NFL Week 6 Opening Odds: San Francisco 49ers At Seattle Seahawks Betting Lines

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Written By Mo Nuwwarah | Last Updated
49ers seahawks opening odds

NFL Week 6 odds feature an NFC West clash on Thursday Night Football between the Seahawks and 49ers that will shape the early division race. Sportsbooks have released betting lines for this game and every other matchup in Week 6 before Week 5 games even begin. You can use the 49ers at Seahawks opening odds as a foundation for your handicapping, with betting markets hovering around even both ways. See if the market overreacts to Week 5 results while factoring in injuries and other situational aspects of the matchup.

The game kicks off at 8:15 p.m. ET on Thursday.

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49ers At Seahawks: NFL Week 6 Odds

Odds below are the best current prices across NFL betting sites. Find opening odds further down in this post.

The 49ers have used the Seahawks as something of a punching bag the past couple of years amid their ascent to clear class of the NFC. They’ve won each of the past five meetings over that time frame, including a 41-23 thumping in the playoffs two seasons ago. The closest of those was a 21-13 game in which the 49ers outgained the Hawks by more than 100 yards, and the score was 21-6 with under four minutes to go.

If Seattle’s game against Detroit was any indication, they’re going to have a tough time stopping this offense once again. Detroit gained 7.8 YPP and scored 42 points.

Outside of that game, the Seahawks have been stout. But the QBs they faced — Bo Nix, Skylar Thompson, and Jacoby Brissett — don’t exactly keep opposing coordinators up at night.

Assuming both teams take care of business this week as big favorites, the winner will have first-place positioning in the NFC West. If the 49ers win on the road, they’ll be in a very strong spot since they’ll still have a home game against Seattle (Week 11).

What do the 49ers at Seahawks Opening Odds mean?

Adjusted for the sportsbook vig at best prices, San Francisco has a 59% implied win rate.

49ers at Seahawks Week 6 Odds

Should the Seahawks be getting the key number of +3 at home here? That appears to be the operative question, as DraftKings Sportsbook opted to open on an expensive +3, while FanDuel Sportsbook is more hesitant to give 49ers odds that much credit.

The Seahawks are one of the tougher-to-read teams in the early going because of their schedule. They played a run of absolute cupcakes to get to 3-0 before falling in a thrilling road game in Detroit.

Unfortunately, Week 5 doesn’t figure to provide a ton of clarity. At full strength, the Giants are respectable, but that’s not the team Seattle will line up against. They might simply collapse without offensive focal point Malik Nabers.

If the Seahawks can’t get stops in that game, we may see this total rise, though. That would indicate their defense was simply a product of the soft start, and we know the market has a lot of respect for the 49ers offense. Brock Purdy has gotten off to an MVP-caliber start, and the San Francisco defense may miss superstar LB Fred Warner.

Photo by AP/Stephen Brashear

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