NFL Week 2 Odds | Point Spreads, Moneylines And Totals

Betting eyes are now focused on the second week of the pro football season. There are NFL Week 2 odds available to bet on now. Top games include the Cincinnati Bengals (+5.5) at Kansas City Chiefs (-5.5), and the Tampa Bay Buccaneers (+7.5) at Detroit Lions (-7.5) Updated spreads, moneylines and totals for those games and more are available below.

NFL Week 2 odds

Updated NFL Week 2 odds are available to bet on below. Second week point spreads, moneylines and totals are available to wager on.

New Orleans Saints (+6) at Dallas Cowboys (-6)

• Point Spread: Saints (+6) at Cowboys (-6)
• Moneyline: Saints (+250) at Cowboys (-320)
• Total: 45.5

The Saints put together a dominant showing at home against the hapless Panthers to open the season, authoring a 47-10 thumping. The Cowboys were impressive in their own right, celebrating Dak Prescott and CeeDee Lamb’s new contract extensions with a 33-17 road victory over the Browns.

Derek Carr, Alvin Kamara and Rashid Shaheed fueled New Orleans’ offensive effort and the defense was particularly dominant, albeit against Bryce Young. The test naturally gets much stiffer this week on the road.

Dallas’ defense was just as impressive against Cleveland, and the newly minted Prescott and Lamb did more than enough to help the offense supplement the strong effort. Yet, like New Orleans, the Cowboys face the prospect of more competent offensive play this week. The total opened at 44.5 points.

BetMGM trading manager Seamus Magee discussed the Cowboys versus Saints total this week with Eli Hershkovich on the Behind The Lines podcast.

“I look at this Cowboys versus Saints game. We opened up 44.5. Some sharp money took us to 45.5. I think you’re going to see a big regression from this Saints offense,” Magee said. “I don’t think they’re going to scrore enough points. The question is, will the Cowboys put up enough points to make this go over?”

Indianapolis Colts (-3) at Green Bay Packers (+3)

• Point Spread: Colts (-3) at Packers (+3)
• Moneyline: Colts (-176) at Packers (+148)
• Total: 41.5

The Colts engaged in an AFC South classic with the Texans but came out on the losing end, 29-27. The Packers had a similar experience in Brazil, dropping a 34-29 decision to the Eagles during which Jordan Love sustained a multi-week knee injury.

Anthony Richardson’s accuracy has room for improvement, but his big-play ability was evident with his three total TDs. Then, two areas of concern coming out of last weekend – the running game and defense – are catching a break on paper this week. Love won’t suit up and Green Bay surrendered a 100-yard, three-TD game to Saquon Barkley last week.

Malik Willis is due to step in for the injured Love, and despite the array of weapons he’ll work with, could struggle due to inexperience. His presence introduces a healthy bit of uncertainty and is the fuel behind Indy’s status as road favorites, not to mention the low total of 42.5 points.

Cleveland Browns (+3) at Jacksonville Jaguars (-3)

• Point Spread: Browns (+3) at Jaguars (-3)
• Moneyline: Browns (+148) at Jaguars (-176)
• Total: 41.5

The Browns were throttled at home by the Cowboys to open the season, 33-17. The Jaguars blew a two-touchdown lead in South Florida to lose to the Dolphins, 20-17.

Deshaun Watson averaged just 3.8 yards per attempt in Week 1 and sparingly connected with top targets Amari Cooper and Jerry Jeudy, while trusted tight end David Njoku suffered an ankle injury that has him labeled week-to-week. 

The Jags’ Trevor Lawrence has some questions surrounding him as well and was besieged by poor pass protection in the second half Sunday. However, Cleveland’s defense uncharacteristically struggled at home versus Dallas and was much more generous last season on the road. The opening total was 44 points.

“We saw Jacksonville play an insane amount of man defense last week and I think that could really give Deshaun Watson problems,” said Connor Allen, of 4for4, on TheLines’ NFL Megapod. “For me it’s a lean under. I have a hard time gauging either of these teams right now, though.”

Cincinnati Bengals (+5.5) at Kansas City Chiefs (-5.5)

• Point Spread: Bengals (+5.5) at Chiefs (-5.5)
• Moneyline: Bengals (+220) at Chiefs (-270)
• Total: 47.5

The Bengals were shockingly upset at home by the Patriots by a 16-10 score despite Ja’Marr Chase suiting up. The Chiefs opened the 2024 NFL season with an hard-fought 27-20 win over the Ravens. The Chiefs opened as 5.5-point favorites, while the opening total is 47.5 points.

Las Vegas Raiders (+8.5) at Baltimore Ravens (-8.5)

• Point Spread: Raiders (+8.5) at Ravens (-8.5)
• Moneyline: Raiders (+385) at Ravens (-500)
• Total: 41.5

The Raiders played their traditional feisty brand of Antonio Pierce ball against the Chargers in their opener but came up short, 22-10. The Ravens had their own season-opening loss, albeit by inches, in a 27-20 defeat at the hands of the Chiefs on Thursday night.

Gardner Minshew’s numbers were acceptable and he figures to only get better as he builds rapport with the Big Three of Davante Adams, Jakobi Meyers and Brock Bowers. Zamir White also looks explosive, but the offense as a whole has quite the tall order against the Ravens.

Baltimore appears to have a legitimate star in Isaiah Likely, giving Lamar Jackson yet another weapon. Derrick Henry also seems to be in Titans form and could see a heavy workload in a game where the Ravens may not have much to fear from the opposing offense. The total opened at 41.5.

Jackson did not practice early in the week but appears to be set to go for Sunday. This line has moved a point in the direction of the Raiders over the course of the week.

New York Giants (+2.5) at Washington Commanders (-2.5)

• Point Spread: Giants (+2.5) at Commanders (-2.5)
• Moneyline: Giants (+128) at Commanders (-152)
• Total: 41.5

Daniel Jones looked frighteningly out of sorts in their home opener, falling to the Vikings by a 28-6 score. The Commanders’ Jayden Daniels showed plenty of promise but Dan Quinn’s defense was largely ineffective in a 37-20 loss to the Buccaneers. 

Jones has nowhere to go but up after compiling 240 total yards and 3.5 yards per play vs. Minnesota. The Commanders’ defense could be just what the doctor ordered, especially for explosive rookie Malik Nabers.

Washington got solid play from several new additions and Brian Robinson. New York’s pass rush is a concern, but Daniels’ elite mobility could neutralize it. The opening over under was set at 43.5.

San Francisco 49ers (-4.5) at Minnesota Vikings (+4.5)

• Point Spread: 49ers (-4.5) at Vikings (+4.5)
• Moneyline: 49ers (-235) at Vikings (+194)
• Total: 45.5

The 49ers will be playing on a short week but still opened as a -5 road favorite against the Vikings, according to NFL Week 2 odds. This game had an opening over under of 45.5. The line bumped down to 49ers -4.5 in most spots, likely due to the news that San Fran will once again be without the services of start RB Christian McCaffrey. CMC is still recovering from a calf strain and is now also dealing with Achilles tendinitis.

The Vikings dismantled the Giants, 28-6, in Sam Darnold’s successful debut as the starting QB. Whether Darnold and teammates can come close to replicating their season-opening success is a big if against the Niners defense. The over under has opened at 46 points.

Seattle Seahawks (-3) at New England Patriots (+3)

• Point Spread: Seahawks (-3.5) at Patriots (+3.5)
• Moneyline: Seahawks (-176) at Patriots (+148)
• Total: 38.5

The Patriots pulled off the biggest early-season upset in the NFL. Jerod Mayo’s crew will look to now go 2-0 as they host the Seahawks. NFL Week 2 odds showed that Seattle opened as a -3.5 road favorite.

The Seahawks overcame rookie Bo Nix and the Broncos by a 26-20 score. The Patriots notched a 16-10 road upset of the Bengals.

Seattle’s new offense got off to a solid start in the opener, and Geno Smith and company should serve as a good test for a Pats defense looking to prove Week 1 was no fluke. Jacoby Brissett had precious little to do Sunday with Rhamondre Stevenson and the defense leading the way, but there could be a need for more passing contributions to keep up with a deep Seahawks offense. The opening total is a modest 39 points.

“I like New England’s team total under,” said 4for4’s Connor Allen on TheLines’ NFL Megapod. “You could go alt under. It’s around 14.5, that’s +150. I envision this as a 17-10 type of game.”

Tampa Bay Buccaneers (+7.5) at Detroit Lions (-7.5)

• Point Spread: Buccaneers (+7.5) at Lions (-7.5)
• Moneyline: Buccaneers (+230) at Lions (-280)
• Total: 48.5

Jared Goff and the Lions opened as a -6.5 betting favorite over the Bucs but that number is now at -7.5 in most spots. Baker Mayfield got his quest to prove 2023 was no fluke off to a good start, tossing four TDs in a 37-20 season-opening throttling of the Commanders. The Lions had to claw for victory in their Wild Card rematch with the Rams, emerging with a 26-20 overtime win. 

The Bucs still need to fix an inefficient run game, and the matchup against a brick wall of a Lions’ front seven is far from ideal. However, the air attack could be in good shape again after Detroit struggled to slow down the Rams despite Puka Nacua’s exit.

The Lions will strive to get Amon-Ra St. Brown going after his shocking 3-13 line on six targets Sunday night. However, Jameson Williams’ standout night (5-121-1) line breeds plenty of optimism ahead of this divisional-round rematch from last January. NFL Week 2 odds show that the opening total was set at 50.5 points.

LA Chargers (-6) at Carolina Panthers (+6)

• Point Spread: Chargers (-5.5) at Panthers (+5.5)
• Moneyline: Chargers (-270) at Panthers (+220)
• Total: 39.5

The Jim Harbaugh era in LA is off to a fantastic start as the Chargers dumped the Raiders this past Sunday. Carolina opened as a +5.5 underdog to the Chargers. This game had a low opening total of 39.5, according to NFL Week 2 odds.

The Dave Canales regime had a forgettable debut on the road in New Orleans in the form of a 47-10 loss. True to the Harbaugh brand, the Chargers leaned heavily on the run and their defense against Las Vegas. The same approach could well work against the Panthers, which appear to have a long way to go adapting to Canales’ offense.

Bryce Young offered no solace with his play Sunday and could be hard-pressed to make much improvement in this matchup. Meanwhile, a weak Panthers pass rush could allow Justin Herbert to do some damage through the air.

New York Jets (-4) at Tennessee Titans (+4)

• Point Spread: Jets (-4.5) at Titans (+4.5)
• Moneyline: Jets (-215) at Titans (+180)
• Total: 41.5

Aaron Rodgers and the Jets will be working on a short week but were a -4.5 road favorite against the Titans on the lookahead line. This game had an initial total of 41.5.

BetMGM trading manager Seamus Magee believes the Jets should be favored by even more than -4, which is where the number has been for most of this week.

“I think this Jets line is low against the Titans in Week 2,” Magee told Eli Hershkovich on the Behind The Lines podcast. “I think this is a good get-right game for the Jets. The Titans defense looks pretty good as it stopped the Bears offense. But there’s a lot of new faces in that Bears offense … I think the Jets can win this game by at least 6.”

The Titans couldn’t get Brian Callahan a victory in his head coaching debut last week, blowing an advantage over the Bears to lose by a 24-17 score at Soldier Field.

The Titans will be looking to build on strong debuts from Tony Pollard and Calvin Ridley in this Week 2 matchup. However, the run game may be prioritized, considering the Jets’ daunting secondary.

LA Rams (+1) at Arizona Cardinals (-1)

• Point Spread: Rams (+1) at Cardinals (-1)
• Moneyline: Rams (+110) at Cardinals (-118)
• Total: 50.5

The Rams were dealt a tough loss this past Sunday to the Lions but will look to bounce back at the Cardinals. Arizona opened as a +100 home underdog on the moneyline but by Tuesday morning the Cardinals were favored by -1 on the spread.

The Rams nearly avenged their wild-card loss to the Lions this past Sunday before taking a 26-20 OT loss. The Cardinals gave their host quite a battle, but they couldn’t hold a lead against the Bills in a 34-28 loss.

The Rams’ Matthew Stafford eclipsed 300 yards, but a potential absence by Puka Nacua due to the knee injury he suffered against the Lions changes the entire dynamic of the offense.

Kyler Murray looks all the way back from his ACL tear a year and a half ago, and came close to pulling off a victory with a one-catch contribution from Marvin Harrison Jr. A boost in involvement in Week 2 could supercharge the air attack. The opening total for LAR vs. ARZ was 50.5 points.

Pittsburgh Steelers (-2.5) at Denver Broncos (+2.5)

• Point Spread: Steelers (-3.5) at Broncos (+3.5)
• Moneyline: Steelers (-178) at Broncos (+150)
• Total: 36.5

The Steelers opened as a -3.5 road favorite at Denver. This game had an initial total of 36.5. The Steelers notched a signature 18-10 road win over the Falcons built on a strong run game and defense. The Broncos saw some good things from rookie starter Bo Nix but still fell to the Seahawks on the road, 26-20.

Justin Fields was adequate in the win, but Russell Wilson (calf) could be ready to face his old Broncos squad in this game. New coordinator Arthur Smith looks intent on riding Najee Harris as his main workhorse and that could pay dividends against a suspect Broncos front.

Nix has an unenviable assignment against a ferocious Steelers defense that picked off and sacked Kirk Cousins twice apiece Sunday, but another week of practice reps will certainly do him good.

Chicago Bears (+6.5) at Houston Texans (-6.5)

• Point Spread: Bears (+6.5) at Texans (-6.5)
• Moneyline: Bears (+220) at Texans (-270)
• Total: 46.5

The Texans opened as -6.5 betting favorites against the Bears, who will be playing their first road game in the Caleb Williams era. This game had an opening over under of 46.5.

The Bears almost got the Wiliams era started with a loss before coming back to upend the Titans, 24-17. The Texans opened with a thrilling 29-27 road victory over the Colts.

Williams had an inauspicious debut that saw him fail to throw for even 100 yards, but better days certainly await. One could be this week, as the Texans were fortunate Anthony Richardson missed hitting on several would-be big plays.

Houston has some cleaning up to do on defense, but the offense looks to be in even better form than last year thanks to the additions of Joe Mixon and Stefon Diggs.

Atlanta Falcons (+6.5) at Philadelphia Eagles (-6.5)

• Point Spread: Falcons (+6.5) at Eagles (-6.5)
• Moneyline: Falcons (+245) at Eagles (-300)
• Total: 48.5

The Eagles will have had plenty of rest when this game kicks off. Philly opened as a -6.5 favorite. ATL vs. PHI had an initial total of 48.5.

The Falcons’ new-look, Kirk Cousins-helmed offense fell flat in its debut, with Atlanta taking an 18-10 loss to the Steelers. The Eagles got their season off to a rousing start in Brazil, squeaking by the Packers, 34-29. 

Bijan Robinson encouragingly logged 23 touches in the opener, but Cousins and his pass catchers clearly still have plenty of chemistry to build. An Eagles defense with a two-day rest advantage could be a tough test.

Week 2 opening lines

Here are how NFL Week 2 odds have changed. Opening lines are listed below.

Game	Point Spread	Moneyline	Total
Buffalo Bills at Miami Dolphins	Bills (+1.5) at Dolphins (-1.5)	Bills (+100) at Dolphins (-120)	50.5
New Orleans Saints at Dallas Cowboys	Saints (+6.5) at Cowboys (-6.5)	Saints (+240) at Cowboys (-300)	45.5
Tampa Bay Buccaneers at Detroit Lions	Buccaneers (+6.5) at Detroit Lions (-6.5)	Buccaneers (+270) at Lions (-335)	48.5
Cleveland Browns at Jacksonville Jaguars	Browns (+3) at Jaguars (-3)	Browns (+135) at Jaguars (-160)	42.5
San Francisco 49ers at Minnesota Vikings	49ers (-5.5) at Vikings (+5.5)	49ers (-250) at Vikings (+200)	45.5
LA Chargers at Carolina Panthers	Chargers (-5.5) at Panthers (+5.5)	Chargers (-250) at Panthers (+200)	39.5
Las Vegas Raiders at Baltimore Ravens	Raiders (+8.5) at Ravens (-8.5)	Raiders (+325) at Ravens (-400)	42.5
Seattle Seahawks at New England Patriots	Seahawks (-3) at Patriots (+3)	Seahawks (-165) at Patriots (+140)	39.5
Indianapolis Colts at Green Bay Packers	Colts (-3) at Packers (+3)	Colts (-160) at Packers (+135)	41.5
New York Jets at Tennessee Titans	Jets (-4) at Titans (+4)	Jets (-200) at Titans (+165)	43.5
New York Giants at Washington Commanders	Giants (+2.5) at Commanders (-2.5)	Giants (+120) at Commanders (-145)	41.5
LA Rams at Arizona Cardinals	Rams (-2.5) at Cardinals (+2.5)	Rams (-126) at Cardinals (+108)	48.5
Cincinnati Bengals at Kansas City Chiefs	Bengals (+6) at Chiefs (-6)	Bengals (+200) at Chiefs (-250)	46.5
Pittsburgh Steelers at Denver Broncos	Steelers (-2.5) at Broncos (+2.5)	Steelers (-145) at Broncos (+120)	37.5
Chicago Bears at Houston Texans	Bears (+6.5) at Texans (-6.6)	Bears (+225) at Texans (-275)	46.5
Atlanta Falcons at Philadelphia Eagles	Falcons (+6) at Eagles (-6)	Falcons (+220) at Eagles (-275)	48.5

Lookahead lines

Here is a look at some of the more notable opening point spreads for Week 2 of the NFL season. Note that these lines are from before the first weekend of the pro football season. First, we take a look at the most sizable.

• New Orleans Saints (+6.5) at Dallas Cowboys (-6.5)
• Tampa Bay Buccaneers (+6.5) at Detroit Lions (-6.5)
• San Francisco 49ers (-6.5) at Minnesota Vikings (+6.5)
• Las Vegas Raiders (+7.5) at Baltimore Ravens (-7.5)

And here is a glance at the most narrow opening NFL Week 2 odds on the slate.

• Buffalo Bills (+1.5) at Miami Dolphins (-1.5)
• Cleveland Browns (+1.5) at Jacksonville Jaguars (-1.5)
• New York Giants (+1.5) at Washington Commanders (-1.5)
• LA Rams (-2.5) at Arizona Cardinals (+2.5)
• Pittsburgh Steelers (-2.5) at Denver Broncos (+2.5)