NFL Week 6 Odds: Expert Picks, Lines, Spreads, Over/Unders, Injuries

Written By Brett Gibbons on October 17, 2021

This article will lay out NFL Week 6 odds, where you can watch every game, key injuries, and more.

Week 6 marks the first third of the NFL season in the books (we know, we don’t like saying it, either). Plenty of questions still surround teams that are either under- or over-performing, setting up an interesting slate of games. Highlighting are the Los Angeles Chargers (4-1) visiting the Baltimore Ravens (4-1) and the Arizona Cardinals (5-0) at the Cleveland Browns (3-2).

Let’s dive into the NFL Week 6 odds.

All times listed below are in Eastern Standard Time.

Miami Dolphins (1-4) vs Jacksonville Jaguars (0-5)

Kickoff: 9:30 a.m.
TV Channel: CBS
Look-ahead line: MIA -3
Current Line: MIA (), O/U ()

Miami vs. Jacksonville key injuries

Dolphins vs. Jaguars: Week 6 NFL Betting Preview

Dolphins vs. Jaguars betting news & angles

Team
Angle
News
Time
This feed is updated automatically when something happens.

Los Angeles Chargers (4-1) at Baltimore Ravens (4-1)

Time of game: 1:00 p.m.
TV Channel: CBS
Look-ahead line: BAL -3.5
Current Line: BAL (), O/U ()

Los Angeles Chargers vs. Baltimore key injuries

Chargers vs. Ravens: Week 6 NFL Betting Preview

Chargers vs. Ravens betting news & angles

Team
Angle
News
Time
This feed is updated automatically when something happens.

Minnesota Vikings (2-3) at Carolina Panthers (3-2)

Time of game: 1:00 p.m.
TV Channel: FOX
Look-ahead line: CAR -1
Current Line: MIN (), O/U ()

Minnesota vs. Carolina key injuries

Vikings vs. Panthers: Week 6 NFL Betting Preview

Vikings vs. Panthers betting news & angles

Team
Angle
News
Time
This feed is updated automatically when something happens.

Green Bay Packers (4-1) at Chicago Bears (3-2)

Time of game: 1:00 p.m.
TV Channel: FOX
Look-ahead line: GB -4.5
Current Line: GB (), O/U ()

Green Bay vs. Chicago key injuries

Packers vs. Bears: Week 6 NFL Betting Preview

Packers vs. Bears betting news & angles

Team
Angle
News
Time
This feed is updated automatically when something happens.

Cincinnati Bengals (3-2) at Detroit Lions (0-5)

Time of game: 1:00 p.m.
TV Channel: FOX
Look-ahead line: CIN -3.5
Current Line: CIN (), O/U ()

Cincinnati vs. Detroit key injuries

Bengals vs. Lions: Week 6 NFL Betting Preview

Bengals vs. Lions betting news & angles

Team
Angle
News
Time
This feed is updated automatically when something happens.

Houston Texans (1-4) at Indianapolis Colts (1-4)

Time of game: 1:00 p.m.
TV Channel: CBS
Look-ahead line: OTB
Current Line: IND (), O/U ()

Houston vs. Indianapolis key injuries

Texans vs. Colts: Week 6 NFL Betting Preview

Texans vs. Colts betting news & angles

Team
Angle
News
Time
This feed is updated automatically when something happens.

Los Angeles Rams (4-1) at New York Giants (1-4)

Time of game: 1:00 p.m.
TV Channel: FOX
Look-ahead line: LAR -7
Current Line: LAR (), O/U ()

Los Angeles Rams vs. New York Giants key injuries:

Rams vs. Giants: Week 6 NFL Betting Preview

Rams vs. Giants betting news & angles

Team
Angle
News
Time
This feed is updated automatically when something happens.

Kansas City Chiefs (2-3) at Washington Football Team (2-3)

Time of game: 1:00 p.m.
TV Channel: CBS
Look-ahead line: KC -6.5
Current Line: KC (), O/U ()

Kansas City vs. Washington key injuries

Chiefs vs. Washington: Week 6 NFL Betting Preview

Chiefs vs. Football Team betting news & angles

Team
Angle
News
Time
This feed is updated automatically when something happens.

Arizona Cardinals (5-0) at Cleveland Browns (3-2)

Time of game: 4:05 p.m.
TV Channel: FOX
Look-ahead line: CLE -3
Current Line: CLE (), O/U ()

Arizona vs. Cleveland key injuries

Cardinals vs. Browns: Week 6 NFL Betting Preview

Cardinals vs. Browns betting news & angles

Team
Angle
News
Time
This feed is updated automatically when something happens.

Las Vegas Raiders (3-2) at Denver Broncos (3-2)

Time of game: 4:25 p.m.
TV Channel: CBS
Look-ahead line: DEN -2.5
Current Line: DEN (), O/U ()

Las Vegas vs. Denver key injuries

Broncos vs. Raiders: Week 6 NFL Betting Preview

Broncos vs. Raiders betting news & angles

Team
Angle
News
Time
This feed is updated automatically when something happens.

Dallas Cowboys (4-1) at New England Patriots (2-3)

Time of game: 4:25 p.m.
TV Channel: CBS
Look-ahead line: DAL -1
Current Line: DAL (), O/U ()

Dallas vs. New England key injuries

Cowboys vs. Patriots: Week 6 NFL Betting Preview

Cowboys vs. Patriots betting news & angles

Team
Angle
News
Time
This feed is updated automatically when something happens.

Seattle Seahawks (2-3) at Pittsburgh Steelers (2-3)

Time of game: 8:20 p.m.
TV Channel: NBC
Look-ahead line: SEA -3
Current Line: PIT (), O/U ()

Seattle vs. Pittsburgh key injuries

Seahawks vs. Steelers: Week 6 NFL Betting Preview

Seahawks vs. Steelers betting news & angles

Team
Angle
News
Time
This feed is updated automatically when something happens.

Buffalo Bills (4-1) at Tennessee Titans (3-2)

Time of game: 8:15 p.m.
TV Channel: ESPN
Look-ahead line: BUF -3.5
Current Line: BUF (), O/U ()

Buffalo vs. Tennessee key injuries

Bills vs. Titans: Week 6 NFL Betting Preview

Bills vs. Titans betting news & angles

Team
Angle
News
Time
This feed is updated automatically when something happens.

Keep up-to-date with theLines for NFL Week 6 odds and NFL previews all season long.

Brett Gibbons Avatar
Written by
Brett Gibbons

Brett is an avid sports traveler and former Division-I football recruiter for Bowling Green and Texas State. He’s a graduate of BGSU and works as an auditor for Google content curation products. He’s also contributed to Sports Illustrated and Fansided during his young writing career.

View all posts by Brett Gibbons