San Francisco 49ers Betting Odds

Schedule, Spread, And Predictions

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49ers 2023 season stats
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The San Francisco 49ers will open the 2024 NFL season as the Super Bowl favorite at most sportsbooks. During NFL Week 1, the defending NFC champs will host the New York Jets in a Monday Night Football game. Below, you will find San Francisco 49ers odds for 2024, including a weekly outlook, spreads for every game this season, futures, and more.

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49ers odds

View San Francisco 49ers odds for the upcoming season below, including their NFL Week 1 MNF game versus Aaron Rodgers and the Jets.

Brock Purdy and the San Francisco 49ers opened as a -6 home favorite versus the New York Jets. The reigning NFC West champs were -267 on the moneyline when lines were first released, while the initial total was 45.

49ers Super Bowl odds

The 49ers are the early favorites to win the next Super Bowl with odds ranging between +500 and +600 at most sportsbooks.

49ers NFC West Odds

The 49ers opened the season with -210 odds to repeat as NFC West champs.

49ers Win Total

The 49ers will open the 2024 season with a projected win total of 11.5. The opening price on the over is +100.

49ers prop bets

Search below for San Francisco 49ers odds, team or player props currently being offered at sportsbooks. You can also look around at other teams and players using this tool. Happy shopping!

49ers Roster

Here is a look at the 49ers current roster.

San Francisco 49ers Injuries

Player Pos Position Injury Status Snaps/g Snaps Per Game Comment
Dre Greenlaw LB Achilles Out 0 Greenlaw has suffered a torn Achilles and will miss the start of the 2024-25 season.

49ers stats

Player GP Games Played CMP% Completion Percentage YDS Passing Yards YDS/G Yards Per Game YDS/C Yards Per Completion TDS Passing Touchdowns INT Interceptions thrown RTG Passer Rating
Player GP Games Played INT Interceptions PD Passes Defended FF Fumbles Forced FR Fumbles Recovered SACK QB Sacks TOT Total Tackles SOLO Solo Tackles AST Assisted Tackles

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49ers schedule

View the 49ers schedule for the 2024 – 2025 season below, including live odds for each game.

Here are the opening odds for every 49ers game this season.

Week DateOpponentKickoff TimeOpening Odds
Week 1Monday, September 9New York Jets 8:20 p.m. ET-6
Week 2Sunday, September 15at Minnesota Vikings1 p.m. ET-6
Week 3Sunday, September 22at Los Angeles Rams4:25 p.m. ET-2.5
Week 4Sunday, September 29New England Patriots4:05 p.m. ET-11.5
Week 5Sunday, October 6Arizona Cardinals 4:05 p.m. ET-9.5
Week 6Thursday, October 10 at Seattle Seahawks8:15 p.m. ET-4
Week 7Sunday, October 20Kansas City Chiefs 4:25 p.m. ET-2
Week 8Sunday, October 27Dallas Cowboys8:20 p.m. ET-4.5
Week 10Sunday, November 10at Tampa Bay Buccaneers1 p.m. ET-4
Week 11Sunday, November 17 Seattle Seahawks4:05 p.m. ET-9
Week 12Sunday, November 24at Green Bay Packers4:25 p.m. ET-2.5
Week 13Sunday, December 1at Buffalo Bills8:20 p.m. ET-2
Week 14Sunday, December 8Chicago Bears 4:25 p.m. ET-5.5
Week 15Thursday, December 12Los Angeles Rams8:15 p.m. ET-6.5
Week 16Sunday, December 22 at Miami Dolphins4:25 p.m. ET-1
Week 17Monday, December 30Detroit Lions8:15 p.m. ET-4.5
Week 18Sunday January, 5at Arizona CardinalsTBD-5.5

How to bet on the San Francisco 49ers


The moneyline is the simplest of bets, decided by the straight-up winner and loser of each game. Consider the following example:

  • 49ers -185
  • Panthers +310

The 49ers are considered heavy favorites in this matchup (indicated by -185), requiring a $185 bet to win $100 (plus the initial bet back). The Panthers are the underdog in this matchup, paying out $410 total for a $100 bet ($310 in winnings). How much either team wins or loses by does not matter in moneyline betting, the payout remains the same.

Point spread

Betting on the point spread is determinant on how many points a team wins or loses by. Take the following example:

  • 49ers -6.5 (-110)
  • Dolphins +6.5 (-110)

In this example, San Francisco is favored by 6.5 points, indicated by “-6.5.” If the 49ers win the game 27-20, the 49ers (-6.5) win the bet and would have a total payout of $19.09 on a $10 bet ($9.09 in profit). If the Dolphins keep the game within seven and lose 23-17, the Dolphins (+6.5) would win, and the payout would be the same as listed above.

Point total (over/under)

The point total refers to the over/under line set by books. This number projects the total number of points scored in a game and, like prop betting, is bet whether one thinks the score will go over or under the set point total. For example, the 49ers’ Week 7 matchup with the New England Patriots had a projected point total of 47.5 points. San Francisco won that game 33-7, resulting in 40 points being scored. Those that bet under the point total would have cashed out.

The 49ers have fielded one of the most potent defenses and dangerous running games in the NFL for the past few seasons; the Kyle Shanahan system specializes in diversifying their offensive weapons and getting as many athletes involved in the game as possible. As a result, the 49ers aren’t quick-scoring, one-play threatening, and usually garner lower point totals. Typical over/unders for games involving the 49ers sit between 45 and 49 points.

In-play and live betting

Sometimes, the most thrilling and rewarding bets are bets made while watching the games. These are referred to as live bets or in-play bets. Odds are ever-changing during games, which would prove to be fruitful for sharp and prepared bettors. For example, if the 49ers (-225) were heavily favored against the Raiders (+190) before kickoff, a payout on a $10 bet on the 49ers to win would win just $4.44.

However, say the 49ers fell to a big 17-3 deficit in the first half despite controlling the overall game (due to a costly turnover or special teams gaffe). Odds may swing in favor of the Raiders, who may be a -110 favorite at halftime. Taking the 49ers to come back and win the game could present plus-odds (say, +130). Should a bettor take San Francisco (+130) at halftime and the 49ers pull off the comeback, winners would win $13 instead of $4.44 (plus the initial $10 bet).

This could also be an effective way to “hedge” your bet; say a bettor took the Raiders (+190) in that game, but San Francisco jumps out to a 21-0 first quarter lead and is controlling the overall feel of the game, bettors could hedge by throwing some money down on San Francisco (-270) to return some of the inevitably-lost bet.

Parlays and teasers

You can always string bets together in the form of parlays or teasers. Usually during busy Sundays, bettors can parlay several teams to win or cover against the spread and if all bets are successful, the payouts are multiplied. Teasers function similarly, except they allow bettors to move each point spread to a more favorable line in exchange for diminished odds.


Futures are long-term bets that can range from an offseason to a full season (or beyond). Team win totals, award winners, and player performance are common futures.

49ers 2023 recap

The 49ers earned the No. 1 NFC seed and made a return trip to the conference championship game, this time defeating the Detroit Lions. The Niners played in Super Bowl 58 but lost in OT to the Kansas City Chiefs.

Record: 12-5, First in NFC West

Record ATS: 9-8

Over/under record: 10-7