The AFC East champion Buffalo Bills have clinched a spot in the AFC Championship Game following a 27-25 victory over the Baltimore Ravens. A road conference championship game against the Chiefs is up next. There are Buffalo Bills +360 on DraftKings Bills odds to win the Super Bowl. Below, you can find more Buffalo Bills odds for the current season, including a weekly outlook, spreads for every game, Bills futures, and more from the best football betting sites.
Buffalo Bills odds
Here are the odds for the Buffalo Bills vs. Kansas City Chiefs conference championship game at Arrowhead Stadium (click here for the best NFL promos this week). The game will be played on Sunday, January 26, at 6:30 p.m. ET (CBS).
Buffalo opened as a +1.5 underdog Kansas City, while the game had an initial total of 47.5. The Bills were +105 on the moneyline.
Buffalo Bills Super Bowl odds
Here is a look at Bills Super Bowl odds.
Buffalo Bills AFC East odds
The defending AFC East champion Bills opened as favorites to win the AFC East with odds of +150.
Buffalo Bills Win Total
The Bills opened the 2024 season with a projected win total of 10.5. The opening price on the over was -128.
Buffalo Bills prop bets
Search below for Buffalo Bills odds, team, or player props currently being offered at sportsbooks. You can also look around at other teams and players using this tool. Happy shopping!
Buffalo Bills Injuries
Last Updated on 03.14.2025| Player | Pos Position | Injury | Status | Snaps/g Snaps Per Game | Comment | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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2025 Bills Player Stats
Last Updated on 01.21.2025| Player | GP Games Played | CMP% Completion Percentage | YDS Passing Yards | YDS/G Yards Per Game | YDS/C Yards Per Completion | TDS Passing Touchdowns | INT Interceptions thrown | RTG Passer Rating |
|---|
| Player | GP Games Played | INT Interceptions | PD Passes Defended | FF Fumbles Forced | FR Fumbles Recovered | SACK QB Sacks | TOT Total Tackles | SOLO Solo Tackles | AST Assisted Tackles |
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Buffalo Best Bills betting sites
Here are the best Buffalo Bills betting sites.
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Buffalo Bills schedule
Here are what the Bills opening odds for each game looked like following the schedule release.
| Week | Date | Opponent | Kickoff Time | Opening Odds |
|---|---|---|---|---|
| Week 1 | Sunday, September 8 | Arizona Cardinals | 1 p.m. ET | -7 |
| Week 2 | Thursday, September 12 | at Miami Dolphins | 8:15 p.m. ET | +1.5 |
| Week 3 | Monday, September 23 | Jacksonville Jaguars | 7:30 p.m. ET | -4.5 |
| Week 4 | Sunday, September 29 | at Baltimore Ravens | 8:20 p.m. ET | +3 |
| Week 5 | Sunday, October 6 | at Houston Texans | 1 p.m. ET | +1.5 |
| Week 6 | Monday, October 14 | at New York Jets | 8:15 p.m.ET | +1 |
| Week 7 | Sunday, October 20 | Tennessee Titans | 1 p.m. ET | -7 |
| Week 8 | Sunday, October 27 | at Seattle Seahawks | 4:05 p.m. ET | -2 |
| Week 9 | Sunday, November 3 | Miami Dolphins | 1 p.m. ET | -3 |
| Week 10 | Sunday, November 10 | at Indianapolis Colts | 1 p.m. ET | -2 |
| Week 11 | Sunday, November 17 | Kansas City Chiefs | 4:25 p.m. ET | +1 |
| Week 12 | BYE WEEK | — | — | — |
| Week 13 | Sunday, December 1 | San Francisco 49ers | 8:20 p.m. ET | +2 |
| Week 14 | Sunday, December 8 | at Los Angeles Rams | 4:25 p.m. ET | -1 |
| Week 15 | Sunday, December 15 | at Detroit Lions | 4:25 p.m. ET | +2 |
| Week 16 | Sunday, December 22 | New England Patriots | 1 p.m. ET | -7.5 |
| Week 17 | Sunday, December 29 | New York Jets | 1 p.m. ET | -2.5 |
| Week 18 | Sunday, January 5 | at New England Patriots | 1 p.m. ET | -3.5 |
How to bet on the Buffalo Bills
Moneyline
The moneyline is the simplest of bets, decided by the straight-up winner and loser of each game. Consider the following example:
- Bills -105
- Steelers +130
The Bills are considered slight favorites in this matchup (indicated by -105), requiring a $105 bet to win $100 (plus the initial bet back). The Steelers are the underdog in this matchup, paying out $130 total for a $100 bet ($130 in winnings). How much either team wins or loses by does not matter in moneyline betting, the payout remains the same.
Point spread
Betting on the point spread is determinant on how many points a team wins or loses by. Take the following example:
- Bills -2.5 (-110)
- Dolphins +2.5 (-110)
In this example, Buffalo is favored by 2.5 points, indicated by “-2.5.” If the Bills win the game 23-20, the Bills (-2.5) win the bet and would have a total payout of $19.09 on a $10 bet ($9.09 in profit). If the Dolphins keep the game within three and lose 24-23, the Dolphins (+2.5) would win, and the payout would be the same as listed above.
Point total (over/under)
The point total refers to the over/under line set by books. This number projects the total number of points scored in a game and, like prop betting, is bet whether one thinks the score will go over or under the set point total. For example, a game between the Patriots and Bills had a point total set at 52.5 points. Buffalo win the ballgame 38-9, which resulted in 47 total points. Those who bet the under in this game would cash out.
The expectation for the Bills’ explosive offense should nudge point totals near or above 50 points, though their talented defense might keep those totals perfectly average in the NFL this coming season.
In-play and live betting
Sometimes, the most thrilling and rewarding bets are bets made while games are being played. These are referred to as live bets or in-play bets. Odds are ever-changing during games, which would prove to be fruitful for sharp and prepared bettors. For example, if the Bills (-225) were heavily favored against the Panthers (+190) before kickoff, a payout on a $10 bet on the Bills to win would win just $4.44.
However, say the Bills fell to a big 17-3 deficit in the first half despite controlling the overall game (due to a costly turnover or special teams gaffe). NFL Odds may swing in favor of the Panthers, who may be a -110 favorite at halftime. Taking the Bills to come back and win the game could present plus-odds (say, +130). Should a bettor take Buffalo (+130) at halftime and the Bills pull off the comeback, winners would win $13 instead of $4.44 (plus the initial $10 bet).
This could also be an effective way to “hedge” your bet; say a bettor took the Panthers (+190) in that game, but Buffalo jumps out to a 10-0 first quarter lead and is controlling the overall feel of the game, bettors could hedge by throwing some money down on Buffalo (-270) to return some of the inevitably-lost bet.
Parlays and teasers
You can always string bets together in the form of parlays or teasers. Usually, during busy Sundays, bettors can parlay several teams to win or cover against the spread, and if all bets are successful, the payouts are multiplied. Teasers function similarly, except they allow bettors to move each point spread to a more favorable line in exchange for diminished odds.
Futures
Futures are long-term bets that can range from an offseason to a full season (or beyond). Team win totals, award winners, and player performance are common futures.
Buffalo Bills Odds Summary
The odds for the Buffalo Bills may vary based on player performances and game matchups. To refine your betting strategy, explore the best betting sites for detailed odds and a wide range of betting options. Plus, the best sports betting apps offer the convenience of betting on the go, allowing you to stay updated on line movements and capitalize on opportunities as they arise.