Despite having won many games last year and appearing in the NFC Championship Game, the San Francisco 49ers have a lot on their plate. Will they retain Jimmy Garoppolo? He made it through free agency and the NFL Draft without being moved. Superstar Deebo Samuel also joined the trend of receivers demanding massive contract extensions. Despite having requested a trade out of town, the 49ers appear ready to negotiate and retain Samuel.
Below, you’ll find a complete guide to San Francisco 49ers odds and betting. Included are weekly previews, the latest 49ers betting news, prop betting, and more.
Week 1 Preview: 49ers at Bears
The San Francisco 49ers are early favorites on the road in their Week 1 matchup with the Chicago Bears. These odds can and will change this offseason as roster situations for both teams develop, specifically whether or not Jimmy Garoppolo will be starting for the Niners by Week 1. This game has an over/under of .
49ers betting news
49ers 2022 offseason moves
Key signings: CB Charvarius Ward, EDGE Kerry Hyder, WR Ray-Ray McCloud
Re-signings: RB Jeff Wilson, OL Daniel Brunskill, LB Azeez Al-Shaair
Trades: None
Key losses: RB Raheem Mostert, OL Laken Tomlinson, DL D.J. Jones, OT Tom Compton
Key draft picks: EDGE Drake Jackson, WR Danny Gray, RB Tyrion Davis-Price, QB Brock Purdy
San Francisco 49ers 2022 schedule and betting odds
| Week | Date | Opponent | Kickoff Time |
|---|---|---|---|
| Week 1 | Sunday, Sept. 11 | at Chicago Bears | 1 p.m. ET |
| Week 2 | Sunday, Sept. 18 | vs. Seattle Seahawks | 4:05 p.m. ET |
| Week 3 | Sunday, Sept. 25 | at Denver Broncos | 8:20 p.m. ET |
| Week 4 | Monday, Oct. 3 | vs. Los Angeles Rams | 8:15 p.m. ET |
| Week 5 | Sunday, Oct. 9 | at Carolina Panthers | 4:05 p.m. ET |
| Week 6 | Sunday, Oct. 16 | at Atlanta Falcons | 1 p.m. ET |
| Week 7 | Sunday, Oct. 23 | vs. Kansas City Chiefs | 4:25 p.m. ET |
| Week 8 | Sunday, Oct. 30 | at Los Angeles Chargers | 4:25 p.m. ET |
| Week 9 | Sunday, Nov. 6 | BYE | BYE |
| Week 10 | Sunday, Nov. 13 | vs. Los Angeles Chargers | 8:20 p.m. ET |
| Week 11 | Monday, Nov. 21 | vs. Arizona Cardinals (in Mexico City) | 8:15 p.m. ET |
| Week 12 | Sunday, Nov. 27 | vs. New Orleans Saints | 4:25 p.m. ET |
| Week 13 | Sunday, Dec. 4 | vs. Miami Dolphins | 4:05 p.m. ET |
| Week 14 | Sunday, Dec. 11 | vs. Tampa Bay Buccaneers | 4:25 p.m. ET |
| Week 15 | Thursday, Dec. 15 | at Seattle Seahawks | 8:15 p.m. ET |
| Week 16 | Sunday, Dec. 25 | vs. Washington Commanders | 4:05 p.m. ET |
| Week 17 | Sunday, Jan. 1 | at Las Vegas Raiders | 4:05 p.m. ET |
| Week 18 | Saturday, Jan. 7 OR Sunday, Jan. 8 | vs. Arizona Cardinals | TBD |
San Francisco 49ers futures odds
Futures are long-term bets that can range from an offseason to a full season (or beyond). Team win totals, award winners, and player performance are common futures.
49ers Super Bowl 57 odds
The San Francisco 49ers currently hold odds to win Super Bowl LVII.
Best 49ers betting site(s)
49ers prop bets
Prop bets are based on individual performance, typically surrounding players. With such a volatile rotating cast of running backs this past season, providing sharp bettors with plenty of opportunity in prop betting. For example, Jeff Wilson Jr.’s projected rushing total in the 49ers’ Week 16 matchup with the Arizona Cardinals was 38.5 yards. That game, Wilson exploded for 183 yards on the ground– exceeding everyone’s wildest expectations. Those who bet on Wilson to exceed 38.5 yards (the over) would have cashed out that week.
Search below for San Francisco 49ers odds, team or player props currently being offered at sportsbooks. You can also look around at other teams and players using this tool. Happy shopping!
How to bet on the San Francisco 49ers
Moneyline
The moneyline is the simplest of bets, decided by the straight-up winner and loser of each game. Consider the following example:
- 49ers -185
- Panthers +310
The 49ers are considered heavy favorites in this matchup (indicated by -185), requiring a $185 bet to win $100 (plus the initial bet back). The Panthers are the underdog in this matchup, paying out $410 total for a $100 bet ($310 in winnings). How much either team wins or loses by does not matter in moneyline betting, the payout remains the same.
Point spread
Betting on the point spread is determinant on how many points a team wins or loses by. Take the following example:
- 49ers -6.5 (-110)
- Dolphins +6.5 (-110)
In this example, San Francisco is favored by 6.5 points, indicated by “-6.5.” If the 49ers win the game 27-20, the 49ers (-6.5) win the bet and would have a total payout of $19.09 on a $10 bet ($9.09 in profit). If the Dolphins keep the game within seven and lose 23-17, the Dolphins (+6.5) would win, and the payout would be the same as listed above.
Point total (over/under)
The point total refers to the over/under line set by books. This number projects the total number of points scored in a game and, like prop betting, is bet whether one thinks the score will go over or under the set point total. For example, the 49ers’ Week 7 matchup with the New England Patriots had a projected point total of 47.5 points. San Francisco won that game 33-7, resulting in 40 points being scored. Those that bet under the point total would have cashed out.
The 49ers have fielded one of the most potent defenses and dangerous running games in the NFL for the past few seasons; the Kyle Shanahan system specializes in diversifying their offensive weapons and getting as many athletes involved in the game as possible. As a result, the 49ers aren’t quick-scoring, one-play threatening, and usually garner lower point totals. Typical over/unders for games involving the 49ers sit between 45 and 49 points.
In-play and live betting
Sometimes, the most thrilling and rewarding bets are bets made while games are being played. These are referred to as live bets or in-play bets. Odds are ever-changing during games, which would prove to be fruitful for sharp and prepared bettors. For example, if the 49ers (-225) were heavily favored against the Raiders (+190) before kickoff, a payout on a $10 bet on the 49ers to win would win just $4.44.
However, say the 49ers fell to a big 17-3 deficit in the first half despite controlling the overall game (due to a costly turnover or special teams gaffe). Odds may swing in favor of the Raiders, who may be a -110 favorite at halftime. Taking the 49ers to come back and win the game could present plus-odds (say, +130). Should a bettor take San Francisco (+130) at halftime and the 49ers pull off the comeback, winners would win $13 instead of $4.44 (plus the initial $10 bet).
This could also be an effective way to “hedge” your bet; say a bettor took the Raiders (+190) in that game, but San Francisco jumps out to a 21-0 first quarter lead and is controlling the overall feel of the game, bettors could hedge by throwing some money down on San Francisco (-270) to return some of the inevitably-lost bet.
Parlays and teasers
You can always string bets together in the form of parlays or teasers. Usually during busy Sundays, bettors can parlay several teams to win or cover against the spread and if all bets are successful, the payouts are multiplied. Teasers function similarly, except they allow bettors to move each point spread to a more favorable line in exchange for diminished odds.
49ers 2021 recap
Record: 10-7, Third in NFC West, Eliminated in NFC Championship by Rams.
Record ATS: 9-8
Over/under record: 8-9
What a turnaround for the San Francisco 49ers. They began the year 3-5 and ended up in the NFC Championship Game. They didn’t even have a playoff berth secured until Week 18. Ultimately, subpar quarterback play was their undoing and the season ended on a Jimmy Garoppolo interception. Deebo Samuel was the breakout star of the team while Elijah Mitchell had a terrific rookie season. The defense was stout, but until the QB situation is sorted, this team may have a ceiling.