Buffalo Bills Betting Guide

Schedule, Odds, And Predictions

11 – 6 – 0
Bills 2023 season stats
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When the Bills begin the new season, Buffalo will be looking for new players to step up as veterans Stefon Diggs, Tre’Davious White, Jordan Poyer, and Gabe Davis are now playing for other teams. Up first is a Week 1 home game against the Arizona Cardinals. Below, you can find more Buffalo Bills odds for the upcoming season, including a weekly outlook, spreads for every game, Bills futures, and more.

Bills odds

View Buffalo Bills NFL Week 1 odds for their next game versus the Cardinals at Highmark Stadium.

The Bills opened as a -7 favorite against Arizona, while the game had an initial total of 48.  When the lines were first released, Buffalo was a heavy -355 moneyline favorite.

Bills Super Bowl odds

Here is a look at Bills Super Bowl odds.

Bills AFC East odds

The defending AFC East champion Bills began the season as favorites to win the AFC East with odds of +150.

BillS Win Total

The Bills will open the 2024 season with a projected win total of 10.5. The opening price on the over is -128.

Bills prop bets

Search below for Buffalo Bills odds, team, or player props currently being offered at sportsbooks. You can also look around at other teams and players using this tool. Happy shopping!

Buffalo Bills Injuries

Player Pos Position Injury Status Snaps/g Snaps Per Game Comment
Tommy Doyle OT Undisclosed Out 0 Doyle is dealing with an undisclosed injury and has been placed on the physically unable to perform list.

2024 Bills Player Stats

Last Updated on 06.05.2024
Player GP Games Played CMP% Completion Percentage YDS Passing Yards YDS/G Yards Per Game YDS/C Yards Per Completion TDS Passing Touchdowns INT Interceptions thrown RTG Passer Rating
Player GP Games Played INT Interceptions PD Passes Defended FF Fumbles Forced FR Fumbles Recovered SACK QB Sacks TOT Total Tackles SOLO Solo Tackles AST Assisted Tackles

Bills Roster

Here’s what the Buffalo Bills roster currently looks like.

Best Bills betting sites

Here are the best Buffalo Bills betting sites.

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Bills schedule

The Bills schedule for the 2024 – 2025 season is posted below with betting odds for each game.

Here are what the Bills opening odds for each game looked like following the schedule release.

WeekDateOpponentKickoff TimeOpening Odds
Week 1Sunday, September 8Arizona Cardinals 1 p.m. ET-7
Week 2Thursday, September 12at Miami Dolphins8:15 p.m. ET+1.5
Week 3Monday, September 23Jacksonville Jaguars7:30 p.m. ET-4.5
Week 4Sunday, September 29at Baltimore Ravens8:20 p.m. ET+3
Week 5Sunday, October 6at Houston Texans1 p.m. ET +1.5
Week 6Monday, October 14 at New York Jets 8:15 p.m.ET +1
Week 7Sunday, October 20Tennessee Titans 1 p.m. ET-7
Week 8Sunday, October 27at Seattle Seahawks4:05 p.m. ET-2
Week 9Sunday, November 3Miami Dolphins1 p.m. ET-3
Week 10Sunday, November 10at Indianapolis Colts1 p.m. ET-2
Week 11Sunday, November 17Kansas City Chiefs 4:25 p.m. ET+1
Week 13Sunday, December 1 San Francisco 49ers 8:20 p.m. ET+2
Week 14Sunday, December 8at Los Angeles Rams4:25 p.m. ET-1
Week 15Sunday, December 15at Detroit Lions4:25 p.m. ET+2
Week 16Sunday, December 22New England Patriots1 p.m. ET-7.5
Week 17Sunday, December 29New York Jets1 p.m. ET-2.5
Week 18TBDat New England Patriots TBD-3.5

How to bet on the Buffalo Bills


The moneyline is the simplest of bets, decided by the straight-up winner and loser of each game. Consider the following example:

  • Bills -105
  • Steelers +130

The Bills are considered slight favorites in this matchup (indicated by -105), requiring a $105 bet to win $100 (plus the initial bet back). The Steelers are the underdog in this matchup, paying out $130 total for a $100 bet ($130 in winnings). How much either team wins or loses by does not matter in moneyline betting, the payout remains the same.

Point spread

Betting on the point spread is determinant on how many points a team wins or loses by. Take the following example:

  • Bills -2.5 (-110)
  • Dolphins +2.5 (-110)

In this example, Buffalo is favored by 2.5 points, indicated by “-2.5.” If the Bills win the game 23-20, the Bills (-2.5) win the bet and would have a total payout of $19.09 on a $10 bet ($9.09 in profit). If the Dolphins keep the game within three and lose 24-23, the Dolphins (+2.5) would win, and the payout would be the same as listed above.

Point total (over/under)

The point total refers to the over/under line set by books. This number projects the total number of points scored in a game and, like prop betting, is bet whether one thinks the score will go over or under the set point total. For example, a game between the Patriots and Bills had a point total set at 52.5 points. Buffalo win the ballgame 38-9, which resulted in 47 total points. Those who bet the under in this game would cash out.

The expectation for the Bills’ explosive offense should nudge point totals near or above 50 points, though their talented defense might keep those totals perfectly average in the NFL this coming season.

In-play and live betting

Sometimes, the most thrilling and rewarding bets are bets made while games are being played. These are referred to as live bets or in-play bets. Odds are ever-changing during games, which would prove to be fruitful for sharp and prepared bettors. For example, if the Bills (-225) were heavily favored against the Panthers (+190) before kickoff, a payout on a $10 bet on the Bills to win would win just $4.44.

However, say the Bills fell to a big 17-3 deficit in the first half despite controlling the overall game (due to a costly turnover or special teams gaffe). Odds may swing in favor of the Panthers, who may be a -110 favorite at halftime. Taking the Bills to come back and win the game could present plus-odds (say, +130). Should a bettor take Buffalo (+130) at halftime and the Bills pull off the comeback, winners would win $13 instead of $4.44 (plus the initial $10 bet).

This could also be an effective way to “hedge” your bet; say a bettor took the Panthers (+190) in that game, but Buffalo jumps out to a 10-0 first quarter lead and is controlling the overall feel of the game, bettors could hedge by throwing some money down on Buffalo (-270) to return some of the inevitably-lost bet.

Parlays and teasers

You can always string bets together in the form of parlays or teasers. Usually during busy Sundays, bettors can parlay several teams to win or cover against the spread and if all bets are successful, the payouts are multiplied. Teasers function similarly, except they allow bettors to move each point spread to a more favorable line in exchange for diminished odds.


Futures are long-term bets that can range from an offseason to a full season (or beyond). Team win totals, award winners, and player performance are common futures.

Bills 2023 recap

The AFC East champion Bills, for the third straight season, lost in the Divisional Round of the AFC Playoffs.

Record: 11-6, First in AFC East

Record ATS: 7-10

Over/under record: 6-11