Buffalo Bills Betting Guide

Schedule, Odds, And Predictions


The Buffalo Bills (7-4) square off against the New England Patriots (8-4) in a pivotal AFC East matchup in Week 13. The Bills are favorites at home in a game that’s forecasted to have snow and wind. They’re also third in the NFL in offensive success rate over the last five weeks and top in the NFL in defense EPA on the season. The Patriots lead the NFL in net points and have won six straight games coming into this game on Monday Night Football. The contest has an over/under of   points– a testament to both teams’ defensive prowess and the impending weather.

Below, you can find Buffalo Bills odds for 2021. Included is a weekly outlook, odds for every game this season, futures, and more.

Buffalo Bills Week 13 odds

Bills betting news

This feed is updated automatically when something happens.

Buffalo Bills futures odds

Futures are long-term bets that can range from an offseason to a full season (or beyond). Team win totals, award winners, and player performance are common futures.

Bills Super Bowl odds

The Buffalo Bills are +800 to win Super Bowl LVI– the second-highest mark in the AFC. Despite a blowout loss at the hands of the Colts in Week 12, markets were generally unmoved when it came to Buffalo’s Super Bowl chances.

Compare this line with all 2022 Super Bowl odds

Other futures markets 2021

 Current OddsPreseason Odds
Bills odds to win Super Bowl LVI+600+1000
Bills odds to win AFC+600+500
Bills odds to win AFC East-450-150
Bills odds to make playoffs-5000-350
Buffalo Bills win total12.5 (-130)11 (-110)

Bills prop bets

Prop bets are based on individual performance, typically surrounding players. For example, Josh Allen’s projected passing total against the Denver Broncos in Week 15 of the 2020 season was set at 268.5 yards. If a bettor expected Allen to throw for 269 or more yards, they would bet the over while those who expected Allen to throw for 268 or fewer yards would bet the under. Allen threw for 353 yards that game, giving over bettors the win.

Search below for Buffalo Bills odds, team or player props currently being offered at sportsbooks. You can also look around at other teams and players using this tool. Happy shopping!

Buffalo Bills schedule and odds

Here is the Buffalo Bills 2021 schedule, along with betting odds from DraftKings Sportsbook.

Week DateOpponentKickoff Time
Week 1Sunday, Sept. 12vs. Pittsburgh Steelers1 p.m. ET
Week 2Sunday, Sept. 19at Miami Dolphins1 p.m. ET
Week 3Sunday, Sept. 26vs. Washington Football Team1 p.m. ET
Week 4Sunday, Oct. 3vs. Houston Texans1 p.m. ET
Week 5Sunday, Oct. 10at Kansas City Chiefs8:20 p.m. ET
Week 6Monday, Oct. 18at Tennessee Titans8:15 p.m. ET
Week 8Sunday, Oct. 31vs. Miami Dolphins1 p.m. ET
Week 9Sunday, Nov. 7at Jacksonville Jaguars1 p.m. ET
Week 10Sunday, Nov. 14at New York Jets1 p.m. ET
Week 11Sunday, Nov. 21vs. Indianapolis Colts1 p.m. ET
Week 12Thursday, Nov. 25at New Orleans Saints8:20 p.m. ET
Week 13Monday, Dec. 6vs. New England Patriots8:15 p.m. ET
Week 14Sunday, Dec. 12at Tampa Bay Buccaneers4:25 p.m. ET
Week 15Dec. 18 or Dec. 19 (Sat/Sun)vs. Carolina PanthersTBA
Week 16Sunday, Dec. 26at New England Patriots1 p.m. ET
Week 17Sunday, Jan. 2vs. Atlanta Falcons1 p.m. ET
Week 18Sunday, Jan. 9vs. New York Jets1 p.m. ET

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How to bet on the Buffalo Bills


The moneyline is the simplest of bets, decided by the straight-up winner and loser of each game. Consider the following example:

  • Bills -105
  • Steelers +130

The Bills are considered slight favorites in this matchup (indicated by -105), requiring a $105 bet to win $100 (plus the initial bet back). The Steelers are the underdog in this matchup, paying out $130 total for a $100 bet ($130 in winnings). How much either team wins or loses by does not matter in moneyline betting, the payout remains the same.

Point spread

Betting on the point spread is determinant on how many points a team wins or loses by. Take the following example:

  • Bills -2.5 (-110)
  • Dolphins +2.5 (-110)

In this example, Buffalo is favored by 2.5 points, indicated by “-2.5.” If the Bills win the game 23-20, the Bills (-2.5) win the bet and would have a total payout of $19.09 on a $10 bet ($9.09 in profit). If the Dolphins keep the game within three and lose 24-23, the Dolphins (+2.5) would win, and the payout would be the same as listed above.

Point total (over/under)

The point total refers to the over/under line set by books. This number projects the total number of points scored in a game and, like prop betting, is bet whether one thinks the score will go over or under the set point total. For example, a game between the Patriots and Bills had a point total set at 52.5 points. Buffalo win the ballgame 38-9, which resulted in 47 total points. Those who bet the under in this game would cash out.

The expectation for the Bills’ explosive offense should nudge point totals near or above 50 points, though their talented defense might keep those totals perfectly average in the NFL this coming season.

In-play and live betting

Sometimes, the most thrilling and rewarding bets are bets made while games are being played. These are referred to as live bets or in-play bets. Odds are ever-changing during games, which would prove to be fruitful for sharp and prepared bettors. For example, if the Bills (-225) were heavily favored against the Panthers (+190) before kickoff, a payout on a $10 bet on the Bills to win would win just $4.44.

However, say the Bills fell to a big 17-3 deficit in the first half despite controlling the overall game (due to a costly turnover or special teams gaffe). Odds may swing in favor of the Panthers, who may be a -110 favorite at halftime. Taking the Bills to come back and win the game could present plus-odds (say, +130). Should a bettor take Buffalo (+130) at halftime and the Bills pull off the comeback, winners would win $13 instead of $4.44 (plus the initial $10 bet).

This could also be an effective way to “hedge” your bet; say a bettor took the Panthers (+190) in that game, but Buffalo jumps out to a 10-0 first quarter lead and is controlling the overall feel of the game, bettors could hedge by throwing some money down on Buffalo (-270) to return some of the inevitably-lost bet.

Parlays and teasers

You can always string bets together in the form of parlays or teasers. Usually during busy Sundays, bettors can parlay several teams to win or cover against the spread and if all bets are successful, the payouts are multiplied. Teasers function similarly, except they allow bettors to move each point spread to a more favorable line in exchange for diminished odds.

Bills 2020 recap

Record: 13-3

Record ATS: 11-5

Over/under record: 10-5-1

Buffalo quickly became the favorite Cinderella team in the AFC. Josh Allen made one of the biggest single-season improvements of any quarterback, increasing his completion percentage nearly 10 points. Newly-added Stefon Diggs (acquired from the Vikings in an offseason trade) torched secondaries for the NFL receiving crown in 2020-21. Even longtime veteran Cole Beasley had somewhat of a breakout season, nearly breaking the 1,000-yard mark for the first time in his career (he finished with 967 yards). The Bills finished third in points scored per game (29.9), though the defense took a significant step back from 2019. Their 13-3 record is the franchise’s best since 1991 and ties their highest-ever regular season win total.

11-5 was tied for the league lead in record against the spread (with Miami) as the Bills routinely defied expectations. Their offense was explosive even against some of the NFL’s best defenses– scoring 35 on the Rams in Week 3 (second in points per game allowed) and 59 on the Dolphins in Week 17 (fourth). The Bills were able to outpace almost anyone, which resulted in such a high ATS mark as well as against the point total. Their 10-5-1 record against the point total was good enough for fourth in the NFL.

Bills 2021 offseason moves

  • Trades: None
  • Re-signings: C Mitch Morse (four years, $44.5 million), S Micah Hyde (two years, $19.3 million), G Jon Feliciano (three years, $17 million), LB Matt Milano (four years, $44 million), T Daryl Williams (three years, $24 million), G Forrest Lamp (one year, $1.1 million)
  • Free agent losses: DT Quinton Jefferson (to Raiders)
  • Free agent signings: WR Emmanuel Sanders (one year, $6 million), T Bobby Hart (one year, $900K), RB Matt Breida (one year, $1.1 million)
  • Draft picks: EDGE Gregory Rousseau, EDGE Carlos Basham Jr., WR Marquez Stevenson

Where can I bet on sports in New York?

New York retail sports betting was launched in 2019, and there many options to get a bet down on the Buffalo Bills or any other NFL team. Here’s a list of legal sportsbook options in New York: