NFL Week 16 Odds: Point Spreads, Moneylines And Over Unders For Every Game

Written By Juan Carlos Blanco on December 25, 2022
NFL Week 16 odds

There will be no shortage of pro football throughout a long Christmas weekend as 16 games will be played over five days. Christmas Day will see the Packers +3.5 at the Dolphins -3.5 as well as the Broncos -3 at the Rams +3 and the Bucs -7.5 at the Cardinals +7.5. View live NFL Week 16 odds for all of these games below.

NFL Week 16 odds

View all NFL Week 16 odds below and click on the number you like to bet that price now. Pro football point spreads, moneyline betting odds and over unders are available to wager on.

NFL Week 16 betting lines

Early NFL Week 16 odds have been released, offering bettors a chance to try and exploit some potentially inefficient spreads for the big Christmas weekend slate. Here are some of the key games.

Jaguars +2.5 at Jets

The Jaguars (+2.5) won 19-3 Thursday night in East Rutherford, New Jersey. The game went under the 36.5 total.

Bills at Bears

The Bills authored a spirited comeback against the division-rival Dolphins on Saturday night, topping Miami on a Tyler Bass field goal as time expired and with snow heavily following. The Bears put up a fight against the visiting Eagles before falling to the NFC juggernaut, 25-20.

It certainly wasn’t easy, but Buffalo’s ability to mount a fourth-quarter comeback pushed the Bills to an 11-win tally. Josh Allen and company also have the head-to-head tiebreaker edge over the Chiefs in terms of a No. 1 seed, but with both teams sitting on identical records, the Bills have to continue stacking wins and should therefore be going full throttle against a Bears defense that’s fully attackable through both the ground and air.

Justin Fields almost singlehandedly led the Bears to a win against the Eagles, an opponent that could well be Buffalo’s opponent in Super Bowl LVII and which leaves Chicago battle-tested for this matchup. Nevertheless, Fields could be going into what is already a very unfavorable matchup undermanned in terms of his receiving corps, as Chase Claypool (knee) and Equanimeous St. Brown (concussion) could be sidelined. 

Even with the Soldier Field setting and Chicago’s solid showing Sunday, the Bills are still up to 9-point road favorites when looking at NFL Week 16 odds.

Saints at Browns

The Saints were able to garner their fifth win with a 21-18 victory against the Falcons on Sunday.  The Browns garnered their second win under Deshaun Watson versus the Lamar Jackson-less Ravens, notching a 13-3 home victory Saturday afternoon. 

New Orleans continued rolling with Andy Dalton and an occasional Taysom Hill cameo at quarterback versus the Falcons, and although the Saints almost failed to produce enough points, they managed their fifth win. Nevertheless, the going shapes up as much rougher in this matchup, as the Browns have allowed a stingy 184.7 passing yards per game in the last three and only 9.7 yards per completion at home overall.

Cleveland was actually doing a lot more scoring with Jacoby Brissett under center than Watson, although the latter is naturally still shaking off rust. The matchup against the Saints doesn’t exactly project to do him any favors, however, as New Orleans is giving up just 210.3 passing yards per road game and have allowed 194.7 per contest in the last three specifically. It’s another matter altogether for Nick Chubb and Kareem Hunt on the ground, considering the Saints are allowing 136.1 rushing yards per road game. 

The Browns are narrow, standard 3-point home favorites as the week begins.

Texans at Titans

The Texans gave a superior opponent plenty of trouble for the second straight week before falling to the Chiefs in overtime on Sunday, 30-24. The Titans gave the Chargers a fight out west as well but ultimately fell by a narrow 17-14 margin.

Houston continued rolling with a two-quarterback system versus the Chiefs, although Davis Mills put up 20 more pass attempts than Jeff Driskel and should continue to serve as the primary option at the position. The Texans would be in position to benefit substantially if both Brandin Cooks (calf) and Nico Collins (foot) could make it back for this game, as the Titans have allowed the second-most receptions, third-most receiving yards and second-most receiving touchdowns to wide receivers.

Tennessee’s loss Sunday was the team’s fourth straight and dropped the Titans to 7-7, further endangering their postseason hopes. Ryan Tannehill also suffered an injury scare early in the game when his ankle was rolled on, and although he returned to finish the game, head coach Mike Vrabel noted Monday that his veteran quarterback could conceivably sit this matchup out. Malik Willis has looked anything but NFL-ready during his time on the field as a rookie, so a subsequent confirmed Tannehill absence could certainly narrow the line for this game.

Despite Houston’s recent spirited play and the quarterback question, Tennessee is still a touchdown home favorite on NFL Week 16 odds.

Seahawks at Chiefs

The Seahawks ran into the elite 49ers defense on Thursday night to open the Week 15 slate and ultimately suffered a 21-13 loss. The Chiefs got more than they bargained for against the Texans on the road, but they secured a 30-24 overtime win and their seventh straight AFC West title in the process. 

The Seahawks are coming back to earth after their odds-defying start to the season, as they’ve now lost four of five games. To make matters worse, Tyler Lockett is slated to miss time with a finger injury, which will leave Marquise Goodwin to step into a starting role alongside DK Metcalf. Being minus Lockett is even less ideal than usual against Patrick Mahomes and his high-powered attack, who’s enjoying one of the best seasons of his career despite the offseason loss to Tyreek Hill.

The Chiefs are going to have favorable matchups across the board versus a Seahawks defense that’s starting to spring leaks against both the run and pass. Jerick McKinnon has developed into an effective weapon through both means for KC, recording a pair of touchdowns for the second straight game Sunday, including the game-winning score. Mahomes could also have Mecole Hardman back from injured reserve for this contest, giving him a full arsenal of weaponry now that Kadarius Toney is also back. 

The Chiefs are unsurprisingly 9.5-point home favorites in Week 16 NFL odds as they continue to try and garner the top seed in the AFC.

New York Giants at Minnesota Vikings

The Giants escaped with a 20-12 road win against the Commanders on Sunday night to keep themselves in the thick of the NFC wild-card picture. The Vikings authored the biggest comeback in NFL history on Saturday afternoon, overcoming a 33-point second-half deficit to escape with a 39-36 win.

The Giants once again leaned heavily on the running game and defense for their key divisional win, a formula that’s been the key to Big Blue’s surprising eight-victory tally. However, that formula may need a bit of tweaking for this matchup, considering the Vikings’ high-powered offense and the fact Minnesota has generally been easier to attack through the air. 

The Vikings’ wild comeback pushed them to 11 wins, and the team’s potent offense could be set up for success through both ground and air in this matchup. The Giants have been attackable on the ground all season (150.4 RYPG allowed), meaning Dalvin Cook could be in position to thrive. However, with talented cornerback Adoree’ Jackson out due to a knee injury in recent weeks, New York has been more susceptible to the pass and is allowing 243.7 passing yards per road game compared to just 196.9 per home contest.

Despite Minnesota’s ability to seemingly overcome any deficit, the Vikes are just 3.5-point home favorites, given their propensity for very close games.

Bengals at Patriots

The Bengals started very slow but eventually picked up steam on Sunday in Tampa, ultimately handing the Buccaneers their eighth loss, 34-23. The Patriots lost in about the most dumbfounding way possible to the Raiders, with Chandler Jones picking off a Jakobi Meyers pass attempt during a lateral-fest at the end of regulation and running it back for a game-winning Raiders touchdown.    

Joe Burrow threw for only 200 yards, his lowest figure since Week 2, but also tossed four touchdown passes with his full arsenal of receivers available to him. Cincy is now 10-4, including an impressive 5-3 on the road. The Bengals have now won six straight games, even though half those victories have come by single digits. The Pats shape up as a daunting matchup at home, however, where they’ve held teams to an NFL-low 279.2 total yards per contest. 

Mac Jones threw for only 112 yards on 13 for 31 passing in Sunday’s loss, possibly calling into question his job security yet again. The Pats have now lost three of the last four contests, and although they seem to be able to count on their diverse running game, the air attack could once again find some rough sledding versus a Bengals defense that’s snagged 10 interceptions and just a 60.0 percent completion rate overall.

With the defending AFC champs enjoying plenty of momentum, the Bengals are unsurprisingly 3.5-point road favorites. 

Lions at Panthers

The Lions’ Cinderella run continued in New York on Sunday, with Detroit squeezing out a 20-17 victory over the Jets to move to 7-7. The Panthers couldn’t keep up their recent success, taking a 24-16 loss to the Steelers at home. 

Jared Goff continued playing mistake-free football Sunday, extending his games without an interception to six. The veteran signal-caller’s leadership and command of the offense has been key to his squad’s success, but the going could be more palatable for the D’Andre Swift-Jamaal Williams backfield considering Carolina is allowing 130.9 rushing yards per home game. 

Sam Darnold didn’t perform poorly by any stretch against Pittsburgh, throwing for a season-high 225 yards and one touchdown. However, Carolina’s running game was completely shut down, and it now faces another stiff test against a Lions run defense that’s suddenly become elite against the run by allowing an NFL-low 55.7 rushing yards per contest in the last three. 

The Lions check in as 2.5-point road favorites when looking at NFL Week 16 odds. 

Falcons at Ravens

The Falcons played tough during Desmond Ridder’s first NFL start, but they still fell to the Saints, 21-18. The Ravens were forced to start Tyler Huntley again on Saturday afternoon versus the Browns, leading to an uninspired 13-3 loss to fall to 9-5.

Ridder only completed 50 percent of his passes and threw for just 97 yards while rushing for another 38 yards. The rookie did shower plenty of attention on fellow first-year pro Drake London, and the duo will likely be busy again in this matchup considering the Ravens’ defense has been easier to attack through the air. However, the overall matchup still lines up as extremely daunting, as Baltimore has tallied 14 interceptions and recorded 41 sacks.

Lamar Jackson could be back in action for this contest after missing the last two games with a PCL injury, although that won’t likely be confirmed one way or the other until late in the week. The passing game was virtually non-existent versus Cleveland, but JK Dobbins continued to offer encouraging results with 125 rushing yards on 13 carries. The matchup lines up well all the way around for the Ravens’ offense, as Atlanta is allowing 387 total yards per road game.

Facing a rookie quarterback, the Ravens are unsurprisingly touchdown home favorites, even with the uncertainty regarding Jackson’s status, with the number set to climb if he’s eventually confirmed as available. 

Commanders at 49ers

The Commanders took a tough home loss to the Giants on Sunday night, falling by a 20-12 score. The 49ers handled the Seahawks by a 21-13 score to open the Week 15 slate Thursday night, a game that featured another impressive performance by rookie Brock Purdy. 

Taylor Heinicke put together a solid 249-yard effort Sunday night, but Washington’s meager 12-point tally could be a foreboding sign. The matchup versus the 49ers defense shapes up as exponentially more daunting than that versus the Giants – San Francisco has racked up 13 interceptions and 39 sacks, and the Niners are surrendering an NFL-low 286.1 total yards per game.

Purdy has now completed 69.0 percent of his passes and generated a 6:1 TD:INT over his first three games, and the rookie has mostly looked as unflappable as those numbers would indicate. Naturally, the presence of the likes of Christian McCaffrey and George Kittle certainly has helped, and those two figure to continue enjoying a heavy workload in this contest with Deebo Samuel (knee) still sidelined.

The Niners, which also enjoy a notable rest advantage in this spot, are unsurprisingly comfortable touchdown home favorites when looking at NFL Week 16 odds.

Eagles at Cowboys

The Eagles moved to 13-1 with a hard-fought 25-20 win over the Bears at Soldier Field, but Monday brought the news that the shoulder injury Jalen Hurts sustained on a hit in the second half could keep him out of this divisional showdown. The Cowboys had some adversity to deal with as well, as they blew a big lead versus the Jaguars and ultimately fell in overtime, 40-34.

If Hurts does indeed sit out, it goes without saying there will be a major downgrade for the entirety of the Eagles offense. However, it bears noting backup Gardner Minshew has plenty of experience from his first two seasons in Jacksonville and is a highly mobile player himself, so the gameplan may not change dramatically against a Cowboys defense looking for some redemption after being exposed in the second half versus Jacksonville. 

The Cowboys offense looked to be hitting on all cylinders for a half-plus against the Jaguars, but the defense gave up 33 second-half points. The matchup lines up as much more difficult for Dak Prescott ad company this week, however, as the Eagles have been even better than the Cowboys at getting pressure on the quarterback and picking off passes, recording an NFL-high 55 sacks and 15 interceptions. The path of least resistance could well be on the ground, where the Tony Pollard-Ezekiel Elliott duo will face a Philly defense surrendering 134.1 rushing yards per road contest.

With the Hurts news breaking Monday, the line quickly moved to Cowboys -6 across the board, with more movement naturally a possibility depending on the news the rest of the week.

Raiders at Steelers

The Raiders pulled off a miracle 30-24 win over the Patriots on a Chandler Jones miracle interception of a Jakobi Meyers heave during a series of laterals at the end of regulation. The Steelers were able to put together a strong performance on either side of the ball in a 24-16 road victory over the Panthers to move to 6-8 and remain on the outside fringes of the AFC wild-card picture. 

Derek Carr was able to throw for 231 yards and three touchdowns despite Davante Adams being shut down to the tune of four catches for 28 yards. The return of Hunter Renfrow and Darren Waller from injured reserve helped open up the passing game overall, and the Raiders are in an even better position in this game with Pittsburgh allowing 238.8 passing yards per game and a co-NFL-high 11.8 yards per completion. 

On the other side, it remains to be seen if Kenny Pickett will receive clearance to return from his concussion for this game. However, if Mitch Trubisky is forced to step in again, the Steelers’ passing game should still be in good shape. The veteran signal-caller completed over 70 percent of his passes for the third time this season and didn’t turn the ball over, and he has help from a developing Najee Harris-Jaylen Warren 1-2 punch. The entire cast faces a Raiders team that’s allowed 353.5 total yards per game.

Despite Las Vegas’ recent surge, the Steelers are up to 3-point home favorites when looking at NFL Week 16 odds.

Packers at Dolphins

The Packers take the field Monday night against the Rams coming off a Week 14 bye and looking to build on the momentum Aaron Rodgers had built up with dynamic rookie Christian Watson leading into the week off. The Dolphins suffered a heartbreaking defeat at the hands of the Bills on Saturday night on a last-second field goal, essentially sinking their chances of catching Buffalo for the AFC East crown. 

Green Bay will have a healthy receiving corps for the first time in a long time Monday night, and it remains to be seen if that will have a sizable impact in the cohesiveness of their offense. The Pack released veteran Sammy Watkins earlier Monday in an apparent statement about the confidence they have in their now-intact pass-catching arsenal, and that side of the ball could have a chance for some success against an inconsistent Dolphins pass defense. 

Miami’s collapse notwithstanding, Tua Tagovailoa did look better versus Buffalo than in his disastrous outing against the Chargers the prior Sunday night. Jeff Wilson missed the game against the Bills with a hip injury, but head coach Mike McDaniel said Monday his veteran back was close to suiting up. If both he and Raheem Mostert are available, they could certainly help keep Green Bay’s defense honest by ripping off some big gains, considering the Pack is allowing 154.9 rush yards per road game.

The Dolphins are anywhere from 5.5- to 6.5-point home favorites ahead of Green Bay’s MNF contest.

Broncos at Rams

The Broncos hosted the Cardinals without Russell Wilson (concussion) in Week 15 and were able to pull off a 24-15 win. The Rams take the field Monday night against the Packers at Lambeau following a wild 17-16 comeback in win Baker Mayfield’s team debut on Thursday night to open Week 14. 

Wilson had already cleared concussion protocol ahead of Sunday’s game, so he should be ready to return for this contest. It was ironic that Denver finally snapped its losing streak with Brett Rypien under center, but if Wilson can get Courtland Sutton and Kendall Hinton back from their respective hamstring injuries for this contest, the Broncos should have a fighting chance against a Rams defense that’s struggled at times against the pass. 

How Mayfield looks Monday night with some time with the Rams playbook now under his belt. While the passing game looked lackluster most of the game against the Raiders, the late chemistry Mayfield displayed with Ben Skowronek, Tutu Atwell and Van Jefferson late certainly offers some reason for optimism. Nevertheless, this matchup, like the one Mayfield will encounter Monday night, lends itself much more toward attacking on the ground. 

The Rams are 1-to-1.5-point home favorites ahead of their Monday night clash, but if Wilson is announced as available, this number could well narrow to a Pick ‘Em or perhaps even see Denver as a slim road favorite.

Buccaneers at Cardinals

The Buccaneers’ struggles to put together a complete offensive performance continued in Week 15, with Tom Brady and company looking very strong in the first half before fading and suffering a 34-23 loss to the Bengals. The Cardinals played their first full game without Kyler Murray (knee) and put together a lackluster performance in a 24-15 road loss to the Broncos. 

Brady finished with 312 yards and three touchdowns against Cincy, but he also threw a pair of interceptions and had a fumbled exchange with Leonard Fournette. However, if Brady and his pass catchers can take the good and leave the bad behind in Florida, they’ll have a chance at success against a Cardinals defense that’s allowed 280 passing yards per home game, the second-highest figure in the league. 

The Cardinals’ passing game can succeed under veteran backup Colt McCoy as he’s proven previously, but keeping him protected against a Bucs defense that focuses heavily on disrupting the pocket will be pivotal. McCoy will first have to clear concussion protocol, as he exited Sunday’s game and gave way to Trace McSorley. McSorley threw a pair of interceptions against Denver, and with the Bucs having limited Joe Burrow to 200 yards on Sunday and now having their top safety duo of Antoine Winfield and Mike Edwards back from injury, this could be a daunting matchup for whoever is under center.

Despite the homefield setting for Arizona, they’re 4.5-to-5.5-point home underdogs. 

Chargers at Colts

The Chargers toughed out a surprisingly low-scoring win at home over the Titans in Week 15 by a 17-14 score. The Colts suffered the biggest collapse in NFL history on Saturday afternoon in Minnesota, blowing a 33-point lead to fall, 39-36. 

The Chargers essentially had a fully healthy offense at their disposal Sunday but still struggled to put up points. The Colts defense could actually serve as a softer matchup than the Titans did, however, depending on whether the first-half or second-half version of the unit shows up. Indy allowed over 400 passing yards to Kirk Cousins in the wild loss on Saturday and has also given up 139.5 rushing yards per home contest. Moreover, the Colts have yielded the sixth-most receptions to running backs (79), which certainly could spell success for Austin Ekeler. 

On the other side, Matt Ryan threw for only 182 yards against the Vikings’ suspect secondary along with taking another three sacks and committing another fumble. Now, Ryan has the further challenge of having to likely play the rest of the season without Jonathan Taylor, who suffered a high ankle sprain in the first quarter of the contest and may be sidelined the rest of ’22. Deon Jackson and Zack Moss do look like a capable fill-in duo, and if they’re indeed helming the ground game in this matchup, they’ll face a Chargers defense allowing an AFC-high 161.4 rushing yards per road game. 

The Chargers are up to 4-point road favorites when looking at NFL Week 16 odds.

How point spreads are changing

Here is a look at how NFL Week 16 odds are changing in the days leading up to kickoff of each game.

DateNFL Week 16 Odds: December 19 spreadsNFL Week 16 Odds: December 20 spreads
Thursday, December 22Jaguars +1 at Jets -1Jaguars +1 at Jets -1
Saturday, December 24Bills -8.5 at Bears +8.5Bills -9 at Bears +9
Saturday, December 24Bengals -3.5 at Patriots +3.5Bengals -3.5 at Patriots +3.5
Saturday, December 24Seahawks +9.5 at Chiefs -9.5Seahawks +9.5 at Chiefs -9.5
Saturday, December 24Lions -3 at Panthers +3Lions -3 at Panthers +3
Saturday, December 24Texans +7 at Titans -7Texans +5 at Titans -5
Saturday, December 24Saints +3 at Browns -3Saints +3 at Browns -3
Saturday, December 24Giants +3.5 at Vikings -3.5Giants +3.5 at Vikings -3.5
Saturday, December 24Falcons +7 at Ravens -7Falcons +7.5 at Ravens -7.5
Saturday, December 24Commanders +7 at 49ers -7Commanders +7 at 49ers -7
Saturday, December 24Eagles +2 at Cowboys -2Eagles +5 at Cowboys -5
Saturday, December 24Raiders +3 at Steelers -3Raiders +3 at Steelers -3
Sunday, December 25Packers +4 at Dolphins -4Packers +4 at Dolphins -4
Sunday, December 25Broncos -1.5 at Rams +1.5Broncos -2 at Rams +2
Sunday, December 25Buccaneers -4.5 at Cardinals +4.5Buccaneers -6.5 at Cardinals +6.5
Monday, December 26Chargers -3.5 at Colts +3.5Chargers -4 at Colts +4

And here are what the point spreads for this week of football action initially looked like.

NFL Week 16 Odds: SpreadsNFL Week 16 Odds: MoneylinesNFL Week 16 Odds: Totals
Jaguars +2.5 at Jets -2.5Jaguars +110 at Jets -13042
Bills -10 at Bears +10Bills -475 at Bears +38045.5
Bengals -3 at Patriots +3Bengals -155 at Patriots +13542
Texans +8.5 at Titans -8.5Texans +340 at Titans -42541
Seahawks +9.5 at Chiefs -9.5Seahawks +380 at Chiefs -47548.5
Falcons +6.5 at Ravens -6.5Falcons +250 at Ravens -30041
Lions -2.5 at Panthers +2.5Lions -135 at Panthers +11544.5
Saints +3 at Browns -3Saints +140 at Browns -16539
Giants +4.5 at Vikings -4.5Giants +180 at Vikings -21047
Commanders +6.5 at 49ers -6.5 Commanders +250 at 49ers -30041.5
Eagles +1 at Cowboys -1Eagles -105 at Cowboys -11550.5
Raiders +1 at Steelers -1Raiders -105 at Steelers -11541.5
Packers +4 at Dolphins -4Packers +165 at Dolphins -19546.5
Broncos at Rams PKBroncos -110 at Rams -11035.5
Buccaneers -3 at Cardinals +3Buccaneers -165 at Cardinals +14042
Chargers -2.5 at Colts +2.5Chargers -150 at Colts +13047.5
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Written by
Juan Carlos Blanco

Juan Carlos Blanco has served as a freelance writer for a wide variety of online publications and websites, with an intensive focus on fantasy sports. Juan has provided analysis and comprehensive coverage of the MLB, NBA, NFL, CFL, AAF and AFL while also reporting on news and developments in the daily fantasy sports and online gaming industries.

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