NFL Week 2 Odds: Spreads, Moneylines, Totals And Props

Written By Juan Carlos Blanco on September 18, 2022 - Last Updated on September 20, 2022
NFL Week 2 odds spreads lines

Go here for NFL Week 3 odds for the 2022 season.

Check out NFL Week 2 odds below. There are some tremendous games on tap this Sunday, highlighted by the 1-0 Dolphins taking on the 1-0 Ravens (-3.5) in Baltimore. New England, meanwhile, will be seeking its first win of the year when it travels to Pittsburgh to face the Steelers. And a Monday Night Football twin bill will close out the slate, with the Titans facing the Bills (-10) in Orchard Park, and the Vikings playing at the Eagles (-2). View live lines for those games and all of the second week schedule below.

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NFL Week 2 odds

Compare NFL Week 2 odds and click to bet on the price you like below. There are options to view the point spread, moneyline and totals for every game on the second week slate.

Week 2 lines: Props search tool

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LA Chargers (+4) at Kansas City Chiefs 

Two of the top teams in the NFL went at it Thursday night and the Chiefs toppled the Chargers by a final score of 27-24. The Chargers covered with the line closing at LA +4 at most sportsbooks and the game went under the 52.5 point total.

Washington Commanders () at Detroit Lions ()

The Commanders got the Carson Wentz era off to a strong start Sunday against the Jaguars, with the veteran throwing for 313 yards and four touchdowns to offset a pair of INTs. The Lions put together a trademark feisty effort against a more talented opponent and nearly pulled off a wild comeback before succumbing by a 38-35 score to the Eagles. Wentz, along with the impressive quartet of Terry McLaurin, a finally healthy Curtis Samuel, rookie Jahan Dotson and Antonio Gibson (team-leading 7-72 receiving line Sunday) could certainly make waves against a Lions defense that allowed 243 passing yards to Jalen Hurts on Sunday and a 10-155 tally to A.J. Brown.

Jared Goff, meanwhile, could also continue ramping up his rapport with offseason addition D.J. Chark after connecting with him four times in the opener. D’Andre Swift’s 15-144 line on the ground Sunday was also quite the revelation, and both the air and ground attacks could thrive against a Commanders defense that yielded 383 total yards to Jacksonville. Wentz also got his one-year Colts tenure off to a strong start last season before his infamous late-season fade, but oddsmakers initially gave him the benefit of the doubt and flipped the already narrow line closer to a Pick ‘Em or Commanders -1.

Tampa Bay Buccaneers () at New Orleans Saints ()

The Buccaneers weren’t at their sharpest Sunday night but still took care of business against the Cowboys by a 19-3 score. Chris Godwin exited the contest early with a hamstring injury, though, less than two quarters into his triumphant return from last season’s ACL tear. The Saints appeared well on their way to a loss against the Falcons heading into the fourth quarter Sunday, but Jameis Winston and the rest of the offense came alive over the final 15 minutes to pull off the one-point win.

The news Monday that Godwin is expected to potentially miss multiple games certainly isn’t encouraging for Brady, given he’s had plenty of trouble with the Saints defense since arriving in Tampa Bay in 2020. There could be a case to be made for a lower-scoring game overall, as the Buccaneers defense was very effective against Dak Prescott before his early exit Sunday night and are facing a quarterback many know well and that’s had issues with turnovers in the past in Winston. For the time being, the Buccaneers remain a 2.5-3.0-point favorite, but that could naturally shift slightly over coming days.

New England Patriots () at Pittsburgh Steelers ()

The betting outlook for this game remains firmly in limbo following each team’s first game. The Patriots were not only flat against the Dolphins in South Florida, but quarterback Mac Jones reportedly suffered a back injury that required X-rays following the game. His status will naturally be a major determinant in how oddsmakers and betters view New England’s chances. The Steelers, meanwhile, certainly outperformed expectations in their 23-20 overtime upset of the defending AFC champion Bengals, but it could prove to be quite the costly victory. Reigning DPOY T.J. Watt is feared to have torn a pectoral muscle, while Najee Harris exited the game with a foot injury.

Monday news on Jones was positive, as X-rays were negative and he apparently was just dealing with back spasms. He therefore appears likely to work toward starting this game, although he’ll be challenged against a Pittsburgh defense — even if it’s sans Watt — that was ferocious in attacking Joe Burrow on Sunday. On the other side, Harris said on Tuesday that he plans to play against the Patriots. Pittsburgh’s early-week status as a very narrow home underdog may hold if Harris is ultimately deemed out, although there’s a chance this could get closer to a Pick ‘Em depending on the public.

Miami Dolphins () at Baltimore Ravens ()

The Dolphins continued a recent positive history against the Patriots and kicked off the Mike McDaniel/Tyreek Hill era with a satisfying 20-7 home win in Week 1. Miami’s new-look running game couldn’t get anything going, but Hill and Jaylen Waddle combined for a 12-163-1 line.

The Ravens started slowly against the Jets before getting the offense going downhill in the third quarter. By game’s end Lamar Jackson’s three touchdown passes and a balanced air attack helped make up for a lackluster ground attack. On that subject, the running game could see a nice boost if J.K. Dobbins (knee) is able to make his debut in this contest.

Baltimore’s defense wasn’t tested much by the Joe Flacco-led Jets attack Sunday, so Miami’s more complete attack may pose a much stiffer challenge if the ‘Fins’ season-opening showing is any indication. In what is one of the marquee matchups of the early window, the Dolphins could see their current underdog status of over a field goal shrink by a couple of points, although Dobbins news could have some bearing either way.

Carolina Panthers () at New York Giants ()

The Panthers got the Baker Mayfield era off to a so-so start, with the offseason acquisition finishing with solid numbers but Carolina getting nipped by a 26-24 score thanks to a 58-yard field goal as time expired. Christian McCaffrey was also back at full health but relatively quiet (57 total yards, one TD). New Giants head coach Brian Daboll served immediate notice there’s a new era afoot in the Big Apple, as he made quite a gutsy two-point conversion call that paid off late against the Titans on Sunday to secure a 21-20 win.

On an individual level, the story of the day for the G-Men was the play of Saquon Barkley, who posted a spectacular 18-164-1 line that could be a sign of things to come. The G-Men defense was impressive as the game went on against Tennessee, with New York limiting the Titans to seven second-half points, pitching a fourth-quarter shutout and limiting Derrick Henry to 3.9 yards per carry, 3.2 when factoring out his game-long 18-yard run. Given Mayfield’s past troubles with turnovers and the tough road environment, there’s certainly potential for the Giants defense to carry over its momentum, even while having to also deal with McCaffrey. New York’s status as narrow home favorites could certainly gain more traction as the week unfolds, with the number potentially crossing over the key three-point threshold in coming days.

Indianapolis Colts () at Jacksonville Jaguars ()

For a Colts team that famously underachieved down the stretch last season, a season-opening 20-20 overtime tie against the Texans with a new field general in Matt Ryan under center for Indianapolis may have been about as disheartening as a loss. Ryan did put impressive numbers despite four fumbles and Jonathan Taylor (31-161-1) picked up right where he left off in ’21, but the Jaguars’ new look offense also had its moments in a narrow road loss to the Commanders. While a late Trevor Lawrence INT ultimately sunk Jacksonville’s chances, the offense has a chance to get better each week as the team’s host of new additions, which in a sense also includes “redshirt” running back Travis Etienne, gets more acclimated.

There is reason to believe Indy continues to see its passing game produce nicely in this matchup, considering Jacksonville yielded 313 passing yards and four touchdowns to Carson Wentz in Week 1. Meanwhile, although James Robinson and Etienne combined for 113 rushing yards and two TDs (Robinson) on only 15 carries against Washington, Indy’s stingy front kept Houston to 2.8 yards per carry in the opener. Do oddsmakers and the public place some faith in the strides the Jags showed in the second half Sunday? If so, the current line of -4-to-4.5 for the Colts could see some narrowing.

New York Jets () at Cleveland Browns ()

The Jets’ offense under Joe Flacco doesn’t appear likely to press opposing defenses much if Sunday’s season-opening 24-9 loss to the Ravens is any indication. New York does have some explosive young skill players, yet they may not capitalize fully until Zach Wilson (knee) returns. That said, first impressions of the Jacoby Brissett-helmed offense are that they won’t be any great shakes through the air, either.

Cleveland’s narrow 26-24 win against the Panthers on Sunday wasn’t exactly the result of the passing game – Donovan Peoples-Jones led the team with just 60 yards and newcomer Amari Cooper only recorded a 3-17 line — so there ultimately may not be much movement in the current -4-to-4.5-point figure in favor of Cleveland. Considering the two starting quarterbacks and the quality of a Browns defense which dominated Carolina for a good chunk of the game Sunday, it’s of little surprise the projected total of 40.5 points is the lowest of the week.

Seattle Seahawks () at San Francisco 49ers ()

The Seahawks pulled off one of the biggest upsets of the first week of the season as they took down Russell Wilson and the Broncos. The 49ers are regrouping after what could well prove to be an outlier of a 19-10 loss to the Bears in torrential Week 1 conditions at Soldier Field.

Given the weather and the fact he played without George Kittle (groin), it’s difficult to judge Trey Lance’s performance. Additionally, Eli Mitchell, who exited Sunday’s game against the Bears with yet another knee injury, is now set to miss some time. San Francisco is well-equipped to deal with his absence, considering the presence of Jeff Wilson, rookie third round pick Tyrion Davis-Price and the versatile Deebo Samuel. The Seahawks have talent at the skill positions, though, and will see rookie Kenneth Walker (abdomen) debut in this contest. The NFL Week 2 odds had the 49ers -8.5 prior to Seattle’s upset win on Monday night. That line is now 49ers -10 at most sportsbooks.

Atlanta Falcons () at LA Rams ()

The Falcons arguably outpaced expectations in Marcus Mariota’s first start, nearly upsetting the visiting Saints before a fourth-quarter collapse that led to a one-point loss. 

The Rams have plenty of regrouping themselves following a 31-10 shellacking at the hands of the Bills to open the season Thursday night, a game in which Matthew Stafford was harassed for seven sacks. 

Atlanta’s offense looked perfectly competent Sunday under Mariota and with key pieces like Cordarrelle Patterson and rookie Drake London making significant contributions, meaning this current 10.5-11.5-point line in favor of the home squad could shrink a handful of points in coming days.

Cincinnati Bengals () at Dallas Cowboys ()

The Bengals’ heads still have to be spinning after a bizarre season-opening overtime loss to the Steelers in which Joe Burrow threw four interceptions and took seven sacks. Last year’s phenom rookie kicker Evan McPherson missed two would-be game-winning field goal attempts as well.

The Cowboys managed just three points against the Buccaneers in their Sunday night opener, and to make matters worse, Dak Prescott suffered a thumb fracture that will lead to a multi-game absence. Dallas could have Michael Gallup (knee) back for this interconference matchup, although the fact he’d be catching passes from Cooper Rush negates that impact a bit. Tee Higgins also suffered a concussion against Pittsburgh, so his status will be one to monitor during the week. Prescott’s absence is naturally the biggest story here, of course and the injury unsurprisingly flipped the original line on its head. What started as Cowboys -2.5 is now Bengals -7.5 at most sportsbooks and could keep climbing.

Arizona Cardinals () at Las Vegas Raiders ()

Both teams come into the matchup looking for redemption after first week losses. The Cardinals were embarrassed at home by the Chiefs, while the Raiders lost narrowly on the road to the Chargers. 

The mistake-laden performance was a rare one for veteran quarterback Derek Carr, and the Chargers also did a good job taking away Hunter Renfrow (3-21 line on six targets). Given Arizona allowed 360 passing yards and five touchdowns to Patrick Mahomes in Week 1 while never taking him down, there’s reason to put some faith in a cleaner performance from Carr. The two teams looked pretty different in defeat, however, which, when combined with the Raiders’ homefield edge, explains why Las Vegas’ projected advantage has already grown by as much as two points at multiple sportsbooks from its original 3.5-point number.

Arizona’s passing game looked to be in mostly dire straits while operating without both DeAndre Hopkins (suspension) and Rondale Moore (hamstring). On the other side, Davante Adams was outstanding in his Raiders debut (10-141-1), but Carr’s three picks helped sink Vegas.

The Raiders’ early week status as (-3.5) favorites arguably has plenty of staying power and even some growth potential, given the disparity in both teams’ first week defeats.

Houston Texans () at Denver Broncos ()

The Texans surprised by fighting the Colts to a 20-20 OT tie this past Sunday in a game they arguably should have won before allowing a pair of fourth-quarter TDs. The Broncos, meanwhile, were upset by the Seahawks in Seattle on Monday night.

Both sides of the ball certainly had their moments for Houston in Week 1, but one bothersome trend carried over from last season. The Texans still can’t seem to run the ball consistently. Lovie Smith’s squad averaged only 2.8 yards per carry against Indy despite the presence of impressive rookie Dameon Pierce (11 carries, 33 yards), and they could be in store for another tough afternoon against a Denver defense that ranked in the top half of the league a year ago with 111.3 rushing yards and 4.3 yards per carry allowed.

Houston’s Davis Mills looked like last year’s rookie starting run did a world of good for his confidence, but he’ll get a much stiffer test on the road here in Denver against a talented defense. This line didn’t budge much despite the Broncos showing some vulnerability on Monday Night Football. Wilson and the Broncos are one of the biggest favorites when looking at NFL Week 2 odds as they own a -10 price at most books.

Chicago Bears () at Green Bay Packers ()

The Bears pulled off a big first week upset with a 19-10 rain-soaked win over the 49ers at Soldier Field. However, it’s difficult to gage the performance given the extenuating circumstances, especially with Justin Fields completing under 50.0 percent of his throws.

The Packers’ offense looked putrid in its own right against the Vikings, offering a possible preview of the struggles Aaron Rodgers could endure with his short-handed receiving corps. If Allen Lazard (ankle) can at least return for this primetime matchup, however, his availability and the Lambeau Field environment could lead to much better results. 

We’ve seen Rodgers thrive with a short-handed pass-catching corps before, so even if Lazard sits out again, the future Hall of Fame quarterback could look much better than he did versus Minnesota. Rodgers posted a 6:0 TD:INT against Chicago in two games last season, and his Lambeau performance included a 341-yard, four-touchdown tally in a 45-30 win. While Fields may have some hope of reprising his own solid showing in that game (224 yards, two TDs and 74 rushing yards), he was also guilty of three turnovers (two INTs, one fumble recovery) and is going to be facing a Packers defense aiming for redemption after Week 1.

Whether the Pack can remain the 9.5-point favorite they opened as is a less likely proposition, but the number shouldn’t shrink by more than 1-to-1.5 points even if Lazard can’t play.

Tennessee Titans () at Buffalo Bills ()

The Titans will head into this matchup a bit ornery after blowing a late lead to lose to the Giants, 21-20, at home in Week 1. The Bills will come in with an enormous rest advantage after having opened the season with an impressive Thursday night primetime walloping of the defending champion Rams at SoFi Stadium.

For the early part of last Sunday’s loss to New York, the Tennessee offense appeared to be getting by fairly well without the departed A.J. Brown, and Tannehill did finish with 266 passing yards and a pair of touchdowns. Derrick Henry gained 82 yards on the ground, albeit at 3.9 yards per rush, and rookies Kyle Philips and Treyvon Burks finished with a combined 9-121 line.

Nevertheless, the matchup against a Bills defense that simply pushed around the Rams on their home field for most of the game is going to be difficult. For what it’s worth, there will also likely be some redemption on Buffalo’s mind – Henry gutted the Bills for 143 yards and three touchdowns in last season’s 34-31 win for the Titans in Tennessee. The Bills opened as 6.5-to-7.5-point favorites, and even though that was already a fairly big number for a game between two of the prior season’s playoff contenders, it was up to 9.5-10 points by Monday. 

Minnesota Vikings () at Philadelphia Eagles ()

How much of a statement was the Vikings’ 23-7 win over Aaron Rodgers and the Pack on Sunday, their first game in new head coach Kevin O’Connell’s offense? The results were extremely impressive, especially through the air, but the equally strong defensive effort was helped by a short-handed Green Bay receiving corps. Kirk Cousins and his teammates on that side of the ball garnered the biggest headlines after the veteran quarterback threw for 277 yards and two TDs, with nine of his completions, 184 of his yards and both scoring tosses going to Justin Jefferson.

There was still plenty of opportunity for Dalvin Cook as well (20-90), and he could be featured even more against an Eagles defense that yielded 181 rushing yards at 6.5 yards per carry to Detroit. On the other side, Minnesota will face a more stringent test through the air against A.J. Brown and what should be a highly motivated DeVonta Smith after he was shockingly shut out altogether last week. 

How the lines are changing

Below we will look at how the NFL Week 2 odds change from the lookahead lines to the spreads just prior to kickoff. Here are what the point spreads, moneylines and totals looked like on September 7, ahead of the first weekend of the NFL season.

GameNFL Week 2 odds September 7MoneylineTotal
LA Chargers at Kansas City ChiefsChargers (+3) at Chiefs (-3)Chargers (+140) at Chiefs (-165)Over 52.5 (-110), Under 52.5 (-110)
New England Patriots at Pittsburgh SteelersPatriots (-1) at Steelers (+1)Patriots (-125) at Steelers (+105)Over 43 (-110), Under 43 (-110)
Miami Dolphins at Baltimore RavensDolphins (+4) at Ravens (-4)Dolphins (+160) at Ravens (-160)Over 45.5 (-110), Under 45.5 (-110)
Tampa Bay Buccaneers at New Orleans SaintsBuccaneers (-3) at Saints (+3)Buccaneers (-190) at Saints (+160)Over 47 (-110), Under 47 (-110)
Indianapolis Colts at Jacksonville JagaursColts (-4.5) at Jaguars (+4.5)Colts (-195) at Jaguars (+165)Over 45.5 (-110), Under 45.5 (-110)
Washington Commanders at Detroit LionsCommanders (-1) at Lions (+1)Commanders (-115) at Lions (-105)Over 45.5 (-110), Under 45.5
Carolina Panthers at New York GiantsPanthers (+1) at Giants (-1)Panthers (-110) at Giants (-110)Over 42.5 (-110), Under 42.5 (-110)
Atlanta Falcons at LA RamsFalcons (+13) at Rams (-13)Falcons (+625) at Rams (-900)Over 48 (-105), Under 48 (-115)
Seattle Seahawks at San Francisco 49ersSeahawks (+8.5) at 49ers (-8.5)Seahawks (+320) at 49ers (-390)Over 43.5 (-110), Under 43.5 (-110)
Arizona Cardinals at Las Vegas RaidersCardinals (+2.5) at Raiders (-2.5)Cardinals (+120) at Raiders (-140)Over 51 (-110), Under 51 (-110)
Houston Texans at Denver Broncos Texans (+10.5) at Broncos (-10.5)Texans (+410) at Broncos (-520)Over 43 (-110), Under 43 (-110)
Cincinnati Bengals at Dallas CowboysBengals (+2.5) at Cowboys (-2.5)Bengals (+105) at Cowboys (-125)Over 51.5 (-110), Under 51.5 (-110)
Chicago Bears at Green Bay Packers Bears (+9.5) at Packers (-9.5)Bears (+380) at Packers (-475)Over 45 (-110), Under 45 (-110)
Tennessee Titans at Buffalo BillsTitans (+7) at Bills (-7)Titans (+310) at Bills (-380)Over 51 (-110), Under 51 (-110)
Minnesota Vikings at Philadelphia EaglesVikings (+2.5) at Eagles (-2.5)Vikings (+120) at Eagles (-140)Over 47.5 (-115), Under 47.5 (-105)

And here are how NFL Week 2 spreads are changing in the days leading up to kickoff of each contest.

GameNFL Week 2 Spreads: September 13NFL Week 2 Odds: September 16
LA Chargers at Kansas City ChiefsChargers +4.5 at Chiefs -4.5Chargers +4 at Chiefs -4
New England Patriots at Pittsburgh Steelers Patriots -1 at Steelers +1Patriots -2.5 at Steelers +2.5
Tampa Bay Buccaneers at New Orleans SaintsBuccaneers -2.5 at Saints +2.5Buccaneers -2.5 at Saints +2.5
Indianapolis Colts at Jacksonville JaguarsColts -4 at Jaguars +4Colts -3 at Jaguars +3
New York Jets at Cleveland BrownsJets +6 at Browns -6Jets +6.5 at Browns -6.5
Miami Dolphins at Baltimore RavensDolphins +3.5 at Ravens -3.5Dolphins +3.5 at Ravens -3.5
Carolina Panthers at New York GiantsPanthers +2.5 at Giants -2.5Panthers +1.5 at Giants -1.5
Washington Commanders at Detroit LionsCommanders +2.5 at Lions -2.5Commanders +1.5 at Lions -1.5
Atlanta Falcons at LA RamsFalcons +10.5 at Rams -10.5Falcons +10 at Rams -10
Seattle Seahawks at San Francisco 49ersSeahawks +10 at 49ers -10Seahawks +8.5 at 49ers -8.5
Cincinnati Bengals at Dallas Cowboys Bengals -8 at Cowboys +8Bengals -7 at Cowboys +7
Houston Texans at Denver BroncosTexans +10 at Broncos -10Texans +10 at Broncos -10
Arizona Cardinals at Las Vegas RaidersCardinals +6 at Las Vegas Raiders -6Cardinals +5 at Raiders -5
Chicago Bears at Green Bay Packers Bears +10 at Packers -10Bears +10 at Packers -10
Tennessee Titans at Buffalo BillsTitans +10 at Bills -10Titans +10 at Bills -10
Minnesota Vikings at Philadelphia EaglesVikings +2.5 at Eagles -2.5Vikings +2.5 at Eagles -2.5

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Juan Carlos Blanco

Juan Carlos Blanco has served as a freelance writer for a wide variety of online publications and websites, with an intensive focus on fantasy sports. Juan has provided analysis and comprehensive coverage of the MLB, NBA, NFL, CFL, AAF and AFL while also reporting on news and developments in the daily fantasy sports and online gaming industries.

View all posts by Juan Carlos Blanco