NFL Week 7 Betting Preview: Kansas City Chiefs At San Francisco 49ers

Written By Mo Nuwwarah on October 21, 2022
Chiefs 49ers odds

The Kansas City Chiefs visit the San Francisco 49ers at 4:25 p.m. ET on Sunday, Oct. 23. Primary markets for the game show the Chiefs as spread favorites and on the moneyline. Chiefs 49ers odds feature a total set at .

In this article, we break down everything you need to know before placing a bet on the game, including team matchups, key metrics, weather and the best available NFL Week 7 odds. Click on the odds anywhere in this post to bet now.

Chiefs At 49ers Odds: Spread, Moneyline, Over/Under

When using the odds table, click the dropdown menu and select the type of bet you wish to make. 

Betting the point spread is when you wager on how many points a team will win or lose by. A plus sign in front of the spread denotes the underdog, and a minus sign denotes the favorite.

In this case, the Chiefs would have to win by at least three points if you bet them to cover the point spread (-2.5). A spread bet on the 49ers would win if they win the game or lose by fewer than three. 

Betting the moneyline is simply betting on which particular team will win a game.

The betting total is the number of combined points the two teams will score. Bettors can choose to bet the over or under on how many total points will be scored in the game. 

For more betting guides, click the green NFL Game Previews button at the top of this post.

Editor’s Note

Chiefs At 49ers Player Props

In the props tool search bar, type in a team or player and hit enter. You’ll see the various proposition bets offered by leading online sportsbooks. 

This is a valuable tool that allows bettors to compare odds and stats when considering a prop bet. Unlike bigger markets like moneylines and spreads that often reach a consensus number, shopping for prop bet lines can often reveal sizable differences in the numbers.

Chiefs At 49ers Betting News & Angles

Use this rolling, updating list of news bites about each team to help your handicapping for Chiefs – 49ers odds.

49ers Vs. Chiefs Injury Report

Kansas City Injuries

Bryan CookSConcussionQuestionable
Mike DannaDECalfQuestionable
Rashad FentonCBHamstringQuestionable
Joe ThuneyGAnkleQuestionable

San Francisco Injuries

Arik ArmsteadDEFootQuestionable
Nick BosaDEGroinQuestionable
Samson EbukamDEAchillesQuestionable
Talanoa HufangaSConcussionQuestionable
Drake JacksonDEKneeQuestionable
Mike McGlincheyRTCalfQuestionable
Charvarius WardCBGroinQuestionable
Jimmie WardSHandQuestionable
Trent WilliamsLTAnkleQuestionable

Chiefs Offense Vs. 49ers Defense

Chiefs OffenseStats (Rank)49ers Defense
29.8 (1)Points/Gm14.8 (2)
0.463 (1)Points/Play0.243 (2)
382.3 (5)Yards/Gm255.8 (1)
275.8 (4)Pass Yards/Gm168.3 (2)
106.5 (20)Rush Yards/Gm87.5 (2)
5.9 (6)Yards/Play4.2 (1)
7.2 (7)Yards/Pass5.5 (4)
4.4 (16)Yards/Rush3.3 (1)
50% (2)3rd Down %35.71% (9)
76% (2)Red Zone TD%53.85% (13)
1 (5)Turnovers/Game1.2 (18)
4.56 (6)Sack Rate11.06 (1)

49ers Offense Vs. Chiefs Defense

49ers OffenseStats (Rank)Chiefs Defense
20.3 (19)Points/Gm24.8 (25)
0.343 (16)Points/Play0.379 (23)
340.2 (18)Yards/Gm356.5 (20)
216.2 (22)Pass Yards/Gm266 (27)
124 (12)Rush Yards/Gm90.5 (4)
5.7 (10)Yards/Play5.4 (16)
7.2 (6)Yards/Pass6.5 (13)
4.4 (13)Yards/Rush4.1 (6)
40.54% (15)3rd Down %38.16% (13)
58.82% (14)Red Zone TD%75% (29)
1.5 (22)Turnovers/Game0.8 (26)
4.79 (10)Sack Rate5.41 (24)

Chiefs At 49ers Betting Insights

Why The Chiefs Can Cover The Spread

The 49ers defensive injuries have brought a once incredible defense to its proverbial knees. They actually allowed 28 points to the Atlanta Falcons in a spot where, frankly, the matchup was about as good as possible for the Niners. With this secondary in shambles, how in the world are they going to slow down the Chiefs? There’s an immense amount of pressure on the 49ers front to get to Patrick Mahomes. If they don’t the Chiefs are just going to put up too many points for a grindy San Francisco offense to keep up.

Why The 49ers Can Cover The Spread

Since a strong start, the Chiefs defense has become progressively more vulnerable. Injuries play a role, but its unknown when Rashad Fenton and Trent McDuffie will return. Low-pedigree rookies are taking their place, and Kyle Shanahan will make sure they are targeted. Plus, few teams have tackled worse than the Chiefs, and the 49ers’ best skill players on offense excel at breaking tackles.

Reasons To Bet The Over

Neither defense is healthy. That’s pretty much the story here, and while the number is pretty high, especially by 2022 standards, these offenses are dangerous enough when the opposition is healthy.

Reasons To Bet The Under

QB pressure. The Chiefs don’t bring it at a tremendously high rate, but Chris Jones’ interior disruption made Jimmy Garoppolo very uncomfortable when these teams met in the Super Bowl a few years ago. And we know what the 49ers can do, pressuring opposing passers at the second-highest rate in the NFL.

Chiefs At 49ers Matchups To Watch For

49ers Skill Players Vs. Chiefs Tackling

Tackling has not been a strong suit for the Chiefs, an issue for several years now. This year, PFF has them in the bottom 10 in tackling grade, and the 49ers’ top skill guys are not known to go down easily. Both George Kittle and Deebo Samuel are adept at turning shorter stuff into longer gains. Samuel in particular poses a huge problem here, especially with Rashad Fenton potentially out (his tackling is excellent).

Nick Bosa Vs. Chiefs Tackles

Getting pressure without blitzing has allowed the 49ers defense to excel thus far. They buried the Rams in particular and also brought the Seahawks down, which looks much more impressive in light of Geno Smith’s continued outstanding play. The edges of the Chiefs line have been vulnerable so far, particularly longtime backup Andrew Wylie, pressed into service as a starter. Can a banged up Bosa still dominate? And if he does, can Mahomes escape and make plays?

Travis Kelce Vs. 49ers Coverage

Few teams have as strong a group of linebackers and safeties as the 49ers in terms of coverage. Dre Greenlaw, Fred Warner and Talanoa Hufanga have all been excellent there, but Travis Kelce obviously brings a unique challenge due to his incredible route running and mental connection with Mahomes. Limiting Kelce would go a long way toward rendering the KC offense less potent.

Final thoughts

Years later, the 49ers will look to exact revenge for their Super Bowl loss with the Chiefs coming to their house. However, the run of poor injury luck, a frequent problem in recent years, does not appear to have cleared up. While Trent Williams and Nick Bosa look likely to go, several other pieces in the secondary and up front remain in question. If you like where the injury report is heading, the 49ers make sense as a home underdog play here, probably on the moneyline since points won’t be at a premium in a game with a higher total. As far as props go, look to potentially buy low on some of KC’s receivers against inexperienced 49ers DBs.

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Mo Nuwwarah Avatar
Written by
Mo Nuwwarah

Mo Nuwwarah got his start in gambling early, making his first sports bet on his beloved Fab Five against the UNC Tar Heels in the 1993 NCAA tournament. He lost $5 to his dad and got back into sports betting years later during a 15-year run in the poker industry. A 2011 journalism graduate from Nebraska-Omaha, he combines those skills with his love of sports and statistics to help bettors make more informed decisions with a focus on pro football, baseball and basketball.

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