The San Francisco 49ers continue to deal deal with significant injuries to key players. The 49ers have San Francisco 49ers +100000 on Bet365 Super Bowl odds. Below, you will find San Francisco 49ers odds for 2024, including a weekly outlook, spreads for every game, futures, and more from the best NFL betting sites.
49ers odds
View San Francisco 49ers odds for the current season below, including for their next game.
49ers Super Bowl odds
View 49ers Super Bowl odds below.
49ers NFC West Odds
The 49ers opened the season with -210 odds to repeat as NFC West champs.
49ers Win Total
The 49ers opened the 2024 season with a projected win total of 11.5. The opening price on the over was +100.
49ers prop bets
Search below for San Francisco 49ers odds, team or player props currently being offered at sportsbooks. You can also look around at other teams and players using this tool. Happy shopping!
San Francisco 49ers Injuries
Last Updated on 06.03.2025| Player | Pos Position | Injury | Status | Snaps/g Snaps Per Game | Comment | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
|||||||||||
2025 49ers Player Stats
Last Updated on 12.10.2024| Player | GP Games Played | CMP% Completion Percentage | YDS Passing Yards | YDS/G Yards Per Game | YDS/C Yards Per Completion | TDS Passing Touchdowns | INT Interceptions thrown | RTG Passer Rating |
|---|
| Player | GP Games Played | INT Interceptions | PD Passes Defended | FF Fumbles Forced | FR Fumbles Recovered | SACK QB Sacks | TOT Total Tackles | SOLO Solo Tackles | AST Assisted Tackles |
|---|
Best 49ers betting sites
49ers schedule
Here are the opening odds for every 49ers game this season.
| Week | Date | Opponent | Kickoff Time | Opening Odds |
|---|---|---|---|---|
| Week 1 | Monday, September 9 | New York Jets | 8:20 p.m. ET | -6 |
| Week 2 | Sunday, September 15 | at Minnesota Vikings | 1 p.m. ET | -6 |
| Week 3 | Sunday, September 22 | at Los Angeles Rams | 4:25 p.m. ET | -2.5 |
| Week 4 | Sunday, September 29 | New England Patriots | 4:05 p.m. ET | -11.5 |
| Week 5 | Sunday, October 6 | Arizona Cardinals | 4:05 p.m. ET | -9.5 |
| Week 6 | Thursday, October 10 | at Seattle Seahawks | 8:15 p.m. ET | -4 |
| Week 7 | Sunday, October 20 | Kansas City Chiefs | 4:25 p.m. ET | -2 |
| Week 8 | Sunday, October 27 | Dallas Cowboys | 8:20 p.m. ET | -4.5 |
| Week 9 | BYE WEEK | — | ||
| Week 10 | Sunday, November 10 | at Tampa Bay Buccaneers | 1 p.m. ET | -4 |
| Week 11 | Sunday, November 17 | Seattle Seahawks | 4:05 p.m. ET | -9 |
| Week 12 | Sunday, November 24 | at Green Bay Packers | 4:25 p.m. ET | -2.5 |
| Week 13 | Sunday, December 1 | at Buffalo Bills | 8:20 p.m. ET | -2 |
| Week 14 | Sunday, December 8 | Chicago Bears | 4:25 p.m. ET | -5.5 |
| Week 15 | Thursday, December 12 | Los Angeles Rams | 8:15 p.m. ET | -6.5 |
| Week 16 | Sunday, December 22 | at Miami Dolphins | 4:25 p.m. ET | -1 |
| Week 17 | Monday, December 30 | Detroit Lions | 8:15 p.m. ET | -4.5 |
| Week 18 | Sunday January, 5 | at Arizona Cardinals | TBD | -5.5 |
How to bet on the San Francisco 49ers
Moneyline
The moneyline is the simplest of bets, decided by the straight-up winner and loser of each game. Consider the following example:
- 49ers -185
- Panthers +310
The 49ers are considered heavy favorites in this matchup (indicated by -185), requiring a $185 bet to win $100 (plus the initial bet back). The Panthers are the underdog in this matchup, paying out $410 total for a $100 bet ($310 in winnings). How much either team wins or loses by does not matter in moneyline betting, the payout remains the same.
Point spread
Betting on the point spread is determinant on how many points a team wins or loses by. Take the following example:
- 49ers -6.5 (-110)
- Dolphins +6.5 (-110)
In this example, San Francisco is favored by 6.5 points, indicated by “-6.5.” If the 49ers win the game 27-20, the 49ers (-6.5) win the bet and would have a total payout of $19.09 on a $10 bet ($9.09 in profit). If the Dolphins keep the game within seven and lose 23-17, the Dolphins (+6.5) would win, and the payout would be the same as listed above.
Point total (over/under)
The point total refers to the over/under line set by books. This number projects the total number of points scored in a game and, like prop betting, is bet whether one thinks the score will go over or under the set point total. For example, the 49ers’ Week 7 matchup with the New England Patriots had a projected point total of 47.5 points. San Francisco won that game 33-7, resulting in 40 points being scored. Those that bet under the point total would have cashed out.
The 49ers have fielded one of the most potent defenses and dangerous running games in the NFL for the past few seasons; the Kyle Shanahan system specializes in diversifying their offensive weapons and getting as many athletes involved in the game as possible. As a result, the 49ers aren’t quick-scoring, one-play threatening, and usually garner lower point totals. Typical over/unders for games involving the 49ers sit between 45 and 49 points.
In-play and live betting
Sometimes, the most thrilling and rewarding bets are bets made while watching the games. These are referred to as live bets or in-play bets. Odds are ever-changing during games, which would prove to be fruitful for sharp and prepared bettors. For example, if the 49ers (-225) were heavily favored against the Raiders (+190) before kickoff, a payout on a $10 bet on the 49ers to win would win just $4.44.
However, say the 49ers fell to a big 17-3 deficit in the first half despite controlling the overall game (due to a costly turnover or special teams gaffe). Odds may swing in favor of the Raiders, who may be a -110 favorite at halftime. Taking the 49ers to come back and win the game could present plus-odds (say, +130). Should a bettor take San Francisco (+130) at halftime and the 49ers pull off the comeback, winners would win $13 instead of $4.44 (plus the initial $10 bet).
This could also be an effective way to “hedge” your bet; say a bettor took the Raiders (+190) in that game, but San Francisco jumps out to a 21-0 first quarter lead and is controlling the overall feel of the game, bettors could hedge by throwing some money down on San Francisco (-270) to return some of the inevitably-lost bet.
Parlays and teasers
You can always string bets together in the form of parlays or teasers. Usually during busy Sundays, bettors can parlay several teams to win or cover against the spread and if all bets are successful, the payouts are multiplied. Teasers function similarly, except they allow bettors to move each point spread to a more favorable line in exchange for diminished odds.
Futures
Futures are long-term bets that can range from an offseason to a full season (or beyond). Team win totals, award winners, and player performance are common futures.
Over/under record: 10-7
Compare Betting Sites & Apps For The Best 49ers Odds
For experienced bettors, the odds on the San Francisco 49ers can change quickly due to player performances and game matchups, making it essential to stay up-to-date. Comparing top sports betting sites is key to finding the most favorable odds and a variety of betting markets. Leveraging leading sports betting apps allows you to place bets on the go, track live line movements, and capitalize on emerging opportunities. With a strategic approach and the right tools, you can refine your betting strategy and maximize your potential returns when wagering on the 49ers.