Steelers vs. Patriots Prediction, Odds & Picks for Sept. 20: Pittsburgh Covers

Written By Jason Green | Published at September 20, 2026
Steelers vs. Patriots prediction for Sunday afternoon AFC matchup. The Steelers won their season-opener while the Pats lost.
Sep 13, 2026; Pittsburgh, Pennsylvania, USA; Pittsburgh Steelers quarterback Aaron Rodgers (8) looks to hand off against the Atlanta Falcons during the first quarter at Acrisure Stadium. Mandatory Credit: Barry Reeger-Imagn Images

In an AFC matchup at Gillette Stadium on Sunday afternoon, the New England Patriots play host to the Pittsburgh Steelers. In this Steelers vs. Patriots prediction, we cover the latest odds, key game info, and offer our betting picks.

The Steelers won in Week 1 with a 20-13 win over the Atlanta Falcons in a non-conference matchup.

Meanwhile, the Patriots lost their season opener in the Great Northwest, falling to the Seattle Seahawks 13-10 in a Super Bowl rematch.

Steelers vs. Patriots Odds

At BetMGM Sportsbook, the Patriots are the favorites at -5.5, with the total (Over/Under) set at 41.5.

Steelers' Week 1 Win Not That Impressive

Hey, a win is a win in the NFL, but the Steelers' 20-13 win over the Falcons was less than impressive, as they faced a third-string quarterback and needed a fourth-quarter pick-six.

While the Pittsburgh defense held the Falcons to only 238 yards, the Steelers had 264 yards and 58 rushing yards. T.J. Watt sealed the win with a late pick-six, and Aaron Rodgers threw for 221 yards with a TD and no interceptions. Jaylen Warren rushed for 46 yards, and Michael Pittman Jr. led the way with 58 receiving yards.

Rodgers was only sacked twice, but the offense was sluggish throughout the game. They'll face a strong New England defense, and while the Pats gave up only 285 total yards to the Seahawks, they were facing a backup QB, with Sam Darnold going down in the first drive.

Pittsburgh had two interceptions, and Watt not only had the pick-six but also two sacks.

Many of the top US sportsbooks offer tons of betting markets for this game as well as futures bets such as Super Bowl odds and MVP odds.

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MVP Runner-Up Falls Apart in Patriots’ Loss 

Last season, Drake Maye finished second in MLP voting in a close race. He is far from getting back there after the Week 1 loss to Seattle, where he threw three interceptions in the fourth quarter after New England had a 10-0 lead. He had a chance to redeem himself by marching the Pats down deep into Seahawks territory, but he underthrew a receiver, allowing Seattle to get a pick in their end zone to seal the win.

In the loss to Seattle, six players had at least 20 receiving yards, but the run game stalled: Rhamondre Stevenson rushed for 51 yards but averaged just 2.8 yards per carry.

The Pats locked up their No. 1 wide receiver AJ Brown in the offseason, but he is now on the injured reserve after suffering a high ankle sprain in Week 1.

New England played good defense in the loss to Seattle, but Maye and the Pats’ run game have to get it going at the home opener to get the win on Sunday.

Last season, the Patriots lost to the Steelers early in the regular season and had only one win against a team that finished with a winning record.

Patriots vs. Steelers Prediction and Picks 

Steelers to cover: (+5.5, BetMGM)

This one is a tough call. Maye had the worst game of his career facing the Super Bowl-winning Seahawks, while the Steelers won their opener facing a Falcons team that had their third-string QB under center. On top of that, the Pats made the Super Bowl last season but played a weak schedule, and their playoff run was not overly impressive.

The Steelers beat the Patriots early last season in New England, and while that may not happen again, they will put up a fight and, at least, cover the spread in what I think will be a close game.

Under 41.5: (-110, BetMGM)

Another tough call with the total set very low in this AFC clash. Still, I'm leaning toward the Under, and that was the winning pick for both teams in Week 1 and when they faced each other last season.

Both teams have solid defenses but lack a dynamic offense. This will be a lower-scoring defensive battle, which points to the Under being the solid pick.

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