LA Chargers Betting Guide: Odds And Predictions
Written By Road to CFB | Last Updated at October 15, 2025
Betting on the Los Angeles Chargers? This guide has all the resources you need for informed decisions this season. Included is a weekly outlook, spreads for every game this season, futures, and more.
This guide covers the latest Chargers odds, moneylines, spreads, and totals for upcoming games. You'll also find explanations of bet types, tips for wagering on Los Angeles Chargers games, and a complete schedule to keep you updated throughout the season.
LA Chargers odds
The following are the Chargers' odds (click here for this week's best NFL betting promos).
Los Angeles opened as a -2.5 road favorite with an initial over/under of 43.5. Los Angeles was a -155 moneyline favorite.
Chargers Super Bowl odds
View the Chargers' Super Bowl odds below.
Chargers AFC West odds
The Chargers' odds to win the AFC West opened at +300.
Chargers Win Total
The Chargers opened the season with a projected win total of 8.5. The opening price on the over was +110.
Chargers prop bets
Search below for Los Angeles Chargers odds, team, or player props currently being offered at sportsbooks. You can also look around at other teams and players using this tool. Happy shopping!
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Chargers schedule
Here are the opening odds for each Chargers game following the release of the NFL schedule.
| Week | Date | Opponent | Start Time | Opening Odds |
| Week 1 | Sunday, September 5 | Kansas City Chiefs | 4:05 p.m. ET | -3 |
| Week 2 | Monday, September 15 | At Las Vegas Raiders | 1 p.m. ET | -5 |
| Week 3 | Sunday, September 21 | Denver Broncos | 1 p.m. ET | +2 |
| Week 4 | Sunday, September 28 | At New York Giants | 4:25 p.m. ET | +3 |
| Week 5 | Sunday, October 5 | Washington Commanders | 1 p.m. ET | -- |
| Week 6 | Sunday, October 12 | At Miami Dolphins | 4:05 p.m. ET | -1.5 |
| Week 7 | Sunday, October 19 | Indianapolis Colts | 1:05 p.m. ET | +1 |
| Week 8 | Thursday, October 23 | Minnesota Vikings | 4:15 p.m. ET | -3 |
| Week 9 | Sunday, November 2 | At Tennessee Titans | 1 p.m. ET | +3 |
| Week 10 | Sunday, November 9 | Pittsburgh Steelers | 8:20 p.m. ET | -4 |
| Week 11 | Sunday, November 16 | At Jacksonville Jaguars | 1 p.m. ET | +2 |
| Week 12 | BYE WEEk | -- | -- | -- |
| Week 13 | Sunday, November 30 | Las Vegas Raiders | 4:25 p.m ET | +2.5 |
| Week 14 | Monday, December 8 | Philadelphia Eagles | 8:15 p.m. ET | +6.5 |
| Week 15 | Sunday, December 14 | At Kansas City Chiefs | 1 p.m. ET | -3 |
| Week 16 | Sunday, December 22 | At Dallas Cowboys | 1 p.m. ET | -3.5 |
| Week 17 | TBD | Houston Texans | TBD | -2.5 |
| Week 18 | TBD | At Denver Broncos | TBD | +1 |
How to bet on the Los Angeles Chargers
Moneyline
The moneyline is the simplest of bets, decided by the straight-up winner and loser of each game. Consider the following example:
- Chargers -105
- Cowboys +100
The Chargers are considered slight favorites in this matchup (indicated by -105), requiring a $105 bet to win $100 (plus the initial bet back). The Cowboys are the underdog in this matchup, paying out $200 total for a $100 bet ($100 in winnings). How much either team wins or loses by does not matter in moneyline betting; the payout remains the same.
Point spread
Betting on the point spread is determined by how many points a team wins or loses by. Take the following example:
- Chargers +6.5 (-110)
- Bills -6.5 (-110)
In this example, Los Angeles is the underdog by 6.5 points, indicated by “-6.5.” If the Chargers keep the game within seven points or win outright, the Chargers (+6.5) win the bet and would have a total payout of $19.09 on a $10 bet ($9.09 in profit). If the Bills win the game 27-20 or by more than 6 points, then the Bills (-6.5) would win and the payout would be the same as listed above.
Point total (over/under)
The point total refers to the over/under line set by books. This number projects the total number of points scored in a game and, like prop betting, is bet on whether one thinks the score will go over or under the set point total. For example, the Chargers' Week 7 matchup with the Jacksonville Jaguars had a point total of 54.5 points. L.A. won that game 39-29, totaling 68 points. Those who bet over the point total in the matchup would have cashed out.
The Chargers' offense and defense were middle-of-the-pack, despite having a prolific rookie quarterback, resulting in average point totals for their games. Projected point totals typically ranged between 49 and 53 points in games involving the Chargers and were heavily reliant on their opponents. If L.A. were hosting the Chiefs, an explosive, high-scoring offense, their point total would rise, while if they were playing the Bears, a stout defensive team with a methodical offense, the point total would be lower.
In-play and live betting
Sometimes, the most thrilling and rewarding bets are bets made while games are being played. These are referred to as live bets or in-play bets. NFL odds are ever-changing during games, which can prove fruitful for sharp and prepared bettors. For example, if the Chargers (-225) were heavily favored against the Lions (+190) before kickoff, a payout on a $10 bet on the Chargers to win would just $4.44.
However, say the Chargers fell to a big 17-3 deficit in the first half despite controlling the overall game (due to a costly turnover or special teams gaffe). Odds may swing in favor of the Lions, who may be a -110 favorite at halftime. Taking the Chargers to come back and win the game could present plus-odds (say, +130). Should a bettor take Los Angeles (+130) at halftime and the Chargers pull off the comeback, winners would win $13 instead of $4.44 (plus the initial $10 bet).
This could also be an effective way to "hedge" your bet; say a bettor took the Lions (+190) in that game, but L.A. jumps out to a 24-0 first-quarter lead and is controlling the overall feel of the game, bettors could hedge by throwing some money down on the Chargers (-270) to return some of the inevitably-lost bet.
Parlays and teasers
You can always string bets together in the form of parlays or teasers. Usually, during busy Sundays, bettors can parlay several teams to win or cover against the spread, and if all bets are successful, the payouts are multiplied. Teasers function similarly, except they allow bettors to move each point spread to a more favorable line in exchange for diminished odds.
Futures
Futures are long-term bets that can range from an offseason to a full season (or beyond). Team win totals, award winners, and player performance are common futures.
Los Angeles Chargers Odds Summary
The odds for the Los Angeles Chargers can fluctuate based on player performances and game matchups. To optimize your betting strategy, compare leading sports betting sites for detailed odds and a diverse range of betting markets. Also, use the best sports betting apps to place bets on the go, stay informed about line changes, and take advantage of emerging opportunities.
Los Angeles Chargers betting guide FAQs
