NFL Week 4 Odds: Expert Picks, Lines, Spreads, Over/Unders, Injuries

Written By Brett Gibbons on October 1, 2021 - Last Updated on August 22, 2022
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After three full weeks of football, teams are starting to take shape while others are fighting to right the ship before it’s too late. This article will take a dive into NFL Week 4 odds including injuries, the latest odds, and full betting previews.

Big games on tap this week include two NFC West rivalries, undefeated Carolina at Dallas, and a huge Monday Night Football showdown. This week also marks the first return of Tom Brady to Foxborough as he looks to break the all-time passing record against the Patriots.

Now, let’s dive into the NFL Week 4 odds.

All times listed below are in Eastern Standard Time.

Washington Football Team (1-2) at Atlanta Falcons (1-2)

Kickoff: 1:00 p.m.
TV Channel: FOX
Look-ahead line: WFT -1
Current Line: WFT (), O/U ()

Washington vs. Atlanta key injuries

  • Football Team vs. Falcons Week 4 injury report

Washington Football Team at Atlanta Falcons Week 4 full betting preview

Falcons vs. Football Team betting news & angles

Houston Texans (1-2) at Buffalo Bills (2-1)

Time of game: 1:00 p.m.
TV Channel: CBS
Look-ahead line: BUF -15.5
Current Line: BUF (), O/U ()

Houston vs. Buffalo key injuries

  • Texans vs. Bills Week 4 injury report

Houston Texans at Buffalo Bills Week 4 full betting preview

Texans vs. Bills betting news & angles

Detroit Lions (0-3) at Chicago Bears (1-2)

Time of game: 1:00 p.m.
TV Channel: FOX
Look-ahead line: CHI -6
Current Line: CHI (), O/U ()

Detroit vs. Chicago key injuries

  • Lions vs. Bears Week 4 injury report

Detroit Lions at Chicago Bears Week 4 full betting preview

Lions vs. Bears betting news & angles

Carolina Panthers (3-0) at Dallas Cowboys (2-1)

Time of game: 1:00 p.m.
TV Channel: FOX
Look-ahead line: DAL -3.5
Current Line: DAL (), O/U ()

Carolina vs. Dallas key injuries

  • Panthers vs. Cowboys Week 4 injury report

Carolina Panthers at Dallas Cowboys Week 4 full betting preview

Panthers vs. Cowboys betting news & angles

Indianapolis Colts (0-3) at Miami Dolphins (1-2)

Time of game: 1:00 p.m.
TV Channel: CBS
Look-ahead line: MIA -2.5
Current Line: MIA (), O/U ()

Indianapolis vs. Miami key injuries

  • Colts vs. Dolphins Week 4 injury report

Indianapolis Colts at Miami Dolphins Week 4 betting preview

Colts vs. Dolphins betting news & angles

Cleveland Browns (2-1) at Minnesota Vikings (1-2)

Time of game: 1:00 p.m.
TV Channel: CBS
Look-ahead line: CLE -2.5
Current Line: CLE (), O/U ()

Cleveland vs. Minnesota key injuries

  • Browns vs. Vikings Week 4 injury report

Cleveland Browns at Minnesota Vikings Week 4 full betting preview

Browns vs. Vikings betting news & angles

New York Giants (0-3) at New Orleans Saints (2-1)

Time of game: 1:00 p.m.
TV Channel: FOX
Look-ahead line: NO -6.5
Current Line: NO (), O/U ()

New York vs. New Orleans key injuries:

  • Giants vs. Saints Week 4 injury report

New York Giants at New Orleans Saints Week 4 full betting preview

Giants vs. Saints betting news & angles

Tennessee Titans (2-1) at New York Jets (0-3)

Time of game: 1:00 p.m.
TV Channel: CBS
Look-ahead line: TEN -6.5
Current Line: TEN (), O/U ()

Tennessee vs. New York Jets key injuries

  • Titans vs. Jets Week 4 injury report

Tennessee Titans at New York Jets Week 4 full betting preview

Titans vs. Jets betting news & angles

Kansas City Chiefs (1-2) at Philadelphia Eagles (1-2)

Time of game: 1:00 p.m.
TV Channel: CBS
Look-ahead line: KC -6.5
Current Line: KC (), O/U ()

Kansas City vs. Philadelphia key injuries

  • Chiefs vs. Eagles Week 4 injury report

Kansas City Chiefs at Philadelphia Eagles Week 4 full betting preview

Chiefs vs. Eagles betting news & angles

Arizona Cardinals (3-0) at Los Angeles Rams (3-0)

Time of game: 4:05 p.m.
TV Channel: FOX
Look-ahead line: LAR -5.5
Current Line: LAR (), O/U ()

Arizona vs. Los Angeles Rams key injuries

  • Cardinals vs. Rams Week 4 injury report

Arizona Cardinals at Los Angeles Rams Week 4 full betting preview

Cardinals vs. Rams betting news & angles

Seattle Seahawks (1-2) at San Francisco 49ers (2-1)

Time of game: 4:05 p.m.
TV Channel: FOX
Look-ahead line: SF -3
Current Line: SF (), O/U ()

Seattle vs. San Francisco key injuries

  • Seahawks vs. 49ers Week 4 injury report

Seattle Seahawks at San Francisco 49ers Week 4 full betting preview

Seahawks vs. 49ers betting news & angles

Baltimore Ravens (2-1) at Denver Broncos (3-0)

Time of game: 4:25 p.m.
TV Channel: CBS
Look-ahead line: BAL -1.5
Current Line: BAL (), O/U ()

Baltimore vs. Denver key injuries

  • Ravens vs. Broncos Week 4 injury report

Baltimore Ravens at Denver Broncos Week 4 full betting preview

Ravens vs. Broncos betting news & angles

Pittsburgh Steelers (1-2) at Green Bay Packers (2-1)

Time of game: 4:25 p.m.
TV Channel: CBS
Look-ahead line: GB -6.5
Current Line: GB (), O/U ()

Pittsburgh vs. Green Bay key injuries

  • Steelers vs. Packers Week 4 injury report

Pittsburgh Steelers at Green Bay Packers Week 4 full betting preview

Steelers vs. Packers betting news & angles

Tampa Bay Buccaneers (2-1) at New England Patriots (1-2)

Time of game: 8:20 p.m.
TV Channel: NBC
Look-ahead line: TB -5.5
Current Line: TB (), O/U ()

Tampa Bay vs. New England key injuries

  • Buccaneers vs. Patriots Week 4 injury report

Tampa Bay Buccaneers at New England Patriots Week 4 betting preview

Buccaneers vs. Patriots betting news & angles

Las Vegas Raiders (3-0) at Los Angeles Chargers (2-1)

Time of game: 8:15 p.m.
TV Channel: ESPN
Look-ahead line: LAC -3
Current Line: LAC (), O/U ()

Las Vegas at Los Angeles Chargers key injuries

  • Raiders vs. Chargers Week 4 injury report

Las Vegas Raiders at Los Angeles Chargers Week 4 full betting preview

Raiders vs. Chargers betting news & angles

Keep up-to-date with theLines for NFL Week 4 odds and NFL previews all season long.

Brett Gibbons Avatar
Written by
Brett Gibbons

Brett is an avid sports traveler and former Division-I football recruiter for Bowling Green and Texas State. He’s a graduate of BGSU and works as an auditor for Google content curation products. He’s also contributed to Sports Illustrated and Fansided during his young writing career.

View all posts by Brett Gibbons