NFL Week 5 Sunday Early Afternoon Slate: Best Bets, Picks, Parlays and Props
Written By Nick Crain | Last Updated at October 5, 2025
Sunday’s early window brings plenty of action across the league, with 11 games during the day today. It all starts in London with an early morning matchup and wraps up with a four-game slate in the late afternoon slot. With so many opportunities on the board, there’s plenty of value for bettors who want to mix sharp single plays with well-structured parlays.
With that in mind, here’s a set of Week 5 NFL picks for the daytime slate and why the matchups provide an edge today. Whether you take these standalone or as the larger parlay, these picks come with tremendous value.
Value Game Picks
🏈 Parlay Odds (via Caesars Sportsbook): +249💰
- Leg 1: Colts (-7) vs Raiders (-105)
- Leg 2: Cowboys (ML) vs Jets (-127)
The Colts have been great this season, but there's still some uncertainty about whether or not they're true contenders. Even then, they're 3-1 this season and going up against a team that has only won one game to this point while being at home.
In the Cowboys-Jets game, it does feel like a game that could go either way. But in these toss-up games, it's always safe to go with the better, more experienced quarterback, which is Dak Prescott.
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🏈 Parlay Odds (via BetMGM): +568💰
- Leg 1: Jonathan Taylor Anytime TD Scorer (-210)
- Leg 2: Ashton Jeanty Anytime TD Scorer (-135)
- Leg 3: Daniel Jones Anytime TD Scorer (+160)
The matchup between the Colts and the Raiders is one that features quite a few players who can make plays with their legs. Not only do both squads have phenomenal running backs, but this game features a pair of quarterbacks who can get out and run as well.
If Indianapolis can get into the red zone more than a few times, both Jones and Taylor are great bets to punch it in. From there, Jeanty has broken out in recent games and can score from anywhere on the field.
Taking the Overs
🏈 Parlay Odds (via BetMGM): +264💰
- Leg 1: Vikings/Browns o35.5 Points (-110)
- Leg 2: Chiefs/Jaguars o45.5 Points (-110)
There's no question that the Vikings-Browns matchup will be an interesting one, as it's a pair of teams with different starting quarterbacks than in their respective season openers, and it's in London. Still, 35.5 is a line you don't get often, and these squads both have offensive weapons.
For the Chiefs-Jaguars game, this is one that features a pair of quarterbacks who can put up points in a hurry with their ability to make all types of throws. Especially if this game ends up being close late, we could see a high-scoring fourth quarter.
Whether you’re playing individual legs or stringing them together for a larger payout, these NFL player props and parlays showcase some of the best edges on the Week 5 board. From early kickoffs overseas to afternoon shootouts stateside, there’s no shortage of NFL best bets to ride through Sunday’s slate.
All Odds as of 11:59 p.m. ET on Oct. 4
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