NFL Week 6 Betting Preview: San Fransisco 49ers At Atlanta Falcons

Written By Derek Wagner on October 14, 2022 - Last Updated on October 15, 2022
49ers falcons odds

The San Fransisco 49ers (3-2) visit the Atlanta Falcons (2-3) at 1 p.m. ET on Sunday, Oct. 16. The 49ers are spread favorites and on the moneyline. 49ers Falcons odds feature a total set at .

In this article we break down everything you need to know before placing a bet on the game, including team matchups, key metrics, weather, and the best available odds. Click on 49ers – Falcons odds anywhere in this post to bet now.


When using the 49ers Falcons odds table above, click the dropdown menu and select the type of bet you wish to make. 

Betting on the point spread is when you wager on how many points a team will win or lose by. A “plus” sign in front of the spread is the underdog, and a “minus” sign is the favorite. The Niners would need at least a six-point win if you bet on San Francisco to cover the point spread (-5.5). A spread bet on the Falcons would win if Atlanta wins the game outright or loses by five points or fewer.

Betting the moneyline is simply betting on which particular team will win a game.

The total is the number of combined points the two teams will score. Bettors can decide to bet the over or under on how many total points will be scored in the game


In the props tool search bar, type in a team or player and hit enter. You’ll see the various proposition bets offered by leading online sportsbooks. 

This is a valuable tool that allows bettors to compare odds and stats when considering a prop bet. 


As of Wednesday, the spread for this game on DraftKings Sportsbook is Niners -5.5 with the total set at 44.5 Additional updates can be found below.

49ers Vs. Falcons Injury Report

San Francisco Injuries

Aaron BanksFBKneeQuestionable
Samson EbukamFBAchillesQuestionable
Danny GrayWRIllnessProbable
Robbie GouldKKneeProbable
Tarvarius MooreDBHamstringQuestionable
Emmanuel MoseleyCBKneeOut
Nick BosaFBGroinQuestionable
Javon KinlawDTKneeQuestionable
Trent WilliamsOTAnkleQuestionable
Arik ArmsteadFBAnkleQuestionable
Jimmie WardDBHandQuestionable
Tyler KroftTEKneeQuestionable
Curtis RobinsonLBAnkleQuestionable

Atlanta Injuries

Adetokunbo OgundejiOLBUndisclosedQuestionable
Elijah WilkinsonOTKneeQuestionable
Mykal WalkerILBGroinDoubtful
Kyle PittsTEHamstringQuestionable

49ers Offense Vs. Falcons Defense

49ers OffenseStats (Rank)Falcons Defense
21.6 (16)Points/Gm24.4 (20)
0.4 (5)Points/Play0.4 (16)
339.0 (20)Yards/Gm393.0 (27)
200.2 (25)Pass Yards/Gm278.2 (29)
138.8 (8)Rush Yards/Gm114.8 (17)
5.7 (12)Yards/Play5.9 (22)
7.3 (6)Yards/Pass6.9 (21)
4.6 (12)Yards/Rush4.6 (19)
40.9% (11)3rd Down %47.1% (27)
57.1% (17)Red Zone %57.1% (15)
6 (10)Turnovers7 (13)
9 (10)Sacks8 (25)

Falcons Offense Vs. 49ers Defense

Falcons OffenseStats (Rank)49ers Defense
23.6 (10)Points/Gm12.2 (1)
0.4 (5)Points/Play0.2 (1)
331.4 (25)Yards/Gm249.2 (1)
166.8 (30)Pass Yards/Gm177.8 (3)
164.6 (3)Rush Yards/Gm71.4 (1)
5.6 (15)Yards/Play4.0 (1)
6.8 (12)Yards/Pass5.2 (2)
5.1 (7)Yards/Rush3.0 (1)
39.6% (17)3rd Down %30.0% (3)
61.1% (9)Red Zone %40.0% (6)
8 (22)Turnovers7 (13)
12 (19)Sacks21 (1)


Why the 49ers Can Cover The Spread

The 49ers bolster one of the best defenses in the NFL through five weeks of play. The Niners have allowed a league low 3.0 yards per carry in the NFL. Limiting the Falcons success on the ground and forcing them to throw the football could be the key to the Niners covering this game. The Buccaneers last week held the Falcons to 4.9 yards per carry, but that number was a bit inflated because of Mariota’s 8.7 yards per carry. Overall, the Bucs did a good job forcing the Falcons to have to throw the football.

If you remove Week 1’s monsoon game against the Bears from the equation, the Niners have the third-highest dropback EPA in the NFL. This number is a little inflated itself due to a great game last week against a reeling Panthers team that fired their head coach. Nonetheless, the Niners have found success in the passing game since Garoppolo has taken over for the injured Trey Lance.

The Falcons have not been impressive on the defensive side of the football through five weeks of play. They are the fifth-worst team in defensive EPA allowed and are below average in yards per play allowed, yielding 5.9 yards per play to opponents through five weeks.

To make matters worse, the Falcons defense has the second fewest pressures on the season with 27. To put that into perspective, Nick Bosa almost has more pressures than the entire Falcons defense. The Falcons were only able to sack Tom Brady once last week, even with having a Bucs offensive-line that is riddled with injuries. For purposes of this article, we will count Grady Jarrett’s takedown of Brady as a sack instead of a roughing the passer penalty. All that being said, there is little reason to believe the Falcons will be able to take advantage of the Niners offensive line injuries this week.

Why the Falcons Can Cover The Spread

The Falcons offense has been a surprising bright spot for the team through five weeks. They are tenth in points per game with 23.6, and eighth in points per play with 0.397.

The Falcons have only been outscored in the fourth quarter once this year, against the Saints in Week 1. Regardless of what the score is going into the fourth quarter, this team finds a way to make games interesting at the end of games. If the backdoor cover is open at the end of the game, you can expect the Falcons to put up a fight to win or cover the spread late.

As we have discussed throughout the season so far, trends are worth noting but are not reasons to make bets. This applies to the Falcons who are the only team who remain undefeated against the spread through five weeks of play. They were lucky enough to back door cover the Rams in Week 2 after outscoring them 17-3 in the fourth quarter. Their cover streak could end here however against a stout Niners team.

Another trend worth noting is Kyle Shanahan’s ATS record since joining the 49ers. As a favorite, the Niners are 19-26-1 against the spread. The Niners have been a much better underdog team under Shanahan than they have been a favorite.

Reasons To Bet The Over

Considering that 49ers Falcons odds opened with a total of 43, the betting market has already moved the number upward as a reaction to variables that would drive one towards the over, The Falcons need to manufacture a strong offensive game plan to get this over to come home. Without Nick Bosa and Emmanuel Moseley, this Niners defense could face some regression in this game and allow the Falcons to contribute to the total.

Reasons To Bet The Under

The Falcons were only able to manage 4.3 yards per play in their Week 5 matchup against the Bucs. It was by far their toughest test offensively and they were not able to

The under has come home in four of the five games for the Niners so far this year. Additionally, they were able to hold the Seahawks to only seven points in Week 2. The Seahawks offense is first overall in DVOA (via Football Outsiders).

Kyle Shanahan’s unit manufactures the fifth-slowest tempo in neutral situations through five weeks. In fact, this is the exact same spot the Niners finished in last season regarding offensive tempo. They have no interest in running an up-tempo offense. If they get out to an early lead, look for Kyle Shanahan to try and run out the clock against a Falcons team that likes to make games interesting at the end.


Falcons Vs. 49ers Injury Report

The 49ers defense lost cornerback Emmanuel Moseley to a season ending ACL injury in Week 5 against the Panthers. The Falcons will undoubtedly try to avoid throwing to cornerback Charvarius Ward who leads the NFL in pass break ups with seven. Ward is the tenth-highest graded cornerback in coverage according to PFF. Samuel Womack and Ambry Thomas saw snaps last week when Moseley left the game with his injury. Expect the Falcons to try and test this matchup early and often throughout the game.

To make matters worse for the secondary, safety Jimmie Ward broke his hand on the opening kickoff of the game against the Panthers. Head coach Kyle Shanahan said he could play with a club on his hand after surgery, but it is unclear when he will be able to return to the field right now.

Nick Bosa suffered a groin injury in Week 5 against the Panthers. Bosa could miss a couple weeks, so the Falcons offense could benefit greatly if he missed this game. The 49ers defense is second in the NFL with 63 pressures through five weeks of play. Bosa himself leads the NFL with 23 pressures.

Additionally, Jaylon Moore is filling in at left tackle while Trent Williams and Colton McKivitz are dealing with injuries. Kyle Shannahan has done a good job scheming the offense away from problems, as Jimmy Garoppolo was only sacked twice last week against the Panthers.

49ers run game Vs. Falcons Defense

The Niners offense is averaging the eighth most rushing yards per game in the NFL this season with 138.8. The Falcons did a good job in Week 5 holding the Bucs to 3.0 yards per carry, but I wouldn’t expect them to be able to repeat that performance. The Bucs average the lowest yards per carry in the NFL through five weeks with only 3.1 yards.

In Week 4 against the Browns, the Falcons defense allowed the fifth highest rushing success rate for the week with 54.55 success rate. Although the Niners run game isn’t as dominant as the Browns, it is worth noting after Jeff Wilson’s dominant game last week where he had 17 carries for 120 yards and a score. The Falcons run defense grades below league average according to PFF’s grading scale.

Final thoughts

If the Falcons are able to exploit some key Niners injuries and take an early lead in this game, I may look to live bet this game. I’m expecting a Niners win but am not comfortable laying this many points given the injuries the Niners have sustained on the defensive side of the ball.

TheLines managing editor Stephen Andress is betting Atlanta +4.5 or better, with the 49ers injuries. Best of luck with betting 49ers Falcons odds and props.

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