MLB Opening Day Odds: Lines For Every Thursday Game

Written By Nate Weitzer on April 7, 2022 - Last Updated on April 8, 2022
Opening Day odds MLB baseball

The 2022 MLB season has finally arrived after a winter marred by a lockout. That is all in the past, however, as hope springs eternal for all 30 Major League Baseball teams. Opening Day odds have been posted by top sportsbooks for a few days now, so check them out below as the new season begins.

MLB Opening Day odds

Here are Opening Day odds for Major League Baseball. Compare baseball moneyline betting prices, run line prices and over under prices you like below.

Betting preview

Can The Angels Live Up To Potential? Despite having two generational players in Mike Trout and Shohei Ohtani, the Angels have disappointed in recent seasons. With those two studs and Anthony Rendon anchoring their lineup, the Angels should have plenty of pop, and Ohtani is set to take the mound in their opener against the hated Astros. The Angels have an improved bullpen and will hope that their rotation can hold up behind Ohtani. They will take on LHP Framber Valdez on Thursday, and LAA was able to tag him for 16 ER in three slugfests last year prior to getting blanked by the young southpaw in a meaningless game in late September. The home Angels were -130 on the moneyline at DraftKings Sportsbook Wednesday afternoon.

Cardinals Honor Vets: No, the Cardinals won’t be holding a special celebration for the military, but their fans will be standing in honor of 40-year-old Adam Wainwright and 42-year-old Albert Pujols, who is set to DH for the franchise he carried for so long in his youth. Waino is coming off a career year and needs just 20 more starts with 39-year-old catcher Yadier Molina to break the all-time record with 325 career starts together. St. Louis finished the 2021 season on a high note, but still fired manager Mike Shildt. They will host the Pirates and promising RHP J.T. Brubaker, who struggled with an 0-4 record and 6.08 ERA in four outings against St. Louis last season. The road team Pirates were +165 on the Opening Day odds moneyline Wednesday afternoon.

CY Burnes in Action: On the northside of Chicago, reigning NL CY Young winner Corbin Burnes will lead his Brewers against the Cubs. Burnes dominated the Cubs’ strikeout-prone lineup in three meetings last season, including an 8-inning shutout with 15 Ks at Wrigley last August. The Brewers offense disappointed last season and will look to provide some support for Burnes with the Cubs starting 31-year-old RHP Kyle Hendricks. The Brew Crew went 14-4 against the Cubs last season and the Cubs went 11-26 at Wrigley Field after the All-Star Break. The Cubbies will debut Japanese star Seiya Suzuki, who is +380 to win NL Rookie of the Year. Chicago was a +150 home ‘dog as of Wednesday afternoon.

Shane Bieber Bounce-back Campaign? After winning the CY Young award in 2020, Bieber pitched only 96.4 innings over 16 appearances last season. He will look to lead the new-look Cleveland Guardians to a win at Kansas City and Bieber is sporting a 1.98 ERA with 45 strikeouts over his last five starts against the Royals. Zack Greinke, now 38 years old, will open for the team that drafted him back in 2002. Greinke showed major signs of slippage last year while posting a career-high 17.8% HR/FB ratio and career-low 16.8% K-Rate. He has allowed 17 ER over his last five outings against Cleveland. Due to the perceived pitching mis-match, the Guardians were -125 road favorites Wednesday afternoon.

Mets Mystery Rotation: If Jacob deGrom (arm) and Max Scherzer (hamstring) both get healthy in time for the playoffs, the Mets could have a one-two punch that is unparalleled in the modern game. But neither pitcher is ready to start Opening Day at the Nationals and the Mets are still considering who to use as their opener. Tylor Megill (4-6, 4.52 ERA last season) is the tentative starter for New York. Despite their astronomical payroll, the Mets might have to use a bullpen game in their first game of the season. The Nats will counter with 32-year-old Patrick Corbin (9-16, 5.82 ERA). New York was a -135 road favorite as of Wednesday afternoon. Scherzer will likely start Friday against Washington.

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