San Francisco 49ers Betting Guide

Schedule, Odds, And Predictions

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Despite having the shortest odds to win the Super Bowl of any NFC team a week ago, the 49ers now have the longest odds of the remaining four teams in the NFL heading into Championship Sunday. Their opponent, the Philadelphia Eagles, is the new favorite to hoist the Lombardi Trophy at +250. The Niners survived a rock fight with Dallas, winning 19-12 while holding the Cowboys to a pedestrian 4.7 yards per play. Meanwhile, the Eagles rolled all over the Giants 38-7 and now cruise into the NFC Championship with all phases running at high efficiency. San Francisco opened +1.5 at Philly, but the early money has been all Eagles, pushing the spread up to a juiced -2.5. Below, you’ll find a complete guide to San Francisco 49ers odds during the playoffs.

View Niners NFC Championship odds as well as Super Bowl futures.

The 49ers and Eagles were tied in the NFC title game, 7-7, midway through the second quarter on Sunday.

San Francisco 49ers odds

Here are San Francisco 49ers odds for their NFC Championship game at the Eagles.

The 49ers opened as 1.5-point underdogs at the Eagles, but a flood of early money on Philly has pushed that up to +2.5 (-105) at most shops as of Monday morning. The current spread for the NFC Championship is set at . The 49ers have covered nine of their past ten games and are 13-6 ATS this season, while Philly is 9-9 against the spread and has covered once in its past five games.

The total opened at 46 and ticked down after taking money on the under, but has bounced back up to 46 early in the week. The current total is set at . The 49ers had gone over in four straight games before going under against the Cowboys and are 10-9 to the over this season. The Eagles have gone under in four of their past five games and are 10-8 to the over this season.

The 49ers opened at +105 on the moneyline with the Eagles favored at -125, but the markets have moved significantly in a short amount of time. As of Monday afternoon, San Francisco is +120 at DraftKings, with Philadelphia favored at -140.

49ers Super Bowl odds

The San Francisco 49ers currently hold odds to win Super Bowl LVII.

49ers Super Bowl odds were also made available for hypothetical game matchups. They were as follows:

  • Chiefs -1 vs. 49ers +1
  • Bengals +1 vs. 49ers -1

49ers betting news

49ers prop bets

Search below for San Francisco 49ers odds, team or player props currently being offered at sportsbooks. You can also look around at other teams and players using this tool. Happy shopping!

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San Francisco 49ers 2023 schedule and betting odds

Week DateOpponentKickoff TimeOpening OddsClosing LineFinal Score
Week 1Sunday, Sept. 11at Chicago Bears1 p.m. ET-6.5-6.5Bears 19, 49ers 10
Week 2Sunday, Sept. 18vs. Seattle Seahawks4:05 p.m. ET-7.5-8.549ers 27, Seahawks 7
Week 3Sunday, Sept. 25at Denver Broncos8:20 p.m. ET+2.5-1Broncos 11, 49ers 10
Week 4Monday, Oct. 3vs. Los Angeles Rams8:15 p.m. ET+1-249ers 24, Rams 9
Week 5Sunday, Oct. 9at Carolina Panthers4:05 p.m. ET-3-649ers 37, Panthers 15
Week 6Sunday, Oct. 16at Atlanta Falcons1 p.m. ET-5.5-3.5Falcons 28, 49ers 14
Week 7Sunday, Oct. 23vs. Kansas City Chiefs4:25 p.m. ET+1+0.5Chiefs 44, 49ers 23
Week 8Sunday, Oct. 30at Los Angeles Rams4:25 p.m. ET+4.5+149ers 31, Rams 14
Week 9Sunday, Nov. 6BYEBYE
Week 10Sunday, Nov. 13vs. Los Angeles Chargers8:20 p.m. ETPK-849ers 22, Chargers 16
Week 11Monday, Nov. 21vs. Arizona Cardinals (in Mexico City)8:15 p.m. ET-2.5-9.549ers 38, Cardinals 10
Week 12Sunday, Nov. 27vs. New Orleans Saints4:25 p.m. ET-4-8.549ers 13, Saints 0
Week 13Sunday, Dec. 4vs. Miami Dolphins4:05 p.m. ET-3.5-549ers 33, Dolphins 17
Week 14Sunday, Dec. 11vs. Tampa Bay Buccaneers4:25 p.m. ETPK-3.549ers 35, Buccaneers 7
Week 15Thursday, Dec. 15at Seattle Seahawks8:15 p.m. ET-3-349ers 21, Seahawks 13
Week 16Sunday, Dec. 25vs. Washington Commanders4:05 p.m. ET-6
Week 17Sunday, Jan. 1at Las Vegas Raiders4:05 p.m. ET+1.5
Week 18Saturday, Jan. 7 OR Sunday, Jan. 8vs. Arizona CardinalsTBD-3

49ers 2022 offseason moves

Key signings: CB Charvarius Ward, EDGE Kerry Hyder, WR Ray-Ray McCloud

Re-signings: RB Jeff Wilson, OL Daniel Brunskill, LB Azeez Al-Shaair

Trades: None

Key losses: RB Raheem Mostert, OL Laken Tomlinson, DL D.J. Jones, OT Tom Compton, C Alex Mack (retire)

Key draft picks: EDGE Drake Jackson, WR Danny Gray, RB Tyrion Davis-Price, QB Brock Purdy

How to bet on the San Francisco 49ers


The moneyline is the simplest of bets, decided by the straight-up winner and loser of each game. Consider the following example:

  • 49ers -185
  • Panthers +310

The 49ers are considered heavy favorites in this matchup (indicated by -185), requiring a $185 bet to win $100 (plus the initial bet back). The Panthers are the underdog in this matchup, paying out $410 total for a $100 bet ($310 in winnings). How much either team wins or loses by does not matter in moneyline betting, the payout remains the same.

Point spread

Betting on the point spread is determinant on how many points a team wins or loses by. Take the following example:

  • 49ers -6.5 (-110)
  • Dolphins +6.5 (-110)

In this example, San Francisco is favored by 6.5 points, indicated by “-6.5.” If the 49ers win the game 27-20, the 49ers (-6.5) win the bet and would have a total payout of $19.09 on a $10 bet ($9.09 in profit). If the Dolphins keep the game within seven and lose 23-17, the Dolphins (+6.5) would win, and the payout would be the same as listed above.

Point total (over/under)

The point total refers to the over/under line set by books. This number projects the total number of points scored in a game and, like prop betting, is bet whether one thinks the score will go over or under the set point total. For example, the 49ers’ Week 7 matchup with the New England Patriots had a projected point total of 47.5 points. San Francisco won that game 33-7, resulting in 40 points being scored. Those that bet under the point total would have cashed out.

The 49ers have fielded one of the most potent defenses and dangerous running games in the NFL for the past few seasons; the Kyle Shanahan system specializes in diversifying their offensive weapons and getting as many athletes involved in the game as possible. As a result, the 49ers aren’t quick-scoring, one-play threatening, and usually garner lower point totals. Typical over/unders for games involving the 49ers sit between 45 and 49 points.

In-play and live betting

Sometimes, the most thrilling and rewarding bets are bets made while watching the games. These are referred to as live bets or in-play bets. Odds are ever-changing during games, which would prove to be fruitful for sharp and prepared bettors. For example, if the 49ers (-225) were heavily favored against the Raiders (+190) before kickoff, a payout on a $10 bet on the 49ers to win would win just $4.44.

However, say the 49ers fell to a big 17-3 deficit in the first half despite controlling the overall game (due to a costly turnover or special teams gaffe). Odds may swing in favor of the Raiders, who may be a -110 favorite at halftime. Taking the 49ers to come back and win the game could present plus-odds (say, +130). Should a bettor take San Francisco (+130) at halftime and the 49ers pull off the comeback, winners would win $13 instead of $4.44 (plus the initial $10 bet).

This could also be an effective way to “hedge” your bet; say a bettor took the Raiders (+190) in that game, but San Francisco jumps out to a 21-0 first quarter lead and is controlling the overall feel of the game, bettors could hedge by throwing some money down on San Francisco (-270) to return some of the inevitably-lost bet.

Parlays and teasers

You can always string bets together in the form of parlays or teasers. Usually during busy Sundays, bettors can parlay several teams to win or cover against the spread and if all bets are successful, the payouts are multiplied. Teasers function similarly, except they allow bettors to move each point spread to a more favorable line in exchange for diminished odds.


Futures are long-term bets that can range from an offseason to a full season (or beyond). Team win totals, award winners, and player performance are common futures.

49ers 2021 recap

Record: 10-7, Third in NFC West, Eliminated in NFC Championship by Rams.

Record ATS: 9-8

Over/under record: 8-9

What a turnaround for the San Francisco 49ers. They began the year 3-5 and ended up in the NFC Championship Game. They didn’t even have a playoff berth secured until Week 18. Ultimately, subpar quarterback play was their undoing and the season ended on a Jimmy Garoppolo interception. Deebo Samuel was the breakout star of the team while Elijah Mitchell had a terrific rookie season. The defense was stout, but until the QB situation is sorted, this team may have a ceiling.