TNF Week 2 NFL Parlay Picks & Player Props for Bills vs. Lions

Written By Jason Green | Published at September 17, 2026
NFL parlay picks & player props for Week 2 TNF between Bills and Lions. Each of these teams won their season opening game in close fashion.
Sep 13, 2026; Houston, Texas, USA; Buffalo Bills quarterback Josh Allen (17) passes the ball during the game against the Houston Texans at Reliant Stadium. Mandatory Credit: Troy Taormina-Imagn Images

On Thursday night, in a sweet non-conference showdown, the Buffalo Bills host the Detroit Lions. We found some great TNF Week 2 NFL parlay picks and player props for the early-season matchup.

For the game, BetMGM Sportsbook has the Bills as 4.5-point favorites with the total sitting at 54.5.

In their season openers, each team had a close win: the Lions beat the New Orleans Saints 31-30 in overtime, and the Bills beat the Houston Texans 36-31.

TNF Week 2 NFL Parlay Picks & Player Props

For the game, I am taking the Bills to cover, and while the Lions may give them a fight, it's hard to go against Josh Allen at home, especially giving just 4.5 points.

The total — even at 54.5 — is not a tough call; the Over is the pick. Both teams scored over 30 points last week, but each also gave up at least 30. There will be no lack of offensive fireworks in northern New York on Thursday night, so the Over is the way to go.

Check out the NFL odds for this game and all of the other Week 2 action at the best US sportsbooks.

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Player Prop Bets for TNF 

Here are some solid value player prop bets for Thursday night.

DJ Moore 75+ receiving yards: (+145, BetMGM)

Pretty good odds for Allen’s new target, Moore, who was targeted eight times for 100 receiving yards in the opening win over the Texans. While he did not go over 75 yards in any game last season with the Chicago Bears, he was only targeted an average of five times per game, and Allen will look to get him the rock a lot on Thursday night.

Josh Allen anytime rushing TD: (-130, BetMGM)

Allen is a big body that is hard to take down when the Bills are a threat to score. In the season-opening game, he scampered for a 21-yard TD run and then used that big body to muscle in from one yard out.

Amon-Ra St. Brown 75+ receiving yards: (-180, BetMGM)

While St. Brown had only 67 receiving yards in the win over the Saints, he was targeted 14 times and caught 10. He will be targeted often again as Detroit’s No. 1 receiver, and he will get over 75 receiving yards facing a Buffalo pass defense that gave up 274 passing yards last week.

NFL Thursday Night Parlay Picks in Week 2 

Here is our pick for a three-leg parlay and a couple with two legs.

Bills to cover the 4.5-point spread, Allen to pass for 250+ yards, Jahmyr Gibbs Over 124.5 rushing + receiving yards: (+533, BetMGM)

At +533, a $100 bet on this parlay would net $533 in profit for a total payout of $623.

Jared Goff Over 35.5 passing attempts and Jahmyr Gibbs Over 88.5 rushing yards: (+243, BetMGM)

Goff had 39 pass attempts last week and will air it out often in this game.

Gibbs rushed for 130 yards in Week 1 and has rushed for over 88.5 yards in three of the last five games dating back to last season.

This Detroit duo will be facing a Buffalo team that gave up 381 total yards against the Texans last Sunday.

Parlay Payout on a $100 bet: $243 profit, $343 total.

Dalton Kincaid 50+ receiving yards and Josh Allen 25+ rushing yards: (+159, BetMGM)

Kincaid had a big game in Week 1 with 130 receiving yards and will get his chances against the Lions.

While Allen did not have over 25 rushing yards last week (23), he will scramble often in this game against a strong Detroit pass rush that had five sacks last week. He rushed for at least 25 yards in each of the last eight games of last season.

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