MNF Week 5 NFL Parlay Picks & Player Props: Bills vs. Rams Showdown

Man, what a matchup for Monday night as the Los Angeles Rams host the Buffalo Bills. Here we’ll show you the latest odds, plus some great MNF Week 5 NFL parlay picks & player props.

The Bills (3-1) are coming off their first loss of the season, falling 29-26 to the New England Patriots. The Rams (2-2) evened their record in their last game with a 24-20 win over the Philadelphia Eagles, with Matthew Stafford leading the comeback on two late TD drives.

First things first: before we get into our MNF Week 5 NFL parlay picks & player props, let’s look at the latest odds. Caesars Sportsbook has the Rams as a 3.5-point favorite with a total of 54.5.

MNF Week 5 NFL Parlay Picks

Bills vs. Rams MNF Parlay #1: Stafford Goes Big, Again

• Matthew Stafford Over 280 passing yards: After only passing for 155 yards in the season-opening bad loss to the 49ers, reigning MVP Stafford has passed for at least 317 yards in each of the last three games. He will pass for over 280 yards tonight against a Buffalo pass defense ranked only 27th in the league.
• Matthew Stafford 38+ pass attempts: Stafford will air it out early and often in this game facing a suspect Bills pass defense, and in each of the last two games he has had at least 51 pass attempts.

The odds for this parlay are +254, so a $100 bet would pay $354, for a $254 profit.

MNF Parlay: Stafford with 280+ passing yards and 38+ pass attempts: (+254, DraftKings)

Check out our full parlay betting guide to get all the info for the popualr betting market.

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Bills vs. Rams MNF Parlay #2: Both QBs Turn it Over

• Josh Allen to throw an interception: Allen only has three interceptions on the season but they have all come in the last three games, While the Rams only have three picks on the season they rank second in the league in pass defense and will get a pick tonight.
• Matthew Stafford to throw an interception: Not sure why Stafford has lower odds than Allen to throw a pick, as he has six on the season and has two INTs in each of the last two games.

The odds for this parlay are +229, so a $100 bet would pay $329, for a $229 profit.

MNF Parlay: Josh Allen and Matthew Stafford to each throw an interception: (+229, DraftKings)

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Bills vs. Rams MNF Parlay #3: Rams Come Through in Their House

• Rams to cover the 3.5-point spread: The Rams are coming off a win and are at home while the Bills are coming off a loss. Allen hasn't played well in the last couple of games and will face a Rams pass defense ranked second in the NFL. Stafford has been lighting it up with at least 317 passing yards in each of the last three games and will go big tonight. I don't see an L.A. blowout, but they will get it done at home and win and cover.
• Over 54.5 points: The Bills are the second-highest-scoring team in the NFL (31.8 ppg), but they rank 25th in points allowed, giving up 26.8 ppg on average. The Rams only rank 23rd in scoring (21.3 ppg), but they have scored at least 24 points in each of the last three games. They will score more than that against a struggling Buffalo defense. This game is going to be a high-scoring one, and the total has gone Over in three of the last four games for the Bills.
• Both teams to score 21+ points: I look for this game not only to be close but a high-scoring game, so it is a good bet that both the Bills and the Rams will score 21 or more points.

The odds for this parlay are +519, so a $100 bet would pay $619, for a $519 profit.

MNF Parlay: Rams to cover the spread, Over 54.5 points, both teams to score 21+ points: (+519, BetMGM)

While still very early in the season all the best sportsbooks have Super Bowl odds as well as MVP odds and NFL playoff odds.

Player Props Bets to Consider for MNF Week 5

MNF Player Prop #1: Puka Nacua 7+ Receptions (-162)

Nacua has played only two games, and after five receptions in his first, he had nine in his last. Stafford will air it out often tonight against a Bills pass defense with issues, and he will target Nacua often, which will get him over seven receptions.

Best Bet: Puka Nacua 7+ Receptions: (-162, FanDuel)

MNF Player Prop #2: James Cook III with the most rushing yards in the game (-120)

Great value here for Cook III to have the most rushing yards in the game. He ranks fifth in the league with 421 rushing yards, while the Rams’ leading rusher, Kyren Williams, has 294. Also, Cook III is the Bills' RB1 and the only back with more than two carries. On the flip side, the Rams use two RBs in Williams and Blake Corum (162 yards). Cook has 70 carries, while Williams has 54 and Corum has 33.

Best Bet: James Cook III to have the most rushing yards in the game: (-120, FanDuel)

If you want any information about prop bets be sure to check out our prop betting guide.

MNF Prop Bet #3: Khalil Shakir 50+ receiving yards (+108)

Buffalo’s Shakir leads the Bills in targets, had seven catches for 82 yards in the last game, and has gone for at least 50 yards in two of the four games this season.

Best Bet: Khalil Shakir 50+ receiving yards: (+108, FanDuel)