Buffalo Bills Betting Guide

Schedule, Odds, And Predictions

buffalo bills odds

Sean McDermott and the Buffalo Bills clinched a division crown for the first time since 1995, as well as a spot in the AFC Championship Game. Star quarterback Josh Allen put together a season worthy of MVP consideration and found instant chemistry with newly-acquired receiver Stefon Diggs. They were looking like serious contenders all season long and were on the verge of securing their first Super Bowl berth since 1993 until they were upended by the Kansas City Chiefs. With such a young talented corps on their roster, it won’t be the last time the Bills find themselves making a playoff run.

Some role players’ contracts will have to be retooled this offseason and the only major name– Matt Milano– was signed to a contract extension early. Offensive coordinator Brian Daboll was rumored to be leaving Buffalo to take a head coaching position, but he will ultimately stay put. 2021 remains a crucial offseason and the 2021-22 season presents another opportunity for the Bills to make a run.

In the meantime, Bills fans can celebrate their most successful season in almost 30 years– they earned it.

Best Bills betting site(s)

Buffalo Bills schedule and odds

Here is the Buffalo Bills 2021 schedule, along with betting odds from DraftKings Sportsbook.

Week DateOpponentKickoff TimeOpening Line
Week 1Sunday, Sept. 12vs. Pittsburgh Steelers1 p.m. ETBills -4.5

Bills prop bets

Prop bets are based on individual performance, typically surrounding players. For example, Josh Allen’s projected passing total against the Denver Broncos in Week 15 of the 2020 season was set at 268.5 yards. If a bettor expected Allen to throw for 269 or more yards, they would bet the over while those who expected Allen to throw for 268 or fewer yards would bet the under. Allen threw for 353 yards that game, giving over bettors the win.

Search below for Buffalo Bills team or player props currently being offered at sportsbooks. You can also look around at other teams and players using this tool. Happy shopping!

Bills futures odds

Futures are long-term bets that can range from an offseason to a full season (or beyond). Team win totals, award winners, and player performance are common futures. For example:

2020 Odds to win NFL DROY

  • Chase Young -110
  • Patrick Queen +450
  • Kenneth Murray +1000
  • Jaylon Johnson +1500

This line for the Defensive Rookie of the Year would often be bet before the season starts. Futures allow for bettors to capitalize on players they think are favorites to win awards long before the odds shift away from their favor. For example, Queen opened with odds of +900 to win the DROY award after the NFL Draft; his odds will shift as the season develops based on his performance for the Ravens defense.

Bills Super Bowl LVI odds

The Buffalo Bills are +1200 to win Super Bowl LVI– best in the AFC East and fifth-best overall.

Bills AFC East odds

The Buffalo Bills clinched the AFC East division title, their first since 1995. There were listed between +120 and +160 before the season.

Bills win totals

10.5 wins (-110 over)/(-110 under)

The Bills established themselves as a serious Super Bowl contender in 2020, making it all the way to the AFC Championship Game. With most of last year’s crew in tact (plus another pass catcher Emmanuel Sanders for Josh Allen), expect the Bills to pick up right where they left off.

How to bet on the Buffalo Bills


The moneyline is the simplest of bets, decided by the straight-up winner and loser of each game. Consider the following example:

  • Bills -105
  • Seahawks +130

The Bills are considered slight favorites in this matchup (indicated by -105), requiring a $105 bet to win $100 (plus the initial bet back). The Seahawks are the underdog in this matchup, paying out $130 total for a $100 bet ($130 in winnings). How much either team wins or loses by does not matter in moneyline betting, the payout remains the same.

Point spread

Betting on the point spread is determinant on how many points a team wins or loses by. Take the following example:

  • Bills -2.5 (-110)
  • Dolphins +2.5 (-110)

In this example, Buffalo is favored by 2.5 points, indicated by “-2.5.” If the Bills win the game 23-20, the Bills (-2.5) win the bet and would have a total payout of $19.09 on a $10 bet ($9.09 in profit). If the Dolphins keep the game within three and lose 24-23, the Dolphins (+2.5) would win, and the payout would be the same as listed above.

Point total (over/under)

The point total refers to the over/under line set by books. This number projects the total number of points scored in a game and, like prop betting, is bet whether one thinks the score will go over or under the set point total. For example, a Week 16 game between the Patriots and Bills had a point total set at 52.5 points. Buffalo win the ballgame 38-9, which resulted in 47 total points. Those who bet the under in this game would cash out.

The expectation of 2019’s Bills defense and the expected inaccuracy of Josh Allen resulted in sportsbooks giving the Bills low point totals heading into 2020. However, an explosive offense and vulnerable defense led to lots of Buffalo’s games exceeding point totals, frequently scoring over 55 combined points.

In-play and live betting

Sometimes, the most thrilling and rewarding bets are bets made while games are being played. These are referred to as live bets or in-play bets. Odds are ever-changing during games, which would prove to be fruitful for sharp and prepared bettors. For example, if the Bills (-225) were heavily favored against the Raiders (+190) before kickoff, a payout on a $10 bet on the Bills to win would win just $4.44.

However, say the Bills fell to a big 17-3 deficit in the first half despite controlling the overall game (due to a costly turnover or special teams gaffe). Odds may swing in favor of the Raiders, who may be a -110 favorite at halftime. Taking the Bills to come back and win the game could present plus-odds (say, +130). Should a bettor take Buffalo (+130) at halftime and the Bills pull off the comeback, winners would win $13 instead of $4.44 (plus the initial $10 bet).

This could also be an effective way to “hedge” your bet; say a bettor took the Raiders (+190) in that game, but Buffalo jumps out to a 10-0 first quarter lead and is controlling the overall feel of the game, bettors could hedge by throwing some money down on Buffalo (-270) to return some of the inevitably-lost bet.

Parlays and teasers

You can always string bets together in the form of parlays or teasers. Usually during busy Sundays, bettors can parlay several teams to win or cover against the spread and if all bets are successful, the payouts are multiplied. Teasers function similarly, except they allow bettors to move each point spread to a more favorable line in exchange for diminished odds.

Bills 2020 recap

Record: 13-3

Record ATS: 11-5

Over/under record: 10-5-1

Buffalo quickly became the favorite Cinderella team in the AFC. Josh Allen made one of the biggest single-season improvements of any quarterback, increasing his completion percentage nearly 10 points. Newly-added Stefon Diggs (acquired from the Vikings in an offseason trade) torched secondaries for the NFL receiving crown in 2020-21. Even longtime veteran Cole Beasley had somewhat of a breakout season, nearly breaking the 1,000-yard mark for the first time in his career (he finished with 967 yards). The Bills finished third in points scored per game (29.9), though the defense took a significant step back from 2019. Their 13-3 record is the franchise’s best since 1991 and ties their highest-ever regular season win total.

11-5 was tied for the league lead in record against the spread (with Miami) as the Bills routinely defied expectations. Their offense was explosive even against some of the NFL’s best defenses– scoring 35 on the Rams in Week 3 (second in points per game allowed) and 59 on the Dolphins in Week 17 (fourth). Their ability to outpace almost anyone resulted in such a high ATS mark as well as against the point total. Their 10-5-1 record against the point total was good enough for fourth in the NFL.

Bills 2021 offseason moves

Key trades:

Key re-signings: C Mitch Morse (four years, $44.5 million), S Micah Hyde (two years, $19.3 million), G Jon Feliciano (three years, $17 million), LB Matt Milano (four years, $44 million)

Key free agent losses:

Key free agent signings: WR Emmanuel Sanders (one year)

Key draft picks: EDGE Gregory Rousseau, EDGE Carlos Basham Jr., WR Marquez Stevenson