NFL Week 16 Odds: Pro Football Point Spreads, Moneylines, Over Unders

Written By Juan Carlos Blanco on December 26, 2021
NFL Week 16 odds lines spreads over under

There was pro football played on Christmas Day for the second straight year as the NFL had two holiday games with the Packers edging the Browns and the Colts toppling the Cardinals. Other key games this holiday weekend while looking at NFL Week 16 odds include Bills versus Patriots, Rams versus Vikings, Ravens versus Bengals and Steelers versus Chiefs.

Below are NFL Week 16 odds that are available to bet on now.

NFL Week 16 odds

Here are NFL Week 16 odds from top online sportsbooks. Check out the point spread, moneyline and game total for each contest and click to bet.

Thursday, December 23

San Francisco 49ers at Tennessee Titans – 8:20 p.m. ET

The 49ers won their second in a row and moved to 8-6 in the process with an impressive 31-13 home victory over the Falcons on Sunday. The Titans started off in strong fashion themselves before progressively allowing their Week 15 contest to slip away and ultimately fell to the Steelers by a 19-13 score.

San Francisco got it done without RB Elijah Mitchell again Sunday since the rookie running back was still dealing with a concussion and knee injury. Jeff Wilson impressively stepped up with over 100 yards and Jimmy Garoppolo, George Kittle and Deebo Samuel continued to prove quite the productive trio. The entire pass-catching corps should be in good shape versus a Tennessee squad that’s allowed the most receptions and receiving yards to wideouts in the league, and a return to action by Mitchell would also give the Niners an imposing 1-2 punch, although the Titans do allow an NFL-low 79.9 rushing yards per home game.

The Titans lost Julio Jones to his troublesome hamstring yet again Sunday, with his return timeline unknown at the moment. On the brighter side, A.J. Brown was designated to return from injured reserve Monday. D’Onta Foreman continues to do a very good Derrick Henry Lite impression, as he surpassed 100 yards for the second time in three games Sunday. The Niners don’t present as a bad matchup, allowing 117.6 rushing yards per road contest.

With the 49ers coming on strong, the look-ahead line of Titans -1 notably flipped all the way to 49ers -3.5 early in the week.

Saturday, December 25

Cleveland Browns at Green Bay Packers – 4:30 p.m. ET

Nick Mullens was competent Monday as he filled in for Baker Mayfield (COVID), but the Browns ultimately were unable to put up enough points to put away the Raiders as Las Vegas won, 16-14. The Packers, meanwhile, went into Baltimore on Sunday and came away with a thrilling 31-30 win against a Tyler Huntley-led Ravens squad.

Naturally, there will be a ton of personnel-related questions surrounding Cleveland on what will now be a short week. Both Baker Mayfield and Case Keenum, along with Jarvis Landry, Kareem Hunt and Austin Hooper, were among the players that failed to clear protocols for Week 15 despite the two extra days afforded by the rescheduling. Naturally, if Cleveland is forced to go into Lambeau Field for a late-December game with a short-handed offensive crew that includes Mullens under center, the task will be that much tougher than it already would be.

The Packers became the second team to nip the Ravens this season on a late failed two-point conversion attempt by Baltimore. Green Bay continued to deploy an effective timeshare between Aaron Jones and A.J. Dillon on Sunday, while Aaron Rodgers navigated his perpetually troublesome toe to throw for three touchdowns. Cleveland’s defense has been a much poorer unit on the road – they’re allowing 374.7 total yards per away contest, compared to 275.4 per home game going into Monday afternoon – seemingly setting Rodgers and company up well.

Indianapolis Colts at Arizona Cardinals – 8:15 p.m. ET

The Colts notched a massive victory with respect to their postseason prospects in Week 15, knocking off the Patriots by a 27-17 score Saturday night. In contrast, the Cardinals suffered the biggest upset of the week by far, dropping a 30-12 decision to the Detroit Lions on the road.

Indianapolis was somewhat of a surprise, rising favorite coming into the contest and more than delivered on that designation with a performance that took a page right out of New England’s Week 14 win against the Bills. Frank Reich didn’t quite have Carson Wentz put the ball up a meager three times a la Mac Jones versus Buffalo, but he wasn’t too far off – Indy attempted just 12 passes and instead let Jonathan Taylor do his thing to the tune of 170 rushing yards and a touchdown on 29 carries. The defense also picked off a pair of Jones passes, and if Reich wants to lean on that side of the ball and the ground attack again in this matchup, he may have an edge – Arizona has allowed 129.5 rushing yards per game at home and also appeared to struggle with any type of continuity in the absence of DeAndre Hopkins (knee).

On that subject, Kyler Murray got his true first taste of playing without Hopkins since he’d missed the same three games his star wideout had earlier this season, and the results weren’t pretty. The third-year signal-caller completed a season-low 56.1 percent of his passes and generally appeared out of synch throughout most of the contest. Chase Edmonds did return from injured reserve and worked off some rust with six rushes for 53 yards, and perhaps he’ll begin to take on a bigger role in the short passing game to help make up for Hopkins’ absence.

Following Week 15 outcomes, the Cardinals’ original projected advantage of four points has unsurprisingly already been sliced in half.

Sunday, Dec. 26

Detroit Lions at Atlanta Falcons – 1 p.m. ET

The Lions continued their unlikely late-season “surge” Sunday, knocking off the visiting Cardinals by a 30-12 score for their second victory in three games. The Falcons head out west and were given a rude welcome by the 49ers in the form of a 31-13 throttling that represented a notable setback to their thin postseason hopes.

The good cheer brought about by Detroit’s impressive win Sunday was dampened somewhat by the news Monday that Jared Goff went into COVID-19 protocols. The new, more flexible COVID-19 criteria recently agreed up on between the league and the player’s association may allow Goff to suit up for this contest, which would certainly be an advantage considering the momentum he looks to be building with both rookie Amon-Ra St. Brown and former Rams teammate Josh Reynolds. Then, Detroit seems to be building quite the deep ground attack as well – with D’Andre Swift (shoulder) and Jamaal Williams (COVID-19 protocols) both out again Sunday, rookie Craig Reynolds once again excelled with 112 rushing yards on 26 carries.

Week 15 was a case of Groundhog Day for the Falcons offense, which continues to struggle without Calvin Ridley (personal). Russell Gage continues to do his best to carry the pass-catching corps and Kyle Pitts (77 rec yards Sunday) flashes occasionally, but Atlanta could potentially be challenged against a Detroit defense that played an excellent game in Week 15.

The public has shown faith in Detroit following Sunday’s outcomes, cutting the original look-ahead line of Falcons -6 by over a point as a result.

Baltimore Ravens at Cincinnati Bengals – 1 p.m. ET

The Ravens failed to send a game into overtime by a single point courtesy of a failed two-point conversion for the second time in three games, as Baltimore dropped a 31-30 decision to the Packers in a game during which Tyler Huntley filled in for Lamar Jackson (ankle). The Bengals went into the difficult road environment of Denver’s Empower Field and escaped with a 15-10 win.

The most prominent question surrounding the Ravens this week will naturally be that of Jackson’s health. The star QB reportedly wasn’t truly close to be able to play Sunday, so it remains to be seen how much progress he’ll be able to make in the coming week for what is now a critical division showdown. Huntley certainly demonstrated once again that he’s capable of putting on a pretty convincing and effective Jackson impression, and Baltimore will draw a favorable matchup on paper versus a Cincy defense that’s been much more generous at home (370.0 yards per game allowed) than on the road (321.4).

The Bengals tied the Ravens atop the AFC North with Sunday’s win over Denver, one in which they didn’t look particularly impressive but got the job done. The fact Teddy Bridgewater was forced from the game early may have helped the Bengals defense, which needed a break considering the offense was only able to muster 15 points. Ja’Marr Chase was notably held to just one catch on three yards, and the Joe Burrow-led passing game will presumably need to muster a good bit more than the 157 yards the second-year quarterback threw for Sunday to prevail in this contest.

Despite Baltimore’s narrow loss and Cincinnati’s narrow win Sunday, the look-ahead line of Bengals -2.5 remains unchanged as the week begins.

LA Rams at Minnesota Vikings – 1 p.m. ET

The Rams will play their Week 15 game Tuesday evening against the Seahawks, a contest rescheduled Sunday afternoon thanks to COVID-19 issues on Los Angeles. The Vikings also had an early week contest as they dismissed the Bears, 17-9, Monday night.

The Rams may be back to full strength in terms of their COVID absences by the time this game rolls around. Odell Beckham and Darrell Henderson were already cleared Sunday, leaving Tyler Higbee as the only skill-position player still in protocols ahead of their Tuesday game. Given the Cardinals’ loss to the Lions on Sunday, a win by L.A. in Week 15 will see them head into this contest against Minnesota tied atop the NFC West standings at 10-4.

Buffalo Bills at New England Patriots – 1 p.m. ET

The Bills got back into the win column after two straight losses and a 1-3 stretch overall, toppling the Panthers in Week 15 by a 31-14 score. The Patriots went into Indianapolis on Saturday night and came out worse for wear, falling to Indy by a 27-17 margin.

Buffalo still doesn’t look all the way right on offense, but they were able to get the job done against a Panthers defense that had been particularly effective against the pass. Josh Allen threw for just 210 yards but did post an impressive 3:1 TD:INT, and the offense should some versatility with Devin Singletary compiling 86 rushing yards and a touchdown and Gabriel Davis contributing 85 receiving yards and a pair of scores through the air. The challenge shapes up a lot tougher for this rematch, considering New England limited Allen to 145 passing yards and a 50.0 percent completion rate in Week 13.

The Patriots will certainly have Mac Jones put the ball up more than the three times he famously did in the Week 13 win in Buffalo, and the matchup against Buffalo’s secondary isn’t quite as daunting as when they faced them in Orchard Park. The Bills are allowing nearly 100 yards more per game passing on the road (223.6) than at home (127.6). New England will also hope to have Damien Harris back for this contest after he missed Week 15 with a knee injury.

The Patriots’ original line of -2 has grown slightly despite Week 15 outcomes, with this being one of the most interesting lines to monitor throughout the week.

Jacksonville Jaguars at New York Jets – 1 p.m. ET

The Jaguars opened the Darrell Bevell Era in the same way that defined that of Urban Meyer’s – with a losing effort. Jacksonville blew what was arguably a winnable matchup at home against the Texans, 30-16. The Jets went down to South Florida and played competitively before falling, 31-24.

Trevor Lawrence still struggled to get the ball consistently downfield Sunday, but there was one marked improvement from the last few games of the Meyer regime – James Robinson was back to handling a true lead-back workload. The impressive second-year pro logged a total of 21 touches and could be set for even more work in this matchup, considering the Jets just allowed a 100-yard game to a career change-of-pace back in Duke Johnson.

New York’s Zach Wilson is having his own rookie struggles, with Sunday marking his third straight game with a drop in passing yardage from the prior week. The Jets’ offense is about as dynamic as Jacksonville’s own pedestrian attack, but there his hope rookie back Michael Carter will be more explosive in this game after knocking off some rust Sunday with nine touches following a stay on IR.

Despite both teams taking Week 15 losses, the Jets’ projected look-ahead line of -1 was up to -2.5 as the week began.

New York Giants at Philadelphia Eagles – 1 p.m. ET

The Giants continued their late-season spiral in Week 15 with a loss once again marked by a hapless offense, falling to the Cowboys by a 21-6 score. The Eagles are one of the teams impacted by the Week 15 COVID outbreak, but primarily due to the issues being experienced by their opponent, the Washington Football Team. Philly will face Ron Rivera’s squad on Tuesday evening, leaving them with a particularly short week ahead of this matchup.

The Giants were forced to shut down Daniel Jones on Monday with the neck injury he’d suffered back in Week 12 and that had already caused a three-game absence. That only darkens their already bleak outlook, as it appears it will have to be either Mike Glennon or Jake Fromm the rest of the way for New York. Coach Joe Judge already signaled Monday he’s open to giving Fromm at least one turn as the starter, and realistically, there’s nothing to lose by doing so considering Glennon’s own ineffectiveness and the Giants’ lack of postseason hope.

The Eagles will get Jalen Hurts back from his ankle injury Tuesday, which will set him up for a second start in five days in this matchup. However, it’s worth noting the G-Men gave the second-year quarterback plenty of trouble in the first meeting in Week 12, allowing him just a 45.2 percent completion rate and 129 yards while picking him off three times.

Ahead of Philly’s Tuesday game but following the Giant’s poor Week 15 showing versus Dallas, the lookahead line of Eagles -8.5 has now hit double digits.

Tampa Bay Buccaneers at Carolina Panthers – 1 p.m. ET

The Buccaneers not only slogged through a 9-0 loss to the Saints at home in primetime on Sunday night, but they also learned Monday that they’d lost Chris Godwin for the rest of the season/postseason with an ACL tear. The Panthers didn’t exactly have a pleasant Week 15 experience themselves, dropping a 31-14 decision to the Bills on the road.

It will undoubtedly be an interesting week in Tampa Bay. Mike Evans and Leonard Fournette also suffered hamstring injuries Sunday night, and each will therefore be very questionable for this divisional matchup. Meanwhile, Antonio Brown is slated to come off his three-game suspension for misleading the team about his vaccination status, and the ankle that was previously giving him trouble should be healed at this point. However, Godwin’s injury and the potential absence of Evans flips Brown from luxury depth to absolute necessity at this point in the season.

Of course, Carolina has its own problems. The Panthers are now 5-9 after losing their fourth straight Sunday, and it’s fair to wonder if head coach Matt Rhule’s tenure might be in its final games. Cam Newton isn’t exactly looking too sharp under center, either, as he’s yet to throw for over 200 yards in any of his first four starts and has four interceptions over that span as well. Tampa Bay’s secondary has some injury concerns, but Newton hasn’t shown an ability to capitalize yet.

The line movement thus far is interesting, as the public still believes in the Bucs, at least against the Panthers – the defending champs’ look-ahead line of -11 has shot up all the way to the two-touchdown mark despite the latest developments Monday with Godwin.

LA Chargers at Houston Texans – 1 p.m. ET

The Chargers opened the Week 15 slate with a tough loss to the Chiefs at Arrowhead Stadium, blowing a 14-10 halftime lead to eventually lose 34-28, in overtime. The Texans notched a rare victory, going on the road to Jacksonville and knocking off the Jags by a 30-16 score.

There was plenty of murkiness surrounding Austin Ekeler on Monday, as at first it was reported he’d head to the reserve/COVID-19 list, only for the day’s transactions not to include such a move. The running back wasn’t at Monday’s practice for L.A., whoever, so there could certainly be truth to the rumor. The Bolts can’t afford to dwell on it too much, however, considering they’re right in the thick of the postseason chase at 8-6. Justin Jackson would fill in for Ekeler if need me and makes for a more than serviceable replacement, averaging 4.9 yards per carry over the last three games while scoring a rushing TD in each.

Head coach David Culley seems to have made the right move with young quarterback Davis Mills, as the rookie is gaining plenty of valuable experience and even tasting some success, as was the case Sunday. Mills has shown great chemistry with Brandin Cooks in particular, but the pair faces a tough matchup on paper Week 16. The Chargers have allowed just 221.8 passing yards per contest, although they’ve curiously been a lot more generous at home (251.4 PYPG allowed).

Despite Houston emerging with a Week 15 win and serving as the hosts for this game, the public remains unswayed. The Chargers are still double-digit favorites as the week starts.

Chicago Bears at Seattle Seahawks – 4:05 p.m. ET

The Bears were again unable to put up enough points to earn a victory as they fell at home, 17-9, to the Vikings Monday night. The Seahawks will tangle with the Rams on Tuesday evening in an NFC West tilt that was rescheduled from Sunday afternoon primarily due to Los Angeles’ COVID issues.

Chicago will hope to have a much healthier secondary by the time this game rolls around, as the Bears were forced to play without any of their four starters Monday night due to COVID-19 protocols. Allen Robinson should also have a chance to be cleared ahead of this game, and the entire Chicago offense will enjoy a favorable matchup against Seattle’s shaky defense.

On the Seahawks’ side, there are a couple of prominent names, Alex Collins and Tyler Lockett, currently sidelined that Seattle could get back by the time this game kicks off. In fact, neither player is yet officially ruled out for Tuesday’s game against the Rams, although they’re pretty close against the deadline at this point. Chicago’s defense has been hit hard by conventional injuries throughout the season as well, so this could ultimately prove a relatively high-scoring contest.

Despite each team’s poor records, the Seahawks were comfortable touchdown favorites prior each of their Week 15 contests.

Pittsburgh Steelers at Kansas City Chiefs – 4:25 p.m. ET

The Steelers persevered against the Titans on Sunday, clawing back from yet another early deficit to squeeze out a 19-13 win. The Chiefs got a much-needed resurgent offensive effort in a 34-28 overtime victory against the Chargers to open up the Week 15 slate, Kansas City’s seventh straight win. However,

Pittsburgh’s offense continued to mostly be stuck in neutral Sunday, with even Diontae Johnson, the team’s most consistent skill-position player, seeing a downturn. The Chiefs defense could prove to be a thorny matchup as well, as KC has mostly improved on that side of the ball as the season has gone on.

The matchup for Patrick Mahomes and teammates actually sets up better on the ground than through the air, so Andy Reid may opt to take more of a balanced approach than usual with his offense. Pittsburgh allowed yet another 100-yard rushing performance Sunday to D’Onta Foreman on Sunday, leaving Clyde Edwards-Helaire and Darrel Williams to potentially thrive. Meanwhile, Travis Kelce hit the reserve/COVID-19 list Monday, but as a vaccinated player, he could certainly have a chance to return in time for this game.

Even with both teams notching Week 15 wins, the line has grown from the original Chiefs -9.5 figures.

Denver Broncos at Las Vegas Raiders – 4:25 p.m. ET

The Broncos lost a key hard-fought battle at home in Week 15, dropping a 15-10 decision to the Cincinnati Bengals in a game that Teddy Bridgewater left in an ambulance from due to a concussion that’s already projected to keep him out of this contest as well. The Raiders faced an extremely short-handed Browns offense on Monday afternoon and came close to losing anyhow, escaping with a 16-14 win on a last-second Daniel Carlson field goal.

Drew Lock looked shaky in relief of Bridgewater on Sunday, completing just six of 12 passes for 88 yards and a touchdown while also losing a fumble. Denver will undoubtedly lean likely even heavier on their backfield duo of Melvin Gordon and Javonte Williams with Bridgewater out for such a critical division game. Denver and Las Vegas are both 7-7 coming in, with the Raiders holding the head-to-head edge courtesy of a 34-24 win back in Week 6.

The Raiders got the win Monday and that’s of overriding importance, but Las Vegas has to be concerned about its offense at this point. It’s hasn’t quite been the same since Henry Ruggs was released, and the Raiders are just 2-5 over their last seven. Denver’s defense has played particularly well in the secondary, and if Derek Carr is still down Darren Waller (knee) for this game, it will make his task that much harder.

Denver was a slim road favorite as the week began, but this is certainly a line subject to change as kickoff draws closer.

Washington Football Team at Dallas Cowboys – 8:20 p.m. ET

Washington heads into a rescheduled Tuesday night game against the Eagles to close out Week 15 with Taylor Heinicke and Kyle Allen both on the COVID-19 list, leaving open the possibility at least one is unavailable for this contest as well. The Cowboys moved to 10-4 on Sunday with a 21-6 win over the Giants that wasn’t particularly notable but was more than enough to further solidify Dallas’ postseason chances.

The Cowboys have seen Dak Prescott look merely average over the last few games, but he does have all of his offensive weapons healthy and matches up well against the Football Team. Washington’s run defense is one of the league’s best, but the secondary is exploitable. Prescott has a 7-1 career record versus Washington as well and has been a much better performer at home.

Dallas has already seen its original projected advantage of 9 points grow to double digits early in the week.

Monday, December 27

Miami Dolphins at New Orleans Saints – 8:15 p.m. ET

The Dolphins continued their stellar run Sunday, upending the Jets by a 31-24 score for their sixth straight win. The Saints went into Tampa Bay and shut out the defending champions, notching a 9-0 win over the Buccaneers on Sunday night.

Tua Tagovailoa threw a pair of interceptions and struggled to move the ball at times against New York, but the Dolphins offense was partly bailed out by none other than Duke Johnson, who emerged from mothballs to rush for over 100 yards. If Johnson and Myles Gaskin continue to be deployed with effectiveness in tandem, the Fins could have the right formula to succeed further in the postseason, but the prospects are a bit dim for this matchup in particular – New Orleans is yielding just 89.4 rushing yards per home game.

Taysom Hill had plenty of issues getting into a passing rhythm himself against the Bucs, although the matchup was naturally a very difficult one. Hill has thrown for under 200 yards in each of his last two starts, but he, Alvin Kamara and the rest of the offense should have an easier path to success in this interconference clash. Miami’s defense has been exponentially better at home, as it allows an NFL-high 429.2 total yards per road contest.

With both teams still scrapping for a playoff spot in their respective conference, the Saints are unsurprisingly narrow home favorites.

How the spreads are changing

Thanks to a wild few days on the COVID front, this week’s games won’t conclude until a Tuesday night doubleheader, and Week 16 will be upon us a quick 48 hours later when the 49ers and Titans do battle in Tennessee.

Two Christmas Day contests – Browns-Packers and Colts-Cardinals – set up as highly entertaining holiday watching, while Sunday and Monday night feature Rams-Vikings, Bills-Patriots, Steelers-Chiefs, Washington-Cowboys and Dolphins-Saints clashes among the games with postseason implications.

From a betting perspective, the holiday football extravaganza is an interesting mix of potential wire-to-wire affairs and blowouts. As of Sunday night, five games were double-digit spreads, including two that could have bearing on playoff qualifying/seeding. The remaining contests have lines of 7.5 points or less, including six of 3.5 or lower.

With winter weather and injuries/absences wielding a heavy hand at this point of the season, there are no projected totals of 50 points or greater as the week begins, and eight games are projected at under 45 points.

Here we will look at how the NFL Week 16 odds are changing in the days leading up to kickoff. Here first are the lookahead lines.

  • San Francisco 49ers +1 at Tennessee Titans -1
  • Cleveland Browns +6.5 at Green Bay Packers -6.5
  • Indianapolis Colts +4 at Arizona Cardinals -4
  • Buffalo Bills +2 at New England Patriots -2
  • LA Rams -3 at Minnesota Vikings +3
  • Detroit Lions +6 at Atlanta Falcons -6
  • LA Chargers -10.5 at Houston Texans +10.5
  • Jacksonville Jaguars +1 at New York Jets -1
  • Baltimore Ravens +2.5 at Cincinnati Bengals -2.5
  • New York Giants +8.5 at Philadelphia Eagles -8.5
  • Tampa Bay Buccaneers -11 at Carolina Panthers +11
  • Chicago Bears +7 at Seattle Seahawks -7
  • Denver Broncos -1 at Las Vegas Raiders +1
  • Pittsburgh Steelers +9.5 at Kansas City Chiefs -9.5
  • Washington Football Team +9 at Dallas Cowboys -9
  • New Orleans Saints -3 at Miami Dolphins +3

And here are updated NFL Week 16 odds.

  • San Francisco 49ers -3.5 at Tennessee Titans +3.5
  • Cleveland Browns +7.5 at Green Bay Packers -7.5
  • Indianapolis Colts +1.5 at Arizona Cardinals -1.5
  • Buffalo Bills +1 at New England Patriots -1
  • LA Rams -3.5 at Minnesota Vikings +3.5
  • Detroit Lions +6.5 at Atlanta Falcons -6.5
  • LA Chargers -10.5 at Houston Texans +10.5
  • Jacksonville Jaguars +2.5 at New York Jets -2.5
  • Baltimore Ravens +7 at Cincinnati Bengals -7
  • New York Giants +11 at Philadelphia Eagles -11
  • Tampa Bay Buccaneers -10.5 at Carolina Panthers +10.5
  • Chicago Bears +7 at Seattle Seahawks -7
  • Denver Broncos +1 at Las Vegas Raiders -1
  • Pittsburgh Steelers +11.5 at Kansas City Chiefs -11.5
  • Washington Football Team +10 at Dallas Cowboys -10
  • New Orleans Saints +3 at Miami Dolphins -3
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Juan Carlos Blanco

Juan Carlos Blanco has served as a freelance writer for a wide variety of online publications and websites, with an intensive focus on fantasy sports. Juan has provided analysis and comprehensive coverage of the MLB, NBA, NFL, CFL, AAF and AFL while also reporting on news and developments in the daily fantasy sports and online gaming industries.

View all posts by Juan Carlos Blanco