Buffalo Bills Betting Guide

Schedule, Odds, And Predictions

13 – 4 – 0
Bills 2024 season stats
RANKING 1st IN THE AFC EAST
OFFENSIVE RANK N/A YARDS PER GAME YPG
DEFFENSIVE RANK N/A YARDS PER GAME YPG
POINT DIFFERENTIAL +157 POINTS
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The AFC East champion Buffalo Bills have clinched a spot in the AFC Championship Game following a 27-25 victory over the Baltimore Ravens. A road conference championship game against the Chiefs is up next. There are Buffalo Bills +360 on DraftKings Bills odds to win the Super Bowl. Below, you can find more Buffalo Bills odds for the current season, including a weekly outlook, spreads for every game, Bills futures, and more from the best football betting sites.

Buffalo Bills odds

Here are the odds for the Buffalo Bills vs. Kansas City Chiefs conference championship game at Arrowhead Stadium (click here for the best NFL promos this week). The game will be played on Sunday, January 26, at 6:30 p.m. ET (CBS).

Buffalo opened as a +1.5 underdog Kansas City, while the game had an initial total of 47.5. The Bills were +105 on the moneyline.

Buffalo Bills Super Bowl odds

Here is a look at Bills Super Bowl odds.

Buffalo Bills AFC East odds

The defending AFC East champion Bills opened as favorites to win the AFC East with odds of +150.

Buffalo Bills Win Total

The Bills opened the 2024 season with a projected win total of 10.5. The opening price on the over was -128.

Buffalo Bills prop bets

Search below for Buffalo Bills odds, team, or player props currently being offered at sportsbooks. You can also look around at other teams and players using this tool. Happy shopping!

Buffalo Bills Injuries

Last Updated on 03.14.2025
Player Pos Position Injury Status Snaps/g Snaps Per Game Comment
Larry Ogunjobi DT Suspension Out 0 Ogunjobi has been suspended for the first six games of the 2025-26 season for violating the league’s performance-enhancing substance policy.
Michael Hoecht OLB Suspension Out 0 Hoecht has been suspended for the first six games of the 2025-26 season for violating the league’s performance-enhancing substance policy.

2025 Bills Player Stats

Last Updated on 01.21.2025
Player GP Games Played CMP% Completion Percentage YDS Passing Yards YDS/G Yards Per Game YDS/C Yards Per Completion TDS Passing Touchdowns INT Interceptions thrown RTG Passer Rating
Player GP Games Played INT Interceptions PD Passes Defended FF Fumbles Forced FR Fumbles Recovered SACK QB Sacks TOT Total Tackles SOLO Solo Tackles AST Assisted Tackles

Buffalo Best Bills betting sites

Here are the best Buffalo Bills betting sites.

Rank
Sportsbooks
Bonus
Features
Play
1
Up to $1,500
In Bonus Bets
BetMGM Sportsbook Review
  • Up to $1,500 in Bonus Bets if Your First Bet Doesn't Win*

  • *Bonus Bets Expire in 7 Days. One New Customer Offer Only. Add’l terms. 21+. Gambling Problem? Call 1-800-GAMBLER

  • Use Bonus Code: THELINES

2
Up to $1,000
In Bonus Bets
Bet365 Sportsbook Review
  • Bet $5 Get $150 in Bonus Bets Win or Lose
  • OR First Bet Safety Net up to $1,000
  • 30% Extra on Same Game Parlay Profit
  • T&Cs Apply. Gambling Problem? Call or text 1-800-GAMBLER 21+
  • Use Bonus Code: THELINES
3
Bet $1, Double Your Winnings
On Next 10 Wagers
Caesars Sportsbook Review
  • Stream NFL Games In-App for Free
  • 21+ Gambling problem? Call 1-800-GAMBLER
  • Use Promo Code: THELINESDYW
4
Bet $5
Get $200
In Bonus Bets
FanDuel Sportsbook Review
  • Bet $5, Get $200 in Bonus Bets if Your Bet Wins

  • Available on Desktop, Android & iOS

  • Gambling Problem? Call 1-800-GAMBLER. 21+

  • To Claim: Click Play Now

5
Up to $100
In Bonus Bets
Hard Rock Bet Sportsbook Review
  • Up to $100 in Bonus Bets if First Your Bet Doesn't Win
  • Get Your Bets Boosted
  • 21+. Gambling Problem? Call/Text 1-800-Gambler. T&Cs apply
  • To Claim: Click Play Now
6
Up to $1,000
In No Sweat Bets
Fanatics Sportsbook Review
  • Bet and Get up to $1,000 in No Sweat Bets or Choose Your Own Offer
  • Earn FanCash & Spend it on Team Swag or More Bets
  • 21+. Gambling Problem? Call 1-800-GAMBLER
  • To Claim: Click Play Now
7
Up to $1,350 Bonus
New User Bonus. T&Cs Apply.
DraftKings Sportsbook Review
  • Bet $5 Get $300 in Bonus Bets if Your Bet Wins

  • PLUS Get a $50 Bonus Bet on Deposit

  • PLUS up to $1,000 Deposit Bonus

  • Gambling Problem? Call 1-800-GAMBLER

Buffalo Bills schedule

Here are what the Bills opening odds for each game looked like following the schedule release.

WeekDateOpponentKickoff TimeOpening Odds
Week 1Sunday, September 8Arizona Cardinals 1 p.m. ET-7
Week 2Thursday, September 12at Miami Dolphins8:15 p.m. ET+1.5
Week 3Monday, September 23Jacksonville Jaguars7:30 p.m. ET-4.5
Week 4Sunday, September 29at Baltimore Ravens8:20 p.m. ET+3
Week 5Sunday, October 6at Houston Texans1 p.m. ET +1.5
Week 6Monday, October 14 at New York Jets 8:15 p.m.ET +1
Week 7Sunday, October 20Tennessee Titans 1 p.m. ET-7
Week 8Sunday, October 27at Seattle Seahawks4:05 p.m. ET-2
Week 9Sunday, November 3Miami Dolphins1 p.m. ET-3
Week 10Sunday, November 10at Indianapolis Colts1 p.m. ET-2
Week 11Sunday, November 17Kansas City Chiefs 4:25 p.m. ET+1
Week 12BYE WEEK
Week 13Sunday, December 1 San Francisco 49ers 8:20 p.m. ET+2
Week 14Sunday, December 8at Los Angeles Rams4:25 p.m. ET-1
Week 15Sunday, December 15at Detroit Lions4:25 p.m. ET+2
Week 16Sunday, December 22New England Patriots1 p.m. ET-7.5
Week 17Sunday, December 29New York Jets1 p.m. ET-2.5
Week 18Sunday, January 5at New England Patriots 1 p.m. ET-3.5

How to bet on the Buffalo Bills

Moneyline

The moneyline is the simplest of bets, decided by the straight-up winner and loser of each game. Consider the following example:

  • Bills -105
  • Steelers +130

The Bills are considered slight favorites in this matchup (indicated by -105), requiring a $105 bet to win $100 (plus the initial bet back). The Steelers are the underdog in this matchup, paying out $130 total for a $100 bet ($130 in winnings). How much either team wins or loses by does not matter in moneyline betting, the payout remains the same.

Point spread

Betting on the point spread is determinant on how many points a team wins or loses by. Take the following example:

  • Bills -2.5 (-110)
  • Dolphins +2.5 (-110)

In this example, Buffalo is favored by 2.5 points, indicated by “-2.5.” If the Bills win the game 23-20, the Bills (-2.5) win the bet and would have a total payout of $19.09 on a $10 bet ($9.09 in profit). If the Dolphins keep the game within three and lose 24-23, the Dolphins (+2.5) would win, and the payout would be the same as listed above.

Point total (over/under)

The point total refers to the over/under line set by books. This number projects the total number of points scored in a game and, like prop betting, is bet whether one thinks the score will go over or under the set point total. For example, a game between the Patriots and Bills had a point total set at 52.5 points. Buffalo win the ballgame 38-9, which resulted in 47 total points. Those who bet the under in this game would cash out.

The expectation for the Bills’ explosive offense should nudge point totals near or above 50 points, though their talented defense might keep those totals perfectly average in the NFL this coming season.

In-play and live betting

Sometimes, the most thrilling and rewarding bets are bets made while games are being played. These are referred to as live bets or in-play bets. Odds are ever-changing during games, which would prove to be fruitful for sharp and prepared bettors. For example, if the Bills (-225) were heavily favored against the Panthers (+190) before kickoff, a payout on a $10 bet on the Bills to win would win just $4.44.

However, say the Bills fell to a big 17-3 deficit in the first half despite controlling the overall game (due to a costly turnover or special teams gaffe). NFL Odds may swing in favor of the Panthers, who may be a -110 favorite at halftime. Taking the Bills to come back and win the game could present plus-odds (say, +130). Should a bettor take Buffalo (+130) at halftime and the Bills pull off the comeback, winners would win $13 instead of $4.44 (plus the initial $10 bet).

This could also be an effective way to “hedge” your bet; say a bettor took the Panthers (+190) in that game, but Buffalo jumps out to a 10-0 first quarter lead and is controlling the overall feel of the game, bettors could hedge by throwing some money down on Buffalo (-270) to return some of the inevitably-lost bet.

Parlays and teasers

You can always string bets together in the form of parlays or teasers. Usually, during busy Sundays, bettors can parlay several teams to win or cover against the spread, and if all bets are successful, the payouts are multiplied. Teasers function similarly, except they allow bettors to move each point spread to a more favorable line in exchange for diminished odds.

Futures

Futures are long-term bets that can range from an offseason to a full season (or beyond). Team win totals, award winners, and player performance are common futures.

Buffalo Bills Odds Summary

The odds for the Buffalo Bills may vary based on player performances and game matchups. To refine your betting strategy, explore the best betting sites for detailed odds and a wide range of betting options. Plus, the best sports betting apps offer the convenience of betting on the go, allowing you to stay updated on line movements and capitalize on opportunities as they arise.

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