San Francisco 49ers Betting Guide

Schedule, Odds, And Predictions

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A week after taking care of business in Seattle, Jimmy Garoppolo and the 49ers put up a dud at Denver on Sunday night. The 49ers led 10-5 in the second half and ultimately lost by 1 point after closing as 1-point favorites. San Francisco will host Monday Night Football against the Super Bowl champion Rams in Week 4.

Below, you’ll find a complete guide to San Francisco 49ers odds and betting. Included are weekly previews, the latest 49ers betting news, prop betting, and more.

Week 4 Odds: Rams at 49ers Spread, Total and Moneyline

The San Francisco 49ers are favorites hosting the Rams in the Monday night showdown.

This game has an over/under of . The number has gone under the total in all three of San Francisco’s games this season, and another under could be on the way Monday night.

San Francisco opened as -140 favorites on the moneyline, with the visiting Rams installed as +120 underdogs on Monday morning.

49ers betting news

49ers prop bets

Search below for San Francisco 49ers odds, team or player props currently being offered at sportsbooks. You can also look around at other teams and players using this tool. Happy shopping!

San Francisco 49ers Super Bowl odds

The San Francisco 49ers currently hold odds to win Super Bowl LVII.

Best 49ers betting site(s)

San Francisco 49ers 2022 schedule and betting odds

Week DateOpponentKickoff TimeOpening OddsClosing LineFinal Score
Week 1Sunday, Sept. 11at Chicago Bears1 p.m. ET-6.5-6.5Bears 19, 49ers 10
Week 2Sunday, Sept. 18vs. Seattle Seahawks4:05 p.m. ET-7.5-8.549ers 27, Seahawks 7
Week 3Sunday, Sept. 25at Denver Broncos8:20 p.m. ET+2.5-1Broncos 11, 49ers 10
Week 4Monday, Oct. 3vs. Los Angeles Rams8:15 p.m. ET+1
Week 5Sunday, Oct. 9at Carolina Panthers4:05 p.m. ET-3
Week 6Sunday, Oct. 16at Atlanta Falcons1 p.m. ET-5.5
Week 7Sunday, Oct. 23vs. Kansas City Chiefs4:25 p.m. ET+1
Week 8Sunday, Oct. 30at Los Angeles Chargers4:25 p.m. ET+4.5
Week 9Sunday, Nov. 6BYEBYE
Week 10Sunday, Nov. 13vs. Los Angeles Chargers8:20 p.m. ETPK
Week 11Monday, Nov. 21vs. Arizona Cardinals (in Mexico City)8:15 p.m. ET-2.5
Week 12Sunday, Nov. 27vs. New Orleans Saints4:25 p.m. ET-4
Week 13Sunday, Dec. 4vs. Miami Dolphins4:05 p.m. ET-3.5
Week 14Sunday, Dec. 11vs. Tampa Bay Buccaneers4:25 p.m. ETPK
Week 15Thursday, Dec. 15at Seattle Seahawks8:15 p.m. ET-3
Week 16Sunday, Dec. 25vs. Washington Commanders4:05 p.m. ET-6
Week 17Sunday, Jan. 1at Las Vegas Raiders4:05 p.m. ET+1.5
Week 18Saturday, Jan. 7 OR Sunday, Jan. 8vs. Arizona CardinalsTBD-3

49ers 2022 offseason moves

Key signings: CB Charvarius Ward, EDGE Kerry Hyder, WR Ray-Ray McCloud

Re-signings: RB Jeff Wilson, OL Daniel Brunskill, LB Azeez Al-Shaair

Trades: None

Key losses: RB Raheem Mostert, OL Laken Tomlinson, DL D.J. Jones, OT Tom Compton, C Alex Mack (retire)

Key draft picks: EDGE Drake Jackson, WR Danny Gray, RB Tyrion Davis-Price, QB Brock Purdy

How to bet on the San Francisco 49ers


The moneyline is the simplest of bets, decided by the straight-up winner and loser of each game. Consider the following example:

  • 49ers -185
  • Panthers +310

The 49ers are considered heavy favorites in this matchup (indicated by -185), requiring a $185 bet to win $100 (plus the initial bet back). The Panthers are the underdog in this matchup, paying out $410 total for a $100 bet ($310 in winnings). How much either team wins or loses by does not matter in moneyline betting, the payout remains the same.

Point spread

Betting on the point spread is determinant on how many points a team wins or loses by. Take the following example:

  • 49ers -6.5 (-110)
  • Dolphins +6.5 (-110)

In this example, San Francisco is favored by 6.5 points, indicated by “-6.5.” If the 49ers win the game 27-20, the 49ers (-6.5) win the bet and would have a total payout of $19.09 on a $10 bet ($9.09 in profit). If the Dolphins keep the game within seven and lose 23-17, the Dolphins (+6.5) would win, and the payout would be the same as listed above.

Point total (over/under)

The point total refers to the over/under line set by books. This number projects the total number of points scored in a game and, like prop betting, is bet whether one thinks the score will go over or under the set point total. For example, the 49ers’ Week 7 matchup with the New England Patriots had a projected point total of 47.5 points. San Francisco won that game 33-7, resulting in 40 points being scored. Those that bet under the point total would have cashed out.

The 49ers have fielded one of the most potent defenses and dangerous running games in the NFL for the past few seasons; the Kyle Shanahan system specializes in diversifying their offensive weapons and getting as many athletes involved in the game as possible. As a result, the 49ers aren’t quick-scoring, one-play threatening, and usually garner lower point totals. Typical over/unders for games involving the 49ers sit between 45 and 49 points.

In-play and live betting

Sometimes, the most thrilling and rewarding bets are bets made while games are being played. These are referred to as live bets or in-play bets. Odds are ever-changing during games, which would prove to be fruitful for sharp and prepared bettors. For example, if the 49ers (-225) were heavily favored against the Raiders (+190) before kickoff, a payout on a $10 bet on the 49ers to win would win just $4.44.

However, say the 49ers fell to a big 17-3 deficit in the first half despite controlling the overall game (due to a costly turnover or special teams gaffe). Odds may swing in favor of the Raiders, who may be a -110 favorite at halftime. Taking the 49ers to come back and win the game could present plus-odds (say, +130). Should a bettor take San Francisco (+130) at halftime and the 49ers pull off the comeback, winners would win $13 instead of $4.44 (plus the initial $10 bet).

This could also be an effective way to “hedge” your bet; say a bettor took the Raiders (+190) in that game, but San Francisco jumps out to a 21-0 first quarter lead and is controlling the overall feel of the game, bettors could hedge by throwing some money down on San Francisco (-270) to return some of the inevitably-lost bet.

Parlays and teasers

You can always string bets together in the form of parlays or teasers. Usually during busy Sundays, bettors can parlay several teams to win or cover against the spread and if all bets are successful, the payouts are multiplied. Teasers function similarly, except they allow bettors to move each point spread to a more favorable line in exchange for diminished odds.


Futures are long-term bets that can range from an offseason to a full season (or beyond). Team win totals, award winners, and player performance are common futures.

49ers 2021 recap

Record: 10-7, Third in NFC West, Eliminated in NFC Championship by Rams.

Record ATS: 9-8

Over/under record: 8-9

What a turnaround for the San Francisco 49ers. They began the year 3-5 and ended up in the NFC Championship Game. They didn’t even have a playoff berth secured until Week 18. Ultimately, subpar quarterback play was their undoing and the season ended on a Jimmy Garoppolo interception. Deebo Samuel was the breakout star of the team while Elijah Mitchell had a terrific rookie season. The defense was stout, but until the QB situation is sorted, this team may have a ceiling.