Eagles vs. Bears Prediction, Odds & Picks for Sept. 28: Go Birds
The Philadelphia Eagles travel to Soldier Field to face the Chicago Bears on Monday Night Football, and this Week 3 matchup changed dramatically when Caleb Williams was ruled out. Our Eagles vs. Bears prediction breaks down the FanDuel odds, Chicago’s quarterback situation, and the best bets for a game Philadelphia should control.
The Eagles enter at 2-0 after a pair of close wins, including a dramatic road victory over Tennessee in Week 2. Chicago is 1-1 after opening with a 59-point offensive eruption against Carolina before its offense disappeared in a 9-3 loss to Minnesota. The Bears will now turn to veteran Case Keenum under center, with Williams sidelined by a hamstring injury.
Eagles vs. Bears Odds
Philadelphia owns a 2-0 record, while Chicago enters 1-1 and suddenly faces a major early-season test in the NFC. The Eagles are road favorites at FanDuel Sportsbook:
- Spread: Eagles -3.5 (-115) / Bears +3.5 (-105)
- Moneyline: Eagles -198 / Bears +166
- Total: Over 41.5 (-112) / Under 41.5 (-108)
Check the latest NFL odds before betting, as the spread could move with any late injury or weather update.
New Users – Get $250 in Bonus Bets when you wager $5 for 5 days Philadelphia Eagles Betting Trends
The Eagles have not exactly played their cleanest football through two weeks. Philadelphia beat Washington in the opener, then needed a late, game-winning drive from Hurts to escape Tennessee with a 24-20 victory. Here are some noteworthy points:
- The Eagles are 2-0 straight up this season.
- Philadelphia has won each of its first two games by one score.
- The Eagles have a veteran defense directed by Vic Fangio, who has consistently built units that tighten up in scoring position.
For more on the Birds, check current Philadelphia Eagles odds before kickoff.
Chicago Bears Betting Trends
Chicago has been a complete roller coaster.
The Bears hung 59 points on Carolina in Week 1, but the next game was a completely different experience. Weather was a factor against Minnesota, but a 9-3 loss is still a startling offensive reversal for a team whose head coach publicly set a goal of leading the NFL in scoring.
- Chicago is 1-1 straight up this season.
- Caleb Williams is out with a hamstring injury.
- Case Keenum is expected to start, despite Tyson Bagent clearing concussion protocol.
- Chicago’s defense has allowed the fourth-highest yards before contact per rush attempt through two weeks, according to Fantasy Points.
The biggest issue is obvious: Williams will not play Monday night. His Grade 2 hamstring strain is expected to keep him out for multiple weeks, while Keenum is in line to start despite not having played in an NFL game since 2023. Bagent cleared the concussion protocol but is expected to serve as Keenum’s backup.
Ben Johnson is a sharp offensive mind. Since the beginning of 2025, he ranks fifth among qualified play-callers in EPA per play, uses play action at the fourth-highest rate, and ranks sixth in pre-snap motion usage, according to Fantasy Points data supplied for this matchup.
But this is a new situation. Johnson has not previously called plays for a backup quarterback during his time as an NFL offensive coordinator and head coach.
Eagles vs. Bears Prediction: Philadelphia -3.5 (-115)
My best bet is for the Eagles to cover the spread. The quarterback gap is just too extreme to ignore.
Keenum has seen everything during his long career, but that does not mean this is a favorable debut assignment. Philadelphia brings a talented front seven and a veteran defensive coordinator in Fangio, whose units have ranked fifth in EPA per play allowed and 10th in red-zone EPA per play allowed since the beginning of 2024, according to the supplied Fantasy Points data.
Chicago will likely need to be aggressive. Johnson has gone for it on fourth down at the third-highest rate in the league since the start of last season, and that mindset could be magnified with the Bears trying to keep pace. But aggression can cut both ways when the opposing defense can win at the line of scrimmage.
The Bears’ run defense is also a concern. Chicago has allowed too many runners to build momentum before first contact, and that is an awful profile against an Eagles attack built around Hurts, Saquon Barkley, and a physical rushing scheme.
If Philadelphia gets the ground game going, the entire offense opens up. Play action becomes more dangerous, Hurts gets cleaner looks, and Chicago is forced to defend every gap against an offense that becomes miserable to handle when it can remain balanced.
Best Bet: Eagles -3.5 FanDuel, -115
More Eagles vs. Bears Picks, Props And Best Bets
Here are a few more Eagles vs. Bears picks and betting angles to consider:
- Jalen Hurts anytime touchdown: FanDuel, +150 — This is my favorite prop angle. Hurts remains a threat on designed runs, scrambles, and goal-line packages, and Chicago has not done enough to earn confidence against the run.
- Eagles moneyline: FanDuel, -210 — I'd use this as a parlay piece only at the price.
- Jalen Hurts rushing yards: Another interesting player prop angle. The Bears are so bad against the run, and Hurts should be able to navigate. If the game is truly close and ugly, he may have to improvise more. Look for the best price on top sports betting apps.
New Users – Get $250 in Bonus Bets when you wager $5 for 5 days Eagles vs. Bears Broadcast Info
- Date: Monday, Sept. 28, 2026
- Start time: 8:15 p.m. ET
- Location: Soldier Field, Chicago, Illinois
- TV and streaming: ABC and ESPN
The Bears have their work cut out for them without Williams. Keenum can manage a game, and Johnson can give him help through play action, motion, quick throws, and fourth-down aggression. But Philadelphia is the more complete roster, has the better quarterback, and gets a Chicago defense that looked awful in normal weather conditions in the opening week.
For more ways to compare lines and bonuses before kickoff, review the leading NFL betting sites.
Good luck!
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