NFL Week 16 Rundown: Injury News, Lines, Spreads, Over/Unders

Written By Brett Gibbons on December 25, 2021 - Last Updated on August 22, 2022
NFL week 16

With just three more regular season games left, NFL Week 16 offers an enticing slate of matchups with strong playoff implications. The weekend is headlined by the Colts at Cardinals, Ravens at Bengals, and Bills at Patriots.

While this week’s COVID list doesn’t quite hit as badly as last week, there’s plenty of players that will be unavailable for their respective games. Bookmark this article to keep up-to-date with all the latest player news and betting lines.

Cleveland Browns (7-7) at Green Bay Packers (11-3)

Kickoff: Saturday, December 25, 4:30 p.m. ET
TV Channel: FOX/NFL Network
Look-ahead line: GB -6.5
Current Line: GB (), O/U ()

Cleveland vs. Green Bay key injuries

  • Packers vs Browns Week 16 Injury Report

Packers vs. Browns: Week 16 NFL Betting Preview

Cleveland vs. Green Bay betting news & angles

Indianapolis Colts (8-6) at Arizona Cardinals (10-4)

Time of game: Saturday, December 25, 8:15 p.m. ET
TV Channel: NFL Network
Look-ahead line: ARI -4
Current Line: ARI (), O/U ()

Indianapolis vs. Arizona key injuries

  • Cardinals vs Colts Week 16 Injury Report

Cardinals vs. Colts: Week 16 NFL Betting Preview

Indianapolis vs. Arizona betting news & angles

Detroit Lions (2-11-1) at Atlanta Falcons (6-8)

Time of game: 1:00 p.m. ET
TV Channel: FOX
Look-ahead line: ATL -6
Current Line: ATL (), O/U ()

Detroit vs. Atlanta key injuries

  • Falcons vs Lions Week 16 Injury Report

Falcons vs. Lions: Week 16 NFL Betting Preview

Detroit vs. Atlanta betting news & angles

Tampa Bay Buccaneers (10-4) at Carolina Panthers (5-9)

Time of game: 1:00 p.m. ET
TV Channel: FOX
Look-ahead line: TB -11
Current Line: TB (), O/U ()

Tampa Bay vs. Carolina key injuries

  • Buccaneers vs Panthers Week 16 Injury Report

Buccaneers vs. Panthers: Week 16 NFL Betting Preview

Tampa Bay vs. Carolina betting news & angles

Baltimore Ravens (8-6) at Cincinnati Bengals (8-6)

Time of game: 1:00 p.m. ET
TV Channel: CBS
Look-ahead line: CIN -2.5
Current Line: CIN (), O/U ()

Baltimore vs. Cincinnati key injuries

  • Bengals vs Ravens Week 16 Injury Report

Bengals vs. Ravens: Week 16 NFL Betting Preview

Baltimore vs. Cincinnati betting news & angles

Los Angeles Chargers (8-6) at Houston Texans (3-11)

Time of game: 1:00 p.m. ET
TV Channel: CBS
Look-ahead line: LAC -10.5
Current Line: LAC (), O/U ()

L.A. Chargers vs. Houston key injuries

  • Chargers vs Texans Week 16 Injury Report

Chargers vs. Texans: Week 16 NFL Betting Preview

L.A. Chargers vs. Houston betting news & angles

Los Angeles Rams (10-4) at Minnesota Vikings (7-7)

Time of game: 1:00 p.m. ET
TV Channel: FOX
Look-ahead line: LAR -3 (-120)
Current Line: LAR (), O/U ()

L.A. Rams vs. Minnesota key injuries:

  • Rams vs Vikings Week 16 Injury Report

Rams vs. Vikings: Week 16 NFL Betting Preview

L.A. Rams vs. Minnesota betting news & angles

Buffalo Bills (8-6) at New England Patriots (9-5)

Time of game: 1:00 p.m. ET
TV Channel: CBS
Look-ahead line: NE -2
Current Line: NE (), O/U ()

Buffalo vs. New England key injuries

  • Patriots vs Bills Week 16 Injury Report

Patriots vs. Bills: Week 16 NFL Betting Preview

Buffalo vs. New England betting news & angles

Jacksonville Jaguars (2-12) at New York Jets (3-11)

Time of game: 1:00 p.m. ET
TV Channel: CBS
Look-ahead line: NYJ -1
Current Line: NYJ (), O/U ()

Jacksonville vs. N.Y. Jets key injuries

  • Jaguars vs. Jets Week 16 Injury Report

Jets vs. Jaguars: Week 16 NFL Betting Preview

Jacksonville vs. N.Y. Jets betting news & angles

New York Giants (4-10) at Philadelphia Eagles (7-7)

Time of game: 1:00 p.m. ET
TV Channel: FOX
Look-ahead line: PHI -8.5
Current Line: PHI (), O/U ()

N.Y. Giants vs. Philadelphia key injuries

  • Eagles vs Giants Week 16 Injury Report

Eagles vs. Giants: Week 16 NFL Betting Preview

N.Y. Giants vs. Philadelphia betting news & angles

Chicago Bears (4-10) at Seattle Seahawks (5-9)

Time of game: 4:05 p.m. ET
TV Channel: FOX
Look-ahead line: SEA -7
Current Line: SEA (), O/U ()

Chicago vs. Seattle key injuries

  • Seahawks vs Bears Week 16 Injury Report

Seahawks vs. Bears: Week 16 NFL Betting Preview

Chicago vs. Seattle betting news & angles

Pittsburgh Steelers (7-6-1) at Kansas City Chiefs (10-4)

Time of game: 4:25 p.m. ET
TV Channel: CBS
Look-ahead line: KC -9.5
Current Line: KC (), O/U ()

Pittsburgh vs. Kansas City key injuries

  • Chiefs vs Steelers Week 16 Injury Report

Chiefs vs. Steelers: Week 16 NFL Betting Preview

Pittsburgh vs. Kansas City betting news & angles

Denver Broncos (7-7) at Las Vegas Raiders (7-7)

Time of game: 4:25 p.m. ET
TV Channel: CBS
Look-ahead line: DEN -1 (-105)
Current Line: DEN (), O/U ()

Denver vs. Las Vegas injuries

  • Broncos vs Raiders Week 16 Injury Report

Broncos vs. Raiders: Week 16 NFL Betting Preview

Denver vs. Las Vegas betting news & angles

Washington Football Team (6-8) at Dallas Cowboys (10-4)

Time of game: 8:20 p.m. ET
TV Channel: NBC
Look-ahead line: DAL -9
Current Line: DAL (), O/U ()

Washington vs. Dallas key injuries

  • Cowboys vs Washington Week 16 Injury Report

Cowboys vs. Washington: Week 16 NFL Betting Preview

Washington vs. Dallas betting news & angles

Miami Dolphins (7-7) at New Orleans Saints (7-7)

Time of game: 8:15 p.m. ET
TV Channel: ESPN
Look-ahead line: OTB
Current NFL Week 16 Odds: MIA (), O/U ()

Miami vs. New Orleans key injuries

  • Saints vs Dolphins Week 16 Injury Report

Saints vs. Dolphins: Week 16 NFL Betting Preview

Miami vs. New Orleans betting news & angles

Keep up-to-date with theLines for NFL Week 16 odds and NFL previews all season long.

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Written by
Brett Gibbons

Brett is an avid sports traveler and former Division-I football recruiter for Bowling Green and Texas State. He’s a graduate of BGSU and works as an auditor for Google content curation products. He’s also contributed to Sports Illustrated and Fansided during his young writing career.

View all posts by Brett Gibbons