San Francisco 49ers Betting Guide

Schedule, Odds, And Predictions

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San Francisco 49ers odds to win the Super Bowl range from +700 to +1000, the second or third shortest odds behind the Chiefs and Eagles, depending on the sportsbook. HC Kyle Shannahan has proven that he can win no matter who is playing QB. So, despite quarterback being a massive question mark heading into the season, the market is not dissuaded away from San Francisco. Currently, the 49ers plan to enter the season with newly acquired Sam Darnold competing with Trey Lance for the #1 job while Brock Purdy recovers from surgery. Purdy’s injury timeline would have him healthy by Week 1 in the best-case scenario.

Below, you can find San Francisco 49ers odds for 2023. Included is a weekly outlook, odds for every game this season, futures, and more.

San Francisco 49ers odds

View San Francisco 49ers odds for the 2023 NFL season below. 49ers Week 1 odds are already available to bet on. Compare NFL betting odds for their game against the Pittsburgh Steelers.

San Francisco 49ers at Pittsburgh Steelers

The 49ers opened as a -3 favorite for their NFL Week 1 game against the Pittsburgh Steelers. The game had an initial total of 42 points.

49ers Betting

49ers betting futures are also available to bet on now. See the best prices below.

49ers transactions

Key signings: QB Sam Darnold, DT Javon Hargrave, S Tashaun Gipson, DE Austin Bryant, G Jon Feliciano, S Myles Hartsfield, TE Ross Dwelley, DT T.Y. McGill, LB Demetrius Flannigan-Fowles, CB Isaiah Oliver, DE Clelin Ferrell, C Jake Brendel, DT Kevin Givens,  OL Matt Pryor, WR Chris Conley,

Re-signings: LB Marcelino McCrary-Ball, DL Kerry Hyder Jr.

Trades: Acquired K Zane Gonzalez 

Key losses: T Mike McGlinchey, QB Jimmy Garoppolo, S Jimmie Ward, DE Samson Ebukam, CB Emmanuel Moseley, DE Charles Omenihu, LB Azeez Al-Shaair, OL Daniel Brunskill, DT Hassan Ridgeway

Key draft picks: S Ji’Ayir Brown, Penn State (third round, 87th overall), K Jake Moody, Michigan (third round, 99th overall), TE Cameron Latu, Alabama (third round, 101st overall), CB Darrell Luter Jr., South Alabama (fifth round, 155th overall), DL Robert Beal Jr., Georgia (fifth round, 173rd overall), LB Dee Winters, TCU (sixth round, 216th overall), TE Brayden Willis, Oklahoma (seventh round, 247th overall), WR Ronnie Bell, Michigan (seventh round, 253rd overall), LB Jalen Graham, Purdue (seventh round, 255th overall)

49ers Super Bowl odds

The San Francisco 49ers currently hold odds to win the 2024 Super Bowl.

49ers prop bets

Search below for San Francisco 49ers odds, team or player props currently being offered at sportsbooks. You can also look around at other teams and players using this tool. Happy shopping!

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San Francisco 49ers 2023 schedule and betting odds

Week DateOpponentKickoff TimeOpening OddsClosing LineFinal Score
Week 1Sunday, September 10at Pittsburgh Steelers1 p.m. ET-1
Week 2Sunday, September 17at Los Angeles Rams4:05 p.m. ET-4.5
Week 3Thursday, September 21vs. New York Giants8:15 p.m. ET-4.5
Week 4Sunday, October 1vs. Arizona Cardinals 4:25 p.m. ET-9.5
Week 5Sunday, October 8vs. Dallas Cowboys 8:20 p.m. ET-3.5
Week 6Sunday, October 15at Cleveland Browns1 p.m. ET-1
Week 7Monday, October 23at Minnesota Vikings8:15 p.m. ET-1
Week 8Sunday, October 29vs. Cincinnati Bengals4:25 p.m. ET-1
Week 9Bye WeekBYE WEEK
Week 10Sunday, November 12at Jacksonville Jaguars 1 p.m. ET-1
Week 11Sunday, November 19vs. Tampa Bay Buccaneers4:05 p.m. ET-7.5
Week 12Thursday, November 23at Seattle Seahawks8:20 p.m. ET-1.5
Week 13Sunday, December 3at Philadelphia Eagles4:25 p.m.ET+2.5
Week 14Sunday, December 10vs. Seattle Seahawks4:05 p.m. ET+3.5
Week 15Sunday, December 17at Arizona Cardinals 4:05 p.m. -6.5
Week 16Monday, December 25vs. Baltimore Ravens 8:15 p.m. ET-3
Week 17Sunday, December 31at Washington Commanders 1 p.m. ET-3
Week 18TBDLos Angeles RamsTBD-6

How to bet on the San Francisco 49ers


The moneyline is the simplest of bets, decided by the straight-up winner and loser of each game. Consider the following example:

  • 49ers -185
  • Panthers +310

The 49ers are considered heavy favorites in this matchup (indicated by -185), requiring a $185 bet to win $100 (plus the initial bet back). The Panthers are the underdog in this matchup, paying out $410 total for a $100 bet ($310 in winnings). How much either team wins or loses by does not matter in moneyline betting, the payout remains the same.

Point spread

Betting on the point spread is determinant on how many points a team wins or loses by. Take the following example:

  • 49ers -6.5 (-110)
  • Dolphins +6.5 (-110)

In this example, San Francisco is favored by 6.5 points, indicated by “-6.5.” If the 49ers win the game 27-20, the 49ers (-6.5) win the bet and would have a total payout of $19.09 on a $10 bet ($9.09 in profit). If the Dolphins keep the game within seven and lose 23-17, the Dolphins (+6.5) would win, and the payout would be the same as listed above.

Point total (over/under)

The point total refers to the over/under line set by books. This number projects the total number of points scored in a game and, like prop betting, is bet whether one thinks the score will go over or under the set point total. For example, the 49ers’ Week 7 matchup with the New England Patriots had a projected point total of 47.5 points. San Francisco won that game 33-7, resulting in 40 points being scored. Those that bet under the point total would have cashed out.

The 49ers have fielded one of the most potent defenses and dangerous running games in the NFL for the past few seasons; the Kyle Shanahan system specializes in diversifying their offensive weapons and getting as many athletes involved in the game as possible. As a result, the 49ers aren’t quick-scoring, one-play threatening, and usually garner lower point totals. Typical over/unders for games involving the 49ers sit between 45 and 49 points.

In-play and live betting

Sometimes, the most thrilling and rewarding bets are bets made while watching the games. These are referred to as live bets or in-play bets. Odds are ever-changing during games, which would prove to be fruitful for sharp and prepared bettors. For example, if the 49ers (-225) were heavily favored against the Raiders (+190) before kickoff, a payout on a $10 bet on the 49ers to win would win just $4.44.

However, say the 49ers fell to a big 17-3 deficit in the first half despite controlling the overall game (due to a costly turnover or special teams gaffe). Odds may swing in favor of the Raiders, who may be a -110 favorite at halftime. Taking the 49ers to come back and win the game could present plus-odds (say, +130). Should a bettor take San Francisco (+130) at halftime and the 49ers pull off the comeback, winners would win $13 instead of $4.44 (plus the initial $10 bet).

This could also be an effective way to “hedge” your bet; say a bettor took the Raiders (+190) in that game, but San Francisco jumps out to a 21-0 first quarter lead and is controlling the overall feel of the game, bettors could hedge by throwing some money down on San Francisco (-270) to return some of the inevitably-lost bet.

Parlays and teasers

You can always string bets together in the form of parlays or teasers. Usually during busy Sundays, bettors can parlay several teams to win or cover against the spread and if all bets are successful, the payouts are multiplied. Teasers function similarly, except they allow bettors to move each point spread to a more favorable line in exchange for diminished odds.


Futures are long-term bets that can range from an offseason to a full season (or beyond). Team win totals, award winners, and player performance are common futures.

49ers 2021 recap

Record: 10-7, Third in NFC West, Eliminated in NFC Championship by Rams.

Record ATS: 9-8

Over/under record: 8-9

What a turnaround for the San Francisco 49ers. They began the year 3-5 and ended up in the NFC Championship Game. They didn’t even have a playoff berth secured until Week 18. Ultimately, subpar quarterback play was their undoing and the season ended on a Jimmy Garoppolo interception. Deebo Samuel was the breakout star of the team while Elijah Mitchell had a terrific rookie season. The defense was stout, but until the QB situation is sorted, this team may have a ceiling.