NFL Week 6 Odds: Point Spreads, Moneylines And Totals For Every Game

Written By Juan Carlos Blanco on October 16, 2022 - Last Updated on October 17, 2022
NFL Week 6 odds

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Half of the NFL has either a 3-2 or 2-3 record at this stage, which plays into the narrative that parity is running rampant in the league. There are elite teams, of course, as the Bills improved to 4-1 with a 38-3 blasting of the Steelers this past Sunday. The Eagles had a more difficult time with the Cardinals, but improved to 5-0 on the season when all was said and done. Pro football bettors will now turn their attention to NFL Week 6 odds where the Bills and Eagles are involved in two of the more interesting spreads. Josh Allen and company are -2.5 on the road against the Chiefs +2.5. Jalen Hurts and the Eagles are -4.5 at home against the 4-1 Cowboys +4.5. Chicago and Washington kicked off the sixth week of the season Thursday night with the Commanders emerging with a 12-7 win.

NFL Week 6 odds

View all of the NFL Week 6 odds below and click on the price you like to bet now. Pro football spreads, moneylines and over unders from top sportsbooks are available to wager on here.

NFL Week 6 betting lines

There are several sizable spreads when looking at NFL Week 6 odds Sunday morning. Aaron Rodgers and the Packers are -7.5 favorites over Zach Wilson and the Jets +7.5. Another lopsided line is Matthew Stafford and the Rams as -10 home favorites over the Panthers +10. That line is not too surprising considering Carolina fired Matt Rhule this week and Steve Wilks was named the interim head coach, though it would have been hefty regardless. Tom Brady will return to Pittsburgh, where his Buccaneers are -8 road favorites over the Steelers +8. There are some narrow spreads in here, too, as the Bengals -2.5 face the Saints +2.5 in New Orleans. The Colts are also -2 at home against the Jaguars +2.

Here are the NFL Week 6 spreads that have changed the most over the past week.

  • Buccaneers -6.5 at Steelers +6.5 to Buccaneers -10 at Steelers +10
  • Jets +9.5 at Packers -9.5 to Jets +7.5 at Packers -7.5
  • Bengals PK at Saints PK to Bengals -2.5 at Saints +2.5
  • Bills PK at Chiefs PK to Bills -2.5 at Chiefs +2.5
  • Cowboys +5.5 at Eagles -5.5 to Cowboys +6.5 at Eagles -6.5

Washington Commanders -1 at Chicago Bears +1

The Commanders covered -1 in the expected ugly affair with the Bears Thursday night as Washingington came away with a 12-7 win. Ron Rivera’s team is now 2-4 against the spread this season while the Bears are 2-3-1 ATS.

San Francisco 49ers at Atlanta Falcons

The 49ers thumped the Panthers to the extent they got Matt Rhule booted Monday morning as San Francisco notched a 37-15 win. San Francisco’s offense was a textbook example of balance, netting 244 passing yards and 153 rushing yards. Kyle Shanahan’s crew is now 3-2 on the season.

The Falcons fought hard against the Buccaneers but fell just short by a 21-15 score. The narrow loss was particularly noteworthy when considering Atlanta was missing both Cordarrelle Patterson (IR-knee) and Kyle Pitts (hamstring). Atlanta was also victimized by a highly questionable roughing the passer call. 

The matchup for the Falcons this coming Sunday will be just as tough as San Francisco’s defense has the look of the best unit in the league. The Niners are shutting teams down through both the ground and air, conceding 71.4 rushing yards per game and an equally impressive 177.8 passing yards per contest. Atlanta could have Pitts back for this matchup, but this still has the look of a nightmarish scenario for Marcus Mariota. Mariota will hope to have Drake London (knee) in the lineup, in addition to Pitts.

New England Patriots at Cleveland Browns

The Patriots were forced to roll with Bailey Zappe against the Lions and turned in their best performance of the season by far, recording a 29-0 win over Detroit in which Rhamondre Stevenson put together a career-best 161-yard day on the ground. 

The Browns came up just short for the second straight week, falling to the Chargers by a 30-28 score when Cleveland’s last two drives ended in an end-zone interception and a punt. Jacoby Brissett’s late-game stumbles aside, he did continue to show excellent chemistry with Amari Cooper and David Njoku, while Nick Chubb put together another dominant game on the ground (134 yards, two TDs). 

The Patriots could have Mac Jones (ankle) back for this game, although Zappe has more than held his own in a game-manager role the last game-plus. Jakobi Meyers’ return from a two-game absence due to a knee injury saw him eclipse the century mark and get into the end zone, and he could prove to be a valuable weapon for whomever is under center in this matchup against a Cleveland defense allowing 246.7 passing yards per home game.

The Browns will naturally look to continue pounding the Chubb-Kareem Hunt duo as frequently as possible, and the matchup against the Pats run defense should be favorable. New England is allowing 128.8 rushing yards per game, albeit at a respectable 4.3 RB yards per carry. The task for Brissett against his old head coach, who surely knows how to defend against him, is a lot thornier on paper – the Pats have surrendered only 211.0 passing yards per game. NFL Week 6 odds showed the Pats as +3 underdogs on Monday.

New York Jets at Green Bay Packers

The Jets scored an emotionally satisfying win over the division-rival Dolphins at MetLife Stadium, walloping Miami by a 40-17 score. The victory came with one major asterisk, however, as the Fins were down to third-string quarterback Skyler Thompson two plays into the game after Teddy Bridgewater suffered an elbow injury and concussion.

The Packers had a bad experience of their own this past Sunday, shockingly dropping a 27-22 decision to the surprising Giants. Green Bay also saw promising rookie Christian Watson’s hamstring issues resurface, as he exited the game for good in the third quarter and is now questionable for this contest. 

The Jets continue to expand the role of explosive rookie Breece Hall with considerable success, as he went off for 197 total yards and a rushing touchdown on 20 touches. The tally included a 79-yard reception that showed off his elite speed, which, when complemented by the equally fleet receiver group the team boasts, presents quite the challenge for any defense, even a Packers unit yielding a modest 5.5 yards per play.

The Pack will aim to get back on track against a New York defense that has displayed some tangible improvement thus far, allowing an even stingier 5.2 yards per play while ranking in the top half of the league in yards per game allowed. Green Bay’s offense is still a work in progress considering the team’s revamped receiving corps, but coach Matt LaFleur may opt to lean heavily here on his Aaron Jones-AJ Dillon backfield duo considering Gang Green has given up 151.5 rush yards per contest in its two road games.

With the Pack always enjoying a significant Lambeau Field advantage under Aaron Rodgers, they were unsurprisingly 7-to-7.5-point favorites when looking at NFL Week 6 odds on Monday.

Jacksonville Jaguars at Indianapolis Colts

The Jaguars continued to come back down to earth to a degree Sunday with their second straight loss, a humbling 13-6 defeat at the hands of the Texans. The Colts were able to persevere in a tough road environment to edge out the Broncos by a 12-9 score on Thursday night, a game in which neither team scored a touchdown. 

The Jags’ inability to run the ball consistently against a Houston defense that had been very porous once again early this season is a concern, and even Travis Etienne’s team-high 70 rush yards were largely the byproduct of a 40-yard scamper. The matchup in Week 6 threatens to really make Jacksonville’s offense one-dimensional, as Indy is allowing a minuscule 96.6 rushing yards per game, including 92.5 per home contest.

The Colts have plenty of offensive concerns themselves, however, and they now draw a matchup against a division opponent that’s conceded only 5.1 yards per play. Matt Ryan’s turnover issues continued in the game against Denver with two more interceptions and a pair of fumbles. Indy’s offensive line continues to do Ryan no favors with its shoddy pass protection, but the entire unit could certainly be helped by a potential Jonathan Taylor return from a one-game absence due to an ankle injury. 

Oddsmakers are still affording the Jags some respect/withholding some from the Colts as Indy is just a 2-to-2.5-point home favorite as the week begins. 

Minnesota Vikings at Miami Dolphins

The Vikings got off to a fast start this past Sunday and then hung on to get to 4-1 with a 29-22 win over the Bears. The Dolphins went into MetLife Stadium and were trounced by a 40-17 score courtesy of the Jets, and to make matters worse, Miami was forced to turn to third-string quarterback Skylar Thompson when Teddy Bridgewater suffered a head injury on the second play of the game.

The Vikings still have concerns on defense after facilitating Justin Fields’ best passing day yet of the season (208 yards), but Minnesota’s offense is increasingly comfortable in new head coach Kevin O’Connell’s scheme. Justin Jefferson is playing the alpha wideout role to perfection, and O’Connell appears to be managing Dalvin Cook carefully by mixing in Alexander Mattison more liberally. The Dolphins defense showed some cracks on the ground against the Jets’ Breece Hall on Sunday, leaving a potential avenue for Minnesota to exploit.

The biggest question hanging over the Dolphins this week will naturally be the health of the quarterback position. There’s certainly at least a fighting chance Tua Tagovailoa makes his return from his concussion, but Miami figures to tread very carefully with both him and Bridgewater. If Thompson is forced into his first career start, he’ll face a Vikings team that’s allowed 275.0 passing yards per game in its first two road contests. However, Raheem Mostert’s breakout 113-yard effort Sunday could nudge Mike McDaniel more in the direction of the ground game irrespective of who’s under center.

This will naturally be a line to watch throughout the week as the Fins’ QB situation becomes clearer. The Dolphins were +3 home underdogs when looking at NFL Week 6 odds at the beginning of the week.

Cincinnati Bengals at New Orleans Saints

The Bengals ran into a stingy Ravens defense Sunday night and fell to Baltimore, 19-17, after hanging 41 points apiece on their division rivals in their two games last season. The Saints managed to outlast the Seahawks, 39-32, in Week 6, with Taysom Hill playing more of a role in the win than Andy Dalton, racking up four total touchdowns (three rushing, one passing).

Cincinnati actually saw Joe Mixon have his best rushing day of the season from an efficiency perspective with 5.6 yards per carry. However, Joe Burrow took another pair of sacks and now face a Saints defense that’s collected 10 QB takedowns thus far. New Orleans did have some breakdowns in the secondary against Seattle, however, which coach Zac Taylor may aim to exploit with Ja’Marr Chase, who’s in search of his first 100-yard game since Week 1. 

It remains to be seen whether Dalton will get to face his old squad in Week 6, as there’s a chance Jameis Winston makes it back from his back and ankle injuries after two games off. The other big health question for New Orleans’ offense going into this game involves the receiver position – Michael Thomas will aim to return from his foot injury, while Chris Olave will have to clear concussion protocol after suffering the head injury on a touchdown catch Sunday. 

This is another game with a razor-thin spread as the week begins, with the Bengals a 1-to-1.5-point road favorite for the moment but with movement possible as the Saints’ health issues gain some clarity.

Baltimore Ravens at New York Giants

The Ravens gutted out a 19-17 win over the Bengals on Sunday night for their first home win of the campaign, one they accomplished without Rashod Bateman (foot). The Giants had an enjoyable trip across the pond, upsetting the Packers by a 27-22 score in London.

Baltimore’s offense did look somewhat hamstrung without Bateman, although tight end Mark Andrews predictably stepped up by putting together an 8-89-1 line. New York’s defense, like the team as a whole, as largely outperformed expectations thus far, checking in at a solid No. 12 in terms of total yards per game allowed (326.0). The G-Men have given up a 17-92 line on the ground to QBs, however, encouraging numbers from Lamar Jackson’s perspective.

New York managed to pull off their upset of Green Bay while missing four receivers, a testament to head coach Brian Daboll and his staff. The Giants have also been buoyed immensely by Saquon Barkley’s renaissance, although he’ll have an interesting matchup against a Ravens defense giving up a relatively modest 108.0 rushing yards per game but at 5.0 yards per carry. 

The Giants are the talk of the league, but oddsmakers are still reserving some judgement – Baltimore is still a 5.5-point road favorite when looking at NFL Week 6 odds.

Tampa Bay Buccaneers at Pittsburgh Steelers

The Buccaneers added another victory Sunday, but they continued to look wholly uninspiring while toppling the Falcons by a 21-15 score. The Steelers didn’t have the luxury of an ugly win or anything remotely close, as they were flattened by the Bills, 38-3. 

Tom Brady’s numbers were spectacular for the second straight week Sunday, pushing his total over the last pair of contests to 736 yards. However, the Bucs still couldn’t shake the Falcons until late, and with the help of a very questionable roughing the passer penalty at that. The matchup against the Steelers doesn’t look too daunting on the surface, but Pittsburgh remains a tricky road venue and the defense is capable of ball-hawking (eight interceptions) getting pressure (10 sacks).

Kenny Pickett got plenty of reps if nothing else during Sunday’s shellacking, and he came out of the lopsided loss with an impressive 327 yards on 34-for-52 passing. The rookie continued to display plenty of rapport with draft-class mate George Pickens (6-83), but Pittsburgh’s shaky offensive line will have to keep Pickett upright against a Bucs defense that now has 19 sacks through five games. NFL Week 6 odds show the Bucs enjoying 8-to-8.5-point road favorite status, a number that could grow in the coming days.

Carolina Panthers at LA Rams

The Panthers finally sustained the loss that was one too many for head coach Matt Rhule’s job, as their 37-15 walloping at the hands of the 49ers on Sunday got him the boot Monday morning. The Rams have issues of their own, as they fell to 22-10 to the visiting Cowboys to fall to 2-3 and allowed another five sacks against Matthew Stafford.

The Panthers will move forward with former Cardinals head coach Steve Wilks in the interim role, and he’ll draw a matchup against the defending champs right off the bat. However, as alluded to, it’s certainly a struggling Rams squad that will be hosting Carolina, although Wilks could be down to P.J. Walker at quarterback if Baker Mayfield can’t overcome the high-ankle sprain he suffered in Week 5.

The Rams won’t have too daunting a matchup against Carolina in terms of keeping Stafford upright, as the Panthers only have eight sacks in five games. However, the veteran quarterback will be facing a stingy secondary, one that’s only given up 218.4 passing yards per game and a 62.0 percent completion rate. 

Despite the champs’ own struggles and Mayfield’s own lackluster body of work this season, the betting public is already pushing the line up, with NFL Week 6 odds climbing as high as Rams -10.5 by Monday afternoon.

Arizona Cardinals at Seattle Seahawks

The Cardinals turned in another gutsy effort in Week 5 and fell just short to the Eagles, 20-17, on a missed field goal by fill-in kicker Matt Ammendola. The Seahawks came close to victory themselves but were betrayed by their defense once more, leading to a wild 39-32 loss to the Saints.   

This will be the final game that Kyler Murray will have to make do without DeAndre Hopkins (suspension), but Arizona’s receiving corps has shown improvement since the start of the season. Marquise Brown has done a fine job as Murray’s top option thus far (38-417-3), and he and his position mates could have their best game yet versus a Seattle defense allowing 259.8 passing yards per contest and a 66.9 percent completion rate. James Conner and his backfield mates are in an even better spot, as no team surrenders more than Seattle’s 170.2 rushing yards per game.

On the other side, Geno Smith is playing at – dare we say it – an MVP level, putting together another stellar performance in Week 5 against the Saints with 268 yards and three touchdowns. However, he did lose a critically important weapon in the loss, as Rashaad Penny suffered a broken fibula and high ankle sprain that will sideline him for the season. Rookie Kenneth Walker, who certainly has no shortage of upside, will move into a lead-back role, but the matchup against the Cardinals run defense is far from ideal (97.4 RYPG allowed). 

While this line could certainly see some movement as the week unfolds, for the moment, the Cardinals are 2.5-to-3-point road favorites. 

Buffalo Bills at Kansas City Chiefs

The Bills put together exactly the type of performance they were expected to in Week 6, as the Buffalo throttled an overmatched Steelers squad, 38-3. The Chiefs did not cover the -7 spread against the Raiders Monday night. In fact, it was a squeaker, as KC edged Vegas, 30-29.

The Bills’ Week 5 effort saw the offense clicking at close to all cylinders, particularly the passing attack. Josh Allen now boasts a 14:4 TD:INT heading into this matchup, and it’s one he thoroughly thrived in during two meetings last season. Allen compiled 374 total yards and four total touchdowns in Buffalo’s Week 5 road win and added 397 total yards and four scoring tosses in the classic overtime loss in the divisional round. 

Buffalo is getting a ton of respect ahead of this showdown, which could very well prove to be the game of the season if it’s anywhere close to as entertaining as last year’s postseason game was. The Bills were a -3 favorite at the Chiefs Tuesday morning.

Dallas Cowboys at Philadelphia Eagles

The Cowboys continued to thrive in Dak Prescott’s absence, notching a 22-10 victory over the Rams at SoFi Stadium with only 102 yards from Cooper Rush. The Eagles maintained their unblemished record, albeit barely, escaping the Cardinals by a 20-17 score in the desert.  

Rush was strictly a caretaker in the low-scoring win, as the defense and a ground attack that racked up a whopping 164 rushing yards and a touchdown led the way. Prescott may still not be ready to return for this primetime showdown, as they’re apparently still discomfort in his surgically repaired thumb. Dallas is 4-0 under Rush’s leadership, but he’ll presumably have to get a lot more involved versus a tough secondary for the Cowboys to escape with another win.

The Eagles will also have to be concerned with the Cowboys defense, which now is behind only the 49ers in sacks (20). Philly was limited by the Cardinals secondary and A.J. Brown in particular was held to three receptions for 32 yards, and the star wideout should see plenty of shutdown cornerback Trevon Diggs in this divisional clash. However, Dallas Goedert, who posted a season-best 8-95 line versus the Cardinals could play a big role again against unit that’s given up the fifth-most receptions (28) to tight ends.

With Prescott’s status still up in the air, the Eagles were solid 5-to-5.5-point home favorites to start the week when looking at NFL Week 6 odds, but it will be interesting to see if the public narrows this number during the week.

Denver Broncos at LA Chargers

The Broncos put together another worrisome offensive performance, dropping a 12-9 home decision in overtime to the Colts on Thursday night to start the slate. The Chargers’ defense underperformed in Week 5, but Justin Herbert, still missing Keenan Allen, was able to help pull out a 30-28 win over the Browns. 

Russell Wilson received a PRP injection in his throwing shoulder after the Week 5 loss, as it was revealed he’s been playing with a partially torn lat for the last two games. Wilson isn’t expected to need surgery or miss time, but the injury could certainly go a long way toward explaining his career-low 59.4 percent completion rate thus far. The matchup against the Chargers secondary isn’t completely daunting by the numbers, as L.A. has given up 259.0 passing yards per home game thus far and an elevated 67.2 percent completion rate overall.

The Bolts will hope to finally get Allen back for this matchup, but Herbert has impressively continued to manage well without him courtesy of a big assist from Mike Williams. The athletic wideout has three 100-yard efforts in the last four games, but he and whoever else is available in the pass-catching corps will have a tall order against a Broncos defense that’s surrendered an NFL-low 176.6 passing yards per game and only three passing touchdowns. 

With the two offenses going in completely different directions and Wilson not at full health, the Chargers are unsurprisingly comfortable 4.5-to-5.5-point home favorites to start the week. 

How spreads are changing

We will take stock of how NFL Week 6 odds are changing here, starting with lookahead lines. More point spreads will be added to this table in the days leading up to kickoff of each game. Here, first, are the point spreads from Sunday night, October 9.

DateNFL Week 6 Odds: October 9NFL Week 6 Odds: October 10NFL Week 6 Odds: October 11NFL Week 6 Odds: October 15
Thursday, October 13Commanders -1 at Bears +1Commanders +1 at Bears -1Commanders +1 at Bears -1Commanders -1 at Bears +1
Sunday, October 16Jaguars +1.5 at Colts -1.5Jaguars +1.5 at Colts -1.5Jaguars +2.5 at Colts -2.5Jaguars +2.5 at Colts -2.5
Sunday, October 16Patriots +2.5 at Browns -2.5Patriots +3 at Browns -3Patriots +3 at Browns -3Patriots +2.5 at Browns -2.5
Sunday, October 1649ers -6 at Falcons +649ers -5.5 at Falcons +5.549ers -5.5 at Falcons +5.549ers -4.5 at Falcons +4.5
Sunday, October 16Buccaneers -7.5 at Steelers +7.5Buccaneers -8.5 at Steelers +8.5Buccaneers -8.5 at Steelers +8.5Buccaneers -10 at Steelers +10
Sunday, October 16Jets +7.5 at Packers -7.5Jets +7.5 at Packers -7.5Jets +7 at Packers -7Jets +7 at Packers -7
Sunday, October 16Bengals -1.5 at Saints +1.5Bengals -1.5 at Saints +1.5Bengals -2 at Saints +2Bengals -3 at Saints +3
Sunday, October 16Vikings -3 at Dolphins +3Vikings -3 at Dolphins +3Vikings -3 at Dolphins +3Vikings -3 at Dolphins +3
Sunday, October 16Ravens -5 at Giants +5Ravens -5 at Giants +5Ravens -5.5 at Giants +5.5Ravens -5.5 at Giants +5.5
Sunday, October 16Panthers +9 at Rams -9Panthers +11 at Rams -11Panthers +10.5 at Rams -10.5Panthers +10 at Rams -10
Sunday, October 16Cardinals -2.5 at Seahawks +2.5Cardinals -2.5 at Seahawks +2.5Cardinals -2.5 at Seahawks +2.5Cardinals -2.5 at Seahawks +2.5
Sunday, October 16Bills -1 at Chiefs +1Bills -2.5 at Chiefs +2.5Bills -3 at Chiefs +3Bills -2.5 at Chiefs +2.5
Sunday, October 16Cowboys +5.5 at Eagles -5.5Cowboys +5 at Eagles -5Cowboys +4.5 at Eagles -4.5Cowboys +6.5 at Eagles -6.5
Monday, October 17Broncos +6.5 at Chargers -6.5Broncos +5 at Chargers -5Broncos +5 at Chargers -5Broncos +4.5 at Chargers -4.5
DateNFL Odds: October 5 spreadsNFL Odds: October 5 moneylinesNFL Odds: October 5 Over Unders
Thursday, October 13Commanders -1 at Bears +1Commanders -120 at Bears +10040
Sunday, October 16Patriots +3.5 at Browns -3.5Patriots +155 at Browns -18041.5
Sunday, October 16Vikings +1 at Dolphins -1Vikings +100 at Dolphins -12046.5
Sunday, October 16Bengals PK at Saints PKBengals -110 at Saints -11044
Sunday, October 16Jaguars +2.5 at Colts -2.5Jaguars +115 at Colts -13544
Sunday, October 16Jets +9.5 at Packers -9.5Jets +350 at Packers -43544
Sunday, October 16Buccaneers -6.5 at Steelers +6.5Buccaneers -275 at Steelers +23044.5
Sunday, October 1649ers -6.5 at Falcons +6.549ers -285 at Falcons +24043
Sunday, October 16Ravens -5.5 at Giants +5.5Ravens -240 at Giants +20043.5
Sunday, October 16Panthers +9.5 at Rams -9.5Panthers +340 at Rams -42542
Sunday, October 16Cardinals -2.5 at Seahawks +2.5Cardinals -135 at Seahawks +11547
Sunday, October 16Bills PK at Chiefs PKBills -110 at Chiefs -11053.5
Sunday, October 16Cowboys +5.5 at Eagles -5.5Cowboys +180 at Eagles -21045.5
Monday, October 17Broncos +4 at Chargers -4Broncos +165 at Chargers -19547.5
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Written by
Juan Carlos Blanco

Juan Carlos Blanco has served as a freelance writer for a wide variety of online publications and websites, with an intensive focus on fantasy sports. Juan has provided analysis and comprehensive coverage of the MLB, NBA, NFL, CFL, AAF and AFL while also reporting on news and developments in the daily fantasy sports and online gaming industries.

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