NFL Week 2 Game Preview: Los Angeles Chargers at Kansas City Chiefs Odds

Written By Eli Hershkovich on September 15, 2022
Chiefs Chargers Odds

The Los Angeles Chargers visit the Kansas City Chiefs at 8:20 p.m. ET on Thursday, Sept. 15. The primetime game to kick off NFL Week 2 odds shows the Chiefs as spread favorites and on the moneyline. The point total is set at . Read more for a full analysis on Chiefs – Chargers odds.

In this article, we break down everything you need to know before placing a bet on the game, including team matchups, key metrics, and the best available odds. Click on Chiefs – Chargers odds anywhere in this post to bet now.

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Chiefs vs. Chargers Odds: Spread, Moneyline, Over/Under

When using the odds table above, click the dropdown menu and select the type of bet you wish to make. 

Wagering on the point spread is when you wager on how many points a team will win or lose by. A “plus” sign in front of the spread is the underdog, and a “minus” sign is the favorite. The Chiefs would need at least a five-point if you bet on Kansas City to cover the point spread (-4). A spread bet on the Chargers would win if Los Angeles wins the game or loses by three points or fewer. A push would come into play if Patrick Mahomes & Co. win by exactly four points.

Betting the moneyline is simply betting on which particular team will win a game.

The total is the number of combined points the two teams will score. Bettors can choose to bet the over or under on how many total points will be scored in the game.

Chiefs vs. Chargers Player Props

In the props tool search bar, type in a team or player and hit enter. You’ll see the various proposition bets offered by leading online sportsbooks. 

This is a valuable tool that allows bettors to compare odds and stats when considering a prop bet. 

Chiefs vs. Chargers Betting News

As of Wednesday, the Chiefs have accrued 82% of the spread tickets and 74% of the overall handle, respectively. This data comes from BetMGM Sportsbook, which has Kansas City listed at after opening at -3.5. Additional updates can be found below.

Chiefs vs. Chargers Weather Report

The weather isn’t expected to have much of an impact on this matchup, as the temperature is expected to settle in at 80 degrees by kickoff. Even so, you should we wary of allowing the potential weather to impact your handicap — unless it’s similar to the 49ers at Bears torrential downpour that we witnessed in Week 1.

Chiefs vs. Chargers Injury Report

 InjuryMonday*TuesdayWednesdayInjury Designation
LOS ANGELES CHARGERS
WR Keenan AllenHamstringDNPDNPDNPOUT
CB J.C. JacksonAnkleDNPLimitedLimitedQuestionable
TE Donald Parham, Jr.HamstringDNPDNPDNPOUT
T Rashawn SlaterBackFullFullFull-
LB Drue TranquillBackFullFullFull-
KANSAS CITY CHIEFS
T Orlando BrownKneeLimitedFullFull-
G Trey SmithAnkleLimitedLimitedFullQuestionable
K Harrison ButkerLeft AnkleDNPDNPDNPOUT
QB Patrick MahomesLeft WristFullFullFull-
S Justin ReidHandFullFullFull-
WR JuJu Smth-SchusterShoulderLimitedFullFull-
WR Justin WatsonChestLimitedFullFull-

Chiefs’ Offense vs. Chargers’ Defense

Chiefs OStats (Rank)Chargers D
44.0 (1)Points/Game19.0 (9)
488.0 (2)Yards/Game320.0 (12)
0.667 (1)Points/Play0.339 (15)
7.4 (1)Yards/Play5.7 (20)
62.50% (4)3D Conversion %45.45% (22)
100.00% (1)4D Conversion %50.00% (11)
100.00% (1)RZ Scoring % (TD)66.67% (17)
6.0 (1)TDs/Game2.0 (9)

Chargers’ Offense vs. Chiefs’ Defense

Chargers OStats (Rank)Chiefs D
24.0 (9)Points/Game21.0 (17)
355.0 (16)Yards/Game282.0 (9)
0.369 (11)Points/Play0.333 (12)
5.5 (17)Yards/Play4.5 (6)
42.86% (14)3D Conv %25.00% (4)
N/A (14)4D Conv %75.00% (15)
66.67% (11)RZ Scoring % (TD)100.00% (23)
3.0 (6)TDs/Game3.0 (21)

Chiefs vs. Chargers Betting Insights

Why Chiefs Can Cover The Spread

Similar to last season’s results under the defensive-minded Brandon Staley, the Chargers’ defense gifted the Raiders a rushing EPA that was above league average in their season opener. Chiefs tailbacks Clyde Edwards-Helaire and rookie Isaiah Pacheco could be in for another sound performance on the ground, setting up Mahomes and his receiving core through the air.

But Mahomes’ wrist injury could prove to be an issue on a short week — despite the Chiefs’ positive frame of mind. Moreover, placekicker Harrison Butker (ankle) is out, which could loom large with this spread around the key number of a field goal.

Why Chargers Can Cover The Spread

Although Kansas City surrendered much of Arizona’s scoring output in garbage time in Week 1, Steve Spagnolo’s unit was exposable in 2021. Despite the Chiefs’ second-half resurgence, they still yielded the league’s 10th-highest dropback EPA.

Andy Reid lost a pair of secondary members in the offseason, too, as safety Tyrann Mathieu and cornerback Charvarius Ward bolted town. Plus, first-round rookie Trent McDuffie, who was the starting nickelback to begin the 2022 campaign, suffered a season-ending torn ACL.

Even without Los Angeles wideout Keenan Allen (knee), Justin Herbert & Co. possess an explosive offense that generated the seventh-highest dropback EPA within the Week 1 slate. Considering the Chargers sat on the ball for much of the second half, that level of efficiency is even more impressive.

But the betting market may not be taking it into account enough, as this spread spiked after the look-ahead line was only Kansas City -2.5. Admittedly, the line movement also correlates with the aforementioned wound to Allen, along with corner J.C. Jackson (ankle, questionable).

The Chiefs closed at -6.5 at home and -3 on the road, respectively, against Staley’s crew last season. Therefore, there could be pushback amongst some bettors because of Los Angeles’ current market rating. Kansas City would’ve been a 4.5-point favorite on a neutral field in 2021, yet the spread would be -2 this time around.

Nevertheless, it’s warranted given the Chargers’ upgrades on defense — centered around Jackson and edge rusher Khalil Mack — plus Herbert’s development in a high-tempo offense.

Related: Super Bowl 57 Odds

Reasons To Bet The Over

Let’s exclude last week results, with both teams generating a slower pace in their respective second halves. Andy Reid’s unit manufactured the third-highest tempo in neutral situations last season (via Football Outsiders) while Staley’s aggressive mindset helped the Chargers rank No. 6 overall. If the aforementioned Jackson doesn’t suit up, Mahomes will certainly have a better opportunity to exploit Los Angeles’ secondary, leaving Herbert’s squad in catch-up mode via the hurry up.

Reasons To Bet The Under

Should Jackson give it a go, Mahomes will likely be less efficient, as his top-rated dropback EPA was inflated because of the Cardinals’ obscene secondary. The Chargers should be in position to apply heat versus the weaker right side of the Chiefs’ offensive line, too. Keep in mind, Arizona delivered little to no pash rush (albeit blitzing often) on Sunday after losing Chandler Jones in the offseason and J.J. Watt to a calf injury.

That isn’t to say that the Chiefs’ offense isn’t elite. It’s just up against a stout defense, especially if Jackson plays.

If you’re into trends, in the wild-card era (since 1990), totals of 54.5 or higher, Thursday night games are 7-0 to the under. They’ve gone under the total by an average of 13.8 points per game.

Final Thoughts

If you couldn’t tell, I’m on Los Angeles. Unfortunately, I bet Chiefs Chargers odds before the steam came in on Kansas City earlier in the week. Still, I’m expecting the Chargers to at least hang within a field goal.

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Eli Hershkovich Avatar
Written by
Eli Hershkovich

Eli Hershkovich is a lead sports betting writer with TheLines and Catena Media, formerly with Audacy and The Action Network. His goal is to provide you with data and information to lead you to winning bets. Eli is an avid college basketball gambler — among many other sports — and still hasn't forgiven Virginia for ruining his 2018-2019 Texas Tech futures.

View all posts by Eli Hershkovich