NFL Week 4 Game Preview: Los Angeles Rams at San Francisco 49ers

Written By Eli Hershkovich on October 3, 2022 - Last Updated on October 4, 2022
49ers Rams Odds

The Los Angeles Rams visit the San Francisco 49ers at 8:15 p.m. ET on Monday, Oct. 3. This primetime game, wrapping up NFL Week 4 odds, showcases the 49ers as spread favorites and on the moneyline. The total is set at . Read more for a full analysis on 49ers – Rams odds.

In this piece, we’ll break down everything you need to know before placing a bet on Monday Night Football odds, including team matchups, key metrics, and the best available odds. Click on 49ers – Rams odds anywhere in this post to bet now.

49ers vs. Rams Odds: Spread, Moneyline, Over/Under

When using the odds table above, click the dropdown menu and select the type of bet you wish to make. 

Betting on the point spread is when you wager on how many points a team will win or lose by. A “plus” sign in front of the spread is the underdog, and a “minus” sign is the favorite. The 49ers would need at least a two-point win if you bet on San Francisco to cover the point spread (-1.5). A spread bet on the Rams would win if Los Angeles emerges victorious, loses by a single point, or the game concludes with a tie.

Betting the moneyline is simply betting on which particular team will win a game.

The total is the number of combined points the two teams will score. Bettors can choose to bet the over or under on how many total points will be scored in the game.

49ers vs. Rams Player Props

In the props tool search bar, type in a team or player and hit enter. You’ll see the various proposition bets offered by leading online sportsbooks. 

This is a valuable tool that allows bettors to compare odds and stats when considering a prop bet. 

49ers vs. Rams Betting News

As of Monday, the Rams have manufactured 69% of the spread handle and 67% of the tickets, respectively. This data comes via BetMGM Sportsbook, which has Los Angeles priced at after opening at +2.5.

49ers vs. Rams Weather Report

The forecast shows that the conditions shouldn’t have an impact, as the temperature should settle in at 77 degrees by kickoff — with low wind speeds. Be wary of allowing the potential weather to impact your handicap in general.

49ers vs. Rams Injury Report

 PositionInjuryThuFriSatGame Status
Azeez Al-ShaairLBKneeDNPDNPDNPOut
Arik ArmsteadDTFootDNPDNPLPQuestionable
Tyrion Davis-PriceRBAnkleDNPDNPDNPOut
Ross DwelleyTERibDNPDNPLPQuestionable
Danny GrayWRHipDNPDNPDNPDoubtful
Javon KinlawDTKneeDNPDNPLPQuestionable
Trent WilliamsOTAnkleDNPDNPDNPOut
Tarvarius MooreDBHamstringLPDNPDNPOut
Brian AllenCKneeDNPDNP DNPOut
David EdwardsLGKnee-DNP DNPOut
Cobie DurantCBHamstringDNPDNPDNPOut

49ers’ Offense vs. Rams’ Defense

SF OffenseStats (Ranked)LAR Defense
15.7 (28)Points/Game23.3 (20)
323.7 (24)Yards/Game346.3 (17)
0.249 (29)Points/Play0.359 (20)
5.1 (21)Yards/Play5.3 (14)
35.71% (20)3D Conversion %47.37% (26)
40.00% (23)4D Conversion %71.43% (23)
44.44% (27)RZ Scoring % (TD)50.00% (8)
1.7 (23)TDs/Game2.3 (14)

Rams’ Offense vs. 49ers’ Defense

LAR OffenseStats (Ranked)SF Defense
20.3 (15)Points/Game12.3 (3)
306.3 (25)Yards/Game227.0 (2)
0.349 (12)Points/Play0.214 (2)
5.3 (19)Yards/Play3.9 (1)
48.39% (5)3D Conversion %32.50% (9)
50.00% (14)4D Conversion %N/A
60.00% (14)RZ Scoring % (TD)75.00% (29)
2.3 (11)TDs/Game1.7 (6)

49ers vs. Rams Betting Insights

Why 49ers Can Cover The Spread

Although bettors should never blindy follow trends, there are two key factors as to why Kyle Shanahan is 8-3 against the spread against Sean McVay’s.

Shanahan’s zone rushing scheme governed Los Angeles’ front-seven last regular season, tallying a 46.0% Rushing Success Rate (SR). For context, a play is successful if teams produces 50 percent of the yards needed to move the chains on first down, 70 percent of yards to gain on second down, or 100 percent of yards to gain on third or fourth down. The Niners’ combined percentage would’ve equivalent to a top-10 SR any given week.

Nevertheless, Shanahan’s game plan come the 2021 NFC Championship Game didn’t emphasize his ground attack enough. His team would’ve benefited from now-Eagles safety Jaquiski Tartt holding onto a fourth-quarter interception, too. Then again, it adds to the situational angle.

Despite the Rams owning the top-rated Rushing EPA allowed through three games, their opponents have either possessed a pass-oriented offense or been plagued with a negative game script. Even without left tackle Trent Williams (ankle) in the lineup, expect the 49ers’ offense to excel at what it does best.

On the flip side, Los Angeles’ offensive line, which already lost Andrew Whitworth and Logan Bruss, won’t have center Brian Allen (knee) nor left guard David Edwards (knee) available. Couple that with the San Fran’s prowess for pressuring the quarterback (36.5%) without blitzing.

As long as defensive lineman Arik Armstead (foot) and Javon Kinlaw (knee) and are on the field, the defending Super Bowl champs will likely struggle to protect Stafford once again.

Why Rams Can Cover The Spread

Should the 49ers be forced into a negative game script in the second half, trust Jimmy Garoppolo at your own peril. With that being said, Garoppolo’s poor showing in Week 3 could also be accredited to the Broncos’ sound defensive front and secondary, respectively. The Rams don’t measure up in either regard.

Plus, defensive coordinator DeMeco Ryans boasts a brawnier secondary this time around, thanks to the addition of former Chiefs cornerback Charvarius Ward. That aids their ability to blanket stud wideout Cooper Kupp, who combined for 20 catches, 281 receiving yards and a score last season.

Related: Super Bowl 57 Odds

Reasons To Bet The Over

If San Francisco struggles to generate a consistent pass rush, both teams could supply their fair share of efficient drives. But Los Angeles’ inconsistencies on that side of the ball have gone almost unnoticed because of its 2-1 start. The offense has accrued the 13th-lowest overall EPA, and that’s with facing two subpar defenses.

Reasons To Bet The Under

While this angle would normally hit if the Niners dominate in the aforementioned areas, the total is fairly priced. That leaves little room for error, especially if turnovers pile up.

Final Thoughts

Expect the 49ers own the line of scrimmage on both sides of the ball, especially because of the Rams’ depleted offensive line. Let’s hope that your other wagers performed well up until this point. Remember not to chase losing bets just because it’s the final game of the Week 4 slate.

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