NFL Week 5 Odds: Expert Picks, Lines, Spreads, Over/Unders, Injuries

Written By Brett Gibbons on October 10, 2021
nfl week 6 odds

This article will lay out NFL Week 5 odds, where you can watch every game, key injuries, and more.

The Kansas City Chiefs host the Buffalo Bills on Sunday Night Football in the marquee game of the Week 5 slate. The week provides pivotal games for a multitude of teams; according to data collected at Pro Football Reference, teams that began 1-3 made the NFL Playoffs 15% whereas teams that began 1-4 made the playoffs just 5% of the time. Conversely, teams to go from 3-1 to 4-1 jump from 63% to 77%.

Now, let’s dive into the NFL Week 5 odds.

All times listed below are in Eastern Standard Time.

New York Jets (1-3) vs Atlanta Falcons (1-3)

Kickoff: 9:30 a.m.
TV Channel: NFL Network
Look-ahead line: ATL -4
Current Line: ATL (), O/U ()

New York Jets vs. Atlanta key injuries

  • Falcons vs. Jets Week 5 injury report

New York Jets vs. Atlanta Falcons Week 5 full betting preview

Falcons vs. Jets betting news & angles

Philadelphia Eagles (1-3) at Carolina Panthers (3-1)

Time of game: 1:00 p.m.
TV Channel: FOX
Look-ahead line: CAR -3.5
Current Line: CAR (), O/U ()

Philadelphia vs. Carolina key injuries

  • Panthers vs. Eagles Week 5 injury report

Philadelphia Eagles vs. Carolina Panthers Week 5 full betting preview

Eagles vs. Panthers betting news & angles

Green Bay Packers (3-1) at Cincinnati Bengals (3-1)

Time of game: 1:00 p.m.
TV Channel: FOX
Look-ahead line: GB -3.5
Current Line: GB (), O/U ()

Green Bay vs. Cincinnati key injuries

  • Packers vs. Bengals Week 5 injury report

Packers vs. Bengals: Week 5 NFL Betting Preview

Packers vs. Bengals betting news & angles

New England Patriots (1-3) at Houston Texans (1-3)

Time of game: 1:00 p.m.
TV Channel: CBS
Look-ahead line: NE -7
Current Line: NE (), O/U ()

New England vs. Houston key injuries

  • Patriots vs. Texans Week 5 injury report

Patriots vs. Texans: Week 5 NFL Betting Preview

Patriots vs. Texans betting news & angles

Tennessee Titans (2-2) at Jacksonville Jaguars (0-4)

Time of game: 1:00 p.m.
TV Channel: CBS
Look-ahead line: TEN -7
Current Line: TEN (), O/U ()

Tennessee vs. Jacksonville key injuries

  • Titans vs. Jaguars Week 5 injury report

Titans vs. Jaguars: Week 5 NFL Betting Preview

Titans vs. Jaguars betting news & angles

Detroit Lions (0-4) at Minnesota Vikings (1-3)

Time of game: 1:00 p.m.
TV Channel: FOX
Look-ahead line: MIN -7
Current Line: MIN (), O/U ()

Detroit vs. Minnesota key injuries

  • Vikings vs. Lions Week 5 injury report

Vikings vs. Lions: Week 5 NFL Betting Preview

Lions vs. Vikings betting news & angles

Denver Broncos (3-1) at Pittsburgh Steelers (1-3)

Time of game: 1:00 p.m.
TV Channel: FOX
Look-ahead line: DEN -1.5
Current Line: PIT (), O/U ()

Denver vs. Pittsburgh key injuries:

  • Broncos vs. Steelers Week 5 injury report

Steelers vs. Broncos: Week 5 NFL Betting Preview

Broncos vs. Steelers betting news & angles

Miami Dolphins (1-3) at Tampa Bay Buccaneers (3-1)

Time of game: 1:00 p.m.
TV Channel: CBS
Look-ahead line: TB -10
Current Line: TB (), O/U ()

Miami vs. Tampa Bay key injuries

  • Dolphins vs. Buccaneers Week 5 injury report

Buccaneers vs. Dolphins: Week 5 NFL Betting Preview

Dolphins vs. Buccaneers betting news & angles

New Orleans Saints (2-2) at Washington Football Team (2-2)

Time of game: 1:00 p.m.
TV Channel: CBS
Look-ahead line: NO -1.5
Current Line: NO (), O/U ()

New Orleans vs. Washington key injuries

  • Saints vs. Football Team Week 5 injury report

Saints vs. Washington: Week 5 NFL Betting Preview

Saints vs. Football Team betting news & angles

Cleveland Browns (3-1) at Los Angeles Chargers (3-1)

Time of game: 4:05 p.m.
TV Channel: CBS
Look-ahead line: LAC -1
Current Line: LAC (), O/U ()

Cleveland vs. Los Angeles Chargers key injuries

  • Browns vs. Chargers Week 5 injury report

Chargers vs. Browns: Week 5 NFL Betting Preview

Browns vs. Chargers betting news & angles

Chicago Bears (2-2) at Las Vegas Raiders (3-1)

Time of game: 4:05 p.m.
TV Channel: CBS
Look-ahead line: LVR -6.5
Current Line: LVR (), O/U ()

Chicago vs. Las Vegas key injuries

Raiders vs. Bears: Week 5 NFL Betting Preview

Bears vs. Raiders betting news & angles

San Francisco 49ers (2-2) at Arizona Cardinals (4-0)

Time of game: 4:25 p.m.
TV Channel: FOX
Look-ahead line: ARI -1.5
Current Line: ARI (), O/U ()

San Francisco vs. Arizona key injuries

  • 49ers vs. Cardinals Week 5 injury report

Cardinals vs. 49ers: Week 5 NFL Betting Preview

49ers vs. Cardinals betting news & angles

New York Giants (1-3) at Dallas Cowboys (3-1)

Time of game: 4:25 p.m.
TV Channel: FOX
Look-ahead line: DAL -8
Current Line: DAL (), O/U ()

New York Giants vs. Dallas key injuries

  • Giants vs. Cowboys Week 5 injury report

Cowboys vs. Giants: Week 5 NFL Betting Preview

Giants vs. Cowboys betting news & angles

Buffalo Bills (3-1) at Kansas City Chiefs (2-2)

Time of game: 8:20 p.m.
TV Channel: NBC
Look-ahead line: KC -3.5
Current Line: KC (), O/U ()

Buffalo vs. Kansas City key injuries

  • Bills vs. Chiefs Week 5 injury report

Chiefs vs. Bills: Week 5 NFL Betting Preview

Bills vs. Chiefs betting news & angles

Indianapolis Colts (1-3) at Baltimore Ravens (3-1)

Time of game: 8:15 p.m.
TV Channel: ESPN
Look-ahead line: BAL -6.5
Current Line: BAL (), O/U ()

Indianapolis vs. Baltimore key injuries

  • Colts vs. Ravens Week 5 injury report

Ravens vs. Colts: Week 5 NFL Betting Preview

Colts vs. Ravens betting news & angles

Keep up-to-date with theLines for NFL Week 5 odds and NFL previews all season long.

Brett Gibbons Avatar
Written by
Brett Gibbons

Brett is an avid sports traveler and former Division-I football recruiter for Bowling Green and Texas State. He’s a graduate of BGSU and works as an auditor for Google content curation products. He’s also contributed to Sports Illustrated and Fansided during his young writing career.

View all posts by Brett Gibbons