, and they get to play one another again in five weeks.
Matthew Stafford and Sam Darnold are both playing MVP-caliber football, and whoever wins this game will take a massive step towards that accolade. We're going to bet on experience prevailing, with the 37-year-old Stafford having played many more important games than this.
Davante Adams' status, however, could be the deciding factor. Bet the Seahawks if he misses out.
📊 Prediction: Rams 31 Seahawks 27
Kansas City Chiefs @ Denver Broncos
Odds: Chiefs -3.5 (ML: Chiefs -205, Broncos +170 | Over/Under: 43.5 (via DraftKings)
This AFC West rivalry takes on a new twist as the 5-4 Chiefs find themselves on the outside looking in, chasing the 8-2 Broncos.
Both teams have a lot riding on this. Denver could send a clear message to the league that they're a true Super Bowl contender with a win, while Kansas City could see their playoff chances dramatically fall with a loss.
The Chiefs are coming off a bye week, which has given them plenty of time to get healthy. While Denver possesses one of the best defenses in all of football, Bo Nix has been all over the place.
These are just not the games Kansas City loses. Andy Reid has a 22-4 record coming off a bye, and we fully expect that track record to continue.
📊 Prediction: Chiefs 20 Broncos 16
Baltimore Ravens @ Cleveland Browns
Odds: Ravens -8 (ML: Ravens -450, Browns +350 | Over/Under: 45 (via BetMGM)
The Ravens are back in business, going 3-0 since the return of Lamar Jackson to climb back to 4-5 and playoff relevancy. Last week's win over the Vikings could be their biggest of the season so far, with Baltimore having a trio of potential cupcakes in the Browns, Jets, and Bengals to close out November.
The Browns have had the worst offense in the NFL with Dillon Gabriel, averaging 4.1 yards per play. Despite having one of the NFL's best defenses, losing to the Jets now has them in contention for the #1 pick in the 2026 NFL Draft.
While Rashod Bateman and Marlon Humphrey are both questionable, I don't see it factoring too much. Ravens win and cover.
📊 Prediction: Ravens 24 Browns 6
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win NFL Sunday Night Football
Detroit Lions @ Philadelphia Eagles
Odds: Eagles -2.5 (ML: Lions +123, Eagles -150 | Over/Under: 46.5 (via Caesars Sportsbook
The Eagles have proven that they have a lot of problems on defense, while the Lions continue to get very little love at the books.
This is not the same Eagles team that won the Super Bowl last year. They've only won once by multiple scores, while the Lions have taken advantage of weak defenses all year.
Hammer the Lions and the over.
📊 Prediction: Lions 37 Eagles 20
NFL Monday Night Football
Dallas Cowboys @ Las Vegas Raiders
Odds: Cowboys -4.5 (ML: Cowboys -190, Raiders +153 | Over/Under: 50.5 (via Caesars Sportsbook
If the Raiders had an average offensive line, their offense would be extremely dangerous. If the Cowboys had any semblance of a defense, they'd be one of the best teams in football.
Instead, we're forced to suffer through this game on Monday Night Football. At least there will be plenty of points. Unless you want to get in on the betting action or your fantasy football matchup is on the line, you're better off getting some sleep.
📊 Prediction: Cowboys 34 Raiders 24
Bet $1, Double your Winnings on your Next 20 Wagers. Up to $25 Max Bet Per Boost Ready to Bet? Use Our Latest Offers
➤ Caesars Sportsbook Promo Code
All Odds as of 6:00 p.m. on Nov. 11
-
Best NHL Player Props & Parlay Picks Today Dec. 5
-
Expert NBA Picks and Player Props: Best NBA Bets Today Dec. 5
-
Play $5 Get $100 Bonus on Broncos vs Raiders NFL: Use Underdog Code BTSLINES
-
$1500 Bonus Bets If Lose on Seahawks vs Falcons NFL: Use BetMGM Code BTSLINES
-
$1500 Bonus Bets If Lose on Commanders vs Vikings NFL: Use BetMGM Code BTSLINES
-
Promo Code LINESWEEP for Thrillzz: Week 14 NFL: Thrillzz & Betting Odds