San Francisco 49ers Betting Guide

Schedule, Odds, And Predictions

Few teams have come as close to winning a Super Bowl without finishing the job and the San Francisco 49ers will hope that the 2020-21 season ends with redemption. The Niners certainly have the personnel necessary to navigate the NFC and return to the big dance with many key returners and some talented new additions to Kyle Shanahan’s offense.

On this page, you’ll find vital information to bet on the 49ers in the long-term and on individual games. We’ll break down their key transactions, draft picks, and break down their odds for 2020.

San Francisco 49ers Week 2 odds

The Niners’ offense stalled at times late in the fourth quarter and ended up with a 24-20 home loss as 7.5-point favorites. San Francisco once again struggled with a mobile quarterback as Kyler Murray dashed his way to 91 yards and a touchdown on 13 carries. Murray now has 192 rushing yards and two touchdowns in his three games against the 49ers. 

San Francisco gets the perfect medicine after a tough Week 1– the New York Jets. They opened as four-point favorites on the road and have taken the bulk of the early money. 

QB Jimmy Garoppolo will look to avoid interceptions but could not come up with the plays late to get the win. The 49ers needed five yards to extend the drive with less than a minute to go in the game, but Jimmy G could not connect with Trent Taylor. Garoppolo should have much better luck against the Jets, who PFF rated as dead last in pass coverage in Week 1. As long as they avoid turnovers again, the Niners should be able to cruise to a win and cover against an overmatched Jets squad. The Niners defense will also have an easier day as RB Le’Veon Bell will be out on Sunday.

49ers futures odds

49ers Super Bowl odds

San Francisco’s odds to win the Super Bowl increased from +1200 at some books following a strong draft and free agency period. The Niners are the NFC favorites and trail only the defending champion Chiefs and talented Ravens in odds to win it all.

See below for current Super Bowl odds for the 49ers and the other 31 teams in the NFL.

NFC West odds

The Niners slipped from +100 favorites to win the division after being beaten by the Cardinals at home in Week 1. The NFC West is one of the most competitive divisions in all of football and will likely come down to a game or two, just like it has in recent years.

49ers player props

Garoppolo is listed with +2600 odds to win regular season MVP at FanDuel, yet he’s +7500 to win AP Offensive Player of the Year. Stud DE Nick Bosa is the third favorite to win Defensive POY at +1300 odds at FanDuel and he’s second at DK with +1000 odds. Kyle Shanahn is the fourth favorite to win Coach of the Year with +1600 odds at DK.

San Francisco 49ers 2020 schedule and betting odds

WeekDate (Time)OpponentOpening Spread
1Sunday, Sep. 13 (4:25 p.m. ET)vs. Arizona49ers -8.5
2Sunday, Sep. 20 (1 p.m. ET)at NY Jets49ers -5.5
3Sunday, Sep. 27 (1 p.m. ET)at NY Giants49ers -5.5
4Sunday, Oct. 4 (8:20 p.m. ET)vs. Philadelphia49ers -5.5
5Sunday, Oct. 11 (4:05 p.m. ET)vs. MiamiTBA
6Sunday, Oct. 18 (8:20 p.m. ET)vs. LA RamsTBA
7Sunday, Oct. 25 (4:25 p.m. ET)at New England49ers -1
8Sunday, Nov. 1 (4:25 p.m. ET)at SeattleTBA
9Thursday. Nov. 5 (8:20 p.m. ET)vs. Green BayTBA
10Sunday, Nov. 15 (4:25 p.m. ET)at New OrleansSaints -2.5
12Sunday, Nov. 29 (4:05 p.m. ET)at LA RamsTBA
13Monday, Dec. 7 (8:15 p.m. ET)vs. BuffaloTBA
14Sunday, Dec. 13 (4:25 p.m. ET)vs. WashingtonTBA
15Sunday, Dec. 20 (8:20 p.m. ET)at DallasTBA
16Sunday, Dec. 27 (TBA)at ArizonaTBA
17Sunday, Jan. 3 (4:25 p.m. ET)vs. SeattleTBA

How to bet on the 49ers


After opening the season with +3300 odds to win the Super Bowl at most sportsbooks, the Niners routinely exceeded expectations last season. They were the favorites to win it all by December and are once again towards the top of the board in terms of futures odds.

To bet on long-term bets on the Niners, go to the Team Futures tab at your online sportsbook and choose between betting on the Super Bowl Winner, Conference Winner, Division Winner, or Win Totals. These bets all have plus odds, and will be paid out at the end of the season if successful. For example, if the Niners are +450 to win the NFC at DraftKings Sportsbook, so a $20 bet on them to win the NFC would profit $90.


There are a few different ways to bet on individual 49ers games, including the simple method of taking the moneyline. The moneyline is a way to bet on the winner of an NFL game without a point spread. Odds vary depending on how likely the team is to win, so the 49ers were -373 in the NFC Championship last year when they predictably crushed the Packers once again. They were also -457 ahead of a regular season loss to the Falcons, indicating the value of betting an underdog on the moneyline at times.

Point spread

The Niners were excellent against the point spread last year thanks to their ability to play from ahead. This season, they’ll likely be favored in more games with a couple of easy matchups against the NFC East on tap. A point spread handicaps the favored team by setting a line around a key number such as 7.5 or 10.5, which would mean the Niners have to beat the Jets by at least 11 points if the spread is 10.5 for a bet to be successful.

Total (over/under)

As mentioned above, the Niners started slow offensively before taking off behind a strong rushing attack. They stand to continue improvement this season under Shanahan, who is an offensive mastermind. With Samuel, Aiyuk, and Benjamin serving as versatile weapons and TE George Kittle arguably the best player in the game at his position, Garoppolo should be able to move this offense without much difficulty.

You can target the Niners offense by betting the over on point totals, which usually sit somewhere between 40 and 50 points. This refers to the combined point total between the Niners and their opponents, so consider the venue, weather, and strength of the opposing offense before placing any bets. A good example is the 49ers at Saints game last year, which had a modest 45-point total. The 49ers won, 48-46, in a shootout, so the over paid off with ease.

Prop bets

You can take prop bets on individual 49ers players such as Jimmy Garoppolo. Found under the Player Totals tab, these “prop bets” set a number on a player’s expected production over a 16-game season. Garoppolo is projected to pass for 3,950.5 yards and 26.5 TDs according to DK Sportsbook. Take the over or under on those props with -110 odds.

Parlays and teasers

If you feel particularly confident about a result in a 49ers game and want to up the odds, you can always parlay their games with another contest. A parlay refers to combining bets from multiple games or different lines in the same game with improved payouts if all bets are successful. It’s a risky strategy, since the bets pay nothing if even one is not successful.

A teaser is a method that is less risky because it combines bets but “teases” the point spread or total down to a more comfortable range, with less enticing odds than a parlay.

49ers 2019 recap

Record: 13-3
ATS: 9-6-1

The Niners finished atop the NFC with a 13-3 record and cruised past the Vikings and Packers to reach the Super Bowl last season. They led, 20-10, heading into the fourth quarter of the Super Bowl, but Jimmy Garoppolo made a couple costly mistakes and Patrick Mahomes made the Niners pay in a 31-20 comeback win. Head coach Kyle Shanahan notably played a part in blowing a 28-3 lead in the SB when he was OC for the Falcons, so another collapse tarnishes his legacy.

Yet Shanahan put together a dominant team with a strong offense and his vibrant DC Robert Saleh will remain on staff this season. Under Saleh, the Niners finished second in DVOA pass defense, yards allowed per game, and third-down conversion rate allowed. With Raheem Mostert taking over as lead back, the Niners offense was second in rush play percentage and first in rushing TDs produced per game. But San Francisco struggled in the red zone with a 55.5% conversion rate (20th in the NFL) and Garoppolo will have to be better in tight areas if this offense is to become truly elite.

The Niners were darlings against the spread (ATS) last season with a 9-4 record ATS against teams outside of the NFC West. They went 6-2 ATS on the road and 5-1 when listed as underdogs.

While five of their first six games went under the assigned point total, Niners games were 8-4-1 going over the point total after their offense began to take form.

49ers 2020 offseason moves

Key trade departure: DeForest Buckner, DT (to Colts)
Key re-signings: Arik Armstead, DT (five years, $85 million); Dontae Johnson, CB; Jason Verrett, CB; Jimmie Ward, S (three years, $28.5 million)
Key free-agent losses: Emmanuel Sanders, WR (to Saints); Sheldon Day, DT (to Colts), Elijah Lee, LB (to Lions), Levine Toilolo, TE (to Giants)
Key free-agent signings: Trent Williams, OT (from Redskins); Tom Compton, OG (from Jets); Travis Benjamin, WR (from Chargers); Kerry Hyder, LB (from Jets); Joe Walker, LB (from Cardinals)
Key draft picks: Javon Kinlaw, DT (1st round); Brandon Aiyuk, WR (1st round), TE Charlie Woerner (6th round)

Emmanuel Sanders is an incredibly valuable veteran leader, but his on-field value seemed to diminish as the season wore on for the 49ers. Rookie Deebo Samuel became the Niners leading WR and they’ll hope that Arizona State product Brandon Aiyuk can provide another versatile presence as a threat in the passing, running, and return game. Veteran WR Travis Benjamin is also a versatile receiver with excellent speed. The Niners made a splash around the NFL draft by signing former Redskins LT Trent Williams, who sat out last season.

Re-signing Arik Armstead and drafting stud DT Javon Kinlaw helps mitigate the loss of DeForest Buckner. The Niners had one of the deepest defensive lines ever assembled last year and should remain quite fierce at the point of attack. Jimmie Ward returns to form an elite safety tandem with Jaquiski Tartt and the Niners also have incredible depth at CB.