NFL Week 2 Updated Odds: Injuries, Spreads, Totals, Moneylines

Written By Brett Gibbons on September 17, 2022
NFL Week 2 odds

The opening weekend of NFL football resulted in one of the most action-packed Witching Hours in recent memory. Botched kicks, last-second drives, gutty two-point conversions all led to a slate most of us sweated out. Moving ahead to NFL Week 2, the Detroit Lions look to break their record 25 games as an underdog at closing, the Green Bay Packers and Chicago Bears headline Sunday Night Football, and we have TWO Monday Night Football games to unpack.

Below, you’ll find opening and current lines on every game, NFL betting news updates, a look at crucial players from our injury expert, and a weather report for the week. Keep up to date with TheLines all season long for NFL odds and betting strategy.

NFL Week 2 odds

Live NFL News Updates & Betting Angles

Check back all weekend long as TheLines team provides live NFL news and betting analysis for every team as it happens.

Week 2 Player Props

Check out our prop search took below to compare the best player props at every legal US sportsbook. Search for any player on the Week 2 slate and click on the odds you like to be directed to the sportsbook and place your bet!

Best odds for NFL week 2

Miami Dolphins at Baltimore Ravens

Kickoff: 1:00 p.m.
TV Channel: CBS
Look-ahead line: BAL -4
Current Line: BAL (), O/U ()

New York Jets at Cleveland Browns

Time of game: 1:00 p.m.
TV Channel: CBS
Look-ahead line: OTB
Current Line: CLE (), O/U ()

Washington Commanders at Detroit Lions

Time of game: 1:00 p.m.
TV Channel: FOX
Look-ahead line: DET -1
Current Line: DET (), O/U ()

Indianapolis Colts at Jacksonville Jaguars

Time of game: 1:00 p.m.
TV Channel: CBS
Look-ahead line: IND -4.5
Current Line: IND (), O/U ()

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Tampa Bay Buccaneers at New Orleans Saints

Time of game: 1:00 p.m.
TV Channel: FOX
Look-ahead line: TB -3.5
Current Line: TB (), O/U ()

Carolina Panthers at New York Giants

Time of game: 1:00 p.m.
TV Channel: FOX
Look-ahead line: NYG -1
Current Line: NYG (), O/U ()

New England Patriots at Pittsburgh Steelers

Time of game: 1:00 p.m.
TV Channel: CBS
Look-ahead line: NE -1
Current Line: NE (), O/U ()

Atlanta Falcons at Los Angeles Rams

Time of game: 4:05 p.m.
TV Channel: FOX
Look-ahead line: LAR -13
Current Line: LAR (), O/U ()

Seattle Seahawks at San Francisco 49ers

Time of game: 4:05 p.m.
TV Channel: FOX
Look-ahead line: SF -7.5
Current Line: SF (), O/U ()

Cincinnati Bengals at Dallas Cowboys

Time of game: 4:25 p.m.
TV Channel: CBS
Look-ahead line: CIN PK
Current Line: CIN (), O/U ()

Houston Texans at Denver Broncos

Time of game: 4:25 p.m.
TV Channel: CBS
Look-ahead line: DEN -10
Current Line: DEN (), O/U ()

Arizona Cardinals at Las Vegas Raiders

Time of game: 4:25 p.m.
TV Channel: CBS
Look-ahead line: LVR -3.5
Current Line: LVR (), O/U ()

Chicago Bears at Green Bay Packers

Time of game: 8:20 p.m.
TV Channel: NBC
Look-ahead line: GB -8
Current Line: GB (), O/U ()

Tennessee Titans at Buffalo Bills

Time of game: Monday, 7:15 p.m.
TV Channel: ESPN
Look-ahead line: BUF -7
Current Line: BUF (), O/U ()

Minnesota Vikings at Philadelphia Eagles

Time of game: 8:15 p.m.
TV Channel: ABC
Look-ahead line: PHI -2.5
Current Line: PHI (), O/U ()

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Written by
Brett Gibbons

Brett is an avid sports traveler and former Division-I football recruiter for Bowling Green and Texas State. He’s a graduate of BGSU and works as an auditor for Google content curation products. He’s also contributed to Sports Illustrated and Fansided during his young writing career.

View all posts by Brett Gibbons