Arizona Cardinals Odds

Schedule, Betting Guide, And Predictions

Written by

The Arizona Cardinals were thoroughly outplayed by the Rams at home in Week 3, and could have lost by more than the 20-12 final score. The Rams put up 7.4 yards per play to Arizona’s paltry 4.5, as Kyler Murray threw 58 times for only 314 yards. The Cardinals travel to Carolina in Week 4.

Below, you can find Arizona Cardinals odds for 2022. Included is a weekly outlook, odds for every game this season, futures, and more.

Week 4 Preview: Rams at Cardinals Spread, Total & Moneyline

The 1-2 Arizona Cardinals are road underdogs to the 1-2 Carolina Panthers in a late afternoon affair on Sunday. It’s next to impossible to get excited about either of these teams, but Arizona feels slightly undervalued by the market here. The over/under for this matchup is .

Arizona opened as -105 underdogs on the moneyline, with the home Panthers -115 favorites.

Cardinals betting news

Cardinals prop bets

Search below for Arizona Cardinals team or player props currently being offered at sportsbooks. You can also look around at other teams and players using this tool. Happy shopping!

Arizona Cardinals Super Bowl odds

The Arizona Cardinals are to win Super Bowl LVII.

Best Cardinals betting site(s)

DFS Provider
Click To Claim
$10 Free
On Deposit
One Free Sports Entry on Sign Up
Deposit $10 and Get $10
Watch Sports, Play Fantasy, Win Cash!
To Claim: Click Play Now
$25 FREE
On Sign Up
250,000 Fliff Coins 
Plus $25 Fliff Cash on Sign Up
Use Promo Code: PLAYBONUS

Arizona Cardinals 2022 schedule and betting odds

Week DateOpponentKickoff TimeOpening OddsClosing LineFinal Score
Week 1Sunday, Sept. 11vs. Kansas City Chiefs4:25 p.m. ET+3+6Chiefs 44, Cardinals 21
Week 2Sunday, Sept. 18at Las Vegas Raiders4:25 p.m. ET+3.5+5.5Cardinals 29, Raiders 23
Week 3Sunday, Sept. 25vs. Los Angeles Rams4:25 p.m. ET+2+3.5Rams 20, Cardinals 12
Week 4Sunday, Oct. 2at Carolina Panthers4:05 p.m. ET-2.5
Week 5Sunday, Oct. 9vs. Philadelphia Eagles4:25 p.m. ET-2
Week 6Sunday, Oct. 16at Seattle Seahawks4:05 p.m. ET-2.5
Week 7Thursday, Oct. 20vs. New Orleans Saints8:20 p.m. ET-3
Week 8Sunday, Oct. 30at Minnesota Vikings1 p.m. ET+1
Week 9Sunday, Nov. 6vs. Seattle Seahawks4:05 p.m. ET-5.5
Week 10Sunday, Nov. 13at Los Angeles Rams4:25 p.m. ET+6
Week 11Monday, Nov. 21vs. San Francisco 49ers (in Mexico City)8:15 p.m. ET+2.5
Week 12Sunday, Nov. 27vs. Los Angeles Chargers4:05 p.m. ET+1.5
Week 13Sunday, Dec. 4BYEBYE
Week 14Monday, Dec. 12vs. New England Patriots8:15 p.m. ET-2.5
Week 15Sunday, Dec. 18at Denver Broncos4:05 p.m. ET+4
Week 16Sunday, Dec. 25vs. Tampa Bay Buccaneers8:20 p.m. ET+2.5
Week 17Sunday, Jan. 1at Atlanta Falcons1 p.m. ET-3.5
Week 18Saturday, Jan. 7 OR Sunday, Jan. 8at San Francisco 49ersTBD+3

Cardinals 2022 offseason moves

Key signings: OL Will Hernandez, LB Nick Vigil, CB Jeff Gladney

Re-signings: RB James Conner, TE Zach Ertz, OL Justin Pugh, WR AJ Green

Trades: WR Hollywood Brown

Key losses: WR Christian Kirk, RB Chase Edmonds, EDGE Chandler Jones, LB Jordan Hicks, OL Max Garcia

Key draft picks: TE Trey McBride, EDGE Cameron Thomas, EDGE Myjai Sanders

How to bet on the Arizona Cardinals


The moneyline is the simplest of bets, decided by the straight-up winner and loser of each game. Consider the following example:

  • Cardinals -135
  • Giants +180

The Cardinals are considered favorites in this matchup (indicated by -135), requiring a $135 bet to win $100 (plus the initial bet back). The Giants are the underdog in this matchup, paying out $280 total for a $100 bet ($180 in winnings). How much either team wins or loses by does not matter in moneyline betting, the payout remains the same.

Point spread

Betting on the point spread is determinant on how many points a team wins or loses by. Take the following example:

  • Cardinals -4.5 (-110)
  • Broncos +4.5 (-110)

In this example, Arizona is favored by 4.5 points, indicated by “-4.5.” If the Cardinals win the game 27-20, the Cardinals (-4.5) win the bet and would have a total payout of $19.09 on a $10 bet ($9.09 in profit). If the Broncos keep the game within five and lose 23-21, the Broncos (+4.5) would win, and the payout would be the same as listed above.

Point total (over/under)

The point total refers to the over/under line set by books. This number projects the total number of points scored in a game and, like prop betting, is bet whether one thinks the score will go over or under the set point total. For example, the Cardinals’ Week 10 matchup with the Buffalo Bills had a projected point total of 56.5 points. Arizona won the game 32-30 in thrilling fashion, resulting in 62 combined points. Those that bet over the point total would have cashed out that week.

The Cardinals offense, led by Kyler Murray, proved they were able to score quickly and efficiently. However, it was inconsistent at times and the team as a whole was marred by penalties. These factors usually balanced out to give the Cardinals average over/under totals, frequently between 48 and 53 points.

In-play and live betting

Sometimes, the most thrilling and rewarding bets are bets made while games are being played. These are referred to as live bets or in-play bets. Odds are ever-changing during games, which would prove to be fruitful for sharp and prepared bettors. For example, if the Cardinals (-225) were heavily favored against the Jaguars (+190) before kickoff, a payout on a $10 bet on the Cardinals to win would win just $4.44.

However, say the Cardinals fell to a big 21-3 deficit in the first half despite controlling the overall game (due to a costly turnover or special teams gaffe). Odds may swing in favor of the Jaguars, who may be a -110 favorite at halftime. Taking the Cardinals to come back and win the game could present plus-odds (say, +110). Should a bettor take Arizona (+110) at halftime and the Cardinals pull off the comeback, winners would win $11 instead of $4.44 (plus the initial $10 bet).

This could also be an effective way to “hedge” your bet; say a bettor took the Jaguars (+190) in that game, but Arizona jumps out to a 20-3 first half lead and is controlling the overall feel of the game, bettors could hedge by throwing some money down on Arizona (-255) to return some of the inevitably-lost bet.

Parlays and teasers

You can always string bets together in the form of parlays or teasers. Usually during busy Sundays, bettors can parlay several teams to win or cover against the spread and if all bets are successful, the payouts are multiplied. Teasers function similarly, except they allow bettors to move each point spread to a more favorable line in exchange for diminished odds.


Futures are long-term bets that can range from an offseason to a full season (or beyond). Team win totals, award winners, and player performance are common futures.

Cardinals 2021 recap

Record: 11-6, Second in NFC West. Lost Wild Card round to Rams

Record ATS: 10-7

Over/under record: 8-9

Seven straight wins to open the season turned into 4-6 down the stretch and a first-round exit in the playoffs. Defensively, the Cardinals were one of the better teams in the NFL, consistently applying pressure to opposing QBs and forcing turnovers. However, Kliff Kingsbury came under fire when the wheels fell off the offense– supposedly the team’s strongest unit– and Kyler Murray was rendered completely ineffective. With a glut of talent and a team ready to win playoff games, Kingsbury will come under immense pressure to win now.

Where can I bet on sports in Arizona?

Arizona sports betting is expected to launch before the 2021 NFL season, and there will be many options to get a bet down on the Arizona Cardinals or any other NFL team. Here’s a list of legal sportsbook options in Arizona, along with the teams the operators and/or organizations have partnered with: