TNF Week 1 NFL Parlay Picks & Player Props: Best 49ers vs. Rams Bets

Written By Jason Green | Published at September 10, 2026
NFL parlay picks & player props for TNF game between Rams and 49ers. The Rams are a 3.5-point favorite in the game.
Jan 25, 2026; Seattle, WA, USA; Los Angeles Rams quarterback Matthew Stafford (9) passes against the Seattle Seahawks during the first half in the 2026 NFC Championship Game at Lumen Field. Mandatory Credit: Kevin Ng-Imagn Images

The NFL has treated its fans to marquee matchups right from the get-go. In the season opener, the Seahawks beat the Patriots 13-10 in a rematch of last season’s Super Bowl, and tonight in Melbourne, Australia, there is a killer NFC West clash between the San Francisco 49ers and Los Angeles Rams.

For this Thursday night matchup, BetMGM Sportsbook has the Rams as 3.5-point favorites with a total of 48.5.  Not only are the Rams favorites tonight, but US sportsbooks are also giving them the best odds to win the Super Bowl.

Here, we share our TNF Week 1 NFL parlay picks and player prop bets.

TNF Week 1 NFL Parlay Picks & Player Props

Overall, I am taking the Rams to cover the 3,5-point spread. They are loaded and will face a 49ers team already dealing with injuries to key players.

Also, don’t expect a defensive battle in this game, so the Over is the pick, and it was the winning pick in both games between these division rivals last season.

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Player Prop Bets for TNF

Here are some value player prop bets for the Rams vs. 49ers matchup:

Christian McCaffrey anytime TD: (-138, BetMGM)

McCaffrey had the fourth-most all-purpose yards last season and led the 49ers in rushing yards (1,202 yards) and receiving yards (924). The do-everything back combined for 17 touchdowns last season, and he will get one in this game.

The Rams will key in on him on defense, but he will still get plenty of touches and will find the end zone on the Down Under turf.

Kyren Willaims 75 receiving + rushing yards: (-112, BetMGM) 

While Matthew Stafford got most of the press last season for the Rams’ high-octane offense, with good reason, with over 4,700 yards, 46 TDs, and an MVP award, Kyren Williams was a big part of it.

He rushed for 1,252 yards with 281 receiving yards. 75+ rushing + receiving yards is good value for a player who averaged 89.3 rushing + receiving yards last season and went for at least 75 in both games against the 49ers last season.

Brock Purdy Over 21.5 completions: (-111, BetMGM)

While the 49ers will establish the ground game in the first half, they will go to the air more in the second half, trying to keep up with the Rams. That means Brock Purdy will be airing it out more, and he will get to Over 21.5 completions.

NFL Thursday Night Parlay Picks in Week 1

We like this three-leg parlay, which offers solid odds on three bets with good value.

Rams to cover the 3.5-point spread, Stafford to pass for 300+ yards, and Puka Nacua to have 75+ receiving yards: (+425, BetMGM)

With +425 odds, a $100 bet on this parlay would net $425 in profit for a total payout of $525.

Matthew Stafford and Brock Purdy to each pass for 250+ yards: (+180, BetMGM) 

We all know the numbers that Stafford can put up, and last season he averaged 282.2 passing yards per game. While Purdy did not average over 250 passing yards per game, I expect the 49ers to be playing catch-up in the second half.

The former Mr. Irrelevant will be going to the air more, which increases his chances of more passing yards.

Parlay Payout on a $100 bet: $180 profit, $280 total.

Harrison Mevis and Eddie Pinerio to each have over 2.5 extra points: (+300, BetMGM)

Last season, when these two bitter rivals played, the total went Over both times, and the teams combined for 15 scores.

Last season, Mevis was a perfect 39-for-39 on extra point attempts, and Pinerio, who was with the Carolina Panthers, was 33-for-35 on extra points.

In the two games between the Rams and the 49ers, the totals were 49 points and 68 points. Yeah, not defensive battles. This season opener will also be a high-scoring affair with several TDs, so the kickers will get their chances, and with two good ones, both to go Over 2.5 extra points offers solid value.

Parlay Payout on a $100 bet: $300 profit, $400 total.

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