Written By Road to CFB | Last Updated at October 28, 2025
If you are a new user, you can enjoy excellent betting experiences with exciting Bill odds when you place a bet using tips from this Buffalo betting guide. It has been updated in accordance with the Buffalo Bills Team’s schedule for the remainder of the year.
Additionally, this article provides a step-by-step guide on how to place your bets, including in-play and live-play betting, Buffalo Bill odds, point totals, and futures. As you go further, you will find all the necessary information to enhance your betting experience.
Buffalo Bills odds
Here are the odds for the upcoming games of Buffalo Bills as well as other NFL teams. Explore different odds types, for example, Bills point spread today, and click on the prices you like. That will lead lead you to the sportsbook's dedicated page.
Buffalo Bills Super Bowl odds
Here is a look at the Bills' Super Bowl odds.
Buffalo Bills AFC East odds
The defending AFC East champion Bills opened as favorites to win the AFC East with odds of +150.
Buffalo Bills Win Total
The Bills opened the 2024 season with a projected win total of 10.5. The opening price on the over was -128.
Buffalo Bills prop bets
Search below for Buffalo Bills odds, team, or player props currently being offered at sportsbooks. You can also look around at other teams and players using this tool. Happy shopping!
Buffalo Best Bills betting sites
Here are the best Buffalo Bills betting sites.
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Sportsbook
Bonus
Features
Play
1
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Gambling problem? Call 1-800-GAMBLER (Available in the US) Call 877-8-HOPENY or text HOPENY (467369) (NY) Call 1-800-327-5050 (MA) 21+ only. Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). Rewards are non-withdrawable bonus bets that expire in 7 days. In partnership with Kansas Crossing Casino and Hotel. See BetMGM.com for Terms. US promotional offers not available in DC, Mississippi, New York, Nevada, Ontario, or Puerto Rico.
Whatever the moment. It's Never Ordinary at bet365. That's why if you sign up now you will receive $150 in Bonus Bets Win or Lose when you bet $5! Minimum $10 deposit required. Minimum odds -500 of greater. Bonus Bets wager excluded from returns. New customers only. T&CS, time limits and exclusions apply. GAMBLING PROBLEM? CALL OR TEXT 1-800-GAMBLER (AZ/CO/IL/IN/KS/KY/LA/MD/NC/NJ/OH/PA/TN/VA) or 1-800-BETS OFF (IA). 21+ (18+ KY). Must be present in AZ/CO/IA/IL/IN/KS/KY/LA (select parishes)/MD/NC/NJ/OH/PA/TN/VA.
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21+ New users only. Must register using eligible promo code. First bet after registration must qualify. Max. Bonus Bet: $1,000. Bonus Bet expires 14 days after receipt. Void where prohibited. See Caesars.com/promos for full terms. Gambling Problem? 1-800-GAMBLER (1-800-426-2537)
The promotion is available for all new players on Hard Rock Bet. An initial deposit is required, and the players first cash bet must be at least $5 to qualify. Additionally, the qualifying wager must win to receive the $150 in Bonus Bets. To be eligible, the Player must be at least 21 years old, physically located in a Eligible Jurisdiction: AZ, IL, IN, NJ, OH, TN, or VA, and not on any exclusionary lists in any Eligible Jurisdiction. Excluded patrons are prohibited from participating in Promotions. To be eligible all personal and contact data associated to your account must be verifiable. | T&C apply | Gambling Problem? Call 1-800-GAMBLER
Gambling Problem? Call 1-800-GAMBLER or visit RG Help . Call 1-888-789-7777 or visit Helpline and Chat - CONNECTICUT COUNCIL (CT). Hope is here. Home or call (800) 327-5050 for 24/7 support (MA). Visit Home (MD). Call 1-877-8HOPE-NY or text HOPENY (467369) (NY). 21+ (18+ D.C.) and present in select states (for KS, in affiliation with Kansas Star Casino). First online real money wager only. $5 first deposit required. Bonus issued as nonwithdrawable bonus bets which expire 7 days after receipt. See terms at FanDuel Sportsbook
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New Customers: Bet $5+ and get $200 in Bonus Bets if it wins!
GAMBLING PROBLEM? CALL 1-800-GAMBLER, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD). 21+ and present in most states. (18+ DC/KY/NH/WY). Void in ONT/OR/NH. Eligibility restrictions apply. On behalf of Boot Hill Casino & Resort (KS). Pass-thru of per wager tax may apply in IL. 1 per new customer. Must register new account to receive reward Token. Must select Token BEFORE placing min. $5 bet to receive $200 in Bonus Bets if your bet wins. Min. -500 odds req. Token and Bonus Bets are single-use and non-withdrawable. Token expires 1/11/26. Bonus Bets expire in 7 days (168 hours). Stake removed from payout. Terms: sportsbook.draftkings.com/promos. Ends 1/4/26 at 11:59 PM ET. Sponsored by DK.
New customers in AZ, CO, CT, DC, IA, IL, IN, KS, KY, LA, MA, MD, MI, NC, NJ, NY, OH, PA, TV, VA, VT, WV, WY. Must opt-in and wager $10+ cash on any market with odds of -500 or longer to receive $50 in FanCash each day for your first 5 days (issued when qualifying wager settles). Your 5 days begin the day you establish your account. See full Promo Terms and FanCash terms in the Fanatics Sportsbook app.
Buffalo Bills schedule
Here are the Bills' opening odds for each game, following the release of the schedule.
Week
Date
Opponent
Kickoff Time
Opening Odds
Week 1
Sunday, September 9
Baltimore Ravens
1 p.m. ET
-7
Week 2
Thursday, September 14
New York Jets
8:15 p.m. ET
+1.5
Week 3
Monday, September 18
Miami Dolphins
7:30 p.m. ET
-4.5
Week 4
Sunday, September 28
New Orleans Saints
8:20 p.m. ET
+3
Week 5
Sunday, October 5
New England Patriots
1 p.m. ET
+1.5
Week 6
Monday, October 13
Atlanta Falcons
7:15 p.m.ET
+1
Week 7
BYE WEEK
---
---
---
Week 8
Sunday, October 26
Carolina Panthers
1p.m. ET
-2
Week 9
Sunday, November 2
Kansas City Chiefs
4:25 p.m. ET
-3
Week 10
Sunday, November 9
Miami Dolphins
1 p.m. ET
-2
Week 11
Sunday, November 16
Tampa Bay Buccaneers
1 p.m. ET
+1
Week 12
Sunday, November 20
Houston Texas
8:15pm
+2
Week 13
Sunday, November 30
Pittsburgh Steelers
4:25 p.m. ET
+2
Week 14
Sunday, December 7
Cincinnati Bengals
4:25 p.m. ET
-1
Week 15
Sunday, December 14
New England Patriots
1 p.m. ET
+2
Week 16
Sunday, December 21
Cleveland Browns
1 p.m. ET
-7.5
Week 17
Sunday, December 28
Philadelphia Eagles
4:25 pm. ET
+1.5
Week 18
TBD
New York Jets
1 pm. ET
TBD
How to bet on the Buffalo Bills
#
Sportsbook
Bonus
Features
Play
1
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Gambling problem? Call 1-800-GAMBLER (Available in the US) Call 877-8-HOPENY or text HOPENY (467369) (NY) Call 1-800-327-5050 (MA) 21+ only. Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). Rewards are non-withdrawable bonus bets that expire in 7 days. In partnership with Kansas Crossing Casino and Hotel. See BetMGM.com for Terms. US promotional offers not available in DC, Mississippi, New York, Nevada, Ontario, or Puerto Rico.
Whatever the moment. It's Never Ordinary at bet365. That's why if you sign up now you will receive $150 in Bonus Bets Win or Lose when you bet $5! Minimum $10 deposit required. Minimum odds -500 of greater. Bonus Bets wager excluded from returns. New customers only. T&CS, time limits and exclusions apply. GAMBLING PROBLEM? CALL OR TEXT 1-800-GAMBLER (AZ/CO/IL/IN/KS/KY/LA/MD/NC/NJ/OH/PA/TN/VA) or 1-800-BETS OFF (IA). 21+ (18+ KY). Must be present in AZ/CO/IA/IL/IN/KS/KY/LA (select parishes)/MD/NC/NJ/OH/PA/TN/VA.
3
Bet $1, Double your Winnings on your Next 20 Wagers. Up to $25 Max Bet Per Boost
21+ New users only. Must register using eligible promo code. First bet after registration must qualify. Max. Bonus Bet: $1,000. Bonus Bet expires 14 days after receipt. Void where prohibited. See Caesars.com/promos for full terms. Gambling Problem? 1-800-GAMBLER (1-800-426-2537)
The promotion is available for all new players on Hard Rock Bet. An initial deposit is required, and the players first cash bet must be at least $5 to qualify. Additionally, the qualifying wager must win to receive the $150 in Bonus Bets. To be eligible, the Player must be at least 21 years old, physically located in a Eligible Jurisdiction: AZ, IL, IN, NJ, OH, TN, or VA, and not on any exclusionary lists in any Eligible Jurisdiction. Excluded patrons are prohibited from participating in Promotions. To be eligible all personal and contact data associated to your account must be verifiable. | T&C apply | Gambling Problem? Call 1-800-GAMBLER
Gambling Problem? Call 1-800-GAMBLER or visit RG Help . Call 1-888-789-7777 or visit Helpline and Chat - CONNECTICUT COUNCIL (CT). Hope is here. Home or call (800) 327-5050 for 24/7 support (MA). Visit Home (MD). Call 1-877-8HOPE-NY or text HOPENY (467369) (NY). 21+ (18+ D.C.) and present in select states (for KS, in affiliation with Kansas Star Casino). First online real money wager only. $5 first deposit required. Bonus issued as nonwithdrawable bonus bets which expire 7 days after receipt. See terms at FanDuel Sportsbook
6
New Customers: Bet $5+ and get $200 in Bonus Bets if it wins!
GAMBLING PROBLEM? CALL 1-800-GAMBLER, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD). 21+ and present in most states. (18+ DC/KY/NH/WY). Void in ONT/OR/NH. Eligibility restrictions apply. On behalf of Boot Hill Casino & Resort (KS). Pass-thru of per wager tax may apply in IL. 1 per new customer. Must register new account to receive reward Token. Must select Token BEFORE placing min. $5 bet to receive $200 in Bonus Bets if your bet wins. Min. -500 odds req. Token and Bonus Bets are single-use and non-withdrawable. Token expires 1/11/26. Bonus Bets expire in 7 days (168 hours). Stake removed from payout. Terms: sportsbook.draftkings.com/promos. Ends 1/4/26 at 11:59 PM ET. Sponsored by DK.
New customers in AZ, CO, CT, DC, IA, IL, IN, KS, KY, LA, MA, MD, MI, NC, NJ, NY, OH, PA, TV, VA, VT, WV, WY. Must opt-in and wager $10+ cash on any market with odds of -500 or longer to receive $50 in FanCash each day for your first 5 days (issued when qualifying wager settles). Your 5 days begin the day you establish your account. See full Promo Terms and FanCash terms in the Fanatics Sportsbook app.
BetMGM has updated NFL odds for the Buffalo Bills, including spreads, futures, and more.
Visit the NFL page.
Find odds for Buffalo in a futures market (e.g., Super Bowl odds) or game market (e.g., Bills vs. the Patriots).
Add a bet to your Bet Slip.
Add a Stake to see your potential payout.
Place your bet!
Buffalo Bills Futures
Will the Bills win the division? Will an edge rusher go over his regular-season sacks total? How many wins will they have in the regular season?
For example, if you bet $10 on a player to go over his regular-season sacks total, the bet would settle when that player exceeds the total or ends the regular season under the total.
Log in to your account today for updated Super Bowl odds and more futures.
Buffalo Bills Spread
When you bet on a Bills spread, you’re betting on the final margin of the game. For example, if you bet $35 on the Bills -11.5 (-110) against the New England Patriots, Buffalo must win the game by at least 12 points. Alternatively, if you bet $35 on the Bills +5.5 (-105) against the New York Jets, Buffalo must lose by five or fewer points (or win the game).
If the scoring margin is identical to the spread (e.g., -3 or +6), the bet is a push, and your money is refunded.
Buffalo Bills Moneyline
Will the Bills win the game? The margin of victory doesn’t matter in Money Line Betting. For example, if you bet $55 on the Bills -150 against the Arizona Cardinals, Buffalo must win the game. If the game ends in a tie, the bet is a push.
Buffalo Bills Over/Under Total
How many combined points will be scored by both teams? The final result (win, loss, or tie) of the game is irrelevant. For example, if you bet $100 on over 50.5 (-110) in the Bills’ game against the Cincinnati Bengals, the teams must combine for at least 51 points. Otherwise, if you bet $100 on under 50.5 (-110), the teams must combine for 50 or fewer points. If the combined point total is identical to the over/under total, the bet is a push.
Buffalo Bills Parlays
You can combine Bills bets and other bets (NFL, NBA, or any other sport) into a single parlay for more entertainment and a potentially larger payout. For example, if you bet $15 on a two-leg parlay with the Bills’ moneyline (-150) against the Cleveland Browns and the Tennessee Titans’ moneyline (+120) against the Chicago Bears, both legs must hit for the parlay to cash.
When one bet is a push, it becomes eliminated from the parlay, and the odds (and payout) are recalculated without that leg.
Buffalo Bills Odds Summary
The odds for the Buffalo Bills may vary based on player performances and game matchups. To refine your betting strategy, explore the best betting sites for detailed odds and a wide range of betting options. Plus, the best sports betting apps offer the convenience of betting on the go, allowing you to stay updated on line movements and capitalize on opportunities as they arise.
FAQ's
How can one bet on the NFL?
There are several ways to bet on the NFL, but the most common bets are: MoneyLine, Point Spread, and Total.
How do I bet on Buffalo Bills?
To bet on Buffalo Bills odds, there are a few betting apps that you can use: The BetMGM, Fanatics, Caesars, or Bet365 apps.
Are there any exceptions in locations when placing bets?
No, there are no specific exceptions, as long as you are 21 years of age or older and within the United States.
Bet $1, Double your Winnings on your Next 20 Wagers. Up to $25 Max Bet Per Boost 
