Arizona Cardinals Betting Guide: Odds And Predictions

The Arizona Cardinals odds for the upcoming season are now available for every bettor out there. You can bet on moneylines, spreads, and player props involving Marvin Harrison Jr., Trey McBride, and potential Rookie of the Year candidate Jeremiyah Love.

This page helps you formulate and finalize your predictions. We analyzed how Arizona may perform this season, while also covering team props, playoff odds, and more.

Arizona Cardinals Odds This Week

The Arizona Cardinals odds this week were officially published. It includes the moneyline for the team’s first game (Week 1) against the Chargers. Plus, you can bet on the spread and the over/under.

Here are the odds according to FanDuel:

• Moneyline: Arizona Cardinals +450 / Los Angeles Chargers -600
• Spread: Arizona Cardinals +10.5 (-110) / Los Angeles Chargers -10.5 (-110)
• Over/Under: 46.5 points (-110)

NFL odds are also available for all 31 other teams. You can submit your predictions right now for the Super Bowl winner, the MVP winner, and more.

Arizona Cardinals Odds to Win Super Bowl 61

The Arizona Cardinals odds to win the Super Bowl are pretty slim. DraftKings pegs them at +50,000 odds to hoist the Lombardi Trophy. That’s less than a 1% chance of winning, which means Arizona is a massive underdog.

• FanDuel: +100,000
• DraftKings: +50,000
• BetMGM: +50,000

Arizona has also never won a Super Bowl. The team made it to an NFL championship game only once, during the 2008-09 season.

Top online sportsbooks offer Super Bowl odds for every NFL team as well. You can explore other potential underdogs and sleeper teams.

Arizona Cardinals Odds to Make Playoffs

All the best NFL Betting sites, including BetMGM and FanDuel, offer Arizona Cardinals odds to make the playoffs. And the verdict is that it would be a miracle if this team secured a postseason berth.

• FanDuel: +2000
• DraftKings: +2000
• BetMGM: +2000

And it’s really not surprising that the NFL Playoff Odds don’t favor the Cardinals. The team is rebuilding its roster and establishing a new culture under first-year head coach Mike LaFleur.

Keep in mind that every player for Arizona is also a long shot in the NFL MVP Odds. After an abysmal 3-14 season in 2025, bookies simply aren’t confident that a standout player for the Cardinals will make a run at MVP.

Arizona Cardinals Odds to Win Division

The Arizona Cardinals odds to win the division also demonstrate that bookies simply aren’t confident in this team. And that makes sense because AZ haven’t claimed the NFC West since the 2015-16 season. In fact, the Cardinals have claimed the division just three times in team history.

• FanDuel: +10,000
• DraftKings: +10,000
• BetMGM: +10,000

The NFC West odds currently favor the Rams at -105. This represents a 51.2% implied probability that Los Angeles will claim the division.

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More Arizona Cardinals Betting Markets

We now know the Arizona Cardinals betting odds for every major market. But there are other betting options to explore, including moneylines, spreads, over/unders, and player props. This section delivers the goods on guiding you through these markets.

Keep in mind that, via NFL betting apps, you can also access these markets and place bets on your iOS or Android device.

Arizona Cardinals Moneylines

Moneylines are when you bet whether an NFL team will win or lose a game — it’s really that simple. And let’s say you pick Arizona to win at +450 against Los Angeles. If you’re correct, and if you bet $100, you’ll receive $450 in winnings. The Cardinals are a long shot to win, hence why the profitability is so high.

You can even explore NFL win totals and bet on Arizona’s regular season record.

Arizona Cardinals Spreads

The spread represents the point difference between the winner/loser of an NFL match. For Arizona, the spread is at -110 odds for +10.5 points. If the Cardinals win the game or lose by fewer than 10 points, you win the bet.

Many NFL betting promos will even offer you a boost on point spreads. You can use the bonus to increase your payouts, which is especially helpful for spreads which are essentially handicaps.

Arizona Cardinals Totals (Over/Under)

Over/under betting markets involve the combined score within an NFL game. When you add up the scores from the two teams when the game ends, you’ll know whether you won or lost.

For Week 1, the over/under for Arizona versus Los Angeles is 46.5 points, with odds at -110 for both options. Betting $110 on the over or under earns you $100 if your prediction is accurate.

Arizona Cardinals Props

You can also bet on in-game outcomes that don’t involve final scores. With player props, you can make your predictions (and profit from them) on individual performances.

Here are a few prop bets to consider for Arizona’s Week 1 matchup:

• Jeremiyah Love to score a rushing touchdown
• Jacoby Brissett to throw for more than 200.5  passing yards
• Marvin Harrison Jr. to catch for more than 60.5 receiving yards

Arizona Cardinals Prediction Markets

Sportsbooks offer Arizona Cardinals odds and betting markets. Prediction trading platforms, on the other hand, offer contracts for NFL outcomes and events. You can profit from trading on the Arizona Cardinals by buying and selling Yes/No contracts.

If the Cardinals win, and you bought 10 'Yes' shares at $0.25 each, you can cash out. Your profit would be $7.50 ($10 total payout minus your $2.50 cost)

You can even sell your contract early if you lose confidence in your prediction.

Arizona Cardinals Odds FAQ