NFL Week 3 Odds: Point Spreads, Moneylines, Totals For Every Game

Written By Juan Carlos Blanco on September 25, 2022 - Last Updated on September 26, 2022
NFL Week 3 odds

If you are looking for NFL Week 4 odds go here.

The second weekend of the NFL season was a rollercoaster ride and now the majority of the league sits at 1-1 on the year. Bettors, after taking a deep breath, will now look ahead to NFL Week 3 odds. The Steelers and Browns kicked things off on Thursday night, with Cleveland winning 29-17. This Sunday’s ledger is loaded and includes what will be a marquee Bills versus Dolphins showdown in South Florida, the improved Lions facing a notable divisional litmus test in the Vikings, Carson Wentz leading the Commanders against his old Eagles squad, an Aaron Rodgers versus Tom Brady faceoff in Tampa and a 49ers versus Broncos inter-conference clash.

NFL Week 3 odds

View NFL Week 3 odds below and click on the price you like to bet now. Pro football spreads, moneylines and football over unders are available to wager on.

NFL Week 3 betting lines

The largest point spreads while looking at NFL Week 3 odds Sunday morning were the Eagles -6 against the Commanders +6, and the Lions +6 at the Vikings -6. Some of the tighter lines include the Raiders -2 on the road versus the Titans +2, and Packers +1.5 on the road versus the Buccaneers -15.

Week 3 betting lines that have seen the most significant movement since a week ago Wednesday include:

  • Eagles -3 at Commanders +3 to Eagles -6 at Commanders +6
  • Chiefs -3 at Colts +3 to Chiefs -5.5 at Colts +5.5
  • Cowboys +4 at Giants -4 to Cowboys +1 at Giants -1
  • Jaguars +9 at Chargers -9 to Jaguars +3.5 at Chargers -3.5

Below we will deliver NFL Week 3 odds for each game on the slate as well as betting previews for each contest.

Get Up to $1,250 + Credits at Caesars Sportsbook
1
Up to $1,250
On Caesars
Up to $1,250 On Caesars
+ get 1,000 Caesars Reward Credits
+ also get 1,000 Tier Credits
Redeem for free bets, hotel stays, & more! 
Use Promo Code: LEGALFULL

Pittsburgh Steelers at Cleveland Browns

The Browns toppled the Steelers 29-17, covering the -4.5 spread. The game total, which closed at 38 points, went over.

Kansas City Chiefs () at Indianapolis Colts ()

The Chiefs weren’t quite as prolific in a narrow 27-24 win over the Chargers as they were against the Cardinals in their opener, but they still own an unblemished 2-0 record. Indianapolis, meanwhile, endured yet another absolutely miserable afternoon in Jacksonville, losing to the Jaguars by a 24-0 score. Matt Ryan was down both Michael Pittman (quadriceps) and Alec Pierce (concussion), providing something of an excuse for poor numbers. Ryan has now posted a worrisome 1:4 TD:INT through his first two games with Indy.

The Chiefs’ NFL Week 3 odds status as just under a touchdown road favorite is somewhat expected but still jarring to an extent considering Indy’s preseason expectations. 

Baltimore Ravens () at New England Patriots ()

The Ravens will undoubtedly come into this game in an ornery mood following one of the most epic fourth quarter collapses in recent memory. Miami may have exposed some holes in Baltimore’s secondary with a comeback that saw Tua Tagovailoa put the finishing touches on a 469-yard, six-touchdown performance on the way to a 42-38 win for Miami.

The Patriots were extremely lackluster on offense for the second time in as many games to open the season, mustering just 17 points against the Steelers on Sunday. New England had just enough to escape with a three-point win while facing a pedestrian offensive attack.

Oddsmakers aren’t completely buying that Mac Jones and friends will be able to pull off a similar aerial display to that of the Dolphins’ against the Baltimore defense as we look at NFL Week 3 odds. The Ravens are a modest field goal road favorite as the week begins, although there’s naturally some room for that number to shift slightly in either direction.

Houston Texans () at Chicago Bears ()

The Texans may not garner a winning record this season, but after two games under Lovie Smith’s leadership, Houston is undeniably competitive. Following a 20-20 tie in Indy to open the season, Davis Mills and company battled the Broncos for four quarters before succumbing, 16-9, in Week 2.

The Bears looked absolutely inept through the air in a Week 2 Sunday night battle with the Packers, mustering only 10 points and 70 passing yards on their way to a 17-point defeat. The one silver lining as it pertains to this matchup is that Chicago does appear to have a good chance of exploiting the Texans’ defensive Achilles’ heel, stopping the run. Through two games, both David Montgomery and Khalil Herbert have proved an effective tandem, leading to a No. 8 ranking in rush yards per game (139.5). 

Oddsmakers are extending the Bears the courtesy of a 2.5-to-3-point projected advantage as the home team thus far, but if Chicago’s highly questionable Week 2 performance sinks in further with bettors, that number could conceivably narrow as we look at NFL Week 3 odds.

Las Vegas Raiders () at Tennessee Titans ()

The Raiders were another team victimized by a wild Week 2 comeback, blowing a 16-point lead in the fourth quarter thanks in large part to a superhuman effort on the part of the Cardinals’ Kyler Murray before dropping a 29-23 overtime decision.  

Tennessee looked entirely overmatched in their MNF game with the Bills as the Titans lost, 41-7. Las Vegas had been a -1 road favorite on Monday but are now -2 at most sportsbooks. While Las Vegas certainly has the more star-studded offense on paper, the fact is that it hasn’t produced a win in two tries and Davante Adams came down to Earth this past Sunday with a 2-12-1 line lends some uncertainty to their outlook.

Buffalo Bills () at Miami Dolphins ()

Bills versus Dolphins is arguably the marquee matchup of the week now with the Dolphins 2-0 and the Bills looking like the clear-cut top team in the NFL. Buffalo destroyed the Titans on Monday Night Football by a 41-7 count and are also 2-0.

Miami’s 21-point fourth-quarter rally over Baltimore capped off a career-best 469-yard, six-TD performance by Tua Tagovailoa in which he maximized the talents of his dynamic receiver duo of Tyreek Hill and Jaylen Waddle. 

Lost in the otherworldly exploits of Miami’s air attack is the fact Raheem Mostert and Chase Edmonds offered a semblance of balance with a combined 16 carries for 84 yards. The entire offense may be in for quite the uphill battle against Buffalo’s defense, however.

Buffalo thrashed the Dolphins by a 35-0 score in Week 2 last season, and although this year’s Miami team looks stronger, oddsmakers have still made Buffalo as much as a five-point favorite when glancing at NFL Week 3 odds.

Detroit Lions () at Minnesota Vikings ()

The Lions continued to offer evidence that they are a more talented and competitive team this season with their Week 2 performance, as they won a game they arguably would have lost the last couple of years by a 36-27 score.  Jared Goff’s clean 256-yard, four-touchdown performance and the continued emergence of Amon-Ra St. Brown with 184 total yards and a pair of scores gives Minnesota plenty to worry about on a short week.

The Vikings, who’d won eight in a row in this series with Detroit before suffering a 29-27 loss at Ford Field in Week 13 last season, had a lackluster performance in Philadelphia Monday as they fell, 24-7. Minnesota had been a 7-point favorite over the Lions on Monday but it is now Lions +6 in most spots.

Cincinnati Bengals () at New York Jets ()

One would have gotten good odds on the Bengals, not the Jets, being the winless team going into this Week 3 matchup, but that’s precisely what the scenario is.

Cincinnati was within striking distance of its first win against the Cowboys after mounting a comeback from a 17-3 deficit, but Dallas ultimately prevailed via a field goal as time expired. Joe Burrow took another six sacks in the process after enduring seven in Week 1 against the Steelers, going a long way toward explaining the defending AFC champs’ struggles on offense thus far. 

The Jets pulled off one of several Week 2 improbable fourth-quarter comebacks, upending the Browns by a 31-30 score thanks to a throwback performance from Joe Flacco that saw him rack up 307 yards and four touchdowns. Flacco should be back under center for at least one more game in Week 3 before a possible Zach Wilson (knee) return in Week 4.

New York has just three sacks through two games, so the Bengals may not be challenged in the same way they have been as far as protecting Burrow. NFL Week 3 odds show that this line is a lot smaller than it would have been before the season, with Cincy just a 4.5-point road favorite.

Philadelphia Eagles () at Washington Commanders ()

The Eagles defense came to play and then-some Monday night as the high-powered Vikings were held to just 7 points. Jalen Hurts and the offense did its part as they put 24 points on the board.

The Commanders weren’t able to successfully follow up their narrow win over the Jaguars in Week 1 with a road victory against the Lions this past Sunday. Washington tried to mount a comeback after being shut out during the first half, but the defense couldn’t slow down Detroit sufficiently and ultimately conceded four touchdown passes to Jared Goff.

With Washington having shown plenty of defensive lapses in its first two games and the Eagles having performed impressively, Philly is a -5.5 favorite in a stadium they’ve won four of their last five games in.

New Orleans Saints () at Carolina Panthers ()

The Saints endured an ugly 20-10 home loss to the Buccaneers in Week 2, a game in which they didn’t score their only touchdown until late in the fourth quarter. A report also emerged Sunday morning that Jameis Winston is currently playing through multiple back fractures, and his three-interception performance against Tampa Bay would lend credence to the notion the injury is affecting his velocity.

The Panthers certainly weren’t any great shakes on offense themselves in a 19-16 loss to the Giants, with Baker Mayfield turning in a second straight lackluster performance to start the season (14-for-29, 145 yards, one TD). Christian McCaffrey did look like himself again with 15 carries for 102 yards and four catches, but he’ll have a tough assignment against a Saints defense that was much better against Leonard Fournette on Sunday than versus Cordarrelle Patterson in Week 1. 

The Saints are 2.5-to-3-point road favorites when looking at early NFL Week 3 odds but if Winston and Alvin Kamara (ribs) were to be ultimately ruled out for this matchup, the line could certainly shrink.

Jacksonville Jaguars () at LA Chargers ()

The Jaguars offered more tangible evidence they’re an improved team after coming up just short against the Commanders in Week 1, dominating the Colts by a 24-0 score in what may have been the most complete game Jacksonville has played in years.

The Chargers fell to the Chiefs by a narrow 27-24 margin on Thursday night to open Week 2, a game they impressively remained competitive in despite being without Keenan Allen (hamstring). Justin Herbert continued to demonstrate why he’s arguably already achieved elite status in his third season by working around his favorite target’s absence to throw for 334 yards and three touchdowns.

Los Angeles hasn’t been able to get Austin Ekeler going on the ground yet – he’s averaging 2.7 yards per carry through the first two games – and the Bolts could be challenged to do so in Week 3 considering the Jags have allowed the third-fewest rushing yards per game (69.5). 

Despite the fact there could be another Allen absence and L.A. could struggle achieving offensive balance yet again, the improving Jags are still a touchdown road underdog in what will be a major litmus test.

Green Bay Packers () at Tampa Bay Buccaneers ()

The Packers were able to breath a bit of a sigh of relief thanks to a favorable Week 2 matchup against the Bears, which they toppled by a 27-10 score at Lambeau Field. Aaron Rodgers and his pass-catching corps, subject of plenty of scrutiny after a forgettable Week 1 effort against the Vikings, performed much better, with Allen Lazard’s return from an ankle injury helping in that regard.

The Buccaneers and Tom Brady had plenty of offensive adversity to deal with themselves in Week 2. The future HOF quarterback started the game without Chris Godwin (hamstring) and Julio Jones (knee), and he subsequently lost Mike Evans to an ejection early in the fourth quarter of a lackluster 20-10 win.

Monday brought the news that Evans has received a one-game suspension for his part in the bench-clearing brawl that led to his ouster from Sunday’s game. The Pro Bowl wideout will appeal, but if he’s ultimately ruled out for this matchup and either or both of Godwin and Jones remain out, Brady will have an even tougher assignment against a Green Bay defense that held Justin Fields to 70 passing yards Sunday night. (Wednesday, 9/21 update: Evans’ appeal was denied).

Despite less star power than in recent seasons, this game should still attract plenty of betting interest due to the Brady-Rodgers matchup. This line will be fascinating to follow throughout the week as well, with news regarding the Buccaneers’ receiver corps set to make an impact on the current Bucs -2.5. Notably, the Evans’ news has already helped narrow the number to -1-to-1.5.

LA Rams () at Arizona Cardinals ()

The Rams, much like their fellow defending conference champion, the Bengals, still haven’t found 2021 form, but Los Angeles was able to notch its first win of the season Sunday against the Falcons, 31-27. However, the game was a tale of two halves, with L.A. nearly blowing a 21-3 halftime lead. Nevertheless, it was a solid effort overall for the Rams, which got Allen Robinson involved after a Week 1 blanking and harassed Marcus Mariota to the tune of three sacks, two interceptions and a lost fumble.

The Cardinals pulled off one of the more improbable victories they’ll manage this season, scoring 22 unanswered points in the fourth quarter and overtime to erase a 23-7 deficit against the Raiders and notch a 29-23 win. Kyler Murray was a one-man wrecking crew in the late stages of the contest, and there’s some cautious optimism about Marquise Brown’s growing comfort level in the offense after he produced a 6-68 line on 11 targets.

Arizona was a bit better against the pass in Week 2 after getting trampled by Patrick Mahomes and company for five TDs and 360 yards in Week 1. However, Derek Carr still threw for 252 yards and a pair of scores, and the Cardinals could therefore have an uphill battle against Matthew Stafford and Cooper Kupp in particular.

The Cards were swept by the Rams last season, including a seven-point loss at State Farm Stadium. Therefore, the four-point road favorite status for Los Angeles isn’t altogether surprising, and if Rondale Moore (hamstring) is able to make his season debut for the hosts, there could be a slight narrowing of the number.

Atlanta Falcons () at Seattle Seahawks ()

The Falcons showed plenty of fight in Week 2 in fighting back from a 28-3 deficit against the Rams, but Atlanta ultimately came up just short, 31-27. Marcus Mariota and Drake London did continue building on their encouraging Week 1 connection, with the rookie wideout finishing with a team-best 8-86-1 line on 12 targets. 

The Seahawks weren’t anywhere near as competitive while dropping a 27-7 decision to the 49ers, despite San Fran losing Trey Lance early on to what would prove to be a season-ending ankle fracture. Seattle’s only points came via a field-goal block return TD, and Geno Smith was unable to replicate Week 1 magic (197 yards, 1 INT). The Seahawks’ running game was nowhere to be found, either – Rashaad Penny and the debuting Kenneth Walker finished with 25 yards on 10 carries.

There’s plenty of uncertainty regarding the identity and capabilities of these two teams being led by transitional quarterbacks, so early status of the Seahawks as narrow home favorites is certainly subject to some volatility once the betting public has its say over the course of the week. 

San Francisco 49ers () at Denver Broncos ()

The 49ers’ season underwent a significant shift in the matter of one play in Sunday’s 27-7 win over the Seahawks, with Trey Lance suffering a broken ankle that ended his season early in the contest. Jimmy Garoppolo, who San Francisco prudently held onto throughout the offseason and summer, is now back at the helm of the offense and was mistake-free in relief Sunday while throwing for 154 yds, two total TDs). 

The Denver Broncos also pulled out their first win of the season Sunday, but it was in less-than-impressive fashion. Denver’s 16-9 win over the Texans was about as ragged on the offensive end as the final score implies. Additionally, Russell Wilson, who completed just 14 of 31 pass attempts, lost Jerry Jeudy to a rib injury early in the game. X-rays on the star receiver did turn out negative, so he’ll presumably have a chance to do his part to help the passing game look a lot more coherent in Week 3.

The Niners have faced the Bears on a rain-soaked Soldier Field and then faced a Geno Smith-led Seahawks team on a short week at home, so it’s difficult to get a feel for them up to this point. The Broncos’ homefield advantage isn’t enough to avoid a Pick ‘Em or even one-point underdog scenario as the week begins, however. Jeudy’s status will also be one to watch throughout the week.

Dallas Cowboys () at New York Giants ()

The Cowboys ignored the dark cloud that hung over them all week following a 19-3 Week 1 loss that saw Dak Prescott suffer a multi-week thumb injury and toppled the defending AFC champion Bengals on Sunday, 20-17. As he’d done last year in Week 8 against the Bengals, Cooper Rush was more than serviceable in his spot start (235 yards, one TD), while Tony Pollard, CeeDee Lamb and Noah Brown all played important roles in the last-second win.

The Giants continued undefeated in the young Brian Daboll era with a 19-16 victory over the Panthers. Daniel Jones stayed away from mistakes and spread the ball around nicely, while Saquon Barkley wasn’t quite as explosive as in Week 1 but still posted 88 total yards and gave New York’s offense some much-needed balance. 

The two teams naturally know each other well, but there’s an air of uncertainty here with Rush under center for Dallas and Daboll running a new offensive system in New York. The G-Men have been fairly solid on defense overall and the Cowboys’ pass rush can give Jones problems, so the standard 2.5-to-3-point home favorite status for Big Blue and the 39.5-point total aren’t totally surprising in either case but certainly subject to some movement.

How NFL Week 3 lines are changing

Here is a look at how NFL Week 3 odds are changing, starting with lookahead lines. Additional point spreads will be added in the days leading up to kickoff of each contest. September 25 lines are from 9 a.m. ET.

DateNFL Odds: September 14 spreadsNFL Odds: September 18 spreadsNFL Odds: September 19 spreadsNFL Odds: September 21 spreadsNFL Odds: September 23 spreadsNFL Odds: September 25 spreads
Thursday, September 22Steelers +3 at Browns -3Steelers +3.5 at Browns -3.5Steelers +5 at Browns -5Steelers +4.5 at Browns -4.5Steelers +4.5 at Browns -4.5Steelers +4.5 at Browns -4.5
Sunday, September 25Raiders -1 at Titans +1Raiders -1 at Titans +1Raiders -1 at Titans +1Raiders -2 at Titans +2Raiders -2.5 at Titans +2.5Raiders -2 at Titans +2
Sunday, September 25Bills -4.5 at Dolphins +4.5Bills -4.5 at Dolphins +4.5Bills -4.5 at Dolphins +4.5Bills -6 at Dolphins +6Bills -5 at Dolphins +5Bills -4.5 at Dolphins +4.5
Sunday, September 25Ravens -3 at Patriots +3Ravens -3 at Patriots +3Ravens -3 at Patriots +3Ravens -3 at Patriots +3Ravens -3 at Patriots +3Ravens -2.5 at Patriots +2.5
Sunday, September 25Bengals -6 at Jets +6Bengals -4.5 at Jets +4.5Bengals -4.5 at Jets +4.5Bengals -5 at Jets +5Bengals -6 at Jets +6Bengals -6 at Jets +6
Sunday, September 25Chiefs -3 at Colts +3Chiefs -6 at Colts +6Chiefs -6.5 at Colts +6.5Chiefs -6.5 at Colts +6.5Chiefs -5.5 at Colts +5.5Chiefs -5.5 at Colts +5.5
Sunday, September 25Saints -2.5 at Panthers +2.5Saints -3 at Panthers +3Saints -2.5 at Panthers +2.5Saints -2.5 at Panthers +2.5Saints -2.5 at Panthers +2.5Saints -2 at Panthers +2
Sunday, September 25Texans +3 at Bears -3Texans +3 at Bears -3Texans +3 at Bears -3Texans +3 at Bears -3Texans +3 at Bears -3Texans +3 at Bears -3
Sunday, September 25Eagles -3 at Commanders +3Eagles -3 at Commanders +3Eagles -4 at Commanders +4Eagles -6.5 at Commanders +6.5Eagles -6.5 at Commanders +6.5Eagles -6 at Commanders +6
Sunday, September 25Lions +7.5 at Vikings -7.5Lions +7.5 at Vikings -7.5Lions +7 at Vikings -7Lions +6 at Vikings -6Lions +6 at Vikings -6Lions +6 at Vikings -6
Sunday, September 25Jaguars +9 at Chargers -9Jaguars +7 at Chargers -7Jaguars +7 at Chargers -7Jaguars +7 at Chargers -7Jaguars +3 at Chargers -3Jaguars +3.5 at Chargers -3.5
Sunday, September 25Rams -4.5 at Cardinals +4.5Rams -4.5 at Cardinals +4.5Rams -4 at Cardinals +4Rams -3.5 at Cardinals +3.5Rams -3.5 at Cardinals +3.5Rams -3.5 at Cardinals +3.5
Sunday, September 25Falcons +3 at Seahawks -3Falcons +2 at Seahawks -2Falcons +1.5 at Seahawks -1.5Falcons +2 at Seahawks -2Falcons +1 at Seahawks -1Falcons +1 at Seahawks -1
Sunday, September 25Packers +3 at Buccaneers -3Packers +3 at Buccaneers -3Packers +2.5 at Buccaneers -2.5Packers +2 at Buccaneers -2Packers +1.5 at Buccaneers -1.5Packers +1.5 at Buccaneers -1.5
Sunday, September 2549ers +3 at Broncos -349ers +2.5 at Broncos -2.549ers -1 at Broncos +149ers -1.5 at Broncos +1.549ers -1.5 at Broncos +1.549ers -1.5 at Broncos +1.5
Monday, September 26Cowboys +4 at Giants -4Cowboys +3 at Giants -3Cowboys +2.5 at Giants -2.5Cowboys +2.5 at Giants -2.5Cowboys +1.5 at Giants -1Cowboys +1 at Giants -1
Juan Carlos Blanco Avatar
Written by
Juan Carlos Blanco

Juan Carlos Blanco has served as a freelance writer for a wide variety of online publications and websites, with an intensive focus on fantasy sports. Juan has provided analysis and comprehensive coverage of the MLB, NBA, NFL, CFL, AAF and AFL while also reporting on news and developments in the daily fantasy sports and online gaming industries.

View all posts by Juan Carlos Blanco