Arizona Cardinals Odds

Schedule, Betting Guide, And Predictions

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The Arizona Cardinals have lost six straight in a season to forget after their 20-19 loss to the Falcons in Week 17. David Blough took over at QB for Arizona and performed as well as could be expected, going 24 of 40 for 222 yards and 1 TD to 0 INT. The Cardinals’ defense continues to play at an above-average level, holding Atlanta to 4.9 yards per play. The Cardinals will play at San Francisco in Week 18. Below, you can find Arizona Cardinals odds for 2023. Included is a weekly outlook, odds for every game this season, futures, and more.

Week 18 Preview: 49ers vs. Cardinals Spread, Total & Moneyline

The Arizona Cardinals are underdogs at San Francisco in Week 18. The look-ahead line was Cardinals + 10.5, so the market is doing its best to discourage bettors from taking the Niners in a potential blowout. The game could potentially give San Francisco the #1 seed, although multiple factors would need to go their way.

The total opened at 40 and currently sits at points. The total has gone over once in the past five Cardinals games, but the over has hit in four of the past five for the 49ers.

The Cardinals opened as +600 underdogs on the moneyline, with the Falcons favored at -850.

Cardinals betting news

Cardinals prop bets

Search below for Arizona Cardinals team or player props currently being offered at sportsbooks. You can also look around at other teams and players using this tool. Happy shopping!

Arizona Cardinals Super Bowl odds

The Arizona Cardinals are to win Super Bowl LVII.

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Arizona Cardinals 2022-2023 schedule and betting odds

Week DateOpponentKickoff TimeOpening OddsClosing LineFinal Score
Week 1Sunday, Sept. 11vs. Kansas City Chiefs4:25 p.m. ET+3+6Chiefs 44, Cardinals 21
Week 2Sunday, Sept. 18at Las Vegas Raiders4:25 p.m. ET+3.5+5.5Cardinals 29, Raiders 23
Week 3Sunday, Sept. 25vs. Los Angeles Rams4:25 p.m. ET+2+3.5Rams 20, Cardinals 12
Week 4Sunday, Oct. 2at Carolina Panthers4:05 p.m. ET-2.5+1Cardinals 26, Panthers 16
Week 5Sunday, Oct. 9vs. Philadelphia Eagles4:25 p.m. ET-2-2.5Seahawks 19, Cardinals 9
Week 6Sunday, Oct. 16at Seattle Seahawks4:05 p.m. ET-2.5-2.5Seahawks 19, Cardinals 9
Week 7Thursday, Oct. 20vs. New Orleans Saints8:20 p.m. ET-3-2.5Cardinals 42, Saints 34
Week 8Sunday, Oct. 30at Minnesota Vikings1 p.m. ET+1+4Vikings 34, Cardinals 26
Week 9Sunday, Nov. 6vs. Seattle Seahawks4:05 p.m. ET-5.5-2Seahawks 31, Cardinals 21
Week 10Sunday, Nov. 13at Los Angeles Rams4:25 p.m. ET+6+3.5Cardinals 27, Rams 17
Week 11Monday, Nov. 21vs. San Francisco 49ers (in Mexico City)8:15 p.m. ET+2.5+9.549ers 38, Cardinals 10
Week 12Sunday, Nov. 27vs. Los Angeles Chargers4:05 p.m. ET+1.5+2.5Chargers 25, Cardinals 24
Week 13Sunday, Dec. 4BYEBYE
Week 14Monday, Dec. 12vs. New England Patriots8:15 p.m. ET-2.5+2Patriots 27, Cardinals 13
Week 15Sunday, Dec. 18at Denver Broncos4:05 p.m. ET+4+1.5Broncos 24, Cardinals 15
Week 16Sunday, Dec. 25vs. Tampa Bay Buccaneers8:20 p.m. ET+2.5
Week 17Sunday, Jan. 1at Atlanta Falcons1 p.m. ET-3.5
Week 18Saturday, Jan. 7 OR Sunday, Jan. 8at San Francisco 49ersTBD+3

Cardinals 2022 offseason moves

Key signings: OL Will Hernandez, LB Nick Vigil, CB Jeff Gladney

Re-signings: RB James Conner, TE Zach Ertz, OL Justin Pugh, WR AJ Green

Trades: WR Hollywood Brown

Key losses: WR Christian Kirk, RB Chase Edmonds, EDGE Chandler Jones, LB Jordan Hicks, OL Max Garcia

Key draft picks: TE Trey McBride, EDGE Cameron Thomas, EDGE Myjai Sanders

How to bet on the Arizona Cardinals


The moneyline is the simplest of bets, decided by the straight-up winner and loser of each game. Consider the following example:

  • Cardinals -135
  • Giants +180

The Cardinals are considered favorites in this matchup (indicated by -135), requiring a $135 bet to win $100 (plus the initial bet back). The Giants are the underdog in this matchup, paying out $280 total for a $100 bet ($180 in winnings). How much either team wins or loses by does not matter in moneyline betting, the payout remains the same.

Point spread

Betting on the point spread is determinant of how many points a team wins or loses by. Take the following example:

  • Cardinals -4.5 (-110)
  • Broncos +4.5 (-110)

In this example, Arizona is favored by 4.5 points, indicated by “-4.5.” If the Cardinals win the game 27-20, the Cardinals (-4.5) win the bet and would have a total payout of $19.09 on a $10 bet ($9.09 in profit). If the Broncos keep the game within five and lose 23-21, the Broncos (+4.5) would win, and the payout would be the same as listed above.

Point total (over/under)

The point total refers to the over/under line set by books. This number projects the total number of points scored in a game and, like prop betting, is bet whether one thinks the score will go over or under the set point total. For example, the Cardinals’ Week 10 matchup with the Buffalo Bills had a projected point total of 56.5 points. Arizona won the game 32-30 in thrilling fashion, resulting in 62 combined points. Those that bet over the point total would have cashed out that week.

The Cardinals offense, led by Kyler Murray, proved they were able to score quickly and efficiently. However, it was inconsistent at times and the team as a whole was marred by penalties. These factors are usually balanced out to give the Cardinals average over/under totals, frequently between 48 and 53 points.

In-play and live betting

Sometimes, the most thrilling and rewarding bets are bets made while games are being played. These are referred to as live bets or in-play bets. Odds are ever-changing during games, which would prove to be fruitful for sharp and prepared bettors. For example, if the Cardinals (-225) were heavily favored against the Jaguars (+190) before kickoff, a payout on a $10 bet on the Cardinals to win would win just $4.44.

However, say the Cardinals fell to a big 21-3 deficit in the first half despite controlling the overall game (due to a costly turnover or special teams gaffe). Odds may swing in favor of the Jaguars, who may be a -110 favorite at halftime. Taking the Cardinals to come back and win the game could present plus-odds (say, +110). Should a bettor take Arizona (+110) at halftime and the Cardinals pull off the comeback, winners would win $11 instead of $4.44 (plus the initial $10 bet).

This could also be an effective way to “hedge” your bet; say a bettor took the Jaguars (+190) in that game, but Arizona jumps out to a 20-3 first half lead and is controlling the overall feel of the game, bettors could hedge by throwing some money down on Arizona (-255) to return some of the inevitably-lost bet.

Parlays and teasers

You can always string bets together in the form of parlays or teasers. Usually during busy Sundays, bettors can parlay several teams to win or cover against the spread and if all bets are successful, the payouts are multiplied. Teasers function similarly, except they allow bettors to move each point spread to a more favorable line in exchange for diminished odds.


Futures are long-term bets that can range from an offseason to a full season (or beyond). Team win totals, award winners, and player performance are common futures.

Cardinals 2021 recap

Record: 11-6, Second in NFC West. Lost Wild Card round to Rams

Record ATS: 10-7

Over/under record: 8-9

Seven straight wins to open the season turned into 4-6 down the stretch and a first-round exit in the playoffs. Defensively, the Cardinals were one of the better teams in the NFL, consistently applying pressure to opposing QBs and forcing turnovers. However, Kliff Kingsbury came under fire when the wheels fell off the offense– supposedly the team’s strongest unit– and Kyler Murray was rendered completely ineffective. With a glut of talent and a team ready to win playoff games, Kingsbury will come under immense pressure to win now.

Where can I bet on sports in Arizona?

Arizona sports betting is expected to launch before the 2021 NFL season, and there will be many options to get a bet down on the Arizona Cardinals or any other NFL team. Here’s a list of legal sportsbook options in Arizona, along with the teams the operators and/or organizations have partnered with: