49ers vs. Cowboys Odds, Picks & Prediction for Nov. 15: San Francisco Finds Success
The San Francisco 49ers and Dallas Cowboys will face off in a Week 10 NFC matchup. Our 49ers vs. Cowboys odds and prediction article outlines FanDuel odds, betting trends, injuries, and best bets for Sunday.
The 49ers have been one of the best teams in the NFL this season, posting a 7-1 record with a +79 point differential through eight games. The Cowboys haven’t found as much success, entering this game at 4-5 with a +10 point differential.
San Francisco is looking to stay on top of the NFC with a win this week. Dallas hasn’t been an elite team in the first half of the season, but it’s still in the playoff race in a weaker NFC East.
49ers vs. Cowboys Odds
San Francisco brings an NFC-best 7-1 record into this game, sitting a half a game above the Chicago Bears. Dallas is 4-5, but they’re also only 1.5 games behind the New York Giants. The 49ers are road favorites via FanDuel Sportsbook:
- Spread: 49ers -4.5 (-105) / Cowboys +4.5 (-115)
- Moneyline: 49ers (-220) / Cowboys (+184)
- Total: Over 55.5 (-115) / Under 55.5 (-105)
The oddsmakers expect an extremely high-scoring game, with the 49ers at a 68.8% implied win probability, according to our Probability Calculator.
Check the latest NFL odds before betting, as lines tend to shift throughout the week.
New Users - Get $200 in Bonus Bets when you wager $5 for 4 days San Francisco 49ers Betting Trends
The 49ers have been one of the best teams in the NFL this season. They’re first in the NFC by half a game over the Chicago Bears, although they haven’t played the most difficult schedule at this point. Here are some trends for San Francisco this week:
- The 49ers are 7-1 straight up and 5-3 ATS this season.
- The Over is 4-4 in San Francisco games.
- The 49ers rank second in the NFL in points per play (0.492).
- Mike Evans has been ruled out, while several players are questionable.
San Francisco’s been elite on both sides of the ball this season. They’ve scored 27 or more points in five of their eight games this season. They’ve also held their opponents to 17 or fewer points in five games.
The 49ers started the season 6-0 before a shocking loss to the Atlanta Falcons. They bounced back with a 21-point win against the Las Vegas Raiders after their bye, though.
Find more San Francisco 49ers odds here.
Dallas Cowboys Betting Trends
The Cowboys have been wildly inconsistent this season. They’ve been inconsistent throughout the season, with their Week 5 and Week 6 losses to Tampa Bay and Green Bay marking their only consecutive losses. Here are some Dallas trends for this week:
- The Cowboys are 4-5 straight up and 4-4-1 ATS this season.
- The Over is 6-3 in Dallas games.
- Dallas ranks seventh in the NFL in points per play (0.422).
- Several players are dealing with injuries for the Cowboys, but George Pickens is expected to return.
Dallas features an elite offense, scoring 27 or more points in six of their nine games. Their defense has been the issue, holding their opponents to less than 23 points in only two games this season.
The Cowboys continue to deal with injuries, but they’re at a point where they need to stack wins. Losses to Tampa Bay and the Arizona Cardinals are losses that could come back to haunt Dallas later in the season, but those could be forgiven with a win over San Francisco.
Find more Dallas Cowboys odds here.
49ers vs. Cowboys Odds & Prediction: San Francisco Team Total Over 30.5 Points
San Francisco’s team total Over 30.5 points (-115) is my favorite 49ers vs. Cowboys odds and prediction.
The 49ers have found elite offensive success through the first half of the season. They’re averaging 0.492 points per play, which ranks second in the NFL, behind only the Buffalo Bills. They’re averaging 29.4 points per game.
The Cowboys continue to struggle defensively in 2026. They rank 24th in the NFL, allowing 0.408 points per play this season. Overall, they’re giving up 26.2 points per game.
Dallas is getting close to a do-or-die situation for the playoffs, but I’m still expecting their defense to struggle. Even if their offense finds success, that’ll keep San Francisco’s foot on the gas, attacking the Cowboys’ defense late in the game.
Best Bet: San Francisco Team Total Over 30.5 Points (-115 @ FanDuel Sportsbook)
More 49ers vs. Cowboys Odds, Picks, Props and Best Bets
Here are a few more 49ers vs. Cowboys betting angles to consider:
- San Francisco 49ers -4.5 Spread (-105 @ FanDuel Sportsbook) - The 49ers have been one of the best overall teams in the NFL. The Cowboys have a high-powered offense, but they don’t have a defense that can slow San Francisco down.
- Javonte Williams Over 13.5 Receiving Yards (-113 @ FanDuel Sportsbook) - San Francisco’s defense is dominant, but they give up receptions to running backs. Tyler Goodson was recently placed on injured reserve, giving Williams extra opportunities.
- Brock Purdy Over 261.5 Passing Yards (-113 @ FanDuel Sportsbook) - The 49ers are dealing with injuries at wide receiver, but they still have several high-upside options. This is a great matchup against this Dallas defense.
Make sure you’re comparing prices on the top sports betting apps before placing wagers.
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170,000 GC + 7 SC 49ers vs. Cowboys Broadcast Info
- Date: Sunday, Nov. 15, 2026
- Start time: 4:25 p.m. ET
- Location: AT&T Stadium - Arlington, Texas
- TV and streaming: FOX
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