The stadiums were brimming with fans, highly hyped rookies were scoring touchdowns, upsets were pulled and multiple games came down the wire, making for a satisfying first full Sunday of the 2021 NFL regular season.
The Week 2 slate is already underway as Washington edged the Giants Thursday night. Sunday and Monday night bring plenty of intrigue as well, with the Rams versus Colts, Bills versus Dolphins, 49ers versus Eagles and Chiefs versus Ravens matchups standing out.
With the first week of the 2021 pro football season in the books, we turn our attention to a live look at NFL Week 2 lines at leading US sportsbooks.
NFL Week 2 odds
Here are NFL Week 2 odds from the top US sportsbooks with point spread, moneyline and over under betting options.
Lookahead lines vs. current NFL Week 2 odds
Below we will look at how the NFL Week 2 odds change for each game leading up to this weekend’s pro football games.
|Game||Lookahead line||Current spread|
|Giants at Washington||Washington -3||Washington -4|
|Raiders at Steelers||Steelers -6||Steelers -5.5|
|Bengals at Bears||Bears -4.5||Bears -1.5|
|Texans at Browns||Browns -13||Browns -13.5|
|Rams at Colts||Rams -2.5||Rams -3.5|
|Bills at Dolphins||Bills -3||Bills -3.5|
|Patriots at Jets||Patriots -4.5||Patriots -5.5|
|49ers at Eagles||49ers -4.5||49ers -3|
|Saints at Panthers||Saints -3||Saints -3.5|
|Broncos at Jaguars||Broncos -2.5||Broncos -5.5|
|Vikings at Cardinals||Cardinals -1.5||Cardinals -3.5|
|Falcons at Buccaneers||Buccaneers -8||Buccaneers -12.5|
|Cowboys at Chargers||Chargers -1||Chargers -3|
|Titans at Seahawks||Seahawks -4.5||Seahawks -6.5|
|Chiefs at Ravens||Chiefs -1||Chiefs -3.5|
|Lions at Packers||Packers -10||Packers -12.5|
In addition to the lookahead lines and what the current point spreads are, here are what NFL Week 2 odds looked like on Sunday night of this week.
- Giants +4.5 at Washington -4.5
- Bengals +3 at Bears -3
- Texans +12 at Browns -12
- Rams -4.5 at Colts +4.5
- Bills -2.5 at Dolphins +2.5
- Patriots -3.5 at Jets +3.5
- 49ers -3 at Eagles +3
- Raiders +6 at Steelers -6
- Saints -3 at Panthers +3
- Broncos -6.5 at Jaguars +6.5
- Vikings +4 at Cardinals -4
- Falcons +13 at Buccaneers -13
- Cowboys +3 at Chargers -3
- Titans +5 at Seahawks -5
- Chiefs -1.5 at Ravens +1.5
- Lions +10.5 at Packers -10.5
Thursday, Sept. 16
New York Giants (+4) at Washington Football Team
The two NFC East rivals head into their Week 2 matchup in search of their first wins of the season, although each squad looked different in defeat Sunday. The Giants dropped a 27-13 decision to the Broncos that was even more lopsided than the final score. Conversely, Washington nearly pulled off a victory over the visiting Chargers before ultimately falling, 20-16.
New York’s Daniel Jones ran in a meaningless score against Denver as time expired to pretty up the final score just a tad, but the Giants were undeniably outplayed for the final three quarters despite the Broncos losing Jerry Jeudy to a high-ankle sprain. New York already appears to have some notable offensive line issues as well. That could continue to spell trouble in Week 2 for both Saquon Barkley in his quest to find running room and Jones when dropping back.
Washington has its own concerns heading into this matchup. Offseason veteran acquisition Ryan Fitzpatrick went down with a hip injury in the first half Sunday and has been placed on IR. Taylor Heinicke was serviceable in relief (11-for-15, 122 yards, zero INTs) and will be the starter against the Giants. The good news for him is New York’s defense was left reeling by Teddy Bridgewater and company Sunday, yielding 420 total yards.
Sunday, Sept. 19
New Orleans Saints () at Carolina Panthers
The Saints got the post-Drew-Brees era off to a resounding start last week, as New Orleans shook off the Jacksonville, Florida setting of their “home game” to decimate Aaron Rodgers and the Packers by a 38-3 score. Meanwhile, the Panthers got off to an encouraging start with a new QB under center themselves, with Sam Darnold racking up 279 passing yards and a touchdown in his Carolina debut.
New Orleans hit on all cylinders in the rout, with Winston playing mistake-free football and tossing a whopping five touchdowns despite an injury-hampered pass-catching corps. New Orleans’ defense looked just as impressive with two sacks and seven QB hits overall on Aaron Rodgers and Jordan Love. Naturally, every week won’t be as easy, but the Saints have to be heading into their first NFC South showdown of the season with a robust amount of confidence.
Darnold wasn’t the only star for the Panthers on Sunday, as Christian McCaffrey made a long-awaited healthy return to the field and compiled 187 total yards on 30 touches. Darnold looked particularly comfortable dishing the ball to both his star running back and DJ Moore, while his one pass to old Jets battery-mate Robby Anderson went for a 57-yard touchdown. The competition gets exponentially stiffer against New Orleans, however, providing a good early test for Darnold.
Despite the Saints’ dominant showing Sunday, New Orleans began the week as relatively modest road favorite at -3.
Cincinnati Bengals at Chicago Bears ()
The Bengals welcomed back Joe Burrow and Joe Mixon in Sunday’s season-opening overtime win against the Vikings while also seeing a pair of encouraging performances from their talented receiver corps. Meanwhile, the day was much grimmer for the Bears, who were lambasted by the Rams on national television, 34-14.
Cincinnati coaches and fans alike couldn’t have been happier with last week’s outcome from both a team and player-level perspective. Burrow and Mixon both looked like they hadn’t missed a beat after injury-marred 2020 campaigns, while rookie first-round pick Ja’Marr Chase paid immediate dividends with a 101-yard, one-touchdown debut. Tee Higgins also found the end zone while Tyler Boyd (3-32) was quiet, so Cincy is still likely several games away from truly hitting its stride.
The Bears have plenty of work to do this week to get ready for the Bengals’ aggressive attack if their Sunday night performance is any indication. Chicago facilitated a near flawless Matthew Stafford performance in his Rams debut and allowed Darrell Henderson to average 4.4 yards per carry as well. Andy Dalton couldn’t do very much to keep the Bears moving downfield and rookie first-round pick Justin Fields did get two pass attempts in, and it remains to be seen if coach Matt Nagy will have a quick hook for the veteran if matters begin getting desperate in front of the home crowd in Week 2.
Given the respective Week 1 results for these clubs, this could be one of the more interesting lines to monitor throughout the week. For the moment, the Bears are standard 3-point home favorites.
Sunday, 9/19 Update: The line has indeed gotten narrower, with the Bears now just 1.5-2.0-point favorites as kickoff approaches.
Houston Texans at Cleveland Browns ()
The Texans shook off all the preseason rumblings of their 2021 season being a lost cause by dismantling the Jacksonville Jaguars, 37-21, in a game that wasn’t even as close as the final score indicated. The Browns blew a double-digit lead in Arrowhead to forsake an opportunity to notch what would have undoubtedly been a tone-setting season-opening victory.
For at least one week, Houston looked capable on both sides of the ball Sunday, ruining the NFL debuts of Jaguars head coach Urban Meyer and first overall pick Trevor Lawrence in the process. Tyrod Taylor got off to a terrific start with Houston, posting 331 total yards and two passing touchdowns. Houston also made Mark Ingram the bell-cow of its deep veteran backfield in Week 1, but it remains to be seen if that will be the case again in Week 2 with David Johnson and Phillip Lindsay also on hand.
The Browns did play without Odell Beckham, Jr. (knee) Sunday, and they will again be without OBJ against Houston. Cleveland looked strong on offense against KC despite the absence of their No. 1 wideout, and with Nick Chubb and Kareem Hunt already in mid-season form, the Browns could rely heavily on the ground game against what still projects to be highly suspect Texans run defense.
Oddsmakers aren’t buying the Texans’ dominant performance against an inferior opponent, as they entered the week as heavy road underdogs.
LA Rams () at Indianapolis Colts
The Rams appeared invigorated with Matthew Stafford under center in a 34-14 Week 1 pasting of the Bears on Sunday night, with the offseason trade acquisition racking up 321 yards and three touchdowns without an interception. The Colts didn’t have anywhere near the same outcome while rolling out a new quarterback of their own. Despite Carson Wentz looking solid in his first action as a member of the Colts, Indy fell at home to the Seahawks by a 28-16 margin.
Stafford and Cooper Kupp (7-108-1) looked to have instant chemistry in their first regular-season action together, and Los Angeles still boasts the likes of Robert Woods, Van Jefferson and Tyler Higbee in its pass-catching arsenal. They’ll look to keep up their Week 1 form in what should be a favorable matchup against a Colts secondary that allowed Tyler Lockett and DK Metcalf get the best of them on multiple occasions Sunday.
Considering he was just a over a month removed from foot surgery and never saw preseason action as a result of that procedure, Wentz’s 251-yard, two-touchdown effort – which he supplemented with 23 rushing yards – was admirable. Running backs Jonathan Taylor and Nyheim Hines were Wentz’s most frequent targets, however, and although receiver Zach Pascal did record two touchdowns, the former Eagles signal-caller will have to quickly develop more rapport with Michael Pittman and Parris Campbell (Sunday 9/19 Update: Campbell is inactive due to a groin injury) in order to keep up with what looks to be a dangerous Rams passing attack.
The Rams’ performance last Sunday night has helped move the line from an open of -2.5 to -4 on Monday, a very notable development considering Indy’s host status.
Denver Broncos () at Jacksonville Jaguars
The Broncos were another team with a new quarterback that came away with a win Sunday. Denver rode an impressive debut from Teddy Bridgewater and a dominating effort by its defense to notch a 27-13 win over the Giants on the road. The Jaguars saw the highly anticipated debuts of head coach Urban Meyer and first overall pick Trevor Lawrence spoiled by a feisty Texans team that handed them a 37-21 defeat.
Bridgewater looked like the steady veteran he’s proven to be at multiple stops against New York, staying away from turnovers while totaling 264 passing yards and another 19 on the ground. Bridgewater did an excellent job distributing the ball to his deep group of receivers as well, although the wideout corps suffered a big loss for what will likely be several weeks when Jerry Jeudy went down with a gruesome looking high-ankle sprain. Fortunately for Denver, the Jaguars secondary is far from a prohibitive matchup.
There were positives for the Jags despite the Week 1 loss, but those were mostly on the offensive side of the ball. Trevor Lawrence offset his three interceptions with three touchdown passes and over 300 yards through the air, although it took him 51 attempts to get there. Lawrence will be tested in Week 2 against a Broncos defense that figures to have Bradley Chubb (ankle) back in the fold after he was held out of the opener.
Oddsmakers are buying the season-opening performances of both clubs, with the line having moved from an open of -2.5 in favor of Denver to a whopping -6 as of Monday afternoon.
Buffalo Bills () at Miami Dolphins
The Bills’ robust 2021 hype balloon got a quick deflation Sunday, as the Steelers came into town and handed Buffalo a surprising 23-16 loss. Meanwhile, the Dolphins pulled their own road upset, upending the division-rival Patriots by a razor-thin 17-16 margin.
The Bills started off promisingly enough against Pittsburgh with 10-0 halftime lead, but the Steelers defense and special teams helped lead the second-half comeback. Josh Allen, Devin Singletary, Stefon Diggs and Cole Beasley all turned in stat lines that would have seemingly been good enough to secure a victory, so a few tweaks on either side of the ball may be all Buffalo needs to get into the win column in Week 2.
The Dolphins undoubtedly deserve plenty of credit for pulling off a win in Foxborough, but Miami’s victory still leaves some lingering questions. The most pertinent would be attached to quarterback Tua Tagovailoa, who was adequate but unremarkable while throwing for 202 yards with a touchdown and interception. He did display good rapport with both DeVante Parker (4-81) and rookie Jaylen Waddle (4-61-1). The Bills defense, which mostly clamped down on Ben Roethlisberger and company in Week 1, will present a formidable challenge.
Despite each team’s record coming in and Miami’s home-team status, oddsmakers are affording the Bills 3-to 3.5-point road favorite status as of Friday morning, a significant figure.
Sunday, 9/19 Update: Will Fuller will miss Sunday’s game due to a personal issue, leaving Tagovailoa short-handed again in the receiving corps.
New England Patriots () at New York Jets
The Patriots’ 17-16 loss to the Dolphins on Sunday did have some encouraging aspects, the most prominent being the play of rookie QB Mac Jones (281 yards, 1 TD). The Jets’ own rookie signal-caller, Zach Wilson, was impressive in his own right while tossing a pair of scores in a close 19-14 loss to the Panthers.
Jones looked like a seasoned starter in his first pro game while misfiring on only 10 of his 39 attempts, while Damien Harris excelled in the lead-back role with 100 rushing yards and another 17 through the air. The third-year back did commit a back-breaking fumble, however, and given Bill Belichick’s mercurial approach to personnel, it will be interesting to see if rookie Rhamondre Stevenson and James White take on a bigger role against New York.
The difference in the Jets under new head coach Robert Saleh was palpable Sunday and New York nearly pulled off the road upset. The decision to roll with Wilson right from the jump appeared to be instantly validated, and the second overall pick already flashed strong chemistry with new No. 1 wideout Corey Davis.
Despite each team putting together similar performances in Week 1, the Patriots started the week as relatively comfortable road favorites.
Sunday 9/19 Update: Wilson will be without Jamison Crowder for a second straight game, as the veteran wideout will sit out due to a groin injury.
San Francisco 49ers () at Philadelphia Eagles
The 49ers got a lot more than they bargained for against the Lions on the road in Week 1, but they still managed to escape with a 41-33 win. The Eagles had no such close call, with Jalen Hurts becoming one of the big Week 1 stories by leading a dominating 32-6 victory over the Falcons.
San Francisco headed into the season with plenty to be excited about after an injury-marred 2020 campaign that was profoundly disappointing. Many of their expectations regarding now-healthy players were actually fulfilled, as the likes of Deebo Samuel, George Kittle and Nick Bosa all turned in spectacular-to-strong performances. Starting running back Raheem Mostert’s first-half knee injury opened the door for rookie Elijah Mitchell to explode for 104 yards and a touchdown, and Jimmy Garoppolo played with the urgency of a quarterback who’s aware a high-pedigree rookie – Trey Lance, who threw a TD pass on his only pass attempt Sunday – is breathing down his neck.
Where San Fran didn’t look right was on defense in the second half, something that could certainly work to Hurts’ and his teammates’ advantage. The second-year QB exploited a vulnerable Falcons defense and certainly should have a tougher time in Week 2, but his immediate rapport with rookie DeVonta Smith and holdover Jalen Reagor was encouraging. Miles Sanders and Dallas Goedert also reprised their old roles from the Doug Pederson era in the big win and each should enjoy robust opportunities against the Niners.
This has the makings of one of the marquee matchups of the week. After each team’s respective Week 1 performance, the line, which opened as 49ers -4.5, had come down a full point as of Monday afternoon.
Las Vegas Raiders at Pittsburgh Steelers ()
The Raiders grabbed a narrow win in Week 1, toppling Baltimore 33-27 . Meanwhile, the Steelers got their season started with an inspired 23-16 road upset of the Bills that saw them come back from a 10-0 halftime deficit.
The Raiders got a strong performance from their best offensive performer, Darren Waller, in Game 1 as the tight end caught 10 of Derek Carr’s passes for 105 yards and a TD. The Las Vegas running game was less than stellar as Josh Jacobs managed just 34 yards on 10 carries, though he did find the end zone twice.
One of the heartening things about Pittsburgh’s upset victory was the fact it was a true team win. Looked at from another perspective, that might also be considered a bit troubling in the sense the team’s offense couldn’t get going for much of the afternoon. Nevertheless, they could be set up for much more success in what should be an appreciably softer Week 2 matchup. The explosiveness of rookie running back Najee Harris and receiver Diontae Johnson certainly has the potential to give the Raiders defense plenty of trouble.
Minnesota Vikings at Arizona Cardinals ()
The Vikings saw elation turn to heartbreak Sunday in a season-opening overtime loss to the Bengals, with a late Dalvin Cook fumble leading to Cincinnati’s game-winning field goal after Minnesota had overcome a 21-7 second-half deficit. The Cardinals looked elite on both sides of the ball in what was supposed to be a tough road battle against the Titans, dominating Tennessee by a 38-13 score.
The Vikings’ Week 1 box score gives the impression of that all was okay with Mike Zimmer’s club Sunday, but that wasn’t really the case for a significant portion of the game. Kirk Cousins’ 351 passing yards were certainly encouraging, while the fact Minnesota saw a third receiver step up for a change – second-year man Kai Osborn posted a 7-76 line – is promising. The Cardinals didn’t really betray any hint of weakness in the secondary in their win and also shut down Derrick Henry, however, so the Vikes could have their work cut out for them Week 2.
Kyler Murray looked every bit the NFL MVP candidate with five total TDs Sunday and the Chase Edmonds-James Conner duo combined for 116 yards in their first game together. Considering the Vikings allowed big games both through the air and on the ground to the Bengals, coach Kliff Kingsbury has to be licking his chops in anticipation.
The line reflects growing respect for the Cardinals, already moving from 1.5 to as much as 4.0-point favorites as of Monday afternoon.
Atlanta Falcons at Tampa Bay Buccaneers ()
The Falcons looked every bit as disheveled as they were expected to be in a season-opening 32-6 loss to the Eagles under new head coach Arthur Smith. The Buccaneers got their title defense started with an exciting 31-29 victory over the Cowboys on Thursday night, leaving them with plenty of time to work on corrections ahead of this divisional matchup.
Matt Ryan unsurprisingly looked like a different quarterback without Julio Jones to throw to Sunday, even though he’d had his share of experience working without the oft-injured wideout in recent seasons. Ryan was also running Smith’s offense for a full game for the first time, and with both Calvin Ridley and rookie fourth overall pick Kyle Pitts unable to do much against an inspired Eagles defense, Atlanta had no real chance. The going doesn’t get any easier in Week 2 against the Bucs, a worrisome matchup when considering Ryan already took three sacks and nine hits overall against Philly.
Tom Brady and company already looked to be in midseason form on their side of the ball Thursday. The benefit of the legendary quarterback having a season under his belt in Bruce Arians’ aggressive system can’t be overstated, and the matchup in Week 2 should be even softer than the one versus the Cowboys.
The backfield duo of Leonard Fournette and Ronald Jones played only modest roles in the opener, but both could see much more run against a suspect Falcons front in a game that Tampa Bay might build a big lead in.
To no one’s surprise, this game sports the week’s highest spread, and the number has taken a major move in the Bucs’ favor since it opened at -8.
Dallas Cowboys at LA Chargers ()
The Cowboys put up one heck of a fight against the Buccaneers before surrendering a game-ending field-goal drive. Dak Prescott looked to be all the way back from last season’s devastating ankle injury with a 403-yard, three-touchdown performance. The Chargers went on the road and were able to close the deal in their case, squeaking out a 20-16 win against Washington in coach Brandon Staley’s debut.
Prescott, Amari Cooper and CeeDee Lamb all were in Pro Bowl form right from the jump against Tampa Bay, while Ezekiel Elliott appeared to be running harder than late last season in what was an extremely tough matchup. The extra time to prepare for the trip out to Los Angeles will undoubtedly come in handy for Dallas, which is also dealing with the loss of Michael Gallup to injured reserve for at least the next three games as a result of a calf strain suffered in the opener.
The Chargers saw Justin Herbert, Mike Williams and Keenan Allen thrive in their first game under new offensive coordinator Joe Lombardi’s offense. There should also be some opportunities for big plays against the Cowboys’ defense, but L.A. will almost certainly look to get Austin Ekeler more involved as a receiver after he surprising failed to log a target in Week 1.
The Bolts are narrow home favorites, but it will be interesting to see if this line moves closer to a pick ‘em over the course of the week considering the Cowboys’ star power and rest advantage.
Tennessee Titans at Seattle Seahawks ()
The Titans were thoroughly embarrassed on their home field by the Cardinals in Week 1, taking a 38-13 loss in Julio Jones’ team debut. The Seahawks were impressively dominant on both sides of the ball versus the Colts on their way to a 28-16 road win.
Tennessee couldn’t get anything going offensively versus a team in Arizona not especially known for its defense coming into the season. The underwhelming performances by Derrick Henry, Jones and A.J. Brown are all likely outliers, but what could be a longer-term issue is the atrocious pass protection for Ryan Tannehill. The veteran took six sacks overall and was hit nine times, and the Seahawks, which got to the Colts’ Carson Wentz three times overall Sunday, could present a similar problem.
Russell Wilson, Tyler Lockett, D.K. Metcalf and Chris Carson are the cornerstones of Seattle’s offense, and all performed admirably in the win over the Colts. The balance that led to an efficient 381 total yards at 7.2 yards per play won’t be there each week; however, given how Tennessee’s defense looked while giving up five touchdowns to another highly mobile QB in Kyler Murray on Sunday, it could be there again for Seattle in Week 2.
Despite each team’s drastically different Week 1 outcomes, the line had moved only one point to -5.5 in favor of the hosts from its open as of Monday afternoon.
Kansas City Chiefs () at Baltimore Ravens
The Chiefs got quite the scare from the Browns in Week 1 before prevailing late by a 33-29 score thanks in part to a special-teams gaffe on the part of Cleveland. The Ravens will take the field for the first time this season Monday night in Las Vegas after a difficult last few weeks that saw them lose three running backs and starting corner Marcus Peters to season-ending ACL injuries.
The Chiefs defense particularly appeared to be sleepwalking early in Sunday’s game while giving up 22 first-half points. KC’s vaunted offense wasn’t much better in only scoring 10, but by game’s end, all looked to more or less be back to normal in Mahomes World. Tyreek Hill’s 11-catch, 197-yard, one-TD day and Travis Kelce’s pair of receiving scores were par for the course for the stars. The matchup against the Ravens defense should be tougher, but it’s one Mahomes has already conquered on multiple occasions in his career and Kansas City will also enjoy a rest advantage.
The Ravens dropped a bizarre overtime game to the Raiders on Monday night, giving up 17 points to Las Vegas in the third quarter. Baltimore allowed Raider TE Darren Waller to have himself a night as he posted 105 yards on 10 catches. Lamar Jackson predictably had to shoulder the load on offense as he led the team in rushing with 86 yards on 12 carries. Ty’Son Williams had 65 yards on 9 carries and Latavius Murray posted 28 yards on 10 attempts.
The Chiefs were a -3.5 road favorite on Tuesday morning.
Monday, Sept. 20
Detroit Lions at Green Bay Packers ()
The Lions were expected to be a feisty bunch under new head coach Dan Campbell, and they lived up to that expectation in a second half that saw them score 23 points. Meanwhile, the Packers were part of what was arguably the most shocking Week 1 result. Green Bay was positively steamrolled by the Saints, 38-3, in a game that got so out of hand Aaron Rodgers was given an early seat.
During a first half that saw them fall behind to San Francisco by a 31-10 margin, it looked like the same old Lions. However, new QB Jared Goff and what might be the shallowest receiving corps in the league went to work and nearly pulled off at least a tie with a furious fourth-quarter rally. Goff (338 yards, three TDs) wasn’t the only new addition that looked good – former Packer Jamaal Williams had 110 total yards on 17 touches – and this squad looks like it will fight hard under Campbell every week. Nevertheless, the defensive issues are unmistakable, and the Lions will be running into what is sure to be an ornery bunch in Green Bay.
The Packers’ expected foul mood will naturally stem from their Week 1 embarrassment. Chances are that a game in which a healthy Aaron Rodgers-led offense musters just a field goal quickly proves to be total outlier as early as Week 2, but there have to be some concerns in Green Bay considering the blueprint the Saints may have put on tape for other teams. The five TDs allowed by the defense also undoubtedly raised an eyebrow or two, and given how Goff and the air attack appeared to catch fire late against a strong 49ers defense, things could get interesting at Lambeau for a bit.
For the moment, the Packers are unsurprisingly double-digit home favorites despite the season-opening meltdown. Whether that number crawls down a bit into high single digits as the week goes on will be something to keep an eye on.
Sunday, 9/19 Update: Tyrell Williams has been ruled out for the Lions with a concussion and D’Andre Swift carries a questionable tag but is expected to play. The Packers remain firm double-digit favorites.
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