NFL Week 3 Game Preview: Kansas City Chiefs At Indianapolis Colts

Written By Brett Gibbons on September 23, 2022 - Last Updated on September 24, 2022
Chiefs Colts odds

The Kansas City Chiefs (2-0) visit the reeling Indianapolis Colts (0-1-1) at 1:00 p.m. ET on Sunday, Sept. 25 at Lucas Oil Stadium. The Chiefs are a road favorite, a number that’s come down during the course of the week. The Colts are on the moneyline. Chiefs – Colts odds feature a total of .

Below, we’ll break down what you need to know before betting this game, including team matchups, key metrics, props, and the best available Lions at Vikings odds.

Chiefs At Colts Betting Odds

To place a bet, click on the odds in the table below. Toggle between spread, moneyline, and point total in the dropdown menu.

Find the full slate of NFL Week 3 odds here. For more betting guides, click on the green NFL Game Previews button at the top of this post.

Chiefs At Colts Player Props

Search for Kansas City or Indianapolis player props in the search bar below. To find a player, type their name into the search bar and place bets by clicking on the odds in the table.

Chiefs At Colts Betting News & Angles

Chiefs At Colts Injury Report

KANSAS CITY CHIEFS      
PlayerPositionInjuryWedThuFriGame Status
Harrison ButkerKLeft AnkleDNPDNPDNPOut
Michael DannaDECalfDNPDNPDNPOut
Marquez Valdes-ScantlingWRHipFPFPFP(-)
Orlando BrownOTKneeFPFPFP(-)
Trey SmithGAnkleFPFPFP(-)
JuJu Smith-SchusterWRShoulderFPFPFP(-)
Justin WatsonWRChestFPFPFP(-)
Mecole HardmanWRHeelLPLPFP(-)
INDIANAPOLIS COLTS
PlayerPositionInjuryWedThuFriGame Status
Bernhard RaimannOTAnkleDNPLPLPOUT
DeForest BucknerDTHipLPFPFP(-)
Yannick NgakoueDEBackDNPLPLPQuestionable
Michael PittmanWRQuadLPLPFP(-)
Julian BlackmonFSShoulderFPFPFP(-)
Zaire FranklinOLBShoulderFPFPFP(-)
Shaquille LeonardOLBBackFPFPFPOUT
Alec PierceWRConcussionFPFPFP(-)
Grover StewartDTShoulderFPFPFP(-)

Chiefs Offense Vs. Colts Defense

Chiefs OStats (Rank)Colts D
35.5 (2nd)Points/Gm22.0 (17th)
0.592 (1st)Points/Play0.326 (16th)
403.5 (5th)Yards/Gm315.0 (11th)
293.0 (6th)Pass Yards/Gm228.5 (15th)
110.5 (16th)Rush Yards/Gm86.5 (9th)
6.7 (2nd)Yards/Play4.7 (7th)
7.9 (5th)Yards/Pass6.8 (19th)
4.9 (9th)Yards/Rush2.7 (2nd)
45.0% (10th)3rd Down %36.7% (15th)
77.8% (6th)Red Zone TD %66.7% (18th)
0.5 (1st)Turnovers0.5 (23rd)
0.5 (1st)Sacks1.5 (23rd)

Colts Offense Vs. Chiefs Defense

Colts OStats (Rank)Chiefs D
10.0 (32nd)Points/Gm22.5 (18th)
0.145 (32nd)Points/Play0.328 (17th)
367.5 (13th)Yards/Gm341.5 (19th)
252.0 (10th)Pass Yards/Gm252.5 (21st)
115.5 (12th)Rush Yards/Gm89.0 (11th)
5.3 (19th)Yards/Play5.0 (10th)
6.3 (16th)Yards/Pass5.9 (7th)
4.5 (15th)Yards/Rush3.9 (9th)
32.0% (23rd)3rd Down %28.6% (6th)
28.6% (28th)Red Zone TD %75.0% (25th)
2.5 (27th)Turnovers0.5 (23rd)
3.5 (26th)Sacks2.5 (12th)

Chiefs at Colts Betting Insights

Why the Chiefs Can Cover The Spread

The Chiefs are among the Super Bowl favorites for a reason. Patrick Mahomes is proving week in and week out that he doesn’t need a gamebreaking receiver and the run game is getting more involved. The cut-and-dry of this game is that KC is flat out better.

The Colts on the other hand might be playing the worst football in the NFL right now. They’ve played two AFC South foes– generally considered to be the lesser two teams– and came away without a win in either. Matt Ryan is a far cry from his 2018 MVP days and without top receiver Michael Pittman Jr., the Colts scored zero points in Jacksonville.

Playing the hot team to cover less than a touchdown in Colts Chiefs odds against a team going the wrong direction seems like a safe proposition; however, sharp money has been on the Colts.

Why The Colts Can Cover The Spread

That said, is this point spread a bit inflated in reaction to what happened last week? The Colts put up a goose egg against the Jaguars, being beaten 24-0. The offense completely dried up without Pittman on the field and Jonathan Taylor rushed for 54 yards on just nine carries. Certainly Indianapolis is due for an offensive regression to the mean.

It’s clear the market is backing the Colts as a home underdog. The line touched seven points early in the week and it’s crashed fully to 5.5 points. Moving off the key figure of seven and another figure of six is significant; 23% of NFL games end in a six- or seven-point deficit, which is known as the “push rate.” That respected action was coming in on the Colts even after they moved off +7 (a 15% push rate in itself) speaks volumes.

Reasons To Bet The Over

Chiefs Colts odds feature a lofty point total or more than 50– a number that likely would have to be mostly covered by KC. Looking at their recent example against the Cardinals (KC won 44-16), you’d have to expect at least 30 points of that comes from the Chiefs. It’s a tough bet to roll the dice on a Colts offense that’s been this bad, even though they get back Pittman and a few pieces.

However, that’s still a tough ask with the Colts pace of play (they only ran 48 plays against Jacksonville) and inability to generate explosive plays. Full transparency, unless the Chiefs blow the roof off Lucas Oil Stadium, I cannot envision this game going over the total.

Reasons To Bet The Under

The Colts cannot finish drives. Their Red Zone efficiency is among the worst in football, scoring a TD on less than 30% of their trips inside the 20. They face a Chiefs defense that’s held their water despite facing high-powered offenses like the Cardinals and Chargers. The defensive front is disruptive and strong against the run.

Indianapolis can play enough ball control behind Taylor to slow this game down a bit. It’s clear Ryan isn’t the top-flight QB of old and a group of unreliable pass catchers outside of Pittman doesn’t help him much.

When looking for unders, I like to pinpoint a combination of bad or struggling offenses and good-enough defenses. The Colts fit that mold right now. With such a high point total, you have the cushion for a Chiefs blowout (ex. 38-7 or 35-14 doesn’t get it there).

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Chiefs At Colts Props: Matchups To Watch For

Chiefs Defensive Line Vs. Colts Offensive Line

Once upon a time, Indianapolis had the most fearsome offensive line in the NFL. But no matter how talented your OL is, if your quarterback holds onto the football too long, it can make your unit look bad. That was the case with Carson Wentz a year ago and it’s the case with Ryan this year (7th-highest in pocket time at 2.5 seconds). If it weren’t for the Bengals’ disaster giving up sacks, the Colts’ issue would be talked about a lot more often. Ryan’s hit the ground seven times in the first two games, among the most in the league.

With an injury to rotational left tackle Bernhard Raimann, Ryan could be under fire all afternoon. The Chiefs lead the NFL with a 40.1% pressure rate through two games this year.

Matt Ryan interceptions prop: Over/Under / ()

Clyde Edwards-Helaire vs. Shaquille Leonard

Quick disclaimer: Shaquille Leonard changed his name from Darius this past offseason. This is the same All-Pro linebacker that’s lined up for Indy. While he’s a nasty run stopper, his pass coverage ability will be tested in this game. The Chiefs line up Travis Kelce all over the shop, so expect Leonard to have more coverage assignments on Clyde Edwards-Helaire and Jerick McKinnon in this game.

The biggest adaptation KC’s had this season on offense is involving a stable of running backs in the passing game. They have three passing TDs to CEH and McKinnon and the RB position is a go-to around the goalline. Leonard is an athletic freak and has among the highest IQ in the league, but shifts and movements will test his coverage ability a lot.

Clyde Edwards-Helaire anytime TD:
Jerick McKinnon anytime TD:

Final thoughts

I pretty much laid out where I land on this game under the Reasons To Bet The Under section. I am betting under this total, with the best current price coming at (). I laid my bet down at DraftKings Sportsbook on Thursday.

With the entire KC receiving corps being listed for one reason or another on the injury report, I also expect them to get a little more creative and involve their many running backs. When you get running backs involved in the gameplan, unders are a lot more fun. Best of luck handicapping Chiefs Colts odds.

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Brett Gibbons

Brett is an avid sports traveler and former Division-I football recruiter for Bowling Green and Texas State. He’s a graduate of BGSU and works as an auditor for Google content curation products. He’s also contributed to Sports Illustrated and Fansided during his young writing career.

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