NFL Week 4 Odds: Spreads, Moneylines, Totals For Each Game

Written By Juan Carlos Blanco on October 2, 2022 - Last Updated on October 3, 2022
NFL Week 4 odds

The fourth week Sunday of the pro football season is in the books. Go here for NFL Week 5 odds as those lines have already been posted.

NFL Week 4 odds

Legal online sportsbooks have posted NFL Week 4 odds with point spreads, moneylines and totals. Check out lines for every game below.

NFL Week 4 betting lines

The largest spread when looking at NFL Week 4 odds Sunday morning was the Green Bay Packers -9.5 favored over the New England Patriots +9.5. Other sizable lines include the Philadelphia Eagles -6.5 versus Jacksonville Jaguars +6.5 and the LA Chargers -5.5 at the Houston Texans +5.5. Here are the spreads that have changed the most since a week ago Wednesday.

  • Chargers -7 at Texans +7 to Chargers -5.5 at Texans +5.5
  • Cardinals -3 at Panthers +3 to Cardinals +1 at Panthers -1
  • Patriots +6.5 at Packers -6.5 to Patriots +9.5 at Packers -9.5
  • Chiefs -1 at Buccaneers +1 to Chiefs +1 at Buccaneers -1

There are other notable spreads, including the Bills -3 at the Ravens +3. Josh Allen and the Bills were upset by the Dolphins this past Sunday by a score of 21-19. Lamar Jackson and the Ravens, meanwhile, covered the spread in New England as they beat the Patriots by a score of 37-26.

This coming Sunday’s matchups also include a Vikings (-3.5) versus Saints (+3.5) battle in London as the NFL’s annual international series kicks off, and a Patrick Mahomes versus Tom Brady Super Bowl rematch with the Chiefs (+1) battling the Bucs (-1) in Tampa Bay. 

Minnesota Vikings vs. New Orleans Saints

The Vikings got a first-hand taste of just how much of a problem the Lions are evolving into during a 60-minute slugfest at U.S. Bank Stadium that Minnesota managed to escape with a 28-24 win. Dalvin Cook emerged with a shoulder issue the team is currently labeling as a day-to-day injury. 

The Saints weren’t so lucky, as they dropped their second straight to the division-rival Panthers by a 22-14 score. New Orleans’ offense, led by an injured Jameis Winston, wasn’t able to get going until very late to make the final score look deceptively respectable. 

If Cook is ultimately forced to sit out this London contest, super-sub Alexander Mattison will undoubtedly be ready to step in, as he capably has several times over the last couple seasons. The matchup against the New Orleans defense isn’t normally a palatable one, but the Saints did give up a 100-yard rushing performance to Christian McCaffrey on Sunday. 

Considering the Vikes have issues in their secondary – they’ve given up 275.7 passing yards per game through three weeks – even a less-than-100-percent Winston could make noise with the help of Chris Olave and Michael Thomas. Thomas will have to overcome the foot injury he sustained Sunday. 

Kirk Cousins and crew were -3 favorites over the Saints on Tuesday. The game had a total of 43.5.

Cleveland Browns at Atlanta Falcons

The Browns notched a 12-point win over the Steelers to open the Week 3 slate Thursday night, a game in which Jacoby Brissett and Amari Cooper displayed an impressive connection in for the second consecutive game.

The Falcons impressively notched their first win by a 27-23 score across the country in Seattle, a game in which Cordarrelle Patterson generated his second 100-yard game to open the campaign and Marcus Mariota continued to deliver competent performances. 

The Browns’ defense should present a different level of challenge to Atlanta’s better-than-expected offense, however, especially considering Cleveland has the ability to make Arthur Smith’s squad one-dimensional since they only allow 83.7 rushing yards per game.

Oddsmakers are giving the Falcons a fighting chance of keeping this close, however, as their current status as slim home underdogs indicates.

Washington Commanders at Dallas Cowboys

The feel-good vibes from Carson Wentz’s successful Week 1 debut finished evaporating Sunday, as the oft-maligned quarterback took a whopping nine sacks while throwing for just 211 yards in a 24-8 loss to the surging Eagles. Washington also failed to field a viable running game, as Antonio Gibson gained only 38 yards on 12 rushes, albeit with a touchdown.

The Cowboys prevailed for the second straight week Monday night against the Giants, nipping New York by a 23-16 score behind another solid effort from Cooper Rush. The capable backup looks primed to make one final start in this game before a likely Dak Prescott return in Week 5, according to latest reports. Michael Gallup should also be ready to roll for his season debut in this spot after practicing in full each of the last two weeks but then sitting out.

NFL Week 4 odds continue to show the Cowboys as -3 home favorites as of mid-week, the same figure as prior to their MNF win.

Seattle Seahawks at Detroit Lions

The Seahawks continued to get solid play from Geno Smith under center Sunday, but their defense struggled to contain the Falcons on the way to a 27-23 home loss. 

The Lions suffered their own narrow defeat, falling to the Vikings by a 28-24 score on the road but nevertheless continuing to exceed expectations and demonstrating they are indeed the most competitive they’ve been in several seasons.

This game could turn into an offensive showcase, considering Seattle and Detroit both rank in the bottom 10 in total yards allowed per game through three games. However, one concern on the offensive side of the ball for the Lions is the health of the perpetually banged-up D’Andre Swift, who’s now nursing a shoulder sprain that could lead to him missing this game.

Even with the possibility of the star back’s absence, the Lions are nearly touchdown favorites at home, a testament to the overall perception of Detroit as a team on the rise. NFL Week 4 odds have the total of 50 points as the largest of the early window of games.

Tennessee Titans at Indianapolis Colts

It wasn’t pretty, but the Titans managed to get by the winless Raiders by a 24-22 score on Sunday for their first victory, a game that saw Derrick Henry encouragingly get involved in the passing game with five receptions for 58 yards. 

The Colts also broke the ice in the win column with a noteworthy win over the Chiefs by a 20-17 score. Kansas City overcame an early deficit, but Matt Ryan stepped up to lead his new team on a game-winning drive late in the fourth quarter to squeak out the victory.

Ryan got both Michael Pittman and Alec Pierce back from injury Sunday, which certainly played a role in his success. The duo and the rest of the air attack could be set for more success in this matchup, as Tennessee allowed over 300 yards passing to Derek Carr on Sunday and has given up a robust 11.0 yards per completion.

The Colts played impressive defense against Patrick Mahomes and company Sunday, but they’ve lost three straight to Tennessee at home, a trend that could be playing into Indy’s status as relatively narrow home favorites. 

Chicago Bears at New York Giants

The Bears moved to an improbable 2-1 on Sunday with a three-point win over the Texans, although Justin Fields continued to struggle by going 8-for-17 for 106 yards with no touchdowns and two interceptions. David Montgomery also went down with an ankle injury, but Khalil Herbert stepped in to provide 157 rushing yards and two touchdowns.

The Giants came up just short against the Cowboys at home on Monday night by a 23-16 score, with Daniel Jones taking five sacks and failing to reach the 200-yard mark through the air. Saquon Barkley did continue his encouraging early-season play with 126 total yards and a 36-yard touchdown run, but Sterling Shepard’s season-ending ACL tear is naturally a big loss.

Ahead of New York’s Monday night battle, the Giants were 2.5-to-3-point favorites while looking at NFL Week 4 odds. Notably, despite Shepard’s injury, the G-Men are now 3-to-3.5-point favorites as of mid-week.

Jacksonville Jaguars at Philadelphia Eagles

The Jaguars turned in an outstanding all-around effort in a Week 3 trip to L.A., throttling the Chargers by a 38-10 score in a game that saw Trevor Lawrence connect with three different receivers for touchdowns. Los Angeles was playing with an injured Justin Herbert and sans Keenan Allen (hamstring), but it goes without saying a four-touchdown win on the road against a tough opponent was inconceivable for recent Jaguars squads.

The Eagles were just as impressive, toppling the Commanders on the road by a 24-8 score that belies the extent of their dominance. Jalen Hurts continued playing at an MVP level (340 yards, three TD, no INTs) while connecting with DeVonta Smith and A.J. Brown for 13 completions, 154 yards and two touchdowns. Meanwhile, the defense sacked Carson Wentz nine times while limiting Washington to 240 total yards.

This therefore shapes up as another intriguing barometer game for Doug Pederson’s team, and the initial line seems to imply there’s a healthy combination of some Jacksonville skepticism and faith in Philly’s legitimacy – the Jags are up to a touchdown underdog in their head coach’s return to the city he coached five seasons in.

New York Jets at Pittsburgh Steelers

The Jets couldn’t carry over the momentum from their wild Week 2 win over the Browns into Week 3, as they turned in a 27-12 home dud against the Bengals in what was likely Joe Flacco’s final start before the expected return of Zach Wilson (knee) for this game.

The Steelers opened the Week 4 slate Thursday night with a loss to that Cleveland squad by a 29-17 score. Mitch Trubisky actually played his best overall statistical game yet in Pittsburgh, but the offense continues to struggle and questions persist about offensive coordinator Matt Canada’s playcalling.

A Wilson return would certainly lend more intrigue to a game that might otherwise shape up as a defensive slugfest between two teams with plenty of skill-position talent but questionable quarterback play. For the time being, NFL Week 4 odds have the Steelers as standard home favorites of 3-to-3.5 points, but that line could certainly be subject to change should a Wilson return be confirmed.

Buffalo Bills at Baltimore Ravens

The Bills went down to South Florida in Week 3 and succumbed to a combination of a talented Dolphins team and the stifling heat, dropping a narrow 21-19 decision that saw them run out of time just before a final spike in Miami territory. Multiple Buffalo players, including Stefon Diggs, exited the contest at various points due to dehydration.

The Ravens saw Lamar Jackson put on another MVP-caliber display in a 37-26 win over the Patriots at Gillette Stadium in Week 3. The dynamic signal-caller continued to make a highly convincing case for his long sought-after contract extension, racking up 335 total yards and five total touchdowns. J.K. Dobbins also made his return from a horrific August 2021 knee injury, generating 40 yards on nine touches.

This is naturally one of the marquee games of the entire slate, and betting interest should therefore be through the roof. The Ravens’ secondary has shown plenty of vulnerability early, allowing an NFL-high 353.3 passing yards per game and 11.2 yards per completion. That could well spell trouble against Josh Allen and company, and for the moment, there’s plenty of faith in the Bills in the form of a projected advantage of just over a field goal on the road.

LA Chargers at Houston Texans

The Chargers will enter this matchup smarting from an embarrassing, shocking 38-10 home loss to the Jaguars that required Justin Herbert to take a pain-killing injection for his fractured rib cartilage in order to be able to play.

The Texans came up just short yet again, dropping a 23-20 decision to the Bears at Soldier Field in a game in which Houston’s run defense betrayed it once more by allowing a whopping 281 rushing yards overall to the Bears.

Keenan Allen (hamstring) may have a chance to return for this game and Herbert should be feeling a bit better with another week of care for his injury, but the story of this matchup may well be Austin Ekeler. The versatile back has scuffled to 2.5 yards per carry on 32 rush attempts behind an offensive line that’s struggled to create running room, but Houston’s 5.6 yards per carry allowed implies this could be his breakout game.

There’s plenty of faith in a Bolts bounceback as the week begins. NFL Week 4 odds had LA as much as a 6-point favorite at multiple sportsbooks.

Arizona Cardinals at Carolina Panthers

The Cardinals continued their early-season slog partly prompted by a short-handed receiving corps, losing by a 20-12 score to the defending champion Rams at home. Kyler Murray got to 314 yards on sheer volume – he put up a whopping 58 attempts – but there was no magic on the ground and the final point tally underscores they were mostly empty yards.

The Panthers snapped Matt Rhule’s long losing streak with a 22-14 win over the Saints in Week 3, but Baker Mayfield continued to struggle while going 12-for-25 for 170 yards and taking three sacks. Nevertheless, Christian McCaffrey managed a second straight 100-yard game on the ground, the first time he accomplished the feat since Weeks 8-10 of the 2019 season. 

The Cardinals’ defense struggles through the air (281.0 passing yards per game, 11.5 yards per completion allowed) may be a help to Mayfield and his struggling receivers, but McCaffrey could have a battle on his hands trying to break through versus a front that’s yielded a modest 102.7 rushing yards per contest. 

Murray is also looking at a stiff challenge in the form of a tough Panthers defense, and oddsmakers are placing some faith in Carolina’s home-field advantage early in the week by affording them slim favorite status. 

New England Patriots at Green Bay Packers

The Patriots not only took their second loss to the Ravens on Sunday, but Mac Jones emerged from the game worse for wear after sustaining a high ankle sprain that could well keep him out of this contest. On the brighter side, both Rhamondre Stevenson and DeVante Parker stepped up with their best performances of the season, but both could certainly be hamstrung by a likely spot start from Brian Hoyer. 

The Packers clawed their way to a tough 14-12 win over the Buccaneers in Tampa in Week 3, with Aaron Rodgers showing some especially encouraging chemistry with rookie Romeo Doubs (8-73-1). The future Hall of Fame quarterback could now get Christian Watson back for this matchup after he sat out against the Bucs due to a hamstring issue.

With Jones looking highly unlikely to be able to suit up in this game and Green Bay’s already formidable homefield edge, the Pack is unsurprisingly the weeks’ only double-digit favorite already at this point in the week.

Denver Broncos at Las Vegas Raiders

The Broncos certainly couldn’t have envisioned their new Russell Wilson-led offense scoring all of 43 points in its first three games, but it’s been enough to get Denver to a 2-1 record after an 11-10 win over the 49ers on Sunday night. 

The Raiders never expected their early-season struggles, either, and in their case, those have led to an 0-3 mark despite the presence of Davante Adams. Las Vegas fell to the Titans by a 24-22 score Sunday, meaning their trio of defeats have come by a combined 13 points. With head coach Josh McDaniels already under heavy scrutiny given his role as the team’s offensive mastermind, this shapes up as a virtual must-win game against a division rival.

The conundrum for the struggling Raiders offense is a Broncos defense that’s allowed the third-fewest total yards per game (251.3) and a meager 4.7 yards per play. Meanwhile, the 267.0 passing yards per game and 69.1 percent completion rate Vegas has surrendered could be the cure for what ails Wilson, but oddsmakers aren’t quite buying it – Las Vegas is narrowly favored to record its first win as the week begins.

Kansas City Chiefs at Tampa Bay Buccaneers

The Chiefs underwhelmed offensively against a feisty Colts team in Week 3, eventually falling by a 20-17 score in a game during which Patrick Mahomes seemed to take exception with offensive coordinator Eric Bieniemy’s decision to not be more aggressive with his playcalling just before halftime. 

The Buccaneers have plenty of offensive problems of their own, although many of them have been caused by a makeshift receiving corps. That was never more evident in the first three games than Sunday, when Tampa Bay was down Mike Evans (suspension), Chris Godwin (hamstring) and Julio Jones (knee). Tom Brady still willed his way to 270 yards in a narrow 14-12 loss to the Packers, but Tampa Bay’s final scoring tally underscores how much he missed the trio. 

The good news for Brady and the Bucs is that Evans will return for this showdown, while Jones likely will be able to suit up as well after head coach Todd Bowles noted following the loss to Green Bay the veteran could have played through what is reportedly a partially torn PCL. Godwin could presumably have a shot as well, although his situation is unlikely to be far from settled until the end of the week.

The two defenses have played well early, each checking in the top 10 in total yards per game allowed. The modest total of 44-44.5 as the week begins is certainly a nod to that, but those figures and the double-take-worthy status of Tampa Bay as a 2.5-point home underdog imply oddsmakers seem convinced the Bucs’ offensive issues may not be totally rectified by the return of Evans, and presumably, Jones.

LA Rams at San Francisco 49ers

The Rams still don’t look to be at their 2021 Super Bowl-winning level, but L.A. managed a second straight victory in Week 3 with a 20-12 road victory over the Cardinals. The biggest story of the box score may have been the play of Cam Akers, who finally showed some life while taking 12 carries for 61 yards and a touchdown.

The 49ers started off fast against the Broncos in Jimmy Garoppolo’s first start since the NFC Championship Game versus these same Rams in January, but they were edged by an 11-10 score after mustering only three points over the last three quarters. Garoppolo’s 211 passing yards on an 18-for-29 tally were adequate enough, but he threw a pick and took four sacks. 

The Rams lost both regular-season meetings with San Fran last season before finally squeaking by in the conference title game, 20-17. Both defenses have played well the last two weeks, although the Niners have been especially impressive. The fact these two teams know each other so well and San Fran has a quasi-homefield advantage is affording Kyle Shanahan’s squad a slight projected advantage as the week starts.  

How NFL Week 4 lines are changing

This table will look at how NFL Week 4 odds are changing in the days leading up to each game. More point spreads will be added as we get closer to kickoff. The Sunday spreads shown here are from 9 p.m. ET.

DateNFL Odds September 25 spreadsNFL Odds September 26 spreadsNFL Odds September 28 spreadsNFL Odds October 2 spreads
Thursday, September 29Dolphins +3 at Bengals -3Dolphins +3 at Bengals -3Dolphins +4 at Bengals -4Dolphins +4 at Bengals -4
Sunday, October 2Vikings -3 at Saints +3Vikings -2.5 at Saints +2.5Vikings -3 at Saints +3Vikings -3.5 at Saints +3.5
Sunday, October 2Titans +3 at Colts -3Titans +3 at Colts -3Titans +3.5 at Colts -3.5Titans +3.5 at Colts -3.5
Sunday, October 2Bills -3.5 at Ravens +3.5Bills -3 at Ravens +3Bills -3 at Ravens +3Bills -3 at Ravens +3
Sunday, October 2Jets +3.5 at Steelers -3.5 Jets +3.5 at Steelers -3.5Jets +3.5 at Steelers -3.5Jets +3.5 at Steelers -3
Sunday, October 2Bears +2.5 at Giants -2.5Bears +2.5 at Giants -2.5Bears +3 at Giants -3Bears +2.5 at Giants -2.5
Sunday, October 2Browns -3 at Falcons +3Browns -2.5 at Falcons +2.5Browns -1.5 at Falcons +1.5Browns -1 at Falcons +1
Sunday, October 2Seahawks +6 at Lions -6Seahawks +6 at Lions -6Seahawks +4.5 at Lions -4.5Seahawks +3.5 at Lions -3.5
Sunday, October 2Commanders +3 at Cowboys -3Commanders +3 at Cowboys -3Commanders +3 at Cowboys -3Commanders +3 at Cowboys -3
Sunday, October 2Chargers -6.5 at Texans +6.5Chargers -6 at Texans +6Chargers -4.5 at Texans +4.5Chargers -5.5 at Texans +5.5
Sunday, October 2Jaguars +7 at Eagles -7Jaguars +7 at Eagles -7Jaguars +6.5 at Eagles -6.5Jaguars +6.5 at Eagles -6.5
Sunday, October 2Cardinals +1 at Panthers -1Cardinals +1 at Panthers -1Cardinals +2 at Panthers -2Cardinals +1 at Panthers -1
Sunday, October 2Patriots +8.5 at Packers -8.5Patriots +10 at Packers -10Patriots +9.5 at Packers -9.5Patriots +9.5 at Packers -9.5
Sunday, October 2Broncos +1.5 at Raiders -1.5Broncos +1 at Raiders -1Broncos +2.5 at Raiders -2.5Broncos +2.5 at Raiders -2.5
Sunday, October 2Chiefs -2.5 at Buccaneers +2.5Chiefs -2.5 at Buccaneers +2.5Chiefs -2 at Buccaneers +2Chiefs +1 at Buccaneers -1
Monday, October 3Rams +2 at 49ers -2Rams +1.5 at 49ers -1.5Rams +2.5 at 49ers -2.5Rams +1.5 at 49ers -1.5

Initial lines below are from September 21.

DateNFL Odds: September 21 spreadsNFL Odds: September 21 moneylinesNFL Odds: September 21 totals
Thursday, September 29Dolphins +1.5 at Bengals -1.5Dolphins +100 at Bengals -120Over Under 48
Sunday, October 2Vikings -1 at Saints +1Vikings -115 at Saints -105Over Under 44.5
Sunday, October 2Bills -4 at Ravens +4Bills -4 at Ravens +4Over Under 55
Sunday, October 2Jaguars +7 at Eagles -7Jaguars +255 at Eagles -305Over Under 48
Sunday, October 2Titans +3.5 at Colts -3.5Titans +155 at Colts -180Over Under 44.5
Sunday, October 2Jets +3.5 at Steelers -3.5Jets +150 at Steelers -175Over Under 42.5
Sunday, October 2Chargers -7 at Texans +7Chargers -315 at Texans +260Over Under 46
Sunday, October 2Bears +3 at Giants -3Bears +140 at Giants -165Over Under 39.5
Sunday, October 2Seahawks +5.5 at Lions -5.5Seahawks +185 at Lions -215Over Under 46
Sunday, October 2Commanders +2.5 at Cowboys -2.5Commanders +110 at Cowboys -130Over Under 43
Sunday, October 2Browns -3 at Falcons +3Browns -170 at Falcons +145Over Under 45
Sunday, October 2Cardinals -3 at Panthers +3Cardinals -170 at Panthers +145Over Under 46.5
Sunday, October 2Patriots +6.5 at Packers -6.5Patriots +220 at Packers -260Over Under 42.5
Sunday, October 2Broncos +1.5 at Raiders -1.5Patriots +100 at Raiders -120Over 46
Sunday, October 2Chiefs -1 at Buccaneers +1Chiefs -115 at Buccaneers -105Over 48.5
Monday, October 3Rams +1 at 49ers -1Rams -105 at 49ers -115Over 48
Juan Carlos Blanco Avatar
Written by
Juan Carlos Blanco

Juan Carlos Blanco has served as a freelance writer for a wide variety of online publications and websites, with an intensive focus on fantasy sports. Juan has provided analysis and comprehensive coverage of the MLB, NBA, NFL, CFL, AAF and AFL while also reporting on news and developments in the daily fantasy sports and online gaming industries.

View all posts by Juan Carlos Blanco