NFL Week 3 Game Preview: LA Rams At Arizona Cardinals

Written By Mo Nuwwarah on September 25, 2022
Rams Cardinals odds

The LA Rams visit the Arizona Cardinals at 4:25 p.m. ET on Sunday, Sept. 25. Primary markets for the game show the Rams as spread favorites and on the moneyline. The point total is set at . Read on for a full analysis of Rams – Cardinals odds.

In this article, we break down everything you need to know before placing a bet on the game, including team matchups, key metrics, weather and the best available NFL Week 3 odds. Click on the odds anywhere in this post to bet now.

Rams At Cardinals Odds: Spread, Moneyline, Over/Under

When using the odds table, click the dropdown menu and select the type of bet you wish to make. 

Betting the point spread is when you wager on how many points a team will win or lose by. A plus sign in front of the spread denotes the underdog, and a minus sign denotes the favorite.

In this case, the Rams would have to win by at least four points if you bet them to cover the point spread (-3.5). A spread bet on the Cardinals would win if they win the game or lose by four or fewer points. 

Betting the moneyline is simply betting on which particular team will win a game.

The betting total is the number of combined points the two teams will score. Bettors can choose to bet the over or under on how many total points will be scored in the game. 

For more betting guides, click the green NFL Game Previews button at the top of this post.

Editor’s Note

Rams At Cardinals Player Props

In the props tool search bar, type in a team or player and hit enter. You’ll see the various proposition bets offered by leading online sportsbooks. 

This is a valuable tool that allows bettors to compare odds and stats when considering a prop bet. Unlike bigger markets like moneylines and spreads that often reach a consensus number, shopping for prop bet lines can often reveal sizable differences in the numbers.

Rams At Cardinals Betting News & Angles

Use this rolling, updating list of news bites about each team to help your handicapping for Rams – Cardinals odds.

Rams At Cardinals Injury Report

PlayerPositionInjuryWedThuFriGame Status
Van JeffersonWRKneeDNPDNPUnspecified
Brian AllenCKneeDNPDNPUnspecified
Cobie DurantCBHamstringDNPDNPUnspecified
Aaron DonaldDERestDNPFPUnspecified
David LongDBGroinLPDNPUnspecified
Jordan FullerDBHamstring(-)DNPUnspecified
PlayerPositionInjuryWedThuFriGame Status
Rondale MooreWRHamstringDNPDNPDNPOut
Zeke TurnerLBAnkleDNPDNPDNPOut
James ConnerRBAnkleDNPLPLPQuestionable
Kelvin BeachumOTNIR-ResrDNP(-)
Marquise BrownWRNIR-RestDNP(-)
Zach ErtzTENIR-RestDNP(-)
A.J. GreenWRNIR-RestDNP(-)
Rodney HudsonCNIR-Rest(-)
Andy IsabellaWRBackFPFPFP(-)
Trey McBrideTENIR-PersonalDNP(-)
Trayvon MullenCBToeFPFPFP(-)
Justin PughGNIR-RestDNP(-)
J.J. WattDECalfLPFPFP(-)

Rams Offense vs. Cardinals Defense

Rams OStats (Rank)Cardinals D
20.5 (14)Points/Gm33.5 (32)
0.318 (15)Points/Play0.528 (32)
290 (26)Yards/Gm406 (28)
231.5 (15)Pass Yards/Gm302 (31)
58.5 (31)Rush Yards/Gm104 (13)
4.5 (28)Yards/Play6.4 (29)
6 (21)Yards/Pass7.7 (28)
2.7 (32)Yards/Rush4.3 (16)
52.17 (5)3rd Down %57.89 (31)
71.43 (9)Red Zone TD %80 (28)
3 (31)Turnovers/Gm1 (17)
9.41 (26)QB Sacked %1.27 (31)

Cardinals Offense vs. Rams Defense

Cardinals OStats (Rank)Rams D
25 (10)Points/Gm29 (27)
0.355 (13)Points/Play0.509 (31)
347.5 (16)Yards/Gm337 (16)
224.5 (16)Pass Yards/Gm231.5 (16)
123 (11)Rush Yards/Gm105.5 (14)
4.9 (23)Yards/Play5.9 (23)
5.2 (30)Yards/Pass8.1 (31)
4.9 (8)Yards/Rush4.1 (12)
24 (31)3rd Down %60 (32)
85.71 (3)Red Zone TD %66.67 (19)
0.5 (1)Turnovers/Gm3.5 (1)
4.4 (9)QB Sacked %8.06 (10)

Rams At Cardinals Betting Insights

Why The Rams Can Cover The Spread

These teams split the season series last year, each winning on the road. But, everyone saw what happened when it really counted. The Rams completely annihilated the Cardinals in the playoffs. A 34-11 final doesn’t even do it justice as the score was 28-0 late in the third. Kyler Murray had a pathetic 137 yards on 34 attempts as Aaron Donald overwhelmed the Cardinals offensive line. Both teams look weaker this year, but the Cardinals are a miracle fourth quarter away from 0-2. Murray has yet to find anything resembling a rhythm.

Why The Cardinals Can Cover The Spread

As bad as the Cardinals have looked, the Rams haven’t been much better. Buffalo routed them, and even the win over Atlanta was marred by multiple poor interceptions from Matt Stafford. The offense looks far too dependent on Cooper Kupp. If Stafford isn’t healthy, can this team really be trusted laying points on the road in a divisional game?

Reasons To Bet The Over

Market expectations between these teams were no lower than 49.5 for each of their matchups in 2021, so the 48.5 hanging as of mid-week offers a slight discount. Since the first two games saw 57 and 53 scored, that certainly makes some sense. Arizona ranks fourth in pace with LA at 10th, so plenty of plays should occur. If you expect those plays to produce in efficient fashion, you should lean toward the over.

Reasons To Bet The Under

These offenses are off to rocky starts. The Rams got shut down by the Bills, and the Cardinals have started in very concerning fashion, unable to consistently score against the Chiefs and Raiders. Those defenses carried modest at best expectations coming into 2022. Early EPA/play data has the Rams 27th and the Cardinals 12th. Stafford looks less than 100% and Murray looked completely helpless last year against Donald and friends.

Rams At Cardinals Matchups To Watch For

Aaron Donald Vs. Cardinals Interior OL

Pro Football Reference credits the Rams with pressure rates around 30% in their two victories over Arizona last season. When those pressures come from sack artists like Aaron Donald and Leonard Floyd adept at closing the deal, that spells major trouble. While Murray is known for his escapability, the Rams seemed to maintain enough lane discipline that he didn’t have obvious outs. It goes without saying any time Donald suits up, but limiting him ranks of paramount importance.

Rams WRs Vs. Cardinals DBs

Budda Baker is the only plus player in a Cardinals secondary that vastly overperformed last year. Things have not looked as rosy so far this year as the Cardinals rank dead last in EPA/play allowed. Cooper Kupp obviously comes to mind first as a player ready to ravage this group, but Allen Robinson was a far-too-late whistle from a 2 TD day against Atlanta. The pass rush simply isn’t equipped to cover for this secondary any longer, so Baker and Co. must step up and not allow the talented Rams duo to run free.

  • Cooper Kupp receiving yards: Over/Under / ()
  • Allen Robinson receiving yards: / ()

Sean McVay Vs. Cardinals Defensive Coordinator Vance Joseph

Rams head coach Sean McVay put his team consistently behind the sticks with an overabundance of first-down running plays in Week 1. The same issue had cropped up throughout the playoff run last year despite the positive end result. If he displays those same tendencies when his passing game looks to have mismatches against a bad secondary, he can keep the Cardinals in it when they should be buried.

Final thoughts

Both quarterbacks have shown wildly varying levels of play, even from one play to the next. You might see either Stafford or Murray make a spectacular throw only to take a boneheaded sack or hurl the ball right to a safety on the next step. That makes this a rather high-variance game. Divisional home underdogs tend to do well, but consider a wager on Arizona on the moneyline if you like that side. By the same token, the Rams could run away with this and cash alternate tickets if they play like they did in their playoff win last year. Either team looks live to make a comeback if the other goes up early, so looking at live markets makes sense as well.

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Mo Nuwwarah Avatar
Written by
Mo Nuwwarah

Mo Nuwwarah got his start in gambling early, making his first sports bet on his beloved Fab Five against the UNC Tar Heels in the 1993 NCAA tournament. He lost $5 to his dad and got back into sports betting years later during a 15-year run in the poker industry. A 2011 journalism graduate from Nebraska-Omaha, he combines those skills with his love of sports and statistics to help bettors make more informed decisions with a focus on pro football, baseball and basketball.

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