Buffalo Bills Betting Guide

Schedule, Odds, And Predictions

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After 13 weeks of the season, the Buffalo Bills are atop both the AFC standings and Super Bowl 57 odds boards () despite a gauntlet of an AFC East. The Bills pulled out a huge divisional win over the Patriots last week, vaulting themselves to the top overall seed in the AFC. But more AFC East games are on top as Buffalo plays the Jets and Dolphins back-to-back upcoming.

Below, you can find Buffalo Bills odds for 2022. Included is a weekly outlook, odds for every game this season, futures, and more.

NFL Week 14 Odds: Bills Vs. Jets Spread, Total, Moneyline

The Bills are big favorites at home against Mike White and the New York Jets. Buffalo fields one of the best passing defenses in the NFL, which matches up well against the Jets’ one-dimensional passing offense this week. White has thrown for over 300 yards in each of his last two games, however he threw two picks in their last game. The Bills are fourth in the NFL in turnovers forced per game. The over/under for this game is set at points.

Bills betting news

Bills prop bets

Search below for Buffalo Bills odds, team or player props currently being offered at sportsbooks. You can also look around at other teams and players using this tool. Happy shopping!

Buffalo Bills Super Bowl odds

The Buffalo Bills are favorites to win Super Bowl LVII at .

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Buffalo Bills 2022 schedule

Week DateOpponentKickoff TimeOpening Odds
Week 1Thursday, Sept. 8at Los Angeles Rams8:20 p.m. ET+1
Week 2Monday, Sept. 19vs. Tennessee Titans7:15 p.m. ET-7
Week 3Sunday, Sept. 25at Miami Dolphins1 p.m. ET-3.5
Week 4Sunday, Oct. 2at Baltimore Ravens1 p.m. ET-1
Week 5Sunday, Oct. 9vs. Pittsburgh Steelers1 p.m. ET-8
Week 6Sunday, Oct. 16at Kansas City Chiefs4:25 p.m. ET-1.5
Week 7Sunday, Oct. 23BYEBYE
Week 8Sunday, Oct. 30vs. Green Bay Packers8:20 p.m. ET-4
Week 9Sunday, Nov. 6at New York Jets1 p.m. ET-6.5
Week 10Sunday, Nov. 13vs. Minnesota Vikings1 p.m. ET-7.5
Week 11Sunday, Nov. 20vs. Cleveland Browns1 p.m. ETOTB
Week 12Thursday, Nov. 24at Detroit Lions12:30 p.m. ET-8
Week 13Thursday, Dec. 1at New England Patriots8:15 p.m. ET-3
Week 14Sunday, Dec. 11vs. New York Jets1 p.m. ET-9.5
Week 15Saturday, Dec. 17 OR Sunday, Dec. 18vs. Miami DolphinsTBD-6
Week 16Saturday, Dec. 24at Chicago Bears1 p.m. ET-7
Week 17Monday, Jan. 2at Cincinnati Bengals8:30 p.m. ETPK
Week 18Saturday, Jan. 7 OR Sunday, Jan. 8vs. New England PatriotsTBD-7

Bills 2022 offseason moves

Key signings: LB Von Miller, OG Rodger Saffold, WR Jameson Crowder, DL DaQuan Jones, TE OJ Howard, OG David Quassenberry

Re-signings: WR Stefon Diggs, WR Isaiah McKenzie, C Mitch Morse

Trades: None

Key losses: LB A.J. Klein,  DT Daryl Williams, CB Levi Wallace

Key draft picks: CB Kaiir Elam, RB James Cook, P Matt Araiza

How to bet on the Buffalo Bills


The moneyline is the simplest of bets, decided by the straight-up winner and loser of each game. Consider the following example:

  • Bills -105
  • Steelers +130

The Bills are considered slight favorites in this matchup (indicated by -105), requiring a $105 bet to win $100 (plus the initial bet back). The Steelers are the underdog in this matchup, paying out $130 total for a $100 bet ($130 in winnings). How much either team wins or loses by does not matter in moneyline betting, the payout remains the same.

Point spread

Betting on the point spread is determinant on how many points a team wins or loses by. Take the following example:

  • Bills -2.5 (-110)
  • Dolphins +2.5 (-110)

In this example, Buffalo is favored by 2.5 points, indicated by “-2.5.” If the Bills win the game 23-20, the Bills (-2.5) win the bet and would have a total payout of $19.09 on a $10 bet ($9.09 in profit). If the Dolphins keep the game within three and lose 24-23, the Dolphins (+2.5) would win, and the payout would be the same as listed above.

Point total (over/under)

The point total refers to the over/under line set by books. This number projects the total number of points scored in a game and, like prop betting, is bet whether one thinks the score will go over or under the set point total. For example, a game between the Patriots and Bills had a point total set at 52.5 points. Buffalo win the ballgame 38-9, which resulted in 47 total points. Those who bet the under in this game would cash out.

The expectation for the Bills’ explosive offense should nudge point totals near or above 50 points, though their talented defense might keep those totals perfectly average in the NFL this coming season.

In-play and live betting

Sometimes, the most thrilling and rewarding bets are bets made while games are being played. These are referred to as live bets or in-play bets. Odds are ever-changing during games, which would prove to be fruitful for sharp and prepared bettors. For example, if the Bills (-225) were heavily favored against the Panthers (+190) before kickoff, a payout on a $10 bet on the Bills to win would win just $4.44.

However, say the Bills fell to a big 17-3 deficit in the first half despite controlling the overall game (due to a costly turnover or special teams gaffe). Odds may swing in favor of the Panthers, who may be a -110 favorite at halftime. Taking the Bills to come back and win the game could present plus-odds (say, +130). Should a bettor take Buffalo (+130) at halftime and the Bills pull off the comeback, winners would win $13 instead of $4.44 (plus the initial $10 bet).

This could also be an effective way to “hedge” your bet; say a bettor took the Panthers (+190) in that game, but Buffalo jumps out to a 10-0 first quarter lead and is controlling the overall feel of the game, bettors could hedge by throwing some money down on Buffalo (-270) to return some of the inevitably-lost bet.

Parlays and teasers

You can always string bets together in the form of parlays or teasers. Usually during busy Sundays, bettors can parlay several teams to win or cover against the spread and if all bets are successful, the payouts are multiplied. Teasers function similarly, except they allow bettors to move each point spread to a more favorable line in exchange for diminished odds.


Futures are long-term bets that can range from an offseason to a full season (or beyond). Team win totals, award winners, and player performance are common futures.

Bills 2021 recap

Record: 11-6

Record ATS: 9-6-2

Over/under record: 8-9

The young and talented Buffalo Bills made another postseason run. Their Super Bowl hopes were dashed by budding-rival Kansas City in the Divisional Round, but Bills fans have to be excited with what they saw. Josh Allen once again proved his status as a young elite quarterback and receiver Gabriel Davis appears to be a rising star. The team’s biggest question this coming offseason is around Brian Daboll, who has interviewed with and is rumored to be a favorite for several head coaching openings.

Where can I bet on sports in New York?

New York retail sports betting was launched in 2019, and there many options to get a bet down on the Buffalo Bills or any other NFL team. Here’s a list of legal sportsbook options in New York: