NFL Parlay Picks for Preseason Week 3: A 3-Leg Parlay for Thursday Night Action

Written By Jason Green | Published at August 27, 2026
NFL parlay picks for Thursday night games. Here is a three-leg parlay for Thursday night NFL action.
Aug 22, 2026; Cleveland, Ohio, USA; Cleveland Browns quarterback Deshaun Watson (4) scrambles during the second half against the Buffalo Bills at Huntington Bank Field. Mandatory Credit: Ken Blaze-Imagn Images

There are four games on the schedule for Thursday night, so let’s check out some NFL parlay picks for preseason Week 3 action.

FanDuel Sportsbook has odds and props for every preseason game and beyond.

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Pittsburgh Steelers vs. Buffalo Bills 

The Bills have totaled 60 points in their first two preseason games, with solid balance in the passing and running games.

Buffalo has surpassed 295.5 rushing + receiving yards in each of the two games, with 396 in the first one and 368 in the second one. Josh Allen did not play in the last game, and he will not play tonight. However, Kyle Allen and Shane Buechele have played well, and the Bills have rushed for at least 131 yards in each of their preseason games.

The Steelers killed it on defense in their preseason opener, and while they weren't bad in their second game, giving up 17 points, they allowed 288 rushing + receiving yards.

Look for the Bills to have another solid game on the offensive side of the ball.

Parlay Pick No. 1 – Bills Over 295.5 rushing + receiving yards: FanDuel, -114

San Francisco 49ers vs. Las Vegas Raiders 

The total for the 49ers' first preseason game went Under, but it went Over in their last game when their offense lit it up in a 41-17 win over the Los Angeles Chargers.

The total for both of the Raiders' preseason games has gone Over, as they have given up at least 20 points in both games.

San Francisco head coach Kyle Shanahan has stated that very few starters, if any, will play in this game. Still, with injuries and his cautious approach, not many played in the last game, and the team still put up 41 points.

The Raiders’ offense is a work in progress, but they scored 22 points in their last game, a 22-20 win over the Houston Texans. Kirk Cousins has played only one snap in the preseason and may not play in this game. #1 draft pick Fernando Mendoza will see some action, but Aiden O’Connell will likely get most of the reps, and he has starter experience and has been decent in the preseason.

Don’t look for a shootout in this game, but taking the Over 38.5 points is a good bet, as the teams combined for 63 points in their last games.

Parlay Pick No. 2 – Over 38.5 points: FanDuel, -105

New England Patriots vs. Cleveland Browns 

What can we say about the Browns that hasn't already been said? They are a mess, and the press and Cleveland fans have been in an uproar since Deshaun Watson was named the Week 1 starter.

Watson was booed at home in the last game, where he went 5-for-12 for 36 yards with no TDs and a pick, and was then named the season-opener starter. They are at home again, and the boo birds will likely come out again.

And besides the Watson issue, how about the Cleveland defense? They have given up at least 31 points in each of their two preseason games.

The Patriots played to a 13-13 tie in their first preseason game and then beat the Philadelphia Eagles 24-21 in their last one. Most of their starters will not play, but they are a pretty deep team with skilled backups.

The Browns are a mess and were throttled in their last home game. That may not happen again, but the Pats are a good pick to cover against a team in chaos.

Parlay Pick No. 3 – Patriots Moneyline: FanDuel, -142

Payout for NFL Parlay Picks in Preseason Week 3

According to our Parlay Calculator, the overall odds are +524. So, a $100 bet would pay out $624 with a profit of $524.

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Gambling Problem? Call 1-800-GAMBLER or 1-800-MY-RESET. Call 1-888-789-7777 or visit ccpg.org/chat (CT). Hope is here. GamblingHelpLineMA.org or call (800) 327-5050 for 24/7 support (MA). Visit www.mdgamblinghelp.org (MD). Call 1-877-8HOPE-NY or text HOPENY (467369) (NY). 21+ (18+ D.C., KY, WY) and present in select states (for KS, in affiliation with Kansas Star Casino). First online real money wager only. Min $5 wager required for 7 consecutive days.$5 first deposit required. Bonus issued as nonwithdrawable bonus bets which expire 7 days after receipt. Restrictions apply. See terms at sportsbook.fanduel.com. Call 1-877-770-7867 (LA). ™/© 2026 MLB