NFL Week 16 Betting Preview: Los Angeles Chargers At Indianapolis Colts

Written By Jeffrey Schreiber on December 27, 2022
chargers vs. colts odds

The Los Angeles Chargers visit the Indianapolis Colts on Monday Night Football at 8:15 p.m. ET. Primary markets for the game show the Chargers as spread favorites and on the moneyline. Chargers vs. Colts odds feature a total set at

This article breaks down everything you need to know before placing a bet on the game, including team matchups, key metrics, weather, and the best available NFL Week 16 oddsClick on the odds anywhere in this post to bet now.


When using this Chargers vs. Colts odds table, click the dropdown menu and select the type of bet you wish to make. 

Betting the point spread is when you wager on how many points a team will win or lose by. A plus sign in front of the spread denotes the underdog, and a minus sign denotes the favorite.

In this case, the Chargers would have to win by at least four points if you bet them to cover the point spread (-3.5). A spread bet on the Colts would win if they win the game or lose by fewer than four.

Betting the moneyline is simply betting on which particular team will win a game.

The betting total is the number of combined points the two teams will score. Bettors can choose to bet the over or under on how many total points will be scored in the game. 

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In the props tool search bar, type in a team or player and hit enter. You’ll see the various proposition bets offered by leading online sportsbooks. 

This valuable tool allows bettors to compare odds and stats when considering a prop bet. Unlike more significant markets like moneylines and spreads that often reach a consensus number, shopping for prop bet lines can often reveal sizable differences.


Use this rolling, updating list of news bites about each team to help your handicapping for Chargers at Colts odds.

Chargers Vs. Colts Weather

The weather report in Indianapolis for Monday Night Football odds is white (light snow), which means the Lucas Oil Stadium retractable roof will likely be closed.

Chargers Vs. Colts Injury Report

Los Angeles Injuries

PlayerPos.InjuryStatusAvg. Snap Count
Trey PipkinsOTKneeProbable68.5
Jamaree SalyerOGKneeProbable60.6
Bryce CallahanCBGroinQuestionable39.4
Chris Rumph IIOLBQuadProbable35.7
Kemon HallCBHamstringQuestionable16.5

Indianapolis Injuries

PlayerPos.InjuryStatusAvg. Snap Count
Kenny Moore IICBAnkleQuestionable71.6
Jonathan TaylorRBAnkleOut47.6
Kylen GransonTEAnkleQuestionable42.7
Brandon FacysonCBIllnessProbable29.9
Mike StrachanWRConcussionProbable12.4

Chargers Offense Vs. Colts Defense

Chargers OffenseStats (Rank)Colts Defense
22.3 (14)Points/Gm24.1 (23)
0.3 (15)Points/Play0.4 (14)
357.9 (12)Yards/Gm329.3 (12)
274.2 (2)Pass Yards/Gm205.6 (10)
83.7 (31)Rush Yards/Gm123.7 (20)
5.2 (20)Yards/Play5.1 (7)
6.3 (20)Yards/Pass6.5 (13)
3.7 (30)Yards/Rush4.1 (5)
42.0% (13)3rd Down %36.8% (7)
50.0% (25)Red Zone %67.5% (30)
15 (6)Turnovers15 (22)
34 (17)Sacks39 (7)

Colts Offense Vs. Chargers Defense

Colts OffenseStats (Rank)Chargers Defense
17.5 (29)Points/Gm24.3 (25)
0.3 (15)Points/Play0.4 (14)
319.6 (24)Yards/Gm354.5 (21)
214.4 (19)Pass Yards/Gm208.9 (11)
105.2 (25)Rush Yards/Gm145.6 (28)
4.8 (29)Yards/Play5.9 (29)
5.9 (28)Yards/Pass6.8 (19)
4.0 (27)Yards/Rush5.4 (31)
35.2% (27)3rd Down %41.6% (24)
45.0% (31)Red Zone %54.8% (13)
27 (32)Turnovers18 (13)
49 (30)Sacks28 (27)


Why The Chargers Can Cover The Spread

The Chargers will look to strengthen their lead in the AFC Wild Card race. Los Angeles will face a Colts team on the wrong end of the biggest comeback in NFL history last week. Indianapolis forfeited a 33-0 lead at halftime.

The Chargers have a chance to blow out the Colts on Monday night. They have posted the second-highest passing play percentage in the NFL (66.7%) and average 274.2 yards through the air per game (No. 2 in NFL). Minnesota just torched Indianapolis for 460 passing yards and 4 TDs last week. Indy is already one of the worst teams in the league and is even worse without star RB Jonathan Taylor.

Indianapolis came out of nowhere to put up 36 points last week and looked like an entirely different offense. However, it’s important to keep in mind that Minnesota’s defense ranks as one of the worst in the NFL and the Vikings gave the Colts great field position with early turnovers. It was an outlier. That won’t happen this week. The Chargers have only logged 15 giveaways on the year (T-No. 6 in NFL) and have held two great offenses (Dolphins & Titans) to a combined 34 points over the last two weeks. The Colts have scored less than 21 points in a whopping 11 of their 14 games in 2022.

The Colts have lost four of their last five home games and don’t have much left to play for.

Why The Colts Can Cover The Spread

Not only will the Colts have someone different running the ball for them, but they will also have someone different under center. Interim head coach Jeff Saturday announced Wednesday that the Colts would start Nick Foles on Monday instead of Matt Ryan. What the Colts have going for them is Foles having a knack for taking over late in the season and leading his team to wins.

The assumption of rational coaching should call for HC Jeff Saturday to gameplan a run-heavy script for this matchup. The Chargers have been torched by opposing RBs on the ground all year. With Foles making his first start, the Colts will try to slow this game down on the ground and keep the ball out of Justin Herbert’s hands.

The Chargers also tend to play down to their weaker opponents. Indianapolis has shown to play winning teams close this year, and this is a prime spot when everyone has counted them out to cover the spread at home.

Reasons To Bet The Over

The Chargers are suitable for a potential defensive touchdown and some turnovers created, with how well their defense has played recently. A short field or defensive points help speed games up and increase the total points. We saw the Colts defense create these short fields last week, causing turnovers and scoring two D/ST touchdowns.

Reasons To Bet The Under

The Under 45.5 may be the best bet in this game. The Colts have scored less than 21 points in 11 of their 14 games in 2022. The Chargers are averaging just above 22 points scored in their last five games.

The Colts are transitioning to a more ground-based approach under new HC Jeff Saturday. Their contests average one of the fewest combined snaps and present a challenge when targeting points to be scored. This scenario can easily play out in a low-play-volume matchup with the Chargers. As I mentioned earlier, the Chargers often play down to their competition. With the Colts not putting their foot on the gas, look for this game to be relatively low scoring.


Colts running game vs. Chargers interior– Indianapolis wants to run the ball. Although they will be without top running back Jonathan Taylor, that wont stop them from trying to run the football. This game-plan plays into the Chargers weakness on defense. Los Angeles is a bottom-five run defense per PFF. Look for Zach Moss and Deon Jackson to have a productive games on the ground.

Justin Herbert vs. Colts secondary– The Colts defensive backs were shredded last week, surrendering 460 passing yards from Kirk Cousins. Justin Herbert should have all day to throw, with the Colts displaying a bottom-three pass rush per PFF. Herbert has all his weapons healthy for this matchup. Although the Colts struggled in the secondary last week, they check in with a pass defense that grades out in the league’s top half per PFF.


It is not pretty to be betting on this depleted Colts team with nothing to play for. However, we get Indianapolis with more than three points at home. I can’t see Indy playing any worse than they did last week. Give me the Colts at +4 or better. Best of luck betting Chargers vs. Colts odds.

Jeffrey Schreiber Avatar
Written by
Jeffrey Schreiber

Jeffrey Schreiber is a sports betting writer with TheLines and Catena Media. Jeff is recent college graduate with a background in finance and analytics. His goal is to provide readers with data and information behind the "why" to make a bet. His most memorable betting moment came during the divisional round of the 2022 NFL playoffs when he turned $37 in same-game parlay bets into $25,000.

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