San Francisco 49ers Betting Guide: Odds And Predictions
The San Francisco 49ers are known to be both consistent and competitive in the NFL, often placing among the favorites in both conference and Super Bowl rankings. This presents plenty of betting opportunities for both casual and experienced fans.
This page breaks down key info about wagering on the Niners, and provides information on betting markets like moneyline, point spread, totals, and more. It’s ideal for tracking matchups and checking the latest odds, as well as helping you get the most out of betting on the 49ers.
49ers Odds
Check out the San Francisco 49ers odds for the current season below, including other NFL games:
49ers Super Bowl Odds
The latest 49ers odds for a Super Bowl win sit at San Francisco 49ers +100000 on Bet365. View all of the Super Bowl odds below:
49ers NFC West Odds
The 49ers opened the season with -210 odds in pursuit of becoming NFC West champs:
49ers Win Total
The 49ers opened the season with a projected win total of 11.5. The opening price on the over was +100:
49ers Prop Bets
Checking the latest San Francisco 49ers odds, team or player props has never been easier thanks to the below tool. Here you'll find the latest odds currently being offered at sportsbooks for the 49ers and other NFL teams and players:
Best 49ers Betting Sites
Check out the list below containing the best NFL betting sites on the market right now:
Bet $1, Double your Winnings on your Next 20 Wagers. Up to $25 Max Bet Per Boost 
49ers Schedule
Here are the opening odds for every 49ers game this season:
| Week | Date | Opponent | Kickoff Time | Opening Odds |
| Week 1 | Sunday, September 7 | at Seattle Seahawks | 4:05 p.m. ET | -2.5 |
| Week 2 | Sunday, September 14 | at New Orleans Saints | 1 p.m. ET | -7 |
| Week 3 | Sunday, September 21 | Arizona Cardinals | 4:25 p.m. ET | -1.5 |
| Week 4 | Sunday, September 28 | Jacksonville Jaguars | 4:05 p.m. ET | -3.5 |
| Week 5 | Thursday, October 2 | at Los Angeles Rams | 8:15 p.m. ET | +3.5 |
| Week 6 | Sunday, October 12 | at Tampa Bay Buccaneers | 4:25 p.m. ET | +3.5 |
| Week 7 | Sunday, October 19 | Atlanta Falcons | 8:20 p.m. ET | -3 |
| Week 8 | Sunday, October 26 | at Houston Texans | 1 p.m. ET | +2.5 |
| Week 9 | Sunday, November 2 | at New York Giants | 1 p.m. ET | -3.5 |
| Week 10 | Sunday, November 9 | Los Angeles Rams | 4:25 p.m. ET | -2.5 |
| Week 11 | Sunday, November 16 | at Arizona Cardinals | 4:05 p.m. ET | -1.5 |
| Week 12 | Monday, November 24 | Carolina Panthers | 8:15 p.m. ET | -7 |
| Week 13 | Sunday, November 30 | at Cleveland Browns | 1 p.m. ET | -6 |
| Week 14 | BYE WEEK | -- | -- | -- |
| Week 15 | Sunday, December 14 | Tennessee Titans | 4:25 p.m. ET | -7.5 |
| Week 16 | Monday, December 22 | at Indianapolis Colts | 8:15 p.m. ET | -3 |
| Week 17 | Sunday, December 28 | Chicago Bears | 8:20 p.m. ET | -1.5 |
| Week 18 | TBD | Seattle Seahawks | TBD | TBD |
How to Bet on the San Francisco 49ers
Moneyline
Moneyline betting is simply selecting the team that you think will win outright. No point spreads or totals are needed here, just a simple win or lose.
Here’s an example of a moneyline bet:
- San Francisco 49ers: -185
- Carolina Panthers: +310
You can see that San Francisco are clear favorites - the minus sign means you must bet $185 to win $100. On the flip-side though, and if you fancy the underdog, a $100 bet on the Panthers would return $410 total if they pulled off the upset.
The great thing about moneyline is that it doesn’t matter how much each team wins or loses by - it’s all about who wins.
Point total (over/under)
Totals betting focuses on the combined score of both teams. Also called over/under, it’s all about the points rather than who actually wins the game. The total you see is projected by sportsbooks, and you’re betting whether the score will go over or under that number.
Typical 49ers totals tend to range between 45 and 49 points, depending on the opponent. This is due to the team's balanced offense and elite defense, which often results in lower-scoring games.
Example total bet: 49ers vs. Patriots
- O/U 47.5 points
- San Francisco won 33–7, a total of 40 points
- If you bet under, you’d win. If you bet over, your bet would fail.
Point spread
Point spread betting helps level the playing field between teams by allocating a margin of victory or defeat. You decide whether the favorite will cover the spread or if the underdog will stay within it.
If it sounds a little complex, here’s an example point spread bet:
- San Francisco 49ers: -6.5 (-110)
- Atlanta Falcons: +6.5 (-110)
If San Francisco wins 27–20, they cover the spread (the difference between 27 and 20) and a $10 bet returns $19.09 in total. However, if Atlanta narrows the score to 23–17, they cover the +6.5 spread and the return would be the same amount.
Spreads can work well when you’re betting on strong favorites.
In-play and live betting
Live betting, also known as in-play bets, lets you place wagers while the game is happening. Odds move really quickly as the action unfolds, so this type of bet will suit bettors who follow momentum swings. It also allows you to hedge earlier bets if they are not going in your favor.
Example in-play bet scenario:
- Pre-game: 49ers: -225, Raiders: +190 - a $10 bet has a total payout of $14.44.
- Mid-game: 49ers are behind 17–3, odds are now +130. If you back San Francisco at +130 and they go on to win the game, your $10 bet returns $23 total.
Live markets can also help hedge a pre-game bet. For example, if you backed the Raiders early with +190 but the 49ers storm ahead with 21-0 in the first quarter, you could hedge by placing a bet on San Francisco at -270 to reduce losses.
Parlays and teasers
Parlays combine multiple bets into one bet slip for the chance to get a boosted payout. Unlike separate wagers though, a parlay will only pay out if all legs win.
Teasers work in a similar way, but allow you to adjust point spreads to work in your favor. This does result in smaller returns though.
Example parlay:
- 49ers moneyline (-185) & Chiefs -3.5 & Bills over 47.5. If all three bets come in, the payout is much higher than any single bet.
For a teaser bet, you might move the 49ers’ spread from -6.5 to -0.5 to make them only just need to win.
Futures
Futures bets are long-term wagers, and placed weeks or months in advance. They cover events and outcomes like total season wins, playoff results, or player awards.
Example futures:
- 49ers to win the NFC West
- Player to lead NFL in rushing TDs
- 49ers regular-season win total
Final Thoughts: How will the 49ers Odds Compare
As we've established in this guide, it's crucial to compare sports betting sites to find the best odds for the San Francisco 49ers. The lines are always changing, especially when it comes to in-play bets, so you need to know what you're looking for if you plan to maximize your betting experience this season.
The addition of betting apps makes wagering super simple when you're out and about, and allows you to follow the 49ers schedule, keep a tab on the latest odds and capitalize on opportunities. If you're eager to get started, check out the sportsbooks listed on this page and click on one of the banners to head straight to the site.
San Francisco 49ers Betting Guide FAQ
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