NFL Week 5 Betting Preview: San Francisco 49ers At Carolina Panthers

Written By Mo Nuwwarah on October 7, 2022 - Last Updated on October 8, 2022
49ers Panthers odds

The San Francisco 49ers visit the Carolina Panthers at 4:05 p.m. ET on Sunday, Oct. 9. Primary markets for the game show the 49ers as spread favorites and on the moneyline. 49ers Panthers odds feature a total set at .

In this article, we break down everything you need to know before placing a bet on the game, including team matchups, key metrics, weather and the best available NFL Week 5 odds. Click on the odds anywhere in this post to bet now.

49ers At Panthers Odds: Spread, Moneyline, Over/Under

When using the odds table, click the dropdown menu and select the type of bet you wish to make. 

Betting the point spread is when you wager on how many points a team will win or lose by. A plus sign in front of the spread denotes the underdog, and a minus sign denotes the favorite.

In this case, the 49ers would have to win by at least seven points if you bet them to cover the point spread (-6.5). A spread bet on the Panthers would win if they win the game or lose by less than six. 

Betting the moneyline is simply betting on which particular team will win a game.

The betting total is the number of combined points the two teams will score. Bettors can choose to bet the over or under on how many total points will be scored in the game. 

For more betting guides, click the green NFL Game Previews button at the top of this post.

Editor’s Note

49ers At Panthers Player Props

In the props tool search bar, type in a team or player and hit enter. You’ll see the various proposition bets offered by leading online sportsbooks. 

This is a valuable tool that allows bettors to compare odds and stats when considering a prop bet. Unlike bigger markets like moneylines and spreads that often reach a consensus number, shopping for prop bet lines can often reveal sizable differences in the numbers.

49ers At Panthers Betting News & Angles

Use this rolling, updating list of news bites about each team to help your handicapping for 49ers – Panthers odds.

49ers At Panthers Injury Report

CAROLINA PANTHERS      
PlayerPositionInjuryWedThuFriGame Status
Laviska Shenault Jr.WRHamstringDNPDNPDNPOut
Marquis HaynesDEKneeLPFPFPQuestionable
Frankie LuvuOLBShoulderLPDNPLPQuestionable
Stantley Thomas-OliverCBThighDNPDNPDNPOut
Xavier WoodsSHamstringDNPDNPDNPQuestionable
Stephen SullivanTEBackFPDNPDNPOut
Shaq ThompsonOLBKneeLPFPFP(-)
SAN FRANCISCO 49ERS
PlayerPositionInjuryWedThuFriGame Status
Arik ArmsteadDTFoot, AnkleDNPDNPUnspecified
Nick BosaDENo Injury- Resting PlayerDNPFPUnspecified
Tyrion Davis-PriceRBAnkleDNPDNPUnspecified
Javon KinlawDTKneeDNPDNPUnspecified
Tyler KroftTEKneeDNPDNPUnspecified
Colton McKivitzOTKneeDNPDNPUnspecified
Tarvarius MooreDBHamstringDNPDNPUnspecified
Trent WilliamsOTAnkleDNPDNPUnspecified
Ross DwelleyTERibLPLPUnspecified
Jauan JenningsWRAnkleLPLPUnspecified
Danny GrayWRHipFPFPUnspecified

49ers Offense vs. Panthers Defense

49ers OStats (Rank)Panthers D
17.8 (27)Points/Gm21.3 (13)
0.298 (23)Points/Play0.306 (12)
324.5 (24)Yards/Gm346 (18)
189.3 (26)Pass Yards/Gm212 (12)
135.3 (9)Rush Yards/Gm134 (25)
5.5 (15)Yards/Play5 (9)
7 (12)Yards/Pass6 (7)
4.4 (17)Yards/Rush4.1 (12)
37.04 (22)3rd Down %39.06 (17)
40 (31)Red Zone TD %37.5 (4)
1.3 (10)Turnovers/Gm1 (21)
6.09 (16)QB Sacked %4.08 (30)

Panthers Offense vs. 49ers Defense

Panthers OStats (Rank)49ers D
19.5 (17)Points/Gm11.5 (1)
0.364 (12)Points/Play0.187 (1)
262.3 (32)Yards/Gm234.5 (1)
166 (30)Pass Yards/Gm161.3 (2)
96.3 (24)Rush Yards/Gm73.3 (2)
4.9 (27)Yards/Play3.8 (1)
5.7 (28)Yards/Pass5 (3)
4.5 (14)Yards/Rush2.9 (1)
25.53 (32)3rd Down %32.73 (6)
44.44 (28)Red Zone TD %42.86 (5)
1.5 (16)Turnovers/Gm1.5 (12)
8.59 (26)QB Sacked %10.42 (1)

49ers At Panthers Betting Insights

Why The 49ers Can Cover The Spread

How will the Panthers move the ball in this game? Despite not facing the most menacing run of defenses, Baker Mayfield has been arguably the worst QB in the league. DVOA has the Panthers offense second-worst behind only that of the Colts. Now, the 49ers defense looms, which looks like potentially the league’s best. Defensive scores have boosted the Panthers in their past two, and that’s not something they can count on continuing.

Why The Panthers Can Cover The Spread

This doesn’t look like the best situational spot for the 49ers. They’re coming off a huge win over a division rival and now head into a short week where they must also fly across the country. Granted, they did fade the 10 a.m. body clock game, so that helps. But overall, this looms as a potential letdown spot, and the Panthers do have a pretty solid defense that can keep them in the game if they can figure out how to tackle Deebo Samuel.

Reasons To Bet The Over

Well, any total sitting around 39 looks ripe for a potential over. Real offensive incompetence must happen to keep most NFL games south of that number. Granted, that could happen with these two QBs, but 20 points is not a high bar. Even some 49ers blowout scripts will go over — think 31-10, which is close to what happened on Monday Night Football. Also, the extreme levels of incompetence — turnovers — will produce short fields and potentially easy points.

Reasons To Bet The Under

Any game scripts not involving short fields would likely result in an under even this short number. The Panthers look like they’re in for a brutally awful day unless the 49ers completely sleep on them here. While the offense has bumbled all over the field for Carolina, their defense has quietly followed up a decent season with a top-10 ranking so far in EPA/play allowed. This looks like a solid unit on paper and they’ve done solid work so far.

49ers At Panthers Matchups To Watch For

Panthers Offensive Line Vs. 49ers Pass Rush

The 49ers pass rush completely and utterly dominated the Rams on MNF. Not only do they have pass rushing talent like Nick Bosa, but the scheme confounded the Rams linemen into numerous blown protections. The task should become a bit tougher here, surprisingly enough, since Carolina entered the year with an iffy unit. PFF rates them 11th thus far in protecting the passer, though. They’ll have to perform around that level to have a prayer here, since Baker Mayfield is not known for his calm under duress.

Deebo Samuel Vs. Panthers Tackling

Tackling was not a strength last year for the Panthers, as they checked in 25th according to PFF’s numbers. So far this year, they have only slightly improved, up to 17th. Missing tackles is never a good thing, but it’s far more punitive (and common) against Samuel than most players. He showed the Rams exactly what happens with blown tackling when he took a quick screen 57 yards to the house. In a game with a total south of 40, the Panthers simply cannot afford to allow a breakaway TD if they hope to stay in the game.

49ers Left Tackles Vs. Injury Report

All-world 49ers LT Trent Williams was considered a candidate for IR when he went down, so it seems unlikely he comes back this week.

Backup Colton McKivitz sustained a knee injury himself on MNF and did not return. It sounds like he’ll miss at least a month. That left backup RT Jaylon Moore as an emergency fill-in, and he predictably struggled. Carolina does have an ace pass rusher in Brian Burns, so this could be an area they exploit if Williams doesn’t make an amazing recovery.

Final thoughts

The Panthers offense looks likely to find itself in dire straits here. Perhaps no defense has looked better than that of the 49ers thus far, and Baker Mayfield has been a disaster under pressure since basically the minute he stepped onto an NFL field. This could get out of hand in a hurry if Mayfield doesn’t have some time to operate.

On the other hand, it is a fairly sleepy spot for the 49ers, and they have their own potential protection issues with a third-stringer at LT. The early action has poured in on San Francisco, moving the line close to a key number of -7. If it does reach that point or further, it’s probably time to take a look at a play on Carolina in what should be a low-scoring environment.

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Mo Nuwwarah Avatar
Written by
Mo Nuwwarah

Mo Nuwwarah got his start in gambling early, making his first sports bet on his beloved Fab Five against the UNC Tar Heels in the 1993 NCAA tournament. He lost $5 to his dad and got back into sports betting years later during a 15-year run in the poker industry. A 2011 journalism graduate from Nebraska-Omaha, he combines those skills with his love of sports and statistics to help bettors make more informed decisions with a focus on pro football, baseball and basketball.

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