San Francisco 49ers Betting Guide

Schedule, Odds, And Predictions

Just a year after finding themselves in the Super Bowl, Kyle Shanahan’s 49ers missed the playoffs. What could be determined to be a “Super Bowl hangover” was caused by a litany of injuries to key positions including George KittleRaheem Mostert, and Nick Bosa. Almost every starter graced the IR at some point of the season, many of which were season-ending. Shanahan coached a brilliant season with the remaining pieces and the 49ers were in playoff contention until the final quarter of the season.

Much of their talent, especially veteran, was set for free agency, but San Francisco was able to bring back many of their players. Tackle Trent Williams was re-signed to a massive extension, corner Jason Verrett was retained, and Kyle Juszczyk was signed to a five-year deal. While Richard Sherman will not return to the team, the 49ers have what they need moving forward– especially as their roster gets healthier– and they should be in a position to compete again this season.

San Francisco 49ers odds

Best 49ers betting site(s)

49ers prop bets

Prop bets are based on individual performance, typically surrounding players. With such a volatile rotating cast of running backs this past season, providing sharp bettors with plenty of opportunity in prop betting. For example, Jeff Wilson Jr.’s projected rushing total in the 49ers’ Week 16 matchup with the Arizona Cardinals was 38.5 yards. That game, Wilson exploded for 183 yards on the ground– exceeding everyone’s wildest expectations. Those who bet on Wilson to exceed 38.5 yards (the over) would have cashed out that week.

Search below for San Francisco 49ers team or player props currently being offered at sportsbooks. You can also look around at other teams and players using this tool. Happy shopping!

49ers futures odds

Futures are long-term bets that can range from an offseason to a full season (or beyond). Team win totals, award winners, and player performance are common futures. For example:

2020 Odds to win NFL DPOY

  • Nick Bosa +250
  • Aaron Donald +400
  • Myles Garrett +800
  • T.J. Watt +1100

This line for the Defensive Player of the Year would often be bet before the season starts. Futures allow for bettors to capitalize on players they think are favorites to win awards long before the odds shift away from their favor. For example, Aaron Donald opened with odds of +400 to win the DPOY; his odds shifted as the season developed and Donald was the eventual winner of the award come December.

49ers Super Bowl LVI odds

The San Francisco 49ers opened with +1400 odds to win Super Bowl LVI– second-best odds in the NFC West and fourth-best odds in the NFC.

49ers NFC West odds

The 49ers were the first team to be eliminated from NFC West contention during an injury-riddled 2020.

49ers win totals

10.5 wins (+120 over)/(-150 under)

The crew is back and healthy after a year that was decimated with injuries. Better yet, the 49ers are drafting third overall and are expected to select a new franchise quarterback. Just a year removed from a Super Bowl berth, San Francisco is a team that’s expected to compete this year.

San Francisco 49ers 2021 schedule and betting odds

Check back for the complete 49ers 2021 schedule along with the opening spreads for every game.

How to bet on the San Francisco 49ers


The moneyline is the simplest of bets, decided by the straight-up winner and loser of each game. Consider the following example:

  • 49ers -185
  • Panthers +310

The 49ers are considered heavy favorites in this matchup (indicated by -185), requiring a $185 bet to win $100 (plus the initial bet back). The Panthers are the underdog in this matchup, paying out $410 total for a $100 bet ($310 in winnings). How much either team wins or loses by does not matter in moneyline betting, the payout remains the same.

Point spread

Betting on the point spread is determinant on how many points a team wins or loses by. Take the following example:

  • 49ers -6.5 (-110)
  • Dolphins +6.5 (-110)

In this example, San Francisco is favored by 6.5 points, indicated by “-6.5.” If the 49ers win the game 27-20, the 49ers (-6.5) win the bet and would have a total payout of $19.09 on a $10 bet ($9.09 in profit). If the Dolphins keep the game within seven and lose 23-17, the Dolphins (+6.5) would win, and the payout would be the same as listed above.

Point total (over/under)

The point total refers to the over/under line set by books. This number projects the total number of points scored in a game and, like prop betting, is bet whether one thinks the score will go over or under the set point total. For example, the 49ers’ Week 7 matchup with the New England Patriots had a projected point total of 47.5 points. San Francisco won that game 33-7, resulting in 40 points being scored. Those that bet under the point total would have cashed out.

The 49ers have fielded one of the most potent defenses and dangerous running games in the NFL for the past few seasons; the Kyle Shanahan system specializes in diversifying their offensive weapons and getting as many athletes involved in the game as possible. As a result, the 49ers aren’t quick-scoring, one-play threatening, and usually garner lower point totals. Typical over/unders for games involving the 49ers sit between 45 and 49 points.

In-play and live betting

Sometimes, the most thrilling and rewarding bets are bets made while games are being played. These are referred to as live bets or in-play bets. Odds are ever-changing during games, which would prove to be fruitful for sharp and prepared bettors. For example, if the 49ers (-225) were heavily favored against the Raiders (+190) before kickoff, a payout on a $10 bet on the 49ers to win would win just $4.44.

However, say the 49ers fell to a big 17-3 deficit in the first half despite controlling the overall game (due to a costly turnover or special teams gaffe). Odds may swing in favor of the Raiders, who may be a -110 favorite at halftime. Taking the 49ers to come back and win the game could present plus-odds (say, +130). Should a bettor take San Francisco (+130) at halftime and the 49ers pull off the comeback, winners would win $13 instead of $4.44 (plus the initial $10 bet).

This could also be an effective way to “hedge” your bet; say a bettor took the Raiders (+190) in that game, but San Francisco jumps out to a 21-0 first quarter lead and is controlling the overall feel of the game, bettors could hedge by throwing some money down on San Francisco (-270) to return some of the inevitably-lost bet.

Parlays and teasers

You can always string bets together in the form of parlays or teasers. Usually during busy Sundays, bettors can parlay several teams to win or cover against the spread and if all bets are successful, the payouts are multiplied. Teasers function similarly, except they allow bettors to move each point spread to a more favorable line in exchange for diminished odds.

49ers 2020 recap

Record: 6-10

Record ATS: 7-9

Over/under record: 8-8

The follow-up to the 49ers’ Super Bowl LIV appearance was about as disappointed as it gets. The team was riddled with injuries to star players including Nick Bosa, George Kittle, Raheem Mostert, Deebo Samuel, Solomon Thomas, and Jamar Taylor. As a result, San Francisco finished 6-10, which is positive compared to what cards they were dealt in 2020. This season can be effectively written off and fans can look forward to 2021.

49ers 2021 offseason moves

Key trades:

Key re-signings: CB Jason Verrett (one-year), FB Kyle Juszczyk (five years, $27 million), DE Dee Ford (two years, $24 million), T Trent Williams (six years, $138 million), CB Emmanuel Moseley (two years, $10 million)

Key free agent losses:

Key free agent signings: C Alex Mack (one year, $5.5 million)

Draft pick position needs: QB, OL, CB