NFL Week 4 Game Preview: Arizona Cardinals At Carolina Panthers

Written By Mo Nuwwarah on October 2, 2022
cardinals panthers odds

The Arizona Cardinals visit the Carolina Panthers at 4:05 p.m. ET on Sunday, Oct. 2. Primary markets for the game show the Panthers as spread favorites and on the moneyline. Cardinals Panthers odds feature a total set at .

In this article, we break down everything you need to know before placing a bet on the game, including team matchups, key metrics, weather and the best available NFL Week 4 odds. Click on the odds anywhere in this post to bet now.

Cardinals At Panthers Odds: Spread, Moneyline, Over/Under

When using the odds table, click the dropdown menu and select the type of bet you wish to make. 

Betting the point spread is when you wager on how many points a team will win or lose by. A plus sign in front of the spread denotes the underdog, and a minus sign denotes the favorite.

In this case, the Panthers would have to win by at least two points if you bet them to cover the point spread (-1) — a one-point win would push. A spread bet on the Cardinals would win if they win the game. Again, a one-point loss would push. 

Betting the moneyline is simply betting on which particular team will win a game.

The betting total is the number of combined points the two teams will score. Bettors can choose to bet the over or under on how many total points will be scored in the game. 

For more betting guides, click the green NFL Game Previews button at the top of this post.

Editor’s Note

Cardinals At Panthers Player Props

In the props tool search bar, type in a team or player and hit enter. You’ll see the various proposition bets offered by leading online sportsbooks. 

This is a valuable tool that allows bettors to compare odds and stats when considering a prop bet. Unlike bigger markets like moneylines and spreads that often reach a consensus number, shopping for prop bet lines can often reveal sizable differences in the numbers.

Cardinals At Panthers Betting News & Angles

Use this rolling, updating list of news bites about each team to help your handicapping for Cardinals – Panthers odds.

Cardinals At Panthers Injury Report

PlayerPositionInjuryWedThuFriGame Status
Rodney HudsonCKneeDNPLPLPQuestionable
Rashard LawrenceNTHandDNPDNPDNPOut
Justin PughGElbowDNPLPFP(-)
Zeke TurnerLBAnkleDNPDNPDNPOut
J.J. WattDECalfDNPDNPLPQuestionable
Zaven CollinsILBShoulderLPLPLPQuestionable
James ConnerRBKneeLPLPFP(-)
Greg DortchWRBackLPLPFP(-)
Rondale MooreWRHamstringLPLPLPQuestionable
Matt PraterKRight HipLPLPLPQuestionable
Marquise BrownWRNIR - Rest/FootDNPLPQuestionable
Zach ErtzTENIR - RestDNP(-)
Kelvin BeachumOTNIR - RestDNP(-)
PlayerPositionInjuryWedThuFriGame Status
Christian McCaffreyRBThighDNPDNPLPQuestionable
Jaycee HornCBCalfLPFPFP(-)
Ian ThomasTEAnkleLPLPLP(-)
Stantley Thomas-OliverCBAchillesLPLPLPQuestionable
Xavier WoodsSHamstringLPLPLP(-)
Laviska Shenault Jr.WRHamstringLPDNPLPQuestionable
Marquis HaynesDEKneeDNPLPQuestionable
Frankie LuvuOLBShoulderLPFP(-)
Donte JacksonCBAnkleLP(-)

Cardinals Offense vs. Panthers Defense

Cardinals OStats (Rank)Panthers D
20.7 (13)Points/Gm19.7 (12)
0.279 (22)Points/Play0.284 (12)
353.3 (15)Yards/Gm348.7 (18)
248 (13)Pass Yards/Gm214 (13)
105.3 (17)Rush Yards/Gm134.7 (22)
4.8 (29)Yards/Play5 (10)
5.1 (32)Yards/Pass5.9 (8)
4.5 (15)Yards/Rush4.3 (15)
27.91 (30)3rd Down %38.78 (18)
66.67 (7)Red Zone TD %66.67 (21)
0.3 (1)Turnovers/Gm1 (17)
3.97 (6)QB Sacked %4.39 (25)

Panthers Offense vs. Cardinals Defense

Panthers OStats (Rank)Cardinals D
20.7 (13)Points/Gm29 (31)
0.38 (10)Points/Play0.503 (32)
276.3 (30)Yards/Gm383.7 (23)
161.3 (31)Pass Yards/Gm281 (30)
115 (14)Rush Yards/Gm102.7 (11)
5.1 (23)Yards/Play6.7 (32)
6 (23)Yards/Pass8.2 (31)
4.7 (9)Yards/Rush4.5 (17)
27.03 (31)3rd Down %51.85 (32)
37.5 (30)Red Zone TD %69.23 (23)
1 (7)Turnovers/Gm1 (17)
10 (29)QB Sacked %1.9 (31)

Cardinals At Panthers Betting Insights

Why The Cardinals Can Cover The Spread

They have the better quarterback and the better passing offense in this matchup. Sure, the Cardinals have been less efficient than the Panthers, but they have faced far tougher opposition thus far, including Super Bowl contenders in the Rams and Chiefs. Kyler Murray was a prime MVP contender early last season, and this is just a better team than Carolina if he returns to that sort of form.

Why The Panthers Can Cover The Spread

Passing offenses aside, the Panthers are better pretty much everywhere else. They have a far better defense, checking in at 14th in defense DVOA while the Cardinals rank 31st. Their running game looks more dangerous while Christian McCaffrey remains upright, although he’s nursing a minor injury. Even the special teams have a vast disparity, with the Cardinals toward the bottom and the Panthers in the top five according to Football Outsiders. Potentially rainy weather would seem to favor the Panthers as well.

Reasons To Bet The Over

While the Panthers don’t have a good offense, the Cardinals have an absolutely terrible defense, arguably the league’s worst thus far. If Baker Mayfield can’t get the offense moving in this spot, he won’t get them moving ever. The Cardinals in comeback mode will go at blazing speed and run a ton of plays. And if they’re not in comeback mode, Mayfield will probably turn the ball over for some free points in obvious passing situations.

Reasons To Bet The Under

Bad weather and two very uninspiring offenses. And while the Cardinals and Panthers have not played well thus far, both teams have actually done a decent job protecting the football. That means punts, and punts to bad offenses usually means under since sustained drives aren’t going to happen often.

Cardinals At Panthers Matchups To Watch For

Panthers WRs Vs. Cardinals CBs

The Cardinals corners have gotten torched so far, though they have had an admittedly difficult slate of offenses. Still, this did not profile as a good group on paper, with last year’s good results looking flukey. The WR pairing of DJ Moore and Robbie Anderson provides a pretty stiff test. If those two get loose, big plays tend to follow.

  • Anderson receiving prop: O/U /
  • Moore receiving prop: O/U /

Baker Mayfield Vs. Cardinals Pass Rush

Weakness against weakness here. The Cardinals had a decent pass rush last season but lost ace sack artist Chandler Jones and have gotten off to an anemic start. However, Mayfield has always invited far too much pressure in his career by holding the ball too long. Which side wins this battle of weak points could decide whether the Panthers can move the ball.

Cardinals WRs Vs. The Injury Report

Obviously, the Cardinals already must operate without top option Deandre Hopkins. They could at least somewhat paper over that with Greg Dortch playing well and the burgeoning partnership between old college teammates Kyler Murray and Hollywood Brown. But, now Brown is questionable, as is Rondale Moore, yet to see the field this season. AJ Green was already announced out, for whatever that’s worth after his dismal start. Murray may have very little to work with here against a solid secondary, so keep an eye out for who suits up on Sunday.

Final thoughts

The market says these teams are roughly even, and that makes some sense at full strength. However, the Panthers look like the healthier squad as Arizona limps in with a potentially very short-handed receiving corps. Keep an eye on that injury situation. The numbers certainly paint a grim picture for the Cardinals as it’s eye-opening to see them last in yards per play allowed and also last in yards per pass allowed. It seems like an indictment on the coaching since this team does not have bottom-tier talent, so something has to make a leap here or they’ll probably lose another road game. It’s certainly not an easy spot playing at an early body clock time in potentially bad weather.

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Mo Nuwwarah Avatar
Written by
Mo Nuwwarah

Mo Nuwwarah got his start in gambling early, making his first sports bet on his beloved Fab Five against the UNC Tar Heels in the 1993 NCAA tournament. He lost $5 to his dad and got back into sports betting years later during a 15-year run in the poker industry. A 2011 journalism graduate from Nebraska-Omaha, he combines those skills with his love of sports and statistics to help bettors make more informed decisions with a focus on pro football, baseball and basketball.

View all posts by Mo Nuwwarah